Article
Food Science & Technology
Marijke van der Laan, Anna Buttgenbach, Jana Wolf, Lothar Rink, Inga Wessels
Summary: This study demonstrates the opposing effects of zinc on GM-CSFR surface expression in monocytes and PMN. Zinc and GM-CSF, when used in optimized concentrations, can enhance MAPK signaling and increase the expression of Mcl-1 in PMN. The study provides a basis for further in vivo studies on the therapeutic value of zinc in patients with disrupted GM-CSF signaling.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Immunology
Aiko Hasegawa, Shoji Saito, Shogo Narimatsu, Shigeru Nakano, Mika Nagai, Hideki Ohnota, Yoichi Inada, Hirokazu Morokawa, Ikumi Nakashima, Daisuke Morita, Yuichiro Ide, Kazuyuki Matsuda, Haruko Tashiro, Shigeki Yagyu, Miyuki Tanaka, Yozo Nakazawa
Summary: The study aims to develop a novel therapeutic method for R/R AML using GMR CAR-T cells, which showed potent cytotoxic activities against CD116(+) AML cells in vitro and significantly improved long-term in vitro and in vivo anti-tumor effects by incorporating a G4S spacer.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Oncology
Cuicui Liu, Jiankun Qiang, Qiaodan Deng, Jie Xia, Lu Deng, Lei Zhou, Dong Wang, Xueyan He, Ying Liu, Botao Zhao, Jinhui Lv, Zuoren Yu, Qun-Ying Lei, Zhi-Ming Shao, Xiao-Yong Zhang, Lixing Zhang, Suling Liu
Summary: The enzymatic activity of ALDH1A1 promotes breast tumor growth by decreasing intracellular pH and triggering NFkB signaling. Inhibitors of ALDH1A1 and activation of T-cell immunity can cooperatively inhibit tumor growth. ALDH1A1 induces MDSC expansion and creates a pro-cancer immune microenvironment in breast cancer, suggesting a new therapeutic target.
Article
Medicine, Research & Experimental
Adam L. Burrack, Zoe C. Schmiechen, Michael T. Patterson, Ebony A. Miller, Ellen J. Spartz, Meagan R. Rollins, Jackson F. Raynor, Jason S. Mitchell, Tsuneyasu Kaisho, Brian T. Fife, Ingunn M. Stromnes
Summary: We investigated the differential impact of myeloid subsets on immunity to pancreatic ductal adenocarcinoma (PDA). Our study demonstrates that tumor antigenicity shapes the composition and functionality of myeloid cells. The therapeutic effectiveness of adoptive T cell therapy or programmed cell death ligand 1 blockade relies on the presence of type 1 dendritic cells (cDC1), which support the survival and function of antitumor T cells. Our research highlights the essential role of cDC1s in sustaining effective antitumor T cells and reveals differential roles for cDC1s and monocytes/macrophages in guiding T cell fate and immunotherapy response.
Article
Medicine, Research & Experimental
Naphang Ho, Shiwani Agarwal, Michela Milani, Alessio Cantore, Christian J. Buchholz, Frederic B. Thalheimer
Summary: Pre-clinical humanized mouse models are important for evaluating immunotherapies. Comparing different mouse models, it was found that NSG-SGM3 mice reconstituted with human stem cells showed lower efficiency in generating CAR T cells compared to the widely used huNSG model. Macrophages were identified as a potential barrier for gene transfer, but modifying the viral vector surface improved the transduction efficiency of CAR T cells in the presence of macrophages.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Oncology
Yoshinori Kajiwara, Hiroshi Tazawa, Motohiko Yamada, Nobuhiko Kanaya, Takuro Fushimi, Satoru Kikuchi, Shinji Kuroda, Toshiaki Ohara, Kazuhiro Noma, Ryuichi Yoshida, Yuzo Umeda, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara
Summary: GEM-resistant PDAC cells express high levels of PD-L1 and produce high levels of GM-CSF, leading to immunosuppressive tumor microenvironment and accumulation of MDSCs. OBP-702 can effectively inhibit the growth of GEM-resistant PDAC tumors and enhance the anti-tumor efficacy of PD-L1 blockade.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Muhammad S. Alam, Shizuka Otsuka, Nathan Wong, Aamna Abbasi, Matthias M. Gaida, Yu Fan, Daoud Meerzaman, Jonathan D. Ashwell
Summary: The study revealed that TNF can induce the differentiation of mouse CD4(+) T cells into proinflammatory Th17 cells, mediated by the nondeath TNF receptor TNFR2, and also has an impact on the generation of proinflammatory Th1 cells. Additionally, TNFR2-deficient CD4(+) T cells showed lower pathogenicity in EAE and colitis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Rashi Sehgal, Rakhi Maiwall, Vijayaraghavan Rajan, Mojahidul Islam, Sukriti Baweja, Navkiran Kaur, Guresh Kumar, Gayatri Ramakrishna, Shiv K. Sarin, Nirupma Trehanpati
Summary: In cirrhosis patients with sepsis, MDSCs expand and inhibit immune response by increasing FOXP3(+)Tregs and suppressing CD4(+) T-cell proliferation. GM-CSF therapy can suppress MDSCs, improve T-cell functionality, and reduce the presence of Tregs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Yunyun Zou, Nobuhiko Kamada, Seung-Yong Seong, Sang-Uk Seo
Summary: This study explores the phenotypic and functional heterogeneity of myeloid-derived suppressor cells (MDSCs) in tumor-bearing hosts. It identifies CD115(-) monocytic MDSCs as a distinct subtype with the potential to differentiate into OLFM4(hi) polymorphonuclear MDSCs. CD115(-) monocytic MDSCs increase in the blood and bone marrow as tumors progress, while preferentially differentiating into tumor-associated macrophages in the tumor mass.
