Article
Biotechnology & Applied Microbiology
Alexandra Carrier, Julien Prunier, William Poisson, Mallorie Trottier-Lavoie, Isabelle Gilbert, Maria Cavedon, Kisun Pokharel, Juha Kantanen, Marco Musiani, Steeve D. Cote, Vicky Albert, Joelle Taillon, Vincent Bourret, Arnaud Droit, Claude Robert
Summary: This study reports the development of a SNP-array for the endangered Rangifer tarandus using a multi-platform sequencing approach. A total of 63,336 SNPs were selected from a comprehensive catalog of SNPs detected in diverse populations. This SNP-array design allows for the assessment of genetic metrics related to population structure, inbreeding, and sex determination, and is of great importance for conservation planning.
Article
Genetics & Heredity
Tianyu Deng, Pengfei Zhang, Dorian Garrick, Huijiang Gao, Lixian Wang, Fuping Zhao
Summary: Genotype imputation is a crucial step prior to genome-wide association studies or genomic predictions, and its accuracy is influenced by several factors. This simulation-based study investigated the impact of factors such as target marker proportion, SNP density, genetic relationship, and imputation method. Results revealed that target marker proportion or SNP density had the greatest effect on imputation accuracy. Beagle5.1 outperformed Minimac4 in most cases, particularly when imputing from low-coverage whole-genome sequencing data. Overall, low-coverage whole-genome sequencing provided more accurate imputation compared to SNP chip data.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Christopher James O'Grady, Vignesh Dhandapani, John K. Colbourne, Dagmar Frisch
Summary: Whole genome sequencing is crucial for studying genome variation in natural populations, and large dormant eggbanks of aquatic invertebrates provide valuable information on genomic processes over centuries. An optimized workflow for whole genome amplification (WGA) has been developed to address limited DNA amounts in single eggs, allowing successful downstream whole genome sequencing of historical eggs. Comparison of two WGA kits showed high genome coverage breadth in samples, with high recovery of genomic positions with single nucleotide polymorphisms for genotyping, and even obtaining 100% coverage of mitochondrial genomes from the oldest isolates. Mitochondrial DNA serves as an additional source for evolutionary studies of these populations.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Biochemistry & Molecular Biology
Stella Huynh, Alison Cloutier, Simon Yung Wa Sin
Summary: Natural history collections provide valuable specimens for ecological and evolutionary studies. In this study, low-coverage whole genome sequencing was applied to historical and modern parrot specimens to analyze their phylogenomic relationships and population genomics. The results revealed the colonization and dispersal history of Agapornis parrots and identified parental origins of hybrid individuals.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2023)
Article
Biochemistry & Molecular Biology
Runyang Nicolas Lou, Nina Overgaard Therkildsen
Summary: The study compares two batches of low-coverage whole genome sequencing data from the same Atlantic cod populations, showing how batch effects can bias genetic diversity estimates and population structure inference. The analysis reveals that technical differences, such as sequencing chemistry and read type, contribute to batch effects, highlighting the importance of detecting and mitigating these effects in population genomics studies.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Genetics & Heredity
Vylyny Chat, Robert Ferguson, Leah Morales, Tomas Kirchhoff
Summary: Ultra low-coverage whole-genome sequencing (ulcWGS) has shown comparable or superior performance to traditional genotyping arrays in genotype accuracy, with lower cost. It is considered an attractive alternative in next-generation GWAS design.
FRONTIERS IN GENETICS
(2022)
Article
Evolutionary Biology
Jennifer C. C. Nascimento-Schulze, Tim P. P. Bean, Carolina Penaloza, Josephine R. R. Paris, James R. R. Whiting, Alexis Simon, Bonnie A. A. Fraser, Ross D. D. Houston, Nicolas Bierne, Robert P. P. Ellis
Summary: This study developed a multi species medium-density 60K SNP-array for genotyping genetic diversity in the genus Mytilus. It provides a useful tool for investigating ecological and evolutionary processes in these species, as well as for shellfish aquaculture applications such as genetic selection, parentage assignment, inbreeding assessment, and traceability.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Anthony J. Silva, Zhihui Yang, Julia Wolfe, Kirsten A. Hirneisen, Shannon B. Ruelle, Angelica Torres, Donna Williams-Hill, Michael Kulka, Rosalee S. Hellberg
Summary: This study compared the ability of whole-genome sequencing (WGS) and Sanger sequencing to differentiate norovirus strains, showing that WGS enables better genetic differentiation of strains and provides valuable information for outbreak investigation and surveillance efforts.
