Article
Medicine, General & Internal
Lubos Kubicek, Radek Vitasek, David Schwarz, Robert Staffa, Petr Strakos, Stanislav Polzer
Summary: Due to the COVID-19 pandemic, many non-urgent surgeries, including the treatment of abdominal aortic aneurysm (AAA), have been postponed. This study aimed to test the clinical applicability of the probabilistic rupture risk index (PRRI) method in a patient cohort study. The results showed that integrating PRRI into clinical workflow is feasible and can significantly decrease the false positive rate in AAA treatment.
Article
Biochemistry & Molecular Biology
Maciej Jusko, Piotr Kasprzak, Alicja Majos, Waclaw Kuczmik
Summary: Individual anatomical differences may play a crucial role in assessing the risk of rupture for abdominal aortic aneurysms, as shown by the study's findings on diameter ratios and their predictive value for small aneurysms with a high risk of rupture. Further validation of these ratios in larger patient groups is needed.
Article
Medicine, General & Internal
Natalia Niklas, Piotr Gutowski, Arkadiusz Kazimierczak, Pawel Rynio
Summary: The current stratification model of aneurysm rupture is inadequate in certain clinical cases. Our study reveals differences in wall structure between ruptured and unruptured aneurysms, with the AFL/ILT surface ratio potentially serving as a predictive factor for aneurysm rupture and symptom occurrence in AAA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Haiyan Lou, Kehui Nie, Jun Yang, Tiesong Zhang, Jincheng Wang, Weijian Fan, Chenjie Gu, Min Yan, Tao Chen, Tingting Zhang, Junxia Min, Renya Zhan, Jianwei Pan
Summary: This study aimed to develop an individualized rupture risk model for small unruptured intracranial aneurysms (IAs) in an eastern Asian population. The nomogram based on clinical and morphological risk factors showed superior diagnostic performance and clinical effectiveness compared to the traditional PHASES score system.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Annika Niemann, Daniel Behme, Naomi Larsen, Bernhard Preim, Sylvia Saalfeld
Summary: This study proposes a pipeline for analyzing intracranial aneurysms using deep learning-based mesh segmentation, automatic centerline and outlet detection, and automatic generation of a semantic vessel graph. It can extract more morphological parameters and classify the rupture state of the aneurysms.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Article
Clinical Neurology
Junlin Lu, Mingtao Li, Jan-Karl Burkhardt, Yuanli Zhao, Youxiang Li, Xiaolin Chen, Yang Zhao, Jizong Zhao
Summary: This study found that unruptured giant intracranial aneurysms require treatment due to their high rupture rate and mortality. Older age, posterior circulation location, and larger size are risk factors for poor prognosis. Both surgical (ST) and endovascular (ET) treatments showed lower mortality rates than conservative treatment (CT), with ET having a higher recurrence rate and lower complication rate than ST.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Computer Science, Interdisciplinary Applications
Stanislav Polzer, Jan Kracik, Tomas Novotny, Lubos Kubicek, Robert Staffa, Madhavan L. Raghavan
Summary: The study proposed a methodology for estimating the annual risk of rupture of abdominal aortic aneurysms using Bayesian statistics, mechanics, and patient-specific data. Considering past survival significantly improved predictions of future risk, and both patient-specific blood pressure variability and growth had important impacts on the estimates.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Medicine, General & Internal
Jang Hun Kim, Jong-Il Choi, Dong-Jun Lim
Summary: This study investigated the predictors of rupture in small PCoA aneurysms (<5 mm) and found that size ratio, aspect ratio, and bleb formation were significantly associated with rupture. In small PCoA aneurysms, the presence of bleb formation and a higher aspect ratio are more often observed in ruptured aneurysms.
Article
Geosciences, Multidisciplinary
Jannes Muenchmeyer, Ulf Leser, Frederik Tilmann
Summary: The duration of ruptures of the largest earthquakes can range from a few seconds to several minutes. Based on our research, early prediction of earthquake size is difficult, as differentiation between differently sized ruptures only occurs once half of the rupture has been observed. The results suggest a universal initiation behavior for small and large ruptures.
GEOPHYSICAL RESEARCH LETTERS
(2022)
Article
Clinical Neurology
Xin Feng, Xin Tong, Fei Peng, Hao Niu, Peng Qi, Jun Lu, Yang Zhao, Weitao Jin, Zhongxue Wu, He Liu, Yuanli Zhao, Aihua Liu, Daming Wang
Summary: The number of coexisting intracranial aneurysms does not increase the risk of rupture for individual aneurysms, but it may increase the risk of SAH in patients with multiple aneurysms, highlighting the significant additive effect on SAH risk.
Article
Clinical Neurology
Yerkin Medetov, Aisha Babi, Yerbol Makhambetov, Karashash Menlibayeva, Torekhan Bex, Assylbek Kaliyev, Serik Akshulakov
Summary: This study has revealed that younger, smoking patients with stage 3 arterial hypertension are at higher risk for RIA. Small aneurysms (< 6 mm) and location on ACA had increased odds of rupture.
