Article
Critical Care Medicine
Nina A. Thomas, Ralph Ward, Nichole T. Tanner, Alana M. Rojewski, Benjamin Toll, Mulugeta Gebregziabher, Gerard A. Silvestri
Summary: In a secondary analysis of the NLST arm of the American College of Radiology Imaging Network, it was found that only a quarter of lung cancer screening patients received pharmacologic therapy for smoking cessation, and those who did receive treatment were more likely to attempt to quit. Patients with high nicotine dependence benefited most from dual pharmacologic therapy.
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Review
Oncology
Dana Moldovanu, Harry J. de Koning, Carlijn M. van der Aalst
Summary: Randomized-controlled trials have shown that low-dose computed tomography screening can reduce lung cancer mortality, but evidence on integrating smoking cessation support is lacking. Combining lung cancer screening with smoking cessation can significantly reduce mortality risk. Multi-modality interventions delivered by clinicians may be the most successful in influencing smoking behavior.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Randi M. Williams, Marisa Cordon, Ellie Eyestone, Laney Smith, George Luta, Brady J. McKee, Shawn M. Regis, David B. Abrams, Raymond S. Niaura, Cassandra A. Stanton, Vicky Parikh, Kathryn L. Taylor
Summary: This study found that lung cancer screening could serve as a teachable moment for smoking cessation, with individuals who were extremely worried about lung cancer being more motivated to quit smoking and more ready to quit within the next 30 days.
Article
Critical Care Medicine
Jane Turner, Gregory R. Pond, Alain Tremblay, Michael Johnston, Glen Goss, Garth Nicholas, Simon Martel, Rick Bhatia, Geoffrey Liu, Heidi Schmidt, Martin C. Tammemagi, Serge Puksa, Sukhinder Atkar-Khattra, Ming-Sound Tsao, Stephen Lam, John R. Goffin
Summary: The study found that perceived lung cancer risk was positively associated with calculated risk, but not consistently related to worry. Factors such as younger age and family history were associated with higher risk perception, as well as with lung cancer worry and reported intent to quit smoking. Promotion of screening programs may benefit from focusing on factors associated with higher risk perception.
Article
Oncology
Ugo Pastorino, Vito Ladisa, Sara Trussardo, Federica Sabia, Luigi Rolli, Camilla Valsecchi, Roberta E. Ledda, Gianluca Milanese, Paola Suatoni, Mattia Boeri, Gabriella Sozzi, Alfonso Marchiano, Elena Munarini, Roberto Boffi, Silvano Gallus, Giovanni Apolone
Summary: Cytisine, combined with counseling, is an effective and safe medication for smoking cessation, as demonstrated by a study in Italy. It significantly increases the quit rate and can be used to improve lung cancer screening outcomes.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Steven S. Fu, Alexander J. Rothman, David M. Vock, Bruce R. Lindgren, Daniel Almirall, Abbie Begnaud, Anne C. Melzer, Kelsey L. Schertz, Mariah Branson, David Haynes, Patrick Hammett, Anne M. Joseph
Summary: Adding a referral to prescription medication therapy management (MTM) to the tobacco longitudinal care (TLC) program showed positive effects among patients eligible for lung cancer screening (LCS) who did not respond to early treatment; however, decreasing the intensity of TLC among early treatment responders did not show significant improvement.
Article
Critical Care Medicine
Jolie Shen, Kristina Crothers, Erin K. Kross, Kaylee Petersen, Anne C. Melzer, Matthew Triplette
Summary: The study found that provision of smoking cessation resources during shared decision-making encounters for lung cancer screening was moderate overall, but lower in patients with more comorbidities or when not conducted by the primary care provider or specialist. Interventions are needed to improve smoking cessation counseling and resource utilization during LCS encounters.
Article
Critical Care Medicine
Kristie L. Foley, Emily V. Dressler, Kathryn E. Weaver, Erin L. Sutfin, David P. Miller Jr, Christina Bellinger, Carol Kittel, Rebecca J. Stone, W. Jeffrey Petty, Stephanie R. Land, John G. Spangler, Glenn J. Lesser, Caroline Chiles
Summary: This study explores how to implement effective tobacco use treatment during lung cancer screening. Although there was a significant reduction in tobacco use over time, there was no difference between the intervention and control groups.
Review
Oncology
Saverio Caini, Marco Del Riccio, Virginia Vettori, Vieri Scotti, Chiara Martinoli, Sara Raimondi, Giulio Cammarata, Domenico Palli, Marco Banini, Giovanna Masala, Sara Gandini
Summary: This study summarized the current scientific evidence on the impact of quitting smoking at or around diagnosis on the survival of lung cancer (LC) patients. The results showed that quitting smoking at or around diagnosis is significantly associated with improved overall survival among LC patients, regardless of the histological type of LC. Therefore, treating physicians should educate patients about the benefits of quitting smoking and provide them with the necessary support for smoking cessation.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Respiratory System
Parris J. Williams, Keir E. J. Philip, Sara C. Buttery, Alexis Perkins, Ley Chan, Emily C. Bartlett, Anand Devaraj, Samuel Kemp, James Addis, Jane Derbyshire, Michelle Chen, Michael Polkey, Anthony A. Laverty, Nicholas S. Hopkinson
Summary: Immediate smoking cessation support provided during lung health checks increases long-term quit rates and quit attempts.
