Article
Chemistry, Multidisciplinary
Nur Hayati Jasmin, May Zaw Thin, Robert D. Johnson, Laurence H. Jackson, Thomas A. Roberts, Anna L. David, Mark F. Lythgoe, Philip C. Yang, Sean M. Davidson, Patrizia Camelliti, Daniel J. Stuckey
Summary: The study investigates the use of manganese as an imaging biomarker of myocardial viability and the potential application of MEMRI in early diagnosis and treatment. Experimental results confirm the safety of manganese and demonstrate that MEMRI can provide quantitative information on myocardial viability earlier.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elia von Felten, Georgios Benetos, Dimitri Patriki, Dominik C. Benz, Georgios P. Rampidis, Andreas A. Giannopoulos, Adam Bakula, Christoph Grani, Aju P. Pazhenkottil, Catherine Gebhard, Tobias A. Fuchs, Philipp A. Kaufmann, Ronny R. Buechel
Summary: The study found that misalignment between MRAC and PET datasets commonly occurs during adenosine stress MPI on a hybrid PET/MR device, potentially resulting in an increase in false-positive findings. Results suggest that myocardial creep may substantially contribute to this misalignment, emphasizing the importance of careful review and correction of PET/MRAC data.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joyce Mhlanga, Paul Derenoncourt, Adeel Haq, Anita Bhandiwad, Richard Laforest, Barry A. Siegel, Farrokh Dehdashti, Robert J. Gropler, Thomas H. Schindler
Summary: A practical and time-efficient protocol involving intravenous glucose loading and insulin injection showed good image quality in patients with ischemic cardiomyopathy, with reduced preparation time.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Keiichiro Kuronuma, Robert J. H. Miller, Serge D. Van Kriekinge, Donghee Han, Ananya Singh, Heidi Gransar, Damini Dey, Daniel S. Berman, Piotr J. Slomka
Summary: PurposePhase analysis can evaluate left ventricular dyssynchrony, but the prognostic value of phase variables over PET-MPI variables has not been studied. This study aimed to explore the prognostic value of phase variables for predicting mortality. A total of 3963 patients who underwent pharmacological stress-rest Rb-82 PET study were enrolled. Cox proportional hazard analyses showed that stress phase entropy was significantly associated with all-cause mortality, and its addition improved the discriminatory power for mortality prediction.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingwen Huang, Adam J. Mitchell, Ernest V. Garcia, C. David Cooke, Russell Folks, Maria Pernetz, Abhinav Goyal, Marina Piccinelli, Jonathon A. Nye
Summary: This study aimed to develop a measure of longitudinal, radial, and circumferential myocardial strain using 82Rb PET MPI. The results showed that the strain measured with PET MPI using an automated technique correlated well with resting GLS strain obtained by TTE, and the measure is reproducible.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jennifer M. Renaud, Alexis Poitrasson-Riviere, Jonathan B. Moody, Tomoe Hagio, Edward P. Ficaro, Venkatesh L. Murthy
Summary: By establishing normal databases, the diagnostic accuracy of PET MPI analysis can be improved. Normal databases built using 3D PET images have significant advantages in evaluating TPD in patients. The clinical application of these techniques should be considered to support accurate image interpretation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark G. MacAskill, Catriona Wimberley, Timaeus E. F. Morgan, Carlos J. Alcaide-Corral, David E. Newby, Christophe Lucatelli, Andrew Sutherland, Sally L. Pimlott, Adriana A. S. Tavares
Summary: The use of simplified image-derived input function (IDIF) in PET imaging with [F-18]LW223 is acceptable for quantification of TSPO expression in rats, with a minimum scan duration of 100 minutes. Careful assessment of kinetic outcome measures is crucial when conducting system level analyses, especially in evaluating the role of the TSPO heart-brain axis in PET imaging.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Medicine, General & Internal
Dan L. Li, Marvin W. Kronenberg
Summary: Coronary artery disease is a major global health concern with noninvasive imaging tests playing a crucial role in its diagnosis and management. Myocardial perfusion imaging, along with other noninvasive tests such as stress echocardiography, coronary computed tomography angiography, and cardiac magnetic resonance imaging, have been widely used for evaluating ischemia and myocardial viability. The accuracy and clinical significance of these tests are essential in guiding risk stratification and revascularization decisions.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Nicholas T. Thielen, Adison A. Kleinsasser, Jessica L. Freeling
Summary: This study explored the use of myocardial contrast echocardiography (MCE) to assess myocardial infarction (MI) in mice. The MCE parameters were able to differentiate between MI and sham-operated groups, providing complementary information to conventional methods and additional hemodynamic data.
