Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 69, Issue 5, Pages 791-798Publisher
BMC
DOI: 10.1007/s12576-019-00695-4
Keywords
Circadian rhythm; Testosterone; Wheel running; Free-running period; PER2::LUC
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Funding
- JSPS KAKENHI [17H04022]
- Grants-in-Aid for Scientific Research [17H04022] Funding Source: KAKEN
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Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels among others. To investigate whether testosterone replacement improves the age-related decline in circadian rhythmicity, we examined the effects of testosterone on the circadian rhythms of wheel running activity in old male mice. Intact male C57BL/6J mice (18-22months old) were subcutaneously implanted with silicone tubes packed with testosterone propionate (TP) or cholesterol. TP treatment significantly decreased the daily wheel running revolutions in a normal light/dark (LD) cycle and in constant darkness (DD), but did not affect the free-running period. The same experiment performed on young male gonadectomized mice (3-5months old) demonstrated that TP treatment significantly increased activity levels in both LD and DD. These results suggest that testosterone replacement exacerbates the age-related decline in circadian rhythmicity.
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