COMMUNICATIONS BIOLOGY
(2023)
Article
Physiology
Satoshi Okamori, Makoto Ishii, Takanori Asakura, Shoji Suzuki, Ho Namkoong, Shizuko Kagawa, Ahmed E. Hegab, Kazuma Yagi, Hirofumi Kamata, Tatsuya Kusumoto, Takunori Ogawa, Hayato Takahashi, Masaki Yoda, Keisuke Horiuchi, Naoki Hasegawa, Koichi Fukunaga
Summary: The study showed that ADAM10 plays a protective role in regulating influenza virus infection and may be a potential therapeutic target.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Oncology
Mikoto Tanabe, Kohei Hosokawa, Mai Anh Thi Nguyen, Noriharu Nakagawa, Kana Maruyama, Noriaki Tsuji, Ryota Urushihara, Luis Espinoza, Mahmoud Elbadry, Md Mohiuddin, Takamasa Katagiri, Masanori Ono, Hiroshi Fujiwara, Kazuhisa Chonabayashi, Yoshinori Yoshida, Hirohito Yamazaki, Atsushi Hirao, Shinji Nakao
Summary: CD109 suppresses TGF-beta signaling in HSPCs, and the lack of CD109 may increase the sensitivity of PIGA-mutated HSPCs to TGF-beta, leading to the preferential commitment of erythroid progenitor cells to mature red blood cells in immune-mediated BM failure.
Article
Multidisciplinary Sciences
Xiu Teng, Li-Ping Li, Meng Tang, Hui-Fang Li, Xiang-Yi Ren, Ling Jiao, Sha-Sha Wu, Da-Chao Mou, Zhi-Yong Miao
Summary: This study induced a novel T cell subset called Th-GM cells in a mouse CHS model and found that they were mainly expanded at the site of injury and draining lymph nodes. This method can be used to further investigate the biology of Th-GM cells and explore therapeutic strategies centered on GM-CSF in various conditions.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biochemistry & Molecular Biology
Sara Di Carlo, Georg Haecker, Ian E. Gentle
Summary: GM-CSF promotes the ubiquitination and enhanced processing of IL-1 beta through suppression of antioxidant responses, leading to its pro-inflammatory effect.
Article
Multidisciplinary Sciences
Jiajia Wang, Jiaying Wang, Wenxiang Hong, Lulu Zhang, Liqian Song, Qi Shi, Yanfei Shao, Guifeng Hao, Chunyan Fang, Yueping Qiu, Lijun Yang, Zhaoxu Yang, Jincheng Wang, Ji Cao, Bo Yang, Qiaojun He, Qinjie Weng
Summary: Optineurin (OPTN) plays a crucial role in regulating dendritic cell (DC) maturation, where its deficiency leads to Jak2/Stat3 activation and IL-10 production, suppressing DC maturation and function to ameliorate autoimmune responses in mice.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Darshan S. Chandrashekar, Mohammad Athar, Upender Manne, Sooryanarayana Varambally
Summary: Research compared gene expression in human lung epithelial cells infected with different viruses, identifying specific genes associated with SARS-CoV-2, including CSF2 and calcium-binding proteins. These genes are related to respiratory diseases and inflammation. Protein-protein interaction analyses indicated functional roles of CSF2 and S100A9 in COVID-19 disease.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Yiming Peng-Winkler, Inga Wessels, Lothar Rink, Henrike Josephine Fischer
Summary: Zinc plays an important role in T cell activation and metabolic switching, with zinc deprivation promoting metabolic enzyme stimulation and cytokine production, while zinc supplementation has a balancing effect.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anne Kristina Schmitt, Mary-Ann Puppa, Inga Wessels, Lothar Rink
Summary: The combination of zinc and vitamin D3 promotes the differentiation of T-reg cells and reduces the production of Th1 cells. In in vitro models, the combination of therapeutic concentrations of zinc and vitamin D3 effectively suppresses the secretion of IFN-γ compared to single agent treatment. Vitamin D3 also increases intracellular zinc levels. These findings suggest that the combination of zinc and vitamin D3 may be a promising and cost-effective option for treating dysregulated immune responses.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Marijke van der Laan, Anna Buttgenbach, Jana Wolf, Lothar Rink, Inga Wessels
Summary: This study demonstrates the opposing effects of zinc on GM-CSFR surface expression in monocytes and PMN. Zinc and GM-CSF, when used in optimized concentrations, can enhance MAPK signaling and increase the expression of Mcl-1 in PMN. The study provides a basis for further in vivo studies on the therapeutic value of zinc in patients with disrupted GM-CSF signaling.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kristian Kniha, Lothar Rink, Jana Wolf, Stephan Christian Moehlhenrich, Florian Peters, Marius Heitzer, Frank Hoelzle, Ali Modabber
Summary: In this study, implant outcomes in rats were compared between systemic alendronate and zoledronate acid drug administrations, showing significant effects of zoledronic acid on IL-6 release around titanium implants and alendronic acid on IL-6 release around natural teeth. Material incompatibilities and in vitro stimulation of rat spleen cells with titanium and zirconia nanoparticles were also evaluated.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Christina Schier, Jana Foerster (nee Reiter), Monika Heupel, Philipp Doerner, Michael Klaas, Wolfgang Schroeder, Lothar Rink, Alan J. Slusarenko, Martin C. H. Gruhlke
