Article
Endocrinology & Metabolism
Kisoo Pahk, Chanmin Joung, Hyun Woo Kwon, Sungeun Kim
Summary: This study aimed to assess the impact of physical exercise on the psychological stress levels of obese women. The results showed that chronic physical exercise can alleviate psychological stress and reduce inflammation in the body. Furthermore, physical exercise can also reduce the risk of cardiovascular disease. This study provides an explanation for the health benefits of exercise on cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Gayatri Saraf, Jairo Vinicius Pinto, Ariana Cahn, Adam George White, Elham Shahinfard, Nasim Vafai, Vesna Sossi, Lakshmi N. Yatham
Summary: Using PET scanning with [C-11]raclopride tracer, this study investigated dopamine release in the basal ganglia of euthymic BD patients and healthy controls in response to stress. While stress led to dopamine release in all participants, there was no significant difference in dopamine release between euthymic BD patients and healthy controls during a stress task.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Thomas E. Van Dyke, Karim El Kholy, Amorina Ishai, Richard A. P. Takx, Kene Mezue, Shady M. Abohashem, Abdelrahman Ali, Neal Yuan, Priscilla Hsue, Michael T. Osborne, Ahmed Tawakol
Summary: The study showed that inflammation of the periodontium, independently predicted future cardiovascular events through heightened arterial inflammation. The relationship between periodontal inflammation and cardiovascular events was found to be primarily mediated by arterial inflammation, providing important support for a link between periodontal disease and cardiovascular disease.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Clinical Neurology
Luka Rejc, Vanessa Gomez-Vallejo, Ana Joya, Gemma Arsequell, Ander Egimendia, Pilar Castellnou, Xabier Rios-Anglada, Unai Cossio, Zurine Baz, Leyre Iglesias, Estibaliz Capetillo-Zarate, Pedro Ramos-Cabrer, Abraham Martin, Jordi Llop
Summary: In this study, the expression of TSPO and x(c)(-) in an Alzheimer's disease mouse model was longitudinally investigated, and the ability of the novel tracers DPA-714 and FSPG to detect these biomarkers was assessed using PET imaging. The results demonstrated a correlation between the uptake of these tracers and amyloid-beta plaque deposition, suggesting their potential as imaging tools for evaluating disease progression.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Cecile Tissot, Joseph Therriault, Peter Kunach, Andrea L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, Joao Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Summary: This study investigated the agreement between [F-18]MK6240 tau-PET, plasma pTau181, and pTau231 in Alzheimer's disease. The findings suggest that these biomarkers reflect different stages of tau progression and can be useful in diagnosing and evaluating the disease stage.
Review
Clinical Neurology
Naomi Louisa Paula Starmans, Anna Elisabeth Leeuwis, Geert Jan Biessels, Laurens Jaap Kappelle, Wiesje Maria van der Flier, Nelleke Tolboom
Summary: There is insufficient evidence to support the hypothesis that heart disease or carotid occlusive disease (COD) are associated with increased cerebral amyloid-beta burden, based on current studies.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Namhun Lee, Se-Jong Oh, Jang-Woo Park, Kyung-Rok Nam, Kyung-Jun Kang, Kyo-Chul Lee, Yong-Jin Lee, June-Seek Choi, Jeong-Ho Seok, Jae-Yong Choi
Summary: Early life stress can lead to behavioral deficits, including anxiety and depressive phenotypes, as well as dysfunction in neurotransmitter systems in animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Christopher E. J. Doppler, Martin B. Kinnerup, Corinna Brune, Ezequiel Farrher, Matthew Betts, Tatyana D. Fedorova, Jeppe L. Schaldemose, Karoline Knudsen, Rola Ismail, Aline D. Seger, Allan K. Hansen, Kristian Staer, Gereon R. Fink, David J. Brooks, Adjmal Nahimi, Per Borghammer, Michael Sommerauer
Summary: This study investigated neurodegeneration in the locus coeruleus of Parkinson's disease patients, finding reduced MRI contrast and volume in the locus coeruleus, as well as lower noradrenaline transporter density, with a negative correlation between the two. These results suggest distinct patterns of degeneration in different regions of the locus coeruleus in Parkinson's disease.
