Article
Biochemistry & Molecular Biology
Johan Lindqvist, Justin Kolb, Josine de Winter, Paola Tonino, Zaynab Hourani, Siegfried Labeit, Coen Ottenheijm, Henk Granzier
Summary: Nemaline myopathy is a disease characterized by skeletal muscle weakness and atrophy. This study found that levels of the protein MuRF1 are significantly increased in patients with nebulin-based Nemaline myopathy and mouse models of the disease. Knocking out the MuRF1 gene in mouse models led to increased muscle size but did not improve muscle function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dulce Peris-Moreno, Laura Cussonneau, Lydie Combaret, Cecile Polge, Daniel Taillandier
Summary: Skeletal muscle loss is a harmful side effect of chronic diseases, increasing mortality and morbidity. The ubiquitin proteasome system plays a key role in regulating muscle contraction and metabolism through targeting key proteins for degradation or activity modulation via E3 ubiquitin ligases.
Article
Biochemistry & Molecular Biology
Daniela Aravena-Canales, Jorge E. Aedo, Alfredo Molina, Juan Antonio Valdes
Summary: This study revealed that cortisol plays a complex regulatory role in the expression of atrogenes in rainbow trout skeletal muscle, with both early downregulation and later upregulation observed. Membrane-initiated cortisol action was found to regulate murf1 gene expression in rainbow trout myotubes, while having no significant effect on atrogin-1.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Mengyuan Niu, Li Li, Zhonglan Su, Lulu Wei, Wenyuan Pu, Chen Zhao, Yibing Ding, Junaid Wazir, Wangsen Cao, Shiyu Song, Qian Gao, Hongwei Wang
Summary: Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Investigating the key genes and protein-protein interactions revealed that Ddit4 plays a crucial role in cancer cachexia by inhibiting the mTOR pathway. This study sheds light on the underlying pathological mechanisms of cancer cachexia and potential therapeutic targets.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Qifang Li, Kiyo-aki Ishii, Kyoko Kamoshita, Kenta Takahashi, Halimulati Abuduwaili, Hiroaki Takayama, Cynthia M. Galicia-Medina, Ryota Tanida, Hein Ko Oo, Guzel Gafiyatullina, Xingyu Yao, Tuerdiguli Abuduyimiti, Jun Hamazaki, Hisanori Goto, Yujiro Nakano, Yumie Takeshita, Kenichi Harada, Shigeo Murata, Toshinari Takamura
Summary: Muscle atrophy is both a cause and consequence of obesity. Disruption of proteasome function in the skeletal muscles mediates obesity-induced ER stress and insulin resistance. The specific role of proteasome function in skeletal muscles and its regulation by obesity is not well understood.
Article
Biochemistry & Molecular Biology
Kristina Sharlo, Irina Lvova, Sergey Tyganov, Ksenia Zaripova, Svetlana Belova, Tatiana Kostrominova, Boris Shenkman, Tatiana Nemirovskaya
Summary: Skeletal muscle abnormalities and atrophy during unloading can be attributed to excess calcium accumulation, which may be caused by the inhibition of SERCA activity. Treating with SERCA activator CDN1163 can reduce calcium level, thus preventing negative consequences. In this study, unloading for 7 days led to increased fatigue, decreased mitochondrial markers and slow-type myosin, and disrupted calcium homeostasis in Soleus muscle. These changes were prevented by SERCA activation but had no effect on muscle atrophy.
Article
Food Science & Technology
Young-Sool Hah, Won Keong Lee, Sangyeob Lee, Jin-Hee Seo, Eun Ji Kim, Yeong-in Choe, Sang Gon Kim, Jun-Il Yoo
Summary: Sarcopenia, the loss of muscular mass and strength with aging, leads to functional impairment, increased risk of falls and fractures, and loss of independence. Coumestrol has been found to inhibit skeletal muscle loss, but its protective mechanism is poorly understood. This study investigated the protective effect of coumestrol against dexamethasone-induced muscle atrophy using in vitro and in vivo analyses. The results suggest that coumestrol may attenuate dexamethasone-induced muscle atrophy by blocking the ubiquitin-proteasome pathway through suppressing AMPK-FoxO1/3 signaling. Therefore, coumestrol could be a potential treatment for aging sarcopenia.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Young-Sool Hah, Won Keong Lee, Sangyeob Lee, Eun Ji Kim, Jung Hyeon Lee, Seung-Jun Lee, Yeong Ho Ji, Sang Gon Kim, Hyeong-Hwan Lee, Seo Yeon Hong, Jun-Il Yoo
Summary: Sarcopenia is the decline in muscle mass and strength with age, resulting in impaired daily functions and increased risk of falls and fractures. β-sitosterol has shown potential to prevent muscle loss and has a protective effect on muscle mass in mice and cell models.
