Article
Allergy
Ioana Agache, Cezmi Akdis, Mubeccel Akdis, Giorgio Walter Canonica, Thomas Casale, Tomas Chivato, Jonathan Corren, Derek K. Chu, Stefano Del Giacco, Thomas Eiwegger, Breda Flood, Davide Firinu, James E. Gern, Eckard Hamelmann, Nicola Hanania, Irene Hernandez-Martin, Rebeca Knibb, Mika Makela, Parameswaran Nair, Liam O'Mahony, Nikolaos G. Papadopoulos, Alberto Papi, Hae-Sim Park, Luis Perez de Llano, Oliver Pfaar, Santiago Quirce, Joaquin Sastre, Mohamed Shamji, Jurgen Schwarze, Oscar Palomares, Marek Jutel
Summary: Severe asthma poses significant challenges in management, but targeted treatments with biologicals offer new hope for patients. However, further research is needed on issues such as selection of biologicals, response definition, treatment duration, and cost-effectiveness.
Article
Surgery
L. Giammattei, D. Starnoni, M. Messerer, R. T. Daniel
Summary: This article presents the surgical technique of basal cisternostomy, including procedures such as craniotomy and sphenoidal drilling. This promising technique does not require complex maneuvers and can be safely implemented by trained neurosurgeons.
FRONTIERS IN SURGERY
(2022)
Article
Rheumatology
Yarden Yavne, Yonatan Edel, Julia Berman, Tali Eviatar, Daniel Shepshelovich
Summary: This study aimed to characterize the data supporting the updated recommendations for SLE management and highlighted areas that need more high-quality research. The results revealed a scarcity of sufficiently powered high-quality research referenced in the recently published SLE treatment guidelines, indicating the need for well-designed large-scale studies to inform healthcare professionals caring for patients with SLE.
Article
Computer Science, Interdisciplinary Applications
Gregor Lichtner, Brian S. Alper, Carlo Jurth, Claudia Spies, Martin Boeker, Joerg J. Meerpohl, Falk von Dincklage
Summary: This study proposes a FHIR-based format that uses computer-interpretable representations of knowledge artifacts to directly generate evidence-based recommendations. An information model and corresponding representation based on FHIR resources were developed, allowing for the transparent evaluation of evidence and the facilitation of computer-interpretable guideline recommendations.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Health Care Sciences & Services
David D. Kim, Lauren A. Do, Allan T. Daly, John B. Wong, James D. Chambers, Daniel A. Ollendorf, Peter J. Neumann
Summary: The study found substantial variability in the evidentiary rationales for low-value care recommendations across different organizations, with clinical evidence being the most commonly relied upon. Broadening the evidence base to include cost-effectiveness evidence can help determine whether the costs of an intervention are justified by the benefits. Developing a consensus grading structure for the strength and evidentiary rationale may improve efforts to reduce low-value care.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Infectious Diseases
Elske Sieswerda, Mark G. J. de Boer, Marc M. J. Bonten, Wim G. Boersma, Rene E. Jonkers, Roel M. Aleva, Bart-Jan Kullberg, Jeroen A. Schouten, Ewoudt M. W. van de Garde, Theo J. Verheij, Menno M. van der Eerden, Jan M. Prins, W. Joost Wiersinga
Summary: The Dutch Working Party on Antibiotic Policy formed a multidisciplinary expert committee to provide evidence-based recommendations for antibacterial therapy in hospitalized adults with COVID-19. The committee suggested restrictive antibiotic use upon admission and outlined specific criteria for stopping antibiotic treatment. The study emphasized the importance of laboratory tests in guiding antibiotic therapy.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Clinical Neurology
Dylan P. Griswold, Nancy Carney, Nicolas M. Ballarini, Laura L. Fernandez, Angelos Kolias, Peter J. Hutchinson, Andres M. Rubiano
Summary: This study aims to identify the facilitators and barriers to collecting data about patients with severe traumatic brain injury (sTBI) and to implement a stratified protocol across different treatment phases in low-resource settings. The study also aims to determine the possible association between adherence to these protocols and patient outcomes.