Article
Clinical Neurology
Hana Florian, Deli Wang, Steven E. Arnold, Merce Boada, Qi Guo, Ziyi Jin, Hui Zheng, Nahome Fisseha, Hari Varun Kalluri, Beatrice Rendenbach-Mueller, Kumar Budur, Michael Gold, Thomas Aware Investigators, Lealani Acosta, Thomas Ala, Sanka Amadoru, Jeffrey Apter, Steven Arnold, Merce Boada-Rovira, Anne Boerjesson-Hanson, Wendy Bond, Michael Borrie, Gabriella Bottini, Bruce Brew, Mark Brody, James Burke, Jeffrey Burns, Annalisa Chiari, Roger Clarnette, Sharon Cohen, Martin Farlow, Simon Fishman, Norman Foster, Kristian Frederiksen, Giovanni Frisoni, Nigel Gilchrist, Darren Gitelman, Ira Goodman, Marc Gordon, Neill Graff-Radford, Merja Hallikainen, Adrian Ivanoiu, Gregory Jicha, Michael Jonsson, Diana Kerwin, Dineke Koek, James Lah, Ayesha Lall, Elly Lee, Gabriel Leger, Peter Ljubenkov, Camillo Marra, Pablo Martinez-Lage, Joseph Masdeu, Scott McGinnis, Patrizia Mecocci, Philip Morris, Marshall Nash, Allison Perrin, Aimee Pierce, Robert Riesenberg, Juha Rinne, Raquel Sanchez Del Valle, Elio Scarpini, Paul Schulz, Ronald Schwartz, Amanda Smith, Bryan Spann, Sylvie Van Snick, Rik Vandenberghe, Cherian Verghese, Alberto Villarejo, Chuang-Kuo Wu
Summary: Tau accumulation in patients with Alzheimer's disease is closely related to cognitive decline. This study evaluated tilavonemab, an anti-tau monoclonal antibody, in treating patients with early Alzheimer's disease. The results showed that tilavonemab did not demonstrate efficacy in treating early Alzheimer's disease.
Article
Cardiac & Cardiovascular Systems
Bhav Jain, Simar Singh Bajaj, Joseph Alexander Paguio, Jasper Seth Yao, Bruce A. Casipit, Edward Christopher Dee, Deepak L. Bhatt
Summary: This study examined the impact of education, income-to-poverty ratio, and health insurance coverage on healthcare utilization for patients with ASCVD. The results showed that health insurance coverage had the largest disparities in healthcare utilization.
AMERICAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Juliane Conradi, Jonas E. Svensson, Soren V. Larsen, Vibe G. Frokjaer
Summary: This study did not confirm a positive association between the cortisol awakening response (CAR) and prefrontal 5-HTT BPND in an independent dataset, and there were no apparent sex differences in the association. The data do not exclude the involvement of the serotonin transporter system in regulating stress responses in at-risk or manifest depressed states.
Article
Chemistry, Organic
Aaron Schuell, Lisa Grothe, Eduardo Rodrigo, Thomas Erhard, Siegfried R. Waldvogel
Summary: A novel electrosynthetic approach for the synthesis of aryl dibenzothiophenium salts, including the metal-free, electrochemical formation of a C-S bond under ambient conditions, has been reported. The broad applicability of this method has been demonstrated with 14 examples, achieving isolated yields of up to 72%, including nitrogen-containing heterocycles. The resulting sulfonium salts can serve as precursors for the synthesis of [F-18]fluoroarenes found in PET tracer ligands.
Article
Hematology
Jacek Kwiecinski, Marton Kolossvary, Evangelos Tzolos, Mohammed N. Meah, Philip D. Adamson, Nikhil V. Joshi, Michelle C. Williams, Edwin J. R. van Beek, Daniel S. Berman, Pal Maurovich-Horvat, David E. Newby, Marc R. Dweck, Damini Dey, Piotr J. Slomka
Summary: This study investigated the predictive ability of F-18-sodium fluoride positron emission tomography and radiomics-based precision coronary plaque phenotyping derived from coronary computed tomography angiography in risk stratification of patients with coronary artery disease. The results showed that the morphological features of coronary plaques, quantitative plaque volumes, and disease activity on F-18-sodium fluoride positron emission tomography were additive predictors of myocardial infarction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Luka Rejc, Vanessa Gomez-Vallejo, Ana Joya, Oscar Moreno, Ander Egimendia, Pilar Castellnou, Xabier Rios-Anglada, Unai Cossio, Zurine Baz, Rossana Passannante, Ignacio Tobalina-Larrea, Pedro Ramos-Cabrer, Albert Giralt, Magdalena Sastre, Estibaliz Capetillo-Zarate, Urban Kosak, Damijan Knez, Stanislav Gobec, Mariel Marder, Abraham Martin, Jordi Llop
Summary: The study investigated the potential of butyrylcholinesterase (BChE) as an early biomarker for Alzheimer's disease (AD) by analyzing its abundance in the brains of AD model animals and controls. The results suggested that BChE accumulation in the brain is associated with amyloid beta deposition, indicating its promising role as an early biomarker for AD.
