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Medicine, Research & Experimental
Yaozhen Pan, Lei Zhan, Ling Chen, Liwen Chen, Chengyi Sun
Summary: The study shows that the highly expressed miR-660 in liver cancer promotes cell proliferation by targeting PPP2R2A, and regulates cell proliferation by controlling cell cycle progression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Jie Ling Zhang, Hui Fen Zheng, Kai Li, Yi Ping Zhu
Summary: This study investigates the role of miR-495-3p and HMGB1 in colorectal cancer (CRC). The findings suggest that miR-495-3p inhibits the progression of CRC by downregulating HMGB1 expression, indicating its potential as a therapeutic target for CRC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
Yang Bai, Ling Li, Zhiyong Zhang
Summary: This study found that Linc00883 plays a promoting role in the proliferation, invasion, and migration of colorectal cancer cells, and this function is achieved through regulating the miR-577/FKBP14 axis.
Article
Pathology
Cuifeng Xia, Qiang Li, Xianshuo Cheng, Tao Wu, Pin Gao
Summary: miR-4323, a downregulated miRNA in colorectal cancer, decreases cell proliferation rate and induces apoptosis, thereby inactivating the Wnt signaling pathway. It targets the anti-apoptotic protein HDGF, providing a potential therapeutic target for colorectal cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Qingan Jia, Xia Liao, Binghui Xu, Yufang Li, Lei Liang
Summary: This study aimed to investigate the level and function of miR-128-1-5p in colorectal cancer (CRC). The results showed that miR-128-1-5p was downregulated in CRC tissues and cell lines, and it inhibited cell proliferation and induced cell apoptosis by targeting PRKCQ.
CANCER BIOLOGY & THERAPY
(2023)
Article
Medicine, Research & Experimental
Lin Zhou, Jian Li, Yaping Tang, Mei Yang
Summary: The study revealed that exosomal LINC00659 derived from CAFs promotes CRC cell proliferation, invasion, and migration through the miR-342-3p/ANXA2 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Renjie Cui, Nan Jiang, Meiqin Zhang, Sichen Du, Huayuan Ou, Runsheng Ge, Duan Ma, Jin Zhang
Summary: This study demonstrates that AMOTL2 and PPP2R2A act as negative and positive regulators of cell growth in NSCLC cells respectively, functioning in the AMOTL2-PPP2R2A-JUN axis to control cell proliferation by modulating phosphorylation of JUN at the T239 site.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hai-rong Zhang, Shi-yong Wu, Zhong-xue Fu
Summary: The study demonstrated that lncRNA-cCSC1 promotes cell proliferation in colorectal cancer by interacting with miR-124-3p and upregulating the expression of CD44.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Bin Xuan, Yimin Wang
Summary: Exosome-mediated transfer of miR-506-3p reduces proliferation and induces apoptosis in colorectal cancer (CRC) through negative regulation of GSTP1, providing fresh insight into CRC diagnostics and treatment.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Guoqing Gu, Chenxi Hu, Kaiyuan Hui, Huiqin Zhang, Ting Chen, Xin Zhang, Xiaodong Jiang
Summary: This study revealed that high levels of plasma exosomal miR-136-5p are associated with poor clinical response to anlotinib. Anlotinib-resistant NSCLC cells transfer functional miR-136-5p to parental NSCLC cells via exosomes, promoting cell proliferation. Furthermore, miR-136-5p confers anlotinib resistance by targeting PPP2R2A and activating the Akt pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Oncology
Lin Chen, Wei Chen, Changjie Zhao, Qi Jiang
Summary: The study found that LINC01224 was up-regulated in CRC tissues and cells, promoting CRC progression through sponging miR-2467, and may serve as a potential diagnostic biomarker and therapeutic target for CRC patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Kai Li, Jieling Zhang, Mingkang Zhang, Yaohua Wu, Xinyu Lu, Yiping Zhu
Summary: The study revealed that miR-378a-5p is downregulated in colorectal cancer and acts as a tumor suppressor, targeting CDK1 to inhibit CRC cell proliferation.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hongwei Fan, Rong Ai, Suen Mu, Xuemin Niu, Zhengrong Guo, Lin Liu
Summary: Research has found that miR-19a promotes the proliferation, migration, and invasion of colorectal cancer cells. It has been discovered that miR-19a suppresses ferroptosis by negatively regulating IREB2. This finding reveals a novel mechanism of miR-19a-mediated ferroptosis in CRC.
Article
Medicine, Research & Experimental
Tae Won Kim, Haein Ji, Nak Hyeon Yun, Chang Hoon Shin, Hyeon Ho Kim, Yong Beom Cho
Summary: This study identified AFAP1-AS1 and MLK7-AS1 as ceRNAs that promote the progression of colorectal cancer by reducing the levels of tumor-suppressing miRNAs miR-149-5p and miR-485-5p.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biochemistry & Molecular Biology
Xiaodong Zhang, Yi Yang, Weiguang Zhang, Kaixin Huang, Lingsha Xu, Numan Shahid, Yifei Pan, Chengle Xu, Xueli Jiao, Kai Yang
Summary: This study identified the down-regulation of miR-1538 in colorectal cancer (CRC) tissues and cells, and its correlation with tumor size, clinical stage, and prognosis. Functional experiments showed that miR-1538 decreased the protein level of DNMT3A and inhibited the proliferation, migration, and invasion of CRC cells by targeting the 30-UTR of DNMT3A mRNA.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)