Article
Medicine, Research & Experimental
Ming Chen, Pengqiang Zhong, Mengzhi Hong, Jinfeng Tan, Xuegao Yu, Hao Huang, Juan Ouyang, Xiaoping Lin, Peisong Chen
Summary: In this study, low coverage whole genome sequencing (LCWGS) was used to detect suspicious pelvic masses for ovarian cancer, showing high diagnostic value and complementarity with traditional diagnostic methods. The results suggest that LCWGS could be a promising tool for the identification of ovarian cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Cameron M. Nugent, Tony Kess, Matthew K. Brachmann, Barbara L. Langille, Steven J. Duffy, Sarah J. Lehnert, Brendan F. Wringe, Paul Bentzen, Ian R. Bradbury
Summary: Despite the absence of physical barriers and the presence of pelagic stages in many marine taxa, environmental variation is widely recognized as a significant factor driving diversity in marine species. However, understanding the genomic and ecological processes that shape populations remains inadequate for most marine species, which often hinders management and conservation efforts.
Review
Veterinary Sciences
Hanka Brangsch, Harisankar Singha, Karine Laroucau, Mandy Elschner
Summary: Although glanders has been eradicated in most developed countries, it still persists in various countries, causing economic losses to the equine industry. The genetic diversity and global distribution of the causing agent, Burkholderia (B.) mallei, have not been fully assessed due to its high clonality. PCR-based methods and genotyping using tandem repeat regions are established for distinguishing and typing B. mallei. The development of sequencing techniques enables the use of whole genome sequencing data for higher genomic resolution, but the high GC content of B. mallei limits obtaining complete genomic sequences.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Halina Binde Doria, Pauline Hannappel, Markus Pfenninger
Summary: This study investigated the evolutionary adaptation and genomic basis of increased tolerance in Chironomus riparius to cadmium exposure. The results showed a strong genome-wide selective response in all replicates, with pathways related to microtubules and organelles and cellular movement being specifically selected by cadmium exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Wentao Gong, Xiangchun Pan, Dantong Xu, Guanyu Ji, Yifei Wang, Yuhan Tian, Jiali Cai, Jiaqi Li, Zhe Zhang, Xiaolong Yuan
Summary: Whole genome bisulfite sequencing is crucial for methylome studies. This study evaluated the performance of 14 commonly used alignment algorithms for WGBS in multiple mammals and found that the choice of algorithm significantly impacts CpG site counts, methylation levels, and the calling of differentially methylated regions. BSMAP showed the highest accuracy in detecting CpG coordinates and methylation levels.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yann X. C. Bourgeois, Ben H. Warren
Summary: The continuous improvement of high-throughput sequencing techniques has enabled the production of whole genome data in various species, which in turn provides better tools for integrating selection into historical frameworks. However, the plethora of analytical tools may confuse users and hinder the dissemination of the latest methods.
Article
Veterinary Sciences
Nick Vereecke, Arlette Vandekerckhove, Sebastiaan Theuns, Freddy Haesebrouck, Filip Boyen
Summary: In this study, different methods were used to analyze Actinobacillus equuli in horses and new information was obtained through long-read WGS technology. The molecular characteristics of Actinobacillus and its antimicrobial resistance were revealed. These findings provide important new insights into the identification, virulence gene typing, and antimicrobial resistance of equine Actinobacillus species.
