Article
Radiology, Nuclear Medicine & Medical Imaging
Sander C. Ebbers, Caren van Roekel, Manon N. G. J. A. Braat, Maarten W. Barentsz, Marnix G. E. H. Lam, Arthur J. A. T. Braat
Summary: This study confirms a clear dose-response relationship in patients with neuroendocrine tumor liver metastases treated with Y-90 radioembolization. It is suggested to perform Y-90 radioembolization with a minimum planned tumor-absorbed dose of 150 Gy. No significant dose-toxicity relationship was identified in the study.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biology
Srinivas Cheenu Kappadath, Benjamin P. Lopez
Summary: In this study, an ablative dosimetry model was developed to calculate the dose distribution for tumors and at-risk margins, based on numerical mm-scale dose modeling and clinical evidence. The necessary dose metrics needed to achieve complete pathologic necrosis (CPN) following Y-90 radioembolization were calculated for a range of tumor sizes and tumor-to-normal-liver uptake ratios.
Article
Multidisciplinary Sciences
Gefei Chen, Zhonglin Lu, Han Jiang, Ko-Han Lin, Greta S. P. Mok
Summary: In this study, a new VSV method is proposed and compared with PM, MC and other VSV methods for Y-90 RE treatment planning. The results show that LiCKLuKD method has the smallest deviation in the liver and tumors, while LiLuKD and LiCKLuKD perform the best in the lungs.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ammar Sarwar, Alexei Kudla, Jeffrey L. Weinstein, Aamir Ali, Raza Malik, Andrea Bullock, Khalid O. Khwaja, Michael Curry, Salomao Faintuch, Muneeb Ahmed
Summary: This study reviewed the technical feasibility of resin microsphere yttrium-90 radioembolization using the MIRD model and found that prescribed activity calculated by MIRD was significantly higher than BSA model. The results indicated that MIRD prescribed activity with target absorbed doses up to 200 Gy can be successfully administered without prophylactic embolization in selected patients.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. Peter Kim, Daniel Juneau, Claire Cohalan, Shirin A. Enger
Summary: This study aimed to investigate the dose differences due to different self-calibrations and mass density assignments in radioembolization dosimetry. Comparing various methodologies and metrics, significant dose variations in the liver and lungs were found. A mean correction method was introduced to calculate more accurate dose estimates in compromised images.
Article
Medicine, General & Internal
Pia M. Linder, Wenhong Lan, Nils F. Trautwein, Julia Brosch-Lenz, Sebastian von Beschwitz, Juergen Kupferschlaeger, Gerald Reischl, Gerd Groezinger, Helmut Dittmann, Christian la Fougere, Fabian P. Schmidt
Summary: Optimized imaging protocol allows high image quality and quantification accuracy for post-treatment dosimetry of Y-90 radioembolization.
Article
Chemistry, Multidisciplinary
Sara Ungania, Marco D'Arienzo, Sandro Nocentini, Marco D'Andrea, Vicente Bruzzaniti, Raffaella Marconi, Emilio Mezzenga, Bartolomeo Cassano, Erminia Infusino, Antonino Guerrisi, Antonella Soriani, Lidia Strigari
Summary: This study aimed to develop a SPECT/CT imaging protocol for quantitative imaging optimization in radioembolization (RE) treatment, using cutting edge imaging technology and a novel anthropomorphic 3D-printed phantom. The results showed that the xSPECT software allowed for absolute quantification in anthropomorphic geometry, but caution is needed when dealing with spherical objects with a necrotic core.