Article
Cardiac & Cardiovascular Systems
Jamshid Maddahi, Denis Agostini, Timothy M. Bateman, Jeroen J. Bax, Rob S. B. Beanlands, Daniel S. Berman, Sharmila Dorbala, Ernest V. Garcia, James Feldman, Gary V. Heller, Juhani M. Knuuti, Pedro Martinez-Clark, Matthieu Pelletier-Galarneau, Benjamin Shepple, Nagara Tamaki, Francois Tranquart, James E. Udelson
Summary: This study demonstrates that Flurpiridaz F-18 is a novel PET tracer with high diagnostic efficacy and safety for detecting coronary artery disease. It has higher sensitivity and specificity compared to traditional SPECT technique, especially in women and obese patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Valeria Gaudieri, Teresa Mannarino, Emilia Zampella, Roberta Assante, Adriana D'Antonio, Carmela Nappi, Valeria Cantoni, Roberta Green, Mario Petretta, Parthiban Arumugam, Alberto Cuocolo, Wanda Acampa
Summary: The study evaluated the association between impaired coronary vascular function and cardiovascular risk in hypertensive patients without overt coronary artery disease. Results showed that patients with resistant hypertension (RH) were older, had a higher prevalence of left ventricular hypertrophy, and lower hyperemic myocardial blood flow compared to those without RH. Multivariable analysis identified age, RH, and reduced myocardial perfusion reserve as independent predictors of cardiovascular events. Patients with RH and reduced myocardial perfusion reserve had the highest risk of events.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Cell Biology
Anais Moyon, Philippe Garrigue, Samantha Fernandez, Fabien Hubert, Laure Balasse, Pauline Brige, Guillaume Hache, Vincent Nail, Marcel Blot-Chabaud, Francoise Dignat-George, Francesca Rochais, Benjamin Guillet
Summary: The study found that Ga-68-sCD146 PET imaging showed higher AMOT expression after myocardial infarction, with significant correlations with heart perfusion, tissue fibrosis, and functional recovery.
Article
Cardiac & Cardiovascular Systems
Alejandro Gutierrez-Barrios, Inara Alarcon de la Lastra, Lola Canadas-Pruano, William Delgado, Miguel Alba-Sachez, Sergio Gamaza-Chulian, Enrique Diaz-Retamino, Ricardo Zayas-Rueda, German Calle-Perez, Rafael Vazquez-Garcia, Rocio Toro
Summary: The study aimed to evaluate the effect of CCC on myocardial viability of late presentation MI, and found that the presence of early recruited CCC was the main independent predictor of myocardial viability in late presentation MI.
CORONARY ARTERY DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
O. Lindner, M. Hacker, W. Burchert, R. R. Buechel
Summary: This paper presents the results of the first joint survey on the use of SPECT and PET myocardial perfusion imaging (MPI) and cardiac amyloidosis imaging in Austria, Germany, and Switzerland of the year 2021. The survey collected data from nuclear medicine centers through questionnaires and analyzed the differences among the three countries in terms of MPI imaging. The results showed that Switzerland had outstanding use of PET MPI and leading camera equipment, followed by Austria and Germany. Despite procedural differences, the overall standard of MPI imaging was high.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Matthias W. G. Zeller, Cuihua Wang, Edmund J. Keliher, Gregory R. Wojtkiewicz, Aaron Aguirre, Kevin Maresca, Chunyan Su, Leonard Buckbinder, Jing Wang, Matthias Nahrendorf, John W. Chen
Summary: Myeloperoxidase (MPO) is an enzyme involved in post-myocardial infarction injury and is a potential therapeutic target. However, the lack of an imaging reporter to select appropriate patients and assess therapeutic efficacy has hindered clinical development. This study found that an MPO-specific PET imaging agent can track the treatment effect of an MPO inhibitor in experimental myocardial infarction, providing a potential non-invasive method to report MPO activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simona Malaspina, Otto Ettala, Tuula Tolvanen, Johan Rajander, Olli Eskola, Peter J. Bostrom, Jukka Kemppainen
Summary: Heterogeneous increase in PSMA uptake was observed in metastatic prostate cancer patients after ADT, indicating potential response to ADT. The increase in PSMA uptake showed negative correlation with glucose metabolism intensity and serum PSA decrease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olli Moisio, Jenni Virta, Emrah Yatkin, Heidi Liljenback, Senthil Palani, Riikka Viitanen, Maxwell W. G. Miner, Vesa Oikonen, Tuula Tolvanen, Danielle J. Vugts, Pekka Taimen, Xiang-Guo Li, Maija Hollmen, Sirpa Jalkanen, Anne Roivainen