VETERINARY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fergal J. Martin, M. Ridwan Amode, Alisha Aneja, Olanrewaju Austine-Orimoloye, Andrey G. Azov, If Barnes, Arne Becker, Ruth Bennett, Andrew Berry, Jyothish Bhai, Simarpreet Kaur Bhurji, Alexandra Bignell, Sanjay Boddu, Paulo R. Branco Lins, Lucy Brooks, Shashank Budhanuru Ramaraju, Mehrnaz Charkhchi, Alexander Cockburn, Luca Da Rin Fiorretto, Claire Davidson, Kamalkumar Dodiya, Sarah Donaldson, Bilal El Houdaigui, Tamara El Naboulsi, Reham Fatima, Carlos Garcia Giron, Thiago Genez, Gurpreet S. Ghattaoraya, Jose Gonzalez Martinez, Cristi Guijarro, Matthew Hardy, Zoe Hollis, Thibaut Hourlier, Toby Hunt, Mike Kay, Vinay Kaykala, Tuan Le, Diana Lemos, Diego Marques-Coelho, Jose Carlos Marugan, Gabriela Alejandra Merino, Louisse Paola Mirabueno, Aleena Mushtaq, Syed Nakib Hossain, Denye N. Ogeh, Manoj Pandian Sakthivel, Anne Parker, Malcolm Perry, Ivana Pilizota, Irina Prosovetskaia, Jose G. Perez-Silva, Ahamed Imran Abdul Salam, Nuno Saraiva-Agostinho, Helen Schuilenburg, Dan Sheppard, Swati Sinha, Botond Sipos, William Stark, Emily Steed, Ranjit Sukumaran, Dulika Sumathipala, Marie-Marthe Suner, Likhitha Surapaneni, Kyosti Sutinen, Michal Szpak, Francesca Floriana Tricomi, David Urbina-Gomez, Andres Veidenberg, Thomas A. Walsh, Brandon Walts, Elizabeth Wass, Natalie Willhoft, Jamie Allen, Jorge Alvarez-Jarreta, Marc Chakiachvili, Bethany Flint, Stefano Giorgetti, Leanne Haggerty, Garth R. Ilsley, Jane E. Loveland, Benjamin Moore, Jonathan M. Mudge, John Tate, David Thybert, Stephen J. Trevanion, Andrea Winterbottom, Adam Frankish, Sarah E. Hunt, Magali Ruffier, Fiona Cunningham, Sarah Dyer, Robert D. Finn, Kevin L. Howe, Peter W. Harrison, Andrew D. Yates, Paul Flicek
Summary: Ensembl has been providing high-quality genomic resources for vertebrates and model organisms for over 20 years. With the increase in high-quality reference genomes and the development of pangenome representations, Ensembl aims to support downstream research by creating high-quality annotations, tools, and services for species across the tree of life. This report highlights Ensembl's resources for popular reference genomes, the growing annotations, updates to the Variant Effect Predictor, protein structure predictions, and the beta release of their new website.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Amr Kchikich, Nathalie Kirschvink, Sara El Kadili, Marianne Raes, Samira El Otmani, Youssef Chebli, Jean-Loup Bister, Bouchra El Amiri, Said Barrijal, Mouad Chentouf
Summary: This study investigated the effects of Origanum majorana essential oil on the quality of post-thawed Beni Arouss buck semen. The results showed that the addition of 0.02% OM essential oil improved all semen quality parameters.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Biochemistry & Molecular Biology
Dominic J. Barker, Giuseppe Maccari, Xenia Georgiou, Michael A. Cooper, Paul Flicek, James Robinson, Steven G. E. Marsh
Summary: The IPD-IMGT/HLA Database is a searchable repository of highly curated HLA sequences for the HLA community. With the adoption of Next Generation Sequencing technology, the database has grown in size, prompting the development of tools for enhanced user experience and programmatic access.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Adam Frankish, Silvia Carbonell-Sala, Mark Diekhans, Irwin Jungreis, Jane E. Loveland, Jonathan M. Mudge, Cristina Sisu, James C. Wright, Carme Arnan, If Barnes, Abhimanyu Banerjee, Ruth Bennett, Andrew Berry, Alexandra Bignell, Carles Boix, Ferriol Calvet, Daniel Cerdan-Velez, Fiona Cunningham, Claire Davidson, Sarah Donaldson, Cagatay Dursun, Reham Fatima, Stefano Giorgetti, Carlos Garcia Giron, Jose Manuel Gonzalez, Matthew Hardy, Peter W. Harrison, Thibaut Hourlier, Zoe Hollis, Toby Hunt, Benjamin James, Yunzhe Jiang, Rory Johnson, Mike Kay, Julien Lagarde, Fergal J. Martin, Laura Martinez Gomez, Surag Nair, Pengyu Ni, Fernando Pozo, Vivek Ramalingam, Magali Ruffier, Bianca M. Schmitt, Jacob M. Schreiber, Emily Steed, Marie-Marthe Suner, Dulika Sumathipala, Irina Sycheva, Barbara Uszczynska-Ratajczak, Elizabeth Wass, Yucheng T. Yang, Andrew Yates, Zahoor Zafrulla, Jyoti S. Choudhary, Mark Gerstein, Roderic Guigo, Tim J. P. Hubbard, Manolis Kellis, Anshul Kundaje, Benedict Paten, Michael L. Tress, Paul Flicek