APPLIED SCIENCES-BASEL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Heying Duan, Mohamed H. Khalaf, Valentina Ferri, Lucia Baratto, Shyam M. Srinivas, Daniel Y. Sze, Andrei Iagaru
Summary: Tc-99m-MAA SPECT/CT showed great accuracy for treatment planning dosimetry. The SiPM-based PET/CT scanner demonstrated good image quality at a 10-min scan time in one bed position. A 5-min PET/CT scan time revealed acceptable image quality, which is sufficient for dosimetry and treatment verification.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Engineering, Biomedical
E. Courtney Henry, Matthew Strugari, George Mawko, Kimberly D. Brewer, Robert Abraham, S. Cheenu Kappadath, Alasdair Syme
Summary: This study conducted post-administration dosimetry in yttrium-90 radioembolization using micro-CT imaging in a porcine renal model. Results showed that high-resolution micro-CT imaging is crucial for extracting specific dose metrics and may offer new perspectives on dose-response relationships.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Agata Kubik, Anna Budzynska, Krzysztof Kacperski, Maciej Maciak, Michal Kuc, Piotr Piasecki, Maciej Wilinski, Marcin Konior, Miroslaw Dziuk, Edward Iller
Summary: The feasibility of SPECT and PET Y-90 imaging was assessed by visualizing hot and cold foci in phantoms with varying isotope concentrations. PET imaging provided better results than Bremsstrahlung based SPECT imaging, indicating its potential as the method of choice in Y-90 post radioembolization imaging.
Article
Radiology, Nuclear Medicine & Medical Imaging
Osman Oecal, Kerstin Schuette, Christoph J. Zech, Christian Loewe, Otto van Delden, Vincent Vandecaveye, Chris Verslype, Bernhard Gebauer, Christian Sengel, Irene Bargellini, Roberto Iezzi, Alexander Philipp, Thomas Berg, Heinz J. Kluempen, Julia Benckert, Maciej Pech, Antonio Gasbarrini, Holger Amthauer, Peter Bartenstein, Bruno Sangro, Peter Malfertheiner, Jens Ricke, Max Seidensticker
Summary: In patients with advanced hepatocellular carcinoma receiving sorafenib treatment, the combination with radioembolization can enhance tumor response without prolonging survival. Better patient selection and selective treatment could potentially improve outcomes after combination therapy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Courtney Henry, Matthew Strugari, George Mawko, Kimberly Brewer, David Liu, Andrew C. Gordon, Jeffrey N. Bryan, Charles Maitz, Robert Abraham, S. Cheenu Kappadath, Alasdair Syme
Summary: Precision dosimetry in yttrium-90 radioembolization can be achieved through CT imaging, providing improved visualization of dose distribution and accurate dose metrics. CT-based approach offers advantages in reducing partial volume effects, representing dose heterogeneity, and mitigating respiratory motion effects.
Article
Radiology, Nuclear Medicine & Medical Imaging
M. Ghosn, H. Derbel, R. Kharrat, N. Oubaya, S. Mule, J. Chalaye, H. Regnault, G. Amaddeo, E. Itti, A. Luciani, H. Kobeiter, V. Tacher
Summary: The study evaluated the potential of imaging criteria in predicting overall survival of HCC patients after TARE treatment. The results showed that RECIST and mRECIST were the best compromise between reproducibility and ability to predict overall survival.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2021)
Article
Oncology
M. Guerrero, W. Yao, M. Lin, S. J. Becker, J. K. Molitoris, S. Vedam, B. Yi
Summary: This study validates the MIM SurePlan Liver Y90 software by comparing its results with a previously developed Monte Carlo derived voxel dose kernel calculation method. The results show good agreement between the MIM SurePlan Liver Y90 VSV algorithm and the Monte Carlo calculation based on gamma analysis and several dosimetric parameters. However, larger dosimetric differences were observed in lesion mean doses and D 95 , suggesting that these metrics are less robust to changes in calculation grid location and finite volume effects for small lesions.
Article
Oncology
Crystal Seldon Taswell, Matthew Studenski, Thomas Pennix, Bryan Stover, Mike Georgiou, Shree Venkat, Patricia Jones, Joseph Zikria, Lindsay Thornton, Raphael Yechieli, Prasoon Mohan, Lorraine Portelance, Benjamin Spieler
Summary: Assessing the three-dimensional dose coverage of tumors using actual Y-90 biodistribution is a better predictor of treatment response in transarterial radioembolization (TARE) of hepatocellular carcinoma (HCC) with Yttrium-90 (Y-90) microspheres.