Article
Multidisciplinary Sciences
Yumin Wang, Satoshi Ikeda, Katsunori Ikoma
Summary: This study investigated the effects of passive repetitive stretching on muscle mass, myofiber cross-sectional area, protein synthesis pathways, and myogenic regulatory factors in senescence-accelerated mice. The findings suggest that passive stretching can lead to muscle hypertrophy and counteract muscle atrophy mainly by provoking protein turnover. These results are valuable for clinical muscle strengthening and sarcopenia prevention.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Young Mi Seok, Jae-Myung Yoo, Yoonju Nam, Jungeun Kim, Jin Soo Kim, Jun-Ho Son, Hyo Jung Kim
Summary: The study showed that mountain ginseng inhibits dexamethasone-induced muscle atrophy by decreasing MuRF1 and atrogin1, and has positive effects on L6 myotubes.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Engineering, Environmental
Apoorva H. Nagendra, Mohd Altaf Najar, Bipasha Bose, Shenoy P. Sudhee
Summary: Fluoride at high doses is known to be toxic to the musculoskeletal system, primarily affecting bone and cartilage cells. However, there is limited research on the toxicity of fluoride to skeletal muscle. This study found that during skeletal fluorosis, muscle is also affected. Short-term exposure to sodium fluoride (NaF) led to muscle hypertrophy through activation of the IGF1/PI3/Akt/mTOR signaling pathway, while long-term exposure resulted in muscle atrophy due to activation of the ubiquitin-proteasome pathway. Differentially expressed proteins were identified and characterized using proteomic analysis.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Geriatrics & Gerontology
Volker Adams, Antje Schauer, Antje Augstein, Virginia Kirchhoff, Runa Draskowski, Anett Jannasch, Keita Goto, Gemma Lyall, Anita Maennel, Peggy Barthel, Norman Mangner, Ephraim B. Winzer, Axel Linke, Siegfried Labeit
Summary: MyoMed-205 improved myocardial diastolic function and prevented SKM atrophy/function in the HFpEF animal model. Mechanistically, SKM benefited from attenuation of the ubiquitin proteasome system and increased synthesis/activity of proteins of the mitochondrial respiratory chain, while the myocardium benefited from reduced titin modifications and fibrosis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biology
Hirotaka Araki, Shinjiro Hino, Kotaro Anan, Kanji Kuribayashi, Kan Etoh, Daiki Seko, Ryuta Takase, Kensaku Kohrogi, Yuko Hino, Yusuke Ono, Eiichi Araki, Mitsuyoshi Nakao, Christopher Cardozo
Summary: Skeletal muscle shows plasticity in response to stress, with flavin-dependent lysine-specific demethylase-1 (LSD1) playing a role in regulating fiber type-specific responses. LSD1 loss exacerbates glucocorticoid-induced atrophy in fast fiber-dominant muscles by reducing nuclear retention of anti-autophagic transcription factor Foxk1. Additionally, LSD1 depletion enhances endurance exercise-induced hypertrophy in slow fiber-dominant muscles by inducing the expression of oxidative metabolism gene transcription factor ERR gamma. These findings suggest that LSD1 modulators may be potential therapeutic strategies for stress-induced myopathies.
Article
Oncology
Federica Pierucci, Alessia Frati, Chiara Battistini, Fabio Penna, Paola Costelli, Elisabetta Meacci
Summary: In summary, skeletal muscle mass wasting is a serious condition that significantly impacts disease prognosis and life expectancy. This study demonstrates the crucial role of the CerK/C1P axis in skeletal muscle mass associated with cancer or corticosteroids.