Summary: GENCODE provides high quality gene and transcript annotation for the human and mouse genomes, supported by experimental data, serving as a reference for genome biology and clinical genomics. The consortium generates data, develops tools and carries out analyses to support the identification and annotation of transcript structures and their function.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Genetics & Heredity
Ines Carvalho Leonardo, Adriana Alberti, France Denoeud, Maria Teresa Barreto Crespo, Jorge Capelo, Frederic Bustos Gaspar
Summary: This study describes the complete chloroplast genome of Centaurium erythraea subsp. majus, the first available plastome belonging to the Centaurium genus. The genome is 153,107 bp long and contains 129 genes, including tRNA, rRNA, and protein-coding genes. Phylogenetic analysis supports the placement of this subspecies under the Gentianaceae family and provides evidence for lineage divergence within the family. This study is important for conservation, phylogenetic and evolutionary studies, and DNA barcoding applications for food, feed, and supplements safety.
MITOCHONDRIAL DNA PART B-RESOURCES
(2023)
Article
Environmental Studies
Youssef Chebli, Mouad Chentouf, Jean-Francois Cabaraux, Samira El Otmani
Summary: The aim of this study was to investigate the floristic composition, lifespan, life forms, phytogeographic relationships, palatability degree, and forage availability of forest rangelands in Northern Morocco. A total of 358 taxa were recorded, belonging to 228 genera and 66 families. The flora was dominated by Asteraceae, Fabaceae, Poaceae, and Lamiaceae families. The palatable plant group was highly represented with 32 species, and 93% of the identified taxa were evaluated as potential sources of forage. Forest rangelands have a high biodiversity and require rigorous protection to preserve their floristic composition and diversity.
Article
Environmental Sciences
C. Staentzel, O. Schlumberger, A. Barillier, A. Valentini, F. Boyer, J. -N. Beisel
Summary: Habitat changes induced by restoration can promote invasive species, potentially hindering the success of restoration projects. In this study, the effects of the invasive round goby on a restored site along the Old Rhine River were examined. The round goby dominated the overall goby assemblage and its presence led to changes in the food web structure and species interactions. However, its impact on macroinvertebrates six years after restoration was unlikely to mask the restoration consequences.
Article
Chemistry, Applied
Saad Salhi, Mouad Chentouf, Hasnaa Harrak, Abdellatif Rahim, Cansel Cakir, Dilaycan cam, Mehmet Ozturk, Naima Hamidallah, Jean-Francois Cabaraux, Bouchra El Amiri
Summary: This study evaluated the physicochemical and phytochemical parameters, biological activities, and nutritional value of pure date palm pollen and date palm pollen crushed with its spadix. Pure date palm pollen had higher humidity, water activity, and lightness (L*) than date palm pollen crushed with its spadix, but lower total soluble solids and ash contents. Pure date palm pollen exhibited higher antioxidant activity, while date palm pollen crushed with its spadix showed higher enzyme inhibitory and antidiabetic activities. Pure date palm pollen was a rich source of proteins, carbohydrates, minerals, and saturated fatty acids, while date palm pollen crushed with its spadix was a better source of unsaturated fatty acids, mainly linoleic acid. In conclusion, pure date palm pollen has higher nutritional value and can be a valuable supplement for various health applications.