Article
Oncology
William K. Evans, Martin C. Tammemagi, Meghan J. Walker, Erin Cameron, Yvonne W. Leung, Sara Ashton, Julie de Loe, Wanda Doyle, Chantal Bornais, Ellen Allie, Koop Alkema, Caroline A. Bravo, Caitlin McGarry, Michelle Rey, Rebecca Truscott, Gail Darling, Linda Rabeneck
Summary: This study assessed the impact of integrating smoking cessation services into the Pilot program. It observed the rate of acceptance of smoking cessation referral, the quit rate at 1 year, and changes in smoking behaviors among participants.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Medicine, General & Internal
Rafael Meza, Jihyoun Jeon, Iakovos Toumazis, Kevin ten Haaf, Pianpian Cao, Mehrad Bastani, Summer S. Han, Erik F. Blom, Daniel E. Jonas, Eric J. Feuer, Sylvia K. Plevritis, Harry J. de Koning, Chung Yin Kong
Summary: The study modeled the benefits and harms of LDCT screening for lung cancer, finding that starting at age 50 or 55 with a smoking history of 20 pack-years or more had more benefits compared to the 2013 USPSTF recommendations, but also resulted in more false-positive results, overdiagnosed cases, and radiation-related lung cancer deaths.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Public, Environmental & Occupational Health
Rachael L. Murray, Emma O'Dowd
Summary: Despite the decrease in smoking rates since 2000, smoking remains a significant risk factor for premature mortality and lung cancer. Continuing to smoke after a lung cancer diagnosis is associated with increased mortality and tumor recurrence. A recent meta-analysis indicates that quitting smoking around the time of lung cancer diagnosis is associated with improved survival.
LANCET PUBLIC HEALTH
(2023)
Article
Oncology
Silvia Behar Harpaz, Marianne F. Weber, Stephen Wade, Preston J. Ngo, Pavla Vaneckova, Peter E. A. Sarich, Sonya Cressman, Martin C. Tammemagi, Kwun Fong, Henry Marshall, Annette McWilliams, John R. Zalcberg, Michael Caruana, Karen Canfell
Summary: This study assessed the cost-effectiveness of implementing a lung cancer screening program in Australia. The results suggest that lung screening could be cost-effective in certain scenarios, contingent on translating trial results into clinical practice.
BRITISH JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Luz Maria Sanchez-Romero, Christopher J. Cadham, Jana L. Hirschtick, Delvon T. Mattingly, Beomyoung Cho, Nancy L. Fleischer, Andrew Brouwer, Ritesh Mistry, Stephanie R. Land, Jihyoun Jeon, Rafael Meza, David T. Levy
Summary: The prevalence of each tobacco product use varies depending on the survey and frequency threshold adopted, with differences observed between the PATH, NHIS, and TUS-CPS surveys. Different frequency thresholds have a significant impact on the prevalence of other combustibles and e-cigarettes use. The choice of survey and frequency threshold is crucial when monitoring tobacco use patterns.
Review
Oncology
Amy Zhao, Maya Larbi, Kristen Miller, Suzanne O'Neill, Jinani Jayasekera
Summary: The increasing attention on personalized breast cancer care has led to a surge of web-based clinical decision tools. These tools consider patient and tumor characteristics to provide personalized treatment options and outcomes. However, few tools provide information on adverse effects of selected treatments. Future studies should evaluate the feasibility and acceptability of these tools from the perspectives of patients and healthcare providers.
Article
Oncology
Claire C. Conley, Karen J. Wernli, Sarah Knerr, Tengfei Li, Kathleen Leppig, Kelly Ehrlich, David Farrell, Hongyuan Gao, Erin J. A. Bowles, Amanda L. Graham, George Luta, Jinani Jayasekera, Jeanne S. Mandelblatt, Marc D. Schwartz, Suzanne C. O'Neill
Summary: The purpose of this study is to evaluate the direct and indirect effects of a web-based education and decision support tool on intentions for risk-reducing medication and breast MRI among high-risk women. The PMT-informed intervention had no direct effect on intentions, but had significant indirect effects through perceived risk, self-efficacy, and response efficacy.
JOURNAL OF CANCER EDUCATION
(2023)
Review
Health Care Sciences & Services
Christopher J. Cadham, Marie Knoll, Luz Maria Sanchez-Romero, K. Michael Cummings, Clifford E. Douglas, Alex Liber, David Mendez, Rafael Meza, Ritesh Mistry, Aylin Sertkaya, Nargiz Travis, David T. Levy
Summary: The study revealed poor reporting of EE methods in modeling studies, hindering the distinction of meaningful differences in approaches. Improved quality standards for EE would enhance the validity and replicability of computational models.
