Article
Neurosciences
Dhaval Shukla, Bhushan Diwakar Thombre, Priya Baby, Jayanthi Palaninathan, Sivakami Subramanian, P. Prathyusha, Indira Devi Bhagavatula
Summary: The purpose of this study was to develop the GOSE mobile application and validate its effectiveness compared to the traditional interview method. The study found high agreement between the two methods, suggesting that the mobile application can accurately measure GOSE scores. This application has the potential to expedite the assessment process for TBI patients in both clinical practice and research.
Article
Critical Care Medicine
Lindsay Wilson, Kim Boase, Lindsay D. Nelson, Nancy R. Temkin, Joseph T. Giacino, Amy J. Markowitz, Andrew Maas, David K. Menon, Graham Teasdale, Geoffrey T. Manley
Summary: The Glasgow Outcome Scale-Extended (GOSE) is widely used for assessing global disability and recovery after traumatic brain injury, but achieving consistency in its application is challenging. The manual provides guidance on assessment principles, administering the interview, handling borderline cases, and discussing the properties of GOSE. Recommendations for assessor training, accreditation, and monitoring are also outlined.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Nursing
Ruth Shanahan, Pinar Avsar, Chanel Watson, Zena Moore, Declan Patton, Natalie L. Mcevoy, Ger Curley, Tom O'Connor
Summary: The impact of brain tissue oxygenation (PbtO2) monitoring on long-term neurological outcomes and mortality in patients with traumatic brain injuries is still inconclusive. Further research is needed to determine its efficacy and guide clinical practice.
NURSING IN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Lindsay D. Nelson, Brooke E. Magnus, Nancy R. Temkin, Sureyya Dikmen, Steve Balsis
Summary: The study found that the Functional Status Examination (FSE) is more precise in characterizing individual differences in functional limitations after traumatic brain injury compared to the more commonly used Glasgow Outcome Scale-Extended (GOSE). Additionally, the FSE showed consistent test performance regardless of the type of interviewee, indicating its applicability for both TBI patients and significant others. These findings support the FSE as a viable substitute for the GOSE in clinical trials and studies of TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
David A. Zuckerman, Joseph T. Giacino, Yelena G. Bodien
Summary: The outcomes of TBI are diverse and not standardized, with dichotomization of outcomes into favorable and unfavorable categories potentially limiting detection of treatment effects and impacting decision-making processes.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Clinical Neurology
Hao Xu, Yongfei Dong, Dejun Bao, Xiangpin Wei, Chaoshi Niu, Xinfeng Liu
Summary: Traumatic brain injury (TBI) is a major cause of mortality and morbidity in adults and children, with post-traumatic hydrocephalus (PTH) being a serious complication associated with neurocognitive impairment and motor dysfunction. The long-term functional outcomes after shunt dependence are uncertain.