Summary: Bexmarilimab is a new humanized monoclonal antibody targeting CLEVER-1 and is currently being tested for macrophage-guided cancer immunotherapy. This study evaluated the biodistribution and stability of radiolabeled bexmarilimab in rabbits, and found that it rapidly cleared from the blood circulation and showed higher uptake in fibrotic renal cortex. These findings support future human PET studies for bexmarilimab treatment and disease monitoring.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Sport Sciences
Tanja Sjoros, Saara Laine, Taru Garthwaite, Henri Vaha-Ypya, Eliisa Loyttyniemi, Mikko Koivumaki, Noora Houttu, Kirsi Laitinen, Kari K. Kalliokoski, Harri Sievanen, Tommi Vasankari, Juhani Knuuti, Ilkka H. A. Heinonen
Summary: This study aimed to investigate whether a reduction in daily sedentary behavior improves insulin sensitivity in adults with metabolic syndrome. The results showed that reducing sedentary behavior by 40 minutes per day, while increasing moderate-to-vigorous physical activity by 20 minutes per day, resulted in slightly decreased fasting insulin levels, but had no effects on insulin sensitivity or body adiposity.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Cardiac & Cardiovascular Systems
Xu Wang, Inge J. van den Hoogen, Steele C. Butcher, Jurrien H. Kuneman, Michiel A. de Graaf, Vasileios Kamperidis, Mark Boukes, Teemu Maaniitty, Jussi Schultz, Alexander R. van Rosendael, Antti Saraste, Juhani Knuuti, Jeroen J. Bax
Summary: This study found that the volume of necrotic core in coronary atherosclerosis independently predicts myocardial ischemia, beyond the consideration of diameter stenosis alone.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Biotechnology & Applied Microbiology
Vesa Anttila, Antti Saraste, Juhani Knuuti, Marja Hedman, Pekka Jaakkola, Karl -Ludwig Laugwitz, Markus Krane, Anders Jeppsson, Saara Sillanmaeki, Jaya Rosenmeier, Pernilla Zingmark, Anna Rudvik, Pavlo Garkaviy, Christina Watson, Menelas N. Pangalos, Kenneth R. Chien, Regina Fritsche-Danielson, Anna Collen, Li-Ming Gan
Summary: The first clinical study of injecting naked mRNA encoding VEGF-A (AZD8601) into the human heart showed therapeutic cardiovascular effects without serious adverse events.
Article
Cardiac & Cardiovascular Systems
Matias Maenpaa, Iida Kujala, Esa Harjulahti, Iida Stenstrom, Wail Nammas, Juhani Knuuti, Antti Saraste, Teemu Maaniitty
Summary: This study investigates the relationship between coronary artery disease (CAD) and long-term outcomes in patients with different diabetes statuses using coronary computed tomography angiography (CTA) followed by selective use of positron emission tomography (PET) myocardial perfusion imaging. The study finds that the relationship between CAD and long-term outcomes in diabetic patients is similar to that in non-diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Iida Kujala, Wail Nammas, Teemu Maaniitty, Iida Stenstrom, Riku Klen, Jeroen J. Bax, Juhani Knuuti, Antti Saraste
Summary: The study evaluated sex differences in disease profile and outcomes after combined computed tomography angiography (CTA) and positron emission tomography (PET) perfusion imaging in female patients with suspected obstructive coronary artery disease (CAD). The results showed that women had a higher proportion of normal coronary arteries and a lower proportion of abnormal stress myocardial blood flow. The annual adverse event rate was also lower in women. Both in women and men, coronary calcification, non-obstructive CAD, and abnormal stress myocardial blood flow were independent predictors of adverse events. The study concluded that combined coronary CTA and PET myocardial perfusion imaging can equally predict outcomes in women and men.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Antti Saraste, Juhani Knuuti, Frank Bengel
Summary: Nuclear imaging techniques play a significant role in detecting and quantifying pathophysiological processes in heart failure, providing complementary evaluation of cardiac structure and function. It enables the identification of left ventricle dysfunction caused by reversible myocardial ischemia in the presence of viable myocardium. Moreover, nuclear imaging allows assessment of various cellular and subcellular mechanisms of heart failure. It also has value in evaluating cardiac sarcoidosis and amyloidosis, predicting heart failure progression, arrhythmias, and characterizing the response to myocardial injury.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jurrien H. Kuneman, Inge J. Van den Hoogen, Jussi Schultz, Teemu Maaniitty, Alexander R. van Rosendael, Vasileios Kamperidis, Michiel A. de Graaf, Alexander Broersen, J. Wouter Jukema, Jeroen J. Bax, Antti Saraste, Juhani Knuuti
