Journal
JOURNAL OF STRUCTURAL CHEMISTRY
Volume 60, Issue 7, Pages 1180-1188Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S0022476619070217
Keywords
zinc complex; fluorescence; cytotoxic; apoptosis
Funding
- Natural Science Foundation of China [21171118]
- Distinguished Professor Project of Liaoning province
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A novel Zn(II) complex with the formula {[ZnL2(dibe)(2)]center dot 2H(2)O}(n) (synthesized using a carboxylic acid ligand, L = phenylacetic acid, dibe = 4,4 '-bipyridine (bipy)) is synthesized at room temperature, characterized and its DNA binding, cleavage, anticancer properties are studied by elemental analysis, infrared spectroscopy, and single crystal X-ray diffraction. The interaction of the complex with fish sperm DNA (FS-DNA) is monitored, which reveals that the complex has the ability to bind to FS-DNA. The complex is further studied for the gel electrophoresis assay with supercoiled plasmid pBR322 DNA. In addition, anticancer activities of the metal complex investigated through MTT in vitro assays, indicate that the complex shows good cytotoxic activity against cancer cell lines. Flow cytometry and apoptosis experiments show that the complex induces apoptosis of HeLa cells, which demonstrates that the complex exhibits a significant cancer cell inhibitory rate.
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