Article
Biochemistry & Molecular Biology
Ksenia A. Zaripova, Ekaterina P. Kalashnikova, Svetlana P. Belova, Tatiana Y. Kostrominova, Boris S. Shenkman, Tatiana L. Nemirovskaya
Summary: The findings suggest that PANX1 ATP-permeable channels play a crucial role in regulating muscle atrophy processes by modulating the expression of E3 ligases, as well as protein translation and elongation processes during unloading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Sport Sciences
Antony G. Philippe, Fabio Borrani, Anthony M. J. Sanchez, Guillaume Py, Robin Candau
JOURNAL OF SPORTS SCIENCES
(2019)
Article
Sport Sciences
Thibaut Meline, Ludovic Mathieu, Fabio Borrani, Robin Candau, Anthony M. J. Sanchez
JOURNAL OF SPORTS SCIENCES
(2019)
Editorial Material
Neurosciences
Robert Solsona, Anthony M. J. Sanchez
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Editorial Material
Neurosciences
Valentin Dablainville, Anthony M. J. Sanchez
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Review
Biochemistry & Molecular Biology
Robert Solsona, Laura Pavlin, Henri Bernardi, Anthony M. J. Sanchez
Summary: This investigation focuses on the mechanisms involved in the regulation of skeletal muscle mass, with an emphasis on proteosynthesis and new organelle production. The critical roles of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway and its regulators are discussed, along with the importance of ribosome biogenesis, satellite cells involvement, myonuclear accretion, and epigenetic modifications related to protein synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Neurosciences
Robert Solsona, Anthony M. J. Sanchez
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Sport Sciences
Fabio Borrani, Robert Solsona, Robin Candau, Thibaut Meline, Anthony M. J. Sanchez
Summary: This study examined the suitability of a model with exponential terms (Exp-Model) in elite short-track speed skaters. The findings suggest that Exp-Model may better describe training adaptations in elite short-track speed skaters than Imp-Model.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Physiology
Killian Salzmann, Anthony M. J. Sanchez, Fabio Borrani
Summary: This study found that applying different levels of blood flow restriction (BFR) during heavy cycling exercise can slow down the main phase time of VO2, increase the amplitude of the slow component, and accelerate the phase 3 amplitude of O-2 extraction kinetics. This suggests that using BFR in heavy exercise may shift the muscles to a more oxygen-dependent situation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Robert Solsona, Hugues Berthelot, Fabio Borrani, Anthony M. J. Sanchez
Summary: The study found that sprint interval exercises (SIT) with gravity-induced blood flow restriction (G-BFR) led to lower mechanical, cardiorespiratory, and skeletal muscle oxygenation responses compared to other conditions. Training with BFR at 60% occlusive pressure (BFR60) resulted in higher blood accumulation in working muscles, potentially affecting cellular stress. Both hypoxia (HYP) and G-BFR induced local hypoxia, with G-BFR showing higher levels during both exercise bouts and recovery periods.
FRONTIERS IN PHYSIOLOGY
(2021)
Editorial Material
Neurosciences
Tom Normand-Gravier, Robert Solsona, Anthony M. J. Sanchez
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Physiology
Robert Solsona, Romeo Deriaz, Fabio Borrani, Anthony M. J. Sanchez
Summary: This study compared muscle deoxygenation and reoxygenation kinetics during a sprint interval protocol under four different modalities. It found that reoxygenation was delayed in the blood flow restriction condition, and reoxygenation was slower in the gravity-induced blood flow restriction condition.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Margaux Giovanna, Robert Solsona, Anthony M. J. Sanchez, Fabio Borrani
Summary: Peak aerobic power, exercise duration, maximal accumulated oxygen deficit, and VO2 were improved after six RST sessions. However, combined hypoxic stress or partial BFR did not further increase peak aerobic power.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2022)
Article
Sport Sciences
Robert Solsona, Thibaut Meline, Fabio Borrani, Romeo Deriaz, Jerome Lacroix, Tom Normand-Gravier, Robin Candau, Sebastien Racinais, Anthony M. J. Sanchez
Summary: This study compared the effects of three different recovery methods in elite athletes and found that coldwater immersion may slightly impair performance outcomes compared to active recovery and hot-water immersion. More research is needed to confirm these findings.
JOURNAL OF SPORTS SCIENCES
(2023)