Article
Clinical Neurology
Yusong Pei, Zhihua Xu, Guobiao Liang, Hai Jin, Yang Duan, Benqiang Yang, Xinxin Qiao, Hongrui You, Dengxiang Xing
Summary: This study revealed that aneurysm rupture is significantly correlated with carotid artery tortuosity and morphological parameters such as FA and SR. FA, SR, and ECA tortuosity were identified as independent risk factors associated with anterior circulation intracranial aneurysm rupture.
FRONTIERS IN NEUROLOGY
(2021)
Article
Engineering, Biomedical
Konstantinos Garyfallogiannis, Ranjini K. Ramanujam, Rustem I. Litvinov, Tony Yu, Chandrasekaran Nagaswami, John L. Bassani, John W. Weisel, Prashant K. Purohit, Valerie Tutwiler
Summary: Through experiments and simulations, we determined the toughness of plasma clots as a function of fibrin content and found that internal fluid motion significantly contributes to clot toughness. Increasing fibrin content results in increased clot toughness, which can help in understanding and predicting thrombotic embolization.
ACTA BIOMATERIALIA
(2023)
Article
Clinical Neurology
Karl R. Abi-Aad, Rudy J. Rahme, Arjun Syal, Nicole M. De La Pena, Evelyn L. Turcotte, Devi P. Patra, Breck Jones, Brian Chong, Chandan Krishna, Bernard R. Bendok
Summary: In this study, data from 600 patients enrolled in the HEAT trial were analyzed to develop and validate a model for predicting the risk of aneurysmal hemorrhage. Factors such as dome-to-neck ratio, shape, and aneurysm location were found to be associated with an increased risk of hemorrhage.
WORLD NEUROSURGERY
(2023)
Article
Health Care Sciences & Services
Ui Yun Lee, Hyo Sung Kwak
Summary: This study evaluated morphological and hemodynamic factors in assessing the risk of rupture in cerebral aneurysms with a size of >= 7 mm, finding significant correlations between factors like high aspect ratio and low TVR with aneurysm rupture risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Engineering, Biomedical
Adam Wittek, Farah Alkhatib, Radek Vitasek, Stanislav Polzer, Karol Miller
Summary: In this study, two simulation and modelling methods for predicting stress within arterial walls of abdominal aortic aneurysms (AAA) were compared. The non-linear iterative method showed higher peak maximum principal stress and lower stress magnitude in low stress areas compared to the linear method, especially in areas with large AAA curvature. However, both methods performed similarly in distinguishing between AAAs that would rupture and remain intact.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Biophysics
Ondrej Lisicky, Anna Hrubanova, Robert Staffa, Robert Vlachovsky, Jiri Bursa
Summary: In this study, mechanical properties of fibrous tissues of carotid atheroma were investigated through testing 141 specimens harvested from 44 patients. It was found that sex significantly affects stress-strain curves and ultimate strains in females, while loading direction has a significant impact on males.
JOURNAL OF BIOMECHANICS
(2021)
Article
Surgery
Peter Balaz, Slavomir Rokosny, Jiri Herman, Miloslav Pirkl, Robert Vlachovsky, Adam Whitley
Summary: The study aimed to evaluate occlusion rates of saphenous veins treated with the VariClose vein sealing system. Results showed a technical success rate of 94% with a mean follow-up of 5.5 months. Closure rates at 1, 3, 6, and 12 months were 94%, 85%, 69%, and 36% respectively, with no significant differences between centers. The study concluded that the occlusion rates were unexpectedly worse compared to current literature.
Article
Surgery
Tomas Novotny, Robert Staffa, Josef Tomandl, Tomas Krivka, Ondrej Slaby, Lubos Kubicek, Ernest Biros, Marie Tomandlova, Robert Vlachovsky, Jan Sponiar, Lenka Radova, Anna Konieczna
Summary: This study aimed to evaluate the value of L-lactate as a marker for early detection of postoperative intestinal ischemia. The results showed that measuring serum L-lactate levels at proper timepoints might help in the early diagnosis of postoperative intestinal ischemia after aortic surgery.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Michaela Turcanova, Martin Hrton, Petr Dvorak, Kamil Novak, Marketa Hermanova, Zdenek Bednarik, Stanislav Polzer, Jiri Bursa
Summary: The novel method presented in this study utilizes polarized light microscopy to obtain multiple rotated images for accurate and efficient assessment of collagen fiber direction in soft tissues. After validation, the method proved capable of analyzing a large number of pixels in a few seconds, making it a powerful and cost-effective tool for detecting collagen fiber distribution in soft tissues.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Engineering, Biomedical
T. Christian Gasser, Christopher Miller, Stanislav Polzer, Joy Roy
Summary: This article summarizes and critically discusses various modeling approaches for abdominal aortic aneurysm (AAA), as well as reports the outcomes of clinical validation studies on biomechanics-based rupture risk indices. The exploration of AAA wall failure properties and acquisition of robust input data are key areas for further improvement of this technology.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Article
Peripheral Vascular Disease
Tomas Novotny, Robert Staffa, Josef Tomandl, Tomas Krivka, Peter Kruzliak, Marie Tomandlova, Ondrej Slaby, Jan Sponiar, Martin Caprnda, Ludovit Gaspar, Luis Rodrigo, Ioana Mozos, Lubos Kubicek, Ernest Biros, Robert Vlachovsky, Lenka Radova, Anna Konieczna
Summary: This study aimed to explore the perioperative kinetics of procalcitonin (PCT) in patients undergoing aortic surgery and evaluate its ability to detect intestinal ischaemia. The results showed that patients with intestinal ischaemia had higher PCT levels at multiple timepoints postoperatively. The most accurate timepoints for early diagnosis were postoperative day 3, 24 h after vascular reconstruction declamping, and postoperative day 7. However, the specificity of PCT for intestinal ischaemia was low, and the positive predictive value was also low. The main value of PCT is its ability to rule out intestinal ischaemia.