NEUROLOGY AND THERAPY
(2023)
Article
Emergency Medicine
Heather Bick, Tarik Wasfie, Virginia Labond, Jennifer R. Hella, Eric Pearson, Kimberly R. Barber
Summary: The study found that age, GCS, and mode of injury play important roles in leveling trauma patients, especially in elderly patients with traumatic head injury. Age is an independent predictor of mortality and length of stay in these patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Rehabilitation
Marie-Julie Potvin, Pauline Brayet, Veronique Paradis, Charles Overbeek, Erik Therrien, Laurie-Anne Dion, Francis Bernard, Nadia Gosselin, Isabelle Rouleau, Olivier Boucher, Jean-Francois Giguere
Summary: The study aimed to predict long-term functional outcomes in traumatic brain injury patients using the new test EXACT and found that EXACT, in some cases, may predict functional outcomes more accurately than PTA, suggesting it could be a promising tool for future TBI recovery research.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Neurosciences
Jing Wang, Yujiao Lu, Christopher Carr, Krishnan M. Dhandapani, Darrell W. Brann
Summary: This study found that long-term (months) after traumatic brain injury (TBI), there is a significant presence of proinflammatory senescent cells in the brain. The administration of senolytic drugs can improve long-term functional outcomes by reducing inflammation and neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Daniel Vieira de Oliveira, Rita de Cassia Almeida Vieira, Leonardo Zumerkorn Pipek, Regina Marcia Cardoso de Sousa, Camila Pedroso Estevam de Souza, Eduesley Santana-Santos, Wellingson Silva Paiva
Summary: This study aimed to investigate the recovery pattern and survival rate of patients with severe traumatic brain injury (TBI) with focal lesions (FL), and identify factors associated with mortality and unfavorable outcomes. The results showed that patients achieved satisfactory functional recovery within twelve months, with the most significant improvement occurring in the first three months. Clinical and sociodemographic variables were found to be associated with post-trauma outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Mathematical & Computational Biology
Yu Wang, Sharon D. Yeatts, Renee' H. Martin, Robert Silbergleit, Gaylan L. Rockswold, William G. Barsan, Frederick K. Korley, Sarah Rockswold, Byron J. Gajewski
Summary: This study explores the analysis method of sliding scoring of GOS-E and compares the effectiveness of continuous method compared to dichotomous method and ordinal method. The results show that the continuous method has higher power and lower mean squared error, so it is recommended that future severe TBI clinical trials analyze the sliding scoring of GOS-E as continuous.
STATISTICS IN MEDICINE
(2023)
Article
Critical Care Medicine
Timo Roine, Mehrbod Mohammadian, Jussi Hirvonen, Timo Kurki, Jussi P. Posti, Riikka S. K. Takala, Virginia F. Newcombe, Jussi Tallus, Ari J. Katila, Henna-Riikka Maanpaeae, Janek Frantzen, David Menon, Olli Tenovuo
Summary: We investigated the topology of structural brain connectivity networks and found that both global and local network properties are associated with outcome after mild traumatic brain injury. Higher normalized global efficiency, degree, and strength as well as lower small-worldness are correlated with better outcome. The local network properties of the left putamen and the left postcentral gyrus show the most prominent correlations with outcome.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Clinical Neurology
Joel Frohlich, Micah A. Johnson, David L. McArthur, Evan S. Lutkenhoff, John Dell'Italia, Courtney Real, Vikesh Shrestha, Norman M. Spivak, Jesus E. Ruiz Tejeda, Paul M. Vespa, Martin M. Monti
Summary: The study found that sedation-induced burst-suppression (SIBS) was positively associated with outcomes at 6 months in patients with moderate-to-severe traumatic brain injury (TBI), but did not predict outcomes at discharge. These results suggest that burst suppression may have neuroprotective effects in acute patients with TBI etiologies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Marina Levochkina, Leah McQuillan, Nabil Awan, David Barton, John Maczuzak, Claudia Bianchine, Shannon Trombley, Emma Kotes, Joshua Wiener, Audrey Wagner, Jason Calcagno, Andrew Maza, Ryan Nierstedt, Stephanie Ferimer, Amy Wagner
Summary: This study examined the temporal dynamics of NLR post-TBI and its associations with hospital-acquired infections (HAIs), resource utilization, and outcomes. It identified two distinct NLR profiles with high NLR associated with higher rates of HAIs and negative recovery outcomes. The findings highlight the importance of monitoring immune factors post-TBI for infection risk and recovery optimization.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Cassidy Q. B. Mostert, Ranjit D. Singh, Maxime Gerritsen, Erwin J. O. Kompanje, Gerard M. Ribbers, Wilco C. Peul, Jeroen T. J. M. van Dijck
Summary: This systematic review investigated the long-term outcome after severe traumatic brain injury (sTBI) and found limited and heterogeneous literature in this area. Mortality and unfavorable outcome rates were high, but a considerable proportion of survivors achieved favorable outcomes.
ACTA NEUROCHIRURGICA
(2022)