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL
(2023)
Article
Agriculture, Dairy & Animal Science
Anass Ben Moula, Abdellatif Rahim, Mouad Chentouf, Marianne Raes, Nathalie Kirschvink, Bouchra El Amiri
Summary: The aim of this study was to investigate the effect of Spirulina platensis (SP) and Salvia verbenaca (SV) extracts added to skimmed milk (SM) extender on ram sperm quality and fertility. The study found that the selected extracts maintained sperm quality parameters during 24 hours of storage at 4℃. The results showed that SP and SV extracts improved the quality of ram sperm and maintained fertility rate after insemination.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Cell Biology
Kevin M. Andre, Nathalie Giordanengo Aiach, Veronica Martinez-Fernandez, Leo Zeitler, Adriana Alberti, Arach Goldar, Michel Werner, Cyril Denby Wilkes, Julie Soutourina
Summary: Chromatin organization is crucial for transcriptional regulation. Mediator and RSC contribute to chromatin remodeling and transcriptional regulation by establishing physical contact and coordinating their functions.
Article
Genetics & Heredity
Ines Carvalho Leonardo, Adriana Alberti, France Denoeud, Maria Teresa Barreto Crespo, Jorge Capelo, Frederic Bustos Gaspar
Summary: This study presents the complete chloroplast genome of Glandora prostrata subsp. lusitanica, the first of its kind for the Glandora genus. The genome is 150,041 bp long with a GC content of 37.5% and displays a quadripartite structure. It contains 131 annotated genes and phylogenetic analysis confirms its placement under the Boraginaceae family. This research will contribute to the conservation, phylogenetic, and evolutionary studies of this traditional species relevant to aromatic, medicinal, and condiment plants from Portugal.
MITOCHONDRIAL DNA PART B-RESOURCES
(2023)
Article
Multidisciplinary Sciences
Arang Rhie, Sergey Nurk, Monika Cechova, Savannah J. Hoyt, Dylan J. Taylor, Nicolas Altemose, Paul W. Hook, Sergey Koren, Mikko Rautiainen, Ivan A. Alexandrov, Jamie Allen, Mobin Asri, Andrey V. Bzikadze, Nae-Chyun Chen, Chen-Shan Chin, Mark Diekhans, Paul Flicek, Giulio Formenti, Arkarachai Fungtammasan, Carlos Garcia Giron, Erik Garrison, Ariel Gershman, Jennifer L. Gerton, Patrick G. S. Grady, Andrea Guarracino, Leanne Haggerty, Reza Halabian, Nancy F. Hansen, Robert Harris, Gabrielle A. Hartley, William T. Harvey, Marina Haukness, Jakob Heinz, Thibaut Hourlier, Robert M. Hubley, Sarah E. Hunt, Stephen Hwang, Miten Jain, Rupesh K. Kesharwani, Alexandra P. Lewis, Heng Li, Glennis A. Logsdon, Julian K. Lucas, Wojciech Makalowski, Christopher Markovic, Fergal J. Martin, Ann M. Mc Cartney, Rajiv C. Mccoy, Jennifer Mcdaniel, Brandy M. Mcnulty, Paul Medvedev, Alla Mikheenko, Katherine M. Munson, Terence D. Murphy, Hugh E. Olsen, Nathan D. Olson, Luis F. Paulin, David Porubsky, Tamara Potapova, Fedor Ryabov, Steven L. Salzberg, Michael E. G. Sauria, Fritz J. Sedlazeck, Kishwar Shafin, Valery A. Shepelev, Alaina Shumate, Jessica M. Storer, Likhitha Surapaneni, Angela M. Taravella Oill, Francoise Thibaud-Nissen, Winston Timp, Marta Tomaszkiewicz, Mitchell R. Vollger, Brian P. Walenz, Allison C. Watwood, Matthias H. Weissensteiner, Aaron M. Wenger, Melissa A. Wilson, Samantha Zarate, Yiming Zhu, Justin M. Zook, Evan E. Eichler, Rachel J. O'Neill, Michael C. Schatz, Karen H. Miga, Kateryna D. Makova, Adam M. Phillippy
Summary: The Telomere-to-Telomere (T2T) consortium presents the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y), which corrects errors in the reference sequence and adds additional sequence information. This new reference sequence provides a comprehensive view of the Y chromosome and contributes to the complete understanding of the human genome.