Article
Oncology
Justin K. Mikell, Yuni K. Dewaraja, Dawn Owen
SEMINARS IN RADIATION ONCOLOGY
(2020)
Article
Oncology
Samantha J. Simiele, Xiaoping Chen, Choonik Lee, Benjamin S. Rosen, Justin K. Mikell, Jean M. Moran, Joann Prisciandaro
Article
Radiology, Nuclear Medicine & Medical Imaging
Haowei Xiang, Hongki Lim, Jeffrey A. Fessler, Yuni K. Dewaraja
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Review
Oncology
Sara St James, Bryan Bednarz, Stanley Benedict, Jeffrey C. Buchsbaum, Yuni Dewaraja, Eric Frey, Robert Hobbs, Joseph Grudzinski, Emilie Roncali, George Sgouros, Jacek Capala, Ying Xiao
Summary: Radiopharmaceutical therapy (RPT) delivers a radionuclide to target and deliver radiation to cancer cells while minimizing exposure to untargeted cells. Advances in targeting technologies need to be matched with improvements in quantitative imaging and dosimetry methods. Current dosing methods are not optimized and there is a need for personalized dose estimation methods for individual patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Editorial Material
Oncology
Ying Xiao, Emilie Roncali, Robert Hobbs, Sara St James, Bryan Bednarz, Stanley Benedict, Yuni K. Dewaraja, Eric Frey, Joseph Grudzinski, George Sgouros, Jeffrey C. Buchsbaum, Jacek Capala
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Greta S. P. Mok, Yuni K. Dewaraja
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin J. Van, Yuni K. Dewaraja, Mamadou L. Sangogo, Justin K. Mikell
Summary: This study investigated the relationship between predicted biological outcomes of liver tumors and normal tissue via variations in absorbed dose prescription methodologies. Results showed that prescribed dose and model selection contributed to a wide variation in average tumor efficacy. The use of parameterized charting may help guide physicians in transitioning to newer prescription methods.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zongyu Li, Jeffrey A. Fessler, Justin K. Mikell, Scott J. Wilderman, Yuni K. Dewaraja
Summary: The study proposes a residual CNN trained using phantoms generated from patient images, showing potential for real-time patient-specific dosimetry in clinical treatment planning due to its demonstrated improvements in accuracy, resolution, noise, and speed over the DVK/MC approaches.
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvano Gnesin, Justin K. Mikell, Maurizio Conti, John O. Prior, Thomas Carlier, Thiago V. M. Lima, Yuni K. Dewaraja
Summary: Dosimetry-guided treatment planning in selective internal radiation therapy requires accurate measurement of administered activity. This study compared the manufacturer-declared 90Y activity in vials with quantitative assessment using PET/CT. Significant differences in activity calibration were found between glass and resin microspheres, while chloride solutions showed close agreement. These findings highlight the need for further investigations to ensure reliable and accurate patient and dose-effect assessments.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elise C. Covert, Kellen Fitzpatrick, Justin Mikell, Ravi K. Kaza, John D. Millet, Daniel Barkmeier, Joseph Gemmete, Jared Christensen, Matthew J. Schipper, Yuni K. Dewaraja
Summary: The study aimed to quantify the variability in manually delineated hepatocellular carcinoma lesion contours and their impact on radioembolization dosimetry. Results showed that uncertainty in segmented volume significantly affected tumor control probability.
Article
Computer Science, Interdisciplinary Applications
Hanvit Kim, Zongyu Li, Jiye Son, Jeffrey A. Fessler, Yuni K. Dewaraja, Se Young Chun
Summary: This article proposes a physics-guided weakly supervised training framework for fast and accurate scatter estimation in quantitative SPECT. The method utilizes a 100 x shorter MC simulation as weak labels and enhances them with deep neural networks, achieving comparable performance to the supervised counterpart while significantly reducing the computation in labeling.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Theresa Devasia, Yuni Dewaraja, Matthew Schipper, Ka Kit Wong
JOURNAL OF NUCLEAR MEDICINE
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Stephen Graves, Ashok Tiwari, Alexandria Kruzer, Aaron Nelson, David Mirando, Yuni Dewaraja, John Sunderland
JOURNAL OF NUCLEAR MEDICINE
(2020)