Journal
MOLECULAR MEDICINE REPORTS
Volume 20, Issue 3, Pages 2617-2624Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2019.10511
Keywords
asthma; long non-coding RNAs; gene ontology; mechanisms; pathways
Categories
Funding
- National Natural Science Foundation of China [81804043]
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Asthma, a common but poorly controlled disease, is one of the most serious health problems worldwide; however, the mechanisms underlying the development of asthma remain unknown. Long non-coding RNAs (lncRNAs) and mRNAs serve important roles in the initiation and progression of various diseases. The present study aimed to investigate the role of differentially expressed lncRNAs and mRNAs associated with asthma. Differentially expressed lncRNAs and mRNAs were screened between the expression data of 62 patients with asthma and 43 healthy controls. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to investigate the biological functions and pathways associated with the lncRNAs and mRNAs identified. Protein-protein interaction (PPI) networks were subsequently generated. In addition, lncRNA-mRNA weighted co-expression networks were obtained. In total, 159 differentially expressed lncRNAs and 1,261 mRNAs were identified. GO and KEGG analyses revealed that differentially expressed mRNAs regulated asthma by participating in the 'vascular endothelial (VEGF) signaling pathway', 'oxidative phosphorylation', 'Fc epsilon RI signaling pathway', 'amino sugar and nucleotide sugar metabolism', 'histidine metabolism', 'beta-alanine metabolism' and 'extracellular matrix-receptor interaction' (P<0.05). Furthermore, protein kinase B 1 had the highest connectivity degree in the PPI network, and was significantly enriched in the 'VEGF signaling pathway' and 'Fc epsilon RI signaling pathway'. A total of 8 lncRNAs in the lncRNA-mRNA co-expression network were reported to interact with 52 differentially expressed genes, which were enriched in asthma-associated GO and KEGG pathways. The results obtained in the present study may provide insight into the profile of differentially expressed lncRNAs associated with asthma. The identification of a cluster of dysregulated lncRNAs and mRNAs may serve as a potential therapeutic strategy to reverse the progression of asthma.
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