Article
Medical Laboratory Technology
Marie Tomandlova, Tomas Novotny, Robert Staffa, Jindra Smutna, Tomas Krivka, Peter Kruzliak, Ondrej Slaby, Lubos Kubicek, Robert Vlachovsky, Lenka Radova, Josef Tomandl
Summary: This study investigates the perioperative kinetics of D-lactate and ischemia-modified albumin (IMA) and their predictive value in early diagnosis of acute intestinal ischemia. The results suggest that serum levels of IMA and D-lactate can serve as influential predictive markers for postoperative intestinal ischemia, especially after 3 hours from complete declamping of vascular reconstruction.
CLINICAL BIOCHEMISTRY
(2023)
Article
Polymer Science
David Schwarz, Marek Pagac, Josef Petrus, Stanislav Polzer
Summary: This study investigated the effect of moisture on the elastic and failure properties of elastomeric polyurethane. The results showed that moisture had a significant impact on the initial stiffness, while physical aging had an inverse effect on the mechanical properties compared to water immersion. The transition process was completed within 24 hours.
Article
Engineering, Manufacturing
Jan Jansa, Anastasia Volodarskaja, Josef Hlinka, Lucie Zarybnicka, Stanislav Polzer, Martin Kraus, Jiri Hajnys, David Schwarz, Marek Pagac
Summary: This study aims to comprehensively investigate and describe the behavior of material printed out of Ultrafuse 316L stainless steel filament on an affordable ME office-friendly printer. The main focus was on tests of fracture toughness, porosity, and corrosion resistance to determine the mechanical properties of the material.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Medicine, General & Internal
Lubos Kubicek, Radek Vitasek, David Schwarz, Robert Staffa, Petr Strakos, Stanislav Polzer
Summary: Due to the COVID-19 pandemic, many non-urgent surgeries, including the treatment of abdominal aortic aneurysm (AAA), have been postponed. This study aimed to test the clinical applicability of the probabilistic rupture risk index (PRRI) method in a patient cohort study. The results showed that integrating PRRI into clinical workflow is feasible and can significantly decrease the false positive rate in AAA treatment.
Article
Engineering, Biomedical
Stanislav Polzer, Radek Vitasek
Summary: This study investigates the low cycle fatigue of porcine aortic samples and compares the accuracy of linear and logarithmic fits in predicting static strength from cyclic data. The results show that logarithmic fits are more robust in predicting static strength, while linear fits serve as a lower limit estimation. The dispersion of relative values is higher than that of absolute values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
David Schwarz, Jiri Fleisman, Radek Vitasek, Stanislav Polzer
Summary: A new method for estimating the unloaded sample thickness of soft tissues is proposed in this study, which can quickly and reliably estimate the thickness of undeformed samples.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Jiri Jagos, David Schwarz, Stanislav Polzer, Jiri Bursa
Summary: This study investigates the effect of aorto-iliac bifurcation geometry on pressure and wall stress in the aorta. It finds that the angles of the bifurcation have limited impact on pressure and wall stress, while the area ratio between the iliac and aortic luminal cross sections significantly affects them. A lower area ratio may increase blood pressure in the abdominal aorta and potentially be a risk factor for the development of abdominal aortic aneurysm.
MEDICAL ENGINEERING & PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Stanislav Polzer, Sarah Thompson, Swathi Vittalbabu, Arzu Ulu, David Carter, Tara Nordgren, Mona Eskandari
Summary: Knowledge of soft tissue fiber structure is necessary for accurate characterization and modeling of their mechanical response. This study develops an automatic algorithm to simultaneously estimate fiber global orientation, abundance, and waviness in an investigated image.
MICROSCOPY AND MICROANALYSIS
(2023)