Summary: Allicin, a volatile substance produced by injured garlic plants, shows broad antimicrobial activity against selected fungi. It has comparable efficacy to the commonly used antifungal drug amphotericin B. Our study suggests that allicin may be a potential candidate for antifungal therapy in lung and upper respiratory tract infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Theresa Scheurer, Jan Steffens, Agnieszka Markert, Miriam Du Marchie Sarvaas, Christoph Roderburg, Lothar Rink, Frank Tacke, Tom Luedde, Thomas Kraus, Ralf Baumann
Summary: This study investigates the impact of occupationally relevant ultrafine zinc/copper (Zn/Cu) welding fumes on noncoding RNAs (lncRNAs). The results show that, except for CoroMarker, the regulation patterns of the tested lncRNAs in both in vitro and in vivo experiments are consistent and in line with their known functions. Notably, the upregulation of CDR1as, a potential risk marker for cardiovascular diseases, contributes to understanding the underlying mechanisms of subclinical inflammation induced by Zn/Cu exposure in metal workers.
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Chiara A. De Benedictis, Sarah Trame, Lothar Rink, Andreas M. Grabrucker
Summary: This study investigated the zinc intake and bioavailability of over 250 women (both pregnant and non-pregnant) in Ireland and found that 58% of participants were at risk of inadequate zinc intake, with 29% potentially being zinc deficient. The low zinc intake was primarily a result of insufficient consumption of zinc-rich foods and relatively higher intake of foods rich in phytate, a major inhibitor of zinc uptake.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wenlei Liu, Jana Jakobs, Lothar Rink
Summary: Pantoprazole treatment reduces the production and secretion of IFN-gamma and IL-2 in T cells by regulating the expression of Zip8 and pCREB or CREM alpha, respectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Sarah Trame, Andreas Brueggemann, Lothar Rink
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Food Science & Technology
Stefanie Ramona Weisenfeld, Jana Jakobs, Lothar Rink
Summary: ScopeZinc is essential for immune system balance, but the exact mechanisms are still unclear. This study explores the interaction between zinc and the tricarboxylic acid cycle (TCA) and their impact on immune modulation. The results show that zinc and citrate can reduce interferon-gamma (IFN gamma) expression and pro-inflammatory T helper cells (Th1 and Th17), while zinc increases regulatory T cells and citrate decreases them. These findings have implications for understanding the immunosuppressive effects of blood products and the potential risks of high citrate consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biology
Kanokwan Sansuwan, Orapint Jintasataporn, Lothar Rink, Supawit Triwutanon, Inga Wessels
Summary: This article investigates the effects of zinc deficiency and zinc supplementation on Asian sea bass aquacultures. The study finds that altering extracellular zinc conditions significantly affects gene expression and cellular zinc levels in Asian sea bass cells. Zinc deficiency induces a stress response in these cells, which can be prevented with sufficient zinc supplementation. Therefore, zinc supplementation may be recommended to optimize aquacultures of Asian sea bass.
Article
Biochemistry & Molecular Biology
Mary-Ann Puppa, Jana Jakobs, Lothar Rink
Summary: This study investigated the effect of tert-butyl-hydrochinone (tBHQ) stimulation on human PBMC under normal and zinc-depleted conditions. The results showed that zinc influenced the mRNA and protein expression of Nrf2, NQO1, and HO-1, and zinc supplementation inhibited HDAC3 activity, stabilizing Nrf2. Therefore, zinc supplementation has beneficial effects on the redox balance in human cells.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Asad Shahzad, Lothar Rink, Inga Wessels
Summary: This study aims to investigate the correlation between zinc deficiency and MMP-9 transcriptional regulation, focusing on epigenetics as the possible mechanism behind zinc deficiency-induced changes. The effect of differentiation and zinc deficiency on MMP-9 expression and MMP9 promoter accessibility was investigated using the acute promyelocytic cell line NB4. The results showed that zinc deficiency led to upregulated MMP-9 gene expression and increased accessibility of the MMP-9 promoter, while zinc resupplementation reversed these effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)