MEDICAL DECISION MAKING
(2022)
Article
Oncology
Young Chandler, Clyde Schechter, Jinani Jayasekera, Claudine Isaacs, Allison W. Kurian, Christopher Cadham, Jeanne Mandelblatt
Summary: Extending the duration of endocrine therapy from 5 to 10 years modestly improved lifetime breast cancer outcomes, with different absolute benefits for women of different age groups. However, in some patients, the adverse events associated with treatment may outweigh the benefits.
Article
Oncology
Kathryn L. Taylor, Randi M. Williams, Tengfei Li, George Luta, Laney Smith, Kimberly M. Davis, Cassandra Stanton, Raymond Niaura, David Abrams, Tania Lobo, Jeanne Mandelblatt, Jinani Jayasekera, Rafael Meza, Jihyoun Jeon, Pianpian Cao, Eric D. Anderson
Summary: Delivering intensive telephone counseling and nicotine replacement with lung screening is an effective strategy to increase short-term smoking cessation. Methods to maintain short-term effects are needed. Even with modest quit rates, integrating cessation treatment into lung screening programs may have a large impact on tobacco-related mortality.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Environmental Sciences
David T. Levy, Christopher J. Cadham, Yameng Li, Zhe Yuan, Alex C. Liber, Hayoung Oh, Nargiz Travis, Mona Issabakhsh, David T. Sweanor, Luz Maria Sanchez-Romero, Rafael Meza, K. Michael Cummings
Summary: This article presents a public health decision-theoretic framework to examine the impacts of heated tobacco products, nicotine vaping products, and cigarettes on population health. The study shows that the use of heated tobacco products may provide public health benefits for smokers by enabling cessation or discouraging smoking initiation and relapse, but the benefits are reduced when it replaces less harmful nicotine vaping product use. However, the use of heated tobacco products may also negatively impact public health by encouraging non-smokers to smoke or encouraging smoking initiation or relapse. Industry behavior and public policy also play a role in influencing these patterns.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Jinani Jayasekera, Amy Zhao, Clyde Schechter, Kathryn Lowry, Jennifer M. Yeh, Marc D. Schwartz, Suzanne O'Neill, Karen J. Wernli, Natasha Stout, Jeanne Mandelblatt, Allison W. Kurian, Claudine Isaacs
Summary: Recent studies have shown higher than expected rates of recurrence and death in hormone receptor-positive breast cancer. These findings suggest a need to re-evaluate the use of risk-reducing medication in high-risk women.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Jinani Jayasekera, Amy Zhao
Meeting Abstract
Oncology
Jinani Jayasekera, Amy Zhao
Meeting Abstract
Oncology
Jinani Jayasekera, Kathryn P. Lowry, Jennifer M. Yeh, Marc D. Schwartz, Karen J. Wernli, Claudine Isaacs, Allison W. Kurian, Natasha K. Stout
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Jennifer Lee Caswell-Jin, Liyang Sun, Diego Munoz, Ying Lu, Yisheng Li, Hui Huang, John M. Hampton, Juhee Song, Jinani Jayasekera, Clyde Schechter, Oguzhan Alagoz, Natasha K. Stout, Amy Trentham-Dietz, Jeanne S. Mandelblatt, Donald A. Berry, Sandra J. Lee, Xuelin Huang, Allison W. Kurian, Sylvia Plevritis
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
R. Williams, P. Cao, T. Li, G. Luta, L. Smith, J. Mandelblatt, J. Jeon, A. Zhao, D. Levy, K. Davis, C. Stanton, R. Niaura, D. Abrams, T. Lobo, E. Anderson, R. Meza, J. Jayasekera, K. L. Taylor
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Pianpian Cao, Laney Smith, Jeanne S. Mandelblatt, Jihyoun Jeon, Kathryn L. Taylor, Amy Zhao, David T. Levy, Randi M. Williams, Rafael Meza, Jinani Jayasekera
Summary: This study conducted an economic analysis to compare the cost-effectiveness of telephone counseling cessation interventions in lung cancer screening settings. The results showed that telephone-based cessation interventions with nicotine replacement are considered cost-effective in the lung screening setting, and integrating smoking cessation interventions with screening programs can maximize long-term health benefits at reasonable costs.
JNCI CANCER SPECTRUM
(2022)
Article
Substance Abuse
David T. Levy, Christopher J. Cadham, Luz Maria Sanchez-Romero, Marie Knoll, Nargiz Travis, Zhe Yuan, Yameng Li, Ritesh Mistry, Clifford E. Douglas, Jamie Tam, Aylin Sertkaya, Kenneth E. Warner, Rafael Meza
Summary: An expert elicitation was conducted to assess the impact of a menthol cigarette and cigar ban in the United States. The experts estimated that a menthol ban would significantly reduce smoking initiation and combustible tobacco product use among current menthol smokers, leading to many individuals quitting smoking or switching to new nicotine delivery products.
NICOTINE & TOBACCO RESEARCH
(2021)