Article
Oncology
Ainhoa Madariaga, Jenny Lau, Arunangshu Ghoshal, Tomasz Dzierzanowski, Philip Larkin, Jacek Sobocki, Andrew Dickman, Kate Furness, Rouhi Fazelzad, Gregory B. Crawford, Stephanie Lheureux
Summary: This study provides evidence-based recommendations and suggestions for the management of malignant bowel obstruction in patients with advanced cancer, covering various aspects such as symptom management, bowel obstruction resolution, and prognosis.
SUPPORTIVE CARE IN CANCER
(2022)
Editorial Material
Multidisciplinary Sciences
Elena Garralda, Scott A. Laurie, Lesley Seymour, Elisabeth G. E. de Vries
Summary: Early detection of immunotherapy-induced tumor response is crucial, but therapy-induced pseudoprogression can make it complicated. A consensus guideline called iRECIST, a modification of RECIST version 1.1, was developed. This article explores the next steps required to test its validity and proposes novel approaches for response criteria.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Ruud Droeghaag, Valerie N. E. Schuermans, Sem M. M. Hermans, Anouk Y. J. M. Smeets, Inge J. M. H. Caelers, Mickael Hiligsmann, Wouter L. W. van Hemert, Silvia Evers, Henk van Santbrink
Summary: This study aims to improve the quality and comparability of economic evaluations in spine surgery through expert-based recommendations obtained via a modified Delphi study. Steps include systematic review, expert group formation, drafting and validation of statements, and validation by a Delphi-panel to formulate final recommendations.
Article
Biotechnology & Applied Microbiology
Xiancheng Yu, Thuy-Tien Nguyen, Tianchi Wu, Mazdak Ghajari
Summary: This study investigated the difference in cerebrospinal fluid (CSF) cavitation between blasts and impacts, and proposed a mechanism explaining the lower negative pressure produced by blasts in the contrecoup CSF region. Experimental results and computational modeling validated this mechanism. These findings have significant implications for the prevention and diagnosis of blast-induced traumatic brain injury.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Weiying Zhu, Ling Ai, Ying Feng, Haiyan Yuan, Yu Wang, Meitang Wang, Zubing Mei
Summary: This study aims to identify potential predictive factors for successful VBAC, particularly for Chinese women, through a comprehensive literature review and an international Delphi survey. The results will be submitted to international peer-reviewed journals or conferences in perinatal medicine or obstetrics.
Article
Biochemistry & Molecular Biology
Erika Souche, Sergi Beltran, Erwin Brosens, John W. Belmont, Magdalena Fossum, Olaf Riess, Christian Gilissen, Amin Ardeshirdavani, Gunnar Houge, Marielle van Gijn, Jill Clayton-Smith, Matthis Synofzik, Nicole de Leeuw, Zandra C. Deans, Yasemin Dincer, Sebastian H. Eck, Saskia van eer Crabben, Meena Balasubramanian, Holm Graessner, Marc Sturm, Helen Firth, Alessandra Ferlini, Rima Nabbout, Elfride De Baere, Thomas Liehr, Milan Macek, Gert Matthijs, Hans Scheffer, Peter Bauer, Helger G. Yntema, Marjan M. Weiss
Summary: Guidelines for diagnostic Next Generation Sequencing (NGS) were published in 2016 to assist laboratories in implementing and accrediting NGS in a diagnostic setting. With the increasing use of Whole Genome Sequencing (WGS) in rare disease diagnosis, there was a need to re-evaluate and update the previously published guidelines. The aim of these recommendations is to provide technical advice and aid clinical decision-making for geneticists and bioinformaticians.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Health Care Sciences & Services
V. Muralidharan, A. Burgart, R. Daneshjou, S. Rose
Summary: ACCEPT-AI is a framework that provides recommendations for the safe inclusion of pediatric data in AI/ML research. It is based on ethical principles and incorporates various considerations such as age, consent, communication, data protection, and technology. ACCEPT-AI can serve as a guide for researchers, clinicians, regulators, and policymakers, and can be used independently or in conjunction with existing AI/ML guidelines.
NPJ DIGITAL MEDICINE
(2023)
Review
Integrative & Complementary Medicine
Katharina Gaertner, Susanne Ulbrich-Zurni, Stephan Baumgartner, Harald Walