☆ 4.7 Editorial Material

Digital Oncology Social networks for young patients with cancer: the time for system agility

LANCET ONCOLOGY (2019)

Journal

LANCET ONCOLOGY

Volume 20, Issue 6, Pages 765-765

Publisher

ELSEVIER SCIENCE INC

DOI: 10.1016/S1470-2045(19)30346-8

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Oncology

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Summary: The molecular profile of early-onset colonic cancer is not well-defined. This study analyzed the clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. The results showed that early-onset colonic cancer patients had a higher prevalence of microsatellite instability (MSI) and were associated with family history, proximal colon lesions, and BRAF/KRAS mutations. Compared with older patients with MSI cancers, early-onset patients with MSI tumors had more adverse pathological features.

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Article Surgery

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Summary: This study of 400 patients with early-onset rectal cancer found that 12.5% of patients demonstrated microsatellite instability (MSI), which was associated with reduced likelihood of nodal positivity, increased rate of pathological complete response, and improved disease-specific survival.

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