Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 25, Pages 9788-9792Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b04096
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Funding
- NanoBio Lab (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
- construct program of applied characteristic discipline in Hunan University of Science and Engineering
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We report here a unique ion-fishing mechanism as an alternative to conventional carrier or channel mechanisms for mediating highly efficient and exceptionally selective transmembrane K+ flux. The molecular framework, underlying the fishing mechanism and comprising a fishing rod, a fishing line and a fishing bait/hook, is simple yet modularly modifiable. This feature enables rapid construction of a series of molecular ion fishers with distinctively different ion transport patterns. While more efficient ion transports are generally achieved by using 18-crown-6 as the fishing bait/hook, ion transport selectivity (K+/Na+) critically depends on the length of the fishing line, with the most selective MF6-C14 exhibiting exceptionally high selectivity (K+/Na+ = 18) and high activity (EC50 = 1.1 mol % relative to lipid).
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