Summary: Analysis showed that the fraction of non-calcified plaque volume (PV) of total PV is associated with ischemia and outcomes in patients with coronary artery disease (CAD). This ratio could be a simple and clinically useful parameter for predicting outcomes.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Surenjav Chimed, Jan Stassen, Xavier Galloo, Maria Chiara Meucci, Juhani Knuuti, Victoria Delgado, Pieter van der Bijl, Nina Ajmone Marsan, Jeroen J. Bax
Summary: This study investigated the prognostic significance of left ventricular global longitudinal strain (GLS) in patients with HFrEF. It found that patients with GLS ≤10% had a higher incidence of worsening HF compared to those with GLS >10%. After adjusting for various factors, baseline GLS remained independently associated with a higher risk of worsening HF and all-cause mortality in HFrEF patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie E. van Rosendael, Alexander R. van Rosendael, Jurrien H. Kuneman, Manesh R. Patel, Bjarne Linde Norgaard, Timothy A. Fairbairn, Koen Nieman, Takashi Akasaka, Daniel S. Berman, Lynne M. Hurwitz Koweek, Gianluca Pontone, Tomohiro Kawasaki, Niels Peter Ronnow Sand, Jesper M. Jensen, Tetsuya Amano, Michael Poon, Kristian A. Ovrehus, Jeroen Sonck, Mark G. Rabbat, Campbell Rogers, Hitoshi Matsuo, Jonathon A. Leipsic, Ajmone Marsan, J. Wouter Jukema, Jeroen J. Bax, Antti Saraste, Juhani Knuuti
Summary: The V/M ratio assessed by CCTA is a new parameter to investigate the relation of coronary vasculature to the myocardium supplied. Hypertension decreases this ratio by way of myocardial hypertrophy, which could explain the detected abnormal myocardial perfusion reserve in patients with hypertension.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Tanja Sjoeros, Saara Laine, Taru Garthwaite, Henri Vaha-Ypya, Mikko Koivumaki, Olli Eskola, Eliisa Loyttyniemi, Noora Houttu, Kirsi Laitinen, Kari K. Kalliokoski, Harri Sievanen, Tommi Vasankari, Juhani Knuuti, Ilkka H. A. Heinonen
Summary: Interventions aimed at reducing sedentary behavior for 1 hour per day can improve insulin sensitivity in the weight-bearing thigh muscles of sedentary adults with metabolic syndrome. However, this intervention does not have a significant impact on overall muscle and whole body insulin sensitivity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Pepijn A. van Diemen, Ruben W. de Winter, Stefan P. Schumacher, Henk Everaars, Michiel J. Bom, Ruurt A. Jukema, Yvemarie B. Somsen, Pieter G. Raijmakers, Rolf A. Kooistra, Janny Timmer, Teemu Maaniitty, Lourens F. Robbers, Martin B. von Bartheld, Ahmet Demirkiran, Albert C. van Rossum, Johan H. Reiber, Juhani Knuuti, Richard S. Underwood, Eike Nagel, Paul Knaapen, Roel S. Driessen, Ibrahim Danad
Summary: This study compared the diagnostic performance of different imaging techniques in patients with chronic coronary syndrome and documented coronary artery disease. It found that quantitative flow ratio (QFR) performed better than other imaging techniques in detecting hemodynamically significant coronary artery disease.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Eero Lehtonen, Iida Kujala, Jonne Tamminen, Teemu Maaniitty, Antti Saraste, Jarmo Teuho, Juhani Knuuti, Riku Klen
Summary: This study evaluated the incremental value of positron emission tomography myocardial perfusion imaging (PET MPI) over coronary computed tomography angiography (CCTA) in predicting short- and long-term outcomes. The results showed that PET MPI data improved the prediction of adverse events beyond CCTA imaging for the first 4 years, but had no significant incremental prognostic value after that.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Achol A. Bhowmik, Taina R. H. Heikkila, Lauri Polari, Jenni Virta, Heidi Liljenback, Olli Moisio, Xiang-Guo Li, Riikka Viitanen, Sirpa Jalkanen, Jukka Koffert, Diana M. Toivola, Anne Roivainen
Summary: This study investigates the utility of VAP-1-targeted [Ga-68]Ga-DOTA-Siglec-9 PET/CT for assessing inflammation in two mouse models of IBD. The results suggest that this PET tracer is a promising tool for non-invasive imaging of intestinal inflammation.
MOLECULAR IMAGING AND BIOLOGY
(2023)
