Journal
JOURNAL OF RENAL NUTRITION
Volume 30, Issue 2, Pages 92-100Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.jrn.2019.03.083
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Funding
- National Natural Science Foundation of China [H0517/81560132]
- Supporting Project for the Foregoers of Main Disciplines of Jiangxi Province [20162BCB22023]
- 5511'' Innovative Drivers for Talent Teams of Jiangxi Province [20165BCB18018]
- Nature Science Foundation of Jiangxi Province [20181BAB205016]
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Objective: The present study aims to compare the relative efficacy and safety of jinshuibao (JSB) combined with angiotensinconverting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs) in the treatment of diabetic kidney disease. Methods: We searched EMBASE, MEDLINE, PubMed, China National Knowledge Internet, the Chinese Biomedical Database, and Wanfang database for articles from the building of the database to September 2018. Results: Fifty-one randomized controlled trials with 3,955 participants were included. The meta-analysis indicated that compared with the controls, JSB combined with ACEI/ARB group could remarkably improve the overall response rate (odds ratio 4.91; 95% confidence interval [CI] 3.32-7.25) and reduce 24 h proteinuria (mean difference [MD] -0.16; 95% CI -0.19 to -0.13), urine albumin excretion ratio (MD -28.20; 95% CI -36.30 to -20.11), serum creatinine (MD -13.84; 95% CI -18.01 to -9.68), blood urea nitrogen (MD -1.00; 95% CI 1.36 to -0.63), systolic blood pressure (MD -4.57; 95% CI -6.78 to -2.37), diastolic blood pressure (MD -3.96; 95% CI -5.73 to -2.19), fasting blood glucose (MD -0.85; 95% CI -1.45 to -0.24), hemoglobin A1c (MD -0.52; 95% CI -0.83 to -0.21), serum total cholesterol (MD 0.53; 95% CI -0.86 to -0.20), and triglyceride (MD -0.53; 95% CI -0.55 to -0.51). Conclusions: JSB combined with ACEI/ARB in the treatment of diabetic kidney disease is superior to the single application of ACEI/ARB. (C) 2019 by the National Kidney Foundation, Inc. All rights reserved.
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