Article
Multidisciplinary Sciences
S. Boukrouh, A. Noutfia, N. Moula, C. Avril, J. Louvieaux, J. L. Hornick, M. Chentouf, J. F. Cabaraux
Summary: This study aimed to assess the agro-morphology and nutritional value of Sulla flexuosa (L.) Medik. ecotypes in Northern Morocco. The seeds of 21 wild ecotypes were collected and cultivated for two years. Statistical analysis revealed significant variability between the ecotypes, and four groups were identified based on nutritional parameters, forage production, and reproduction. Ecotype 1 showed high productivity and nutritional value, while ecotype 4 was suitable for haymaking.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Bruno Contreras-Moreira, Shradha Saraf, Guy Naamati, Ana M. Casas, Sandeep S. Amberkar, Paul Flicek, Andrew R. Jones, Sarah Dyer
Summary: This study proposes a crop pangenome approach using individual cultivar assemblies to access conserved genes more easily. However, the variability in genome content and inconsistent identifiers have hindered exploration. To overcome these challenges, the concept of pangenes is introduced to summarize a species coding potential and link back to original annotations. The protocol get_pangenes utilizes whole genome alignments to identify syntenic gene models based on coordinate overlaps. Benchmark tests with both small and large plant genomes demonstrate that pangenes accurately recapitulate phylogeny-based orthologies and generate complete soft-core gene sets.
Article
Multidisciplinary Sciences
Arang Rhie, Sergey Nurk, Monika Cechova, Savannah J. Hoyt, Dylan J. Taylor, Nicolas Altemose, Paul W. Hook, Sergey Koren, Mikko Rautiainen, Ivan A. Alexandrov, Jamie Allen, Mobin Asri, Andrey V. Bzikadze, Nae-Chyun Chen, Chen-Shan Chin, Mark Diekhans, Paul Flicek, Giulio Formenti, Arkarachai Fungtammasan, Carlos Garcia Giron, Erik Garrison, Ariel Gershman, Jennifer L. Gerton, Patrick G. S. Grady, Andrea Guarracino, Leanne Haggerty, Reza Halabian, Nancy F. Hansen, Robert Harris, Gabrielle A. Hartley, William T. Harvey, Marina Haukness, Jakob Heinz, Thibaut Hourlier, Robert M. Hubley, Sarah E. Hunt, Stephen Hwang, Miten Jain, Rupesh K. Kesharwani, Alexandra P. Lewis, Heng Li, Glennis A. Logsdon, Julian K. Lucas, Wojciech Makalowski, Christopher Markovic, Fergal J. Martin, Ann M. Mc Cartney, Rajiv C. Mccoy, Jennifer Mcdaniel, Brandy M. Mcnulty, Paul Medvedev, Alla Mikheenko, Katherine M. Munson, Terence D. Murphy, Hugh E. Olsen, Nathan D. Olson, Luis F. Paulin, David Porubsky, Tamara Potapova, Fedor Ryabov, Steven L. Salzberg, Michael E. G. Sauria, Fritz J. Sedlazeck, Kishwar Shafin, Valery A. Shepelev, Alaina Shumate, Jessica M. Storer, Likhitha Surapaneni, Angela M. Taravella Oill, Francoise Thibaud-Nissen, Winston Timp, Marta Tomaszkiewicz, Mitchell R. Vollger, Brian P. Walenz, Allison C. Watwood, Matthias H. Weissensteiner, Aaron M. Wenger, Melissa A. Wilson, Samantha Zarate, Yiming Zhu, Justin M. Zook, Evan E. Eichler, Rachel J. O'Neill, Michael C. Schatz, Karen H. Miga, Kateryna D. Makova, Adam M. Phillippy
Summary: The Telomere-to-Telomere (T2T) consortium presents the complete sequence of a human Y chromosome from the HG002 genome, correcting errors in the reference sequence and adding additional base pairs. This comprehensive reference sequence provides valuable insights into the structure and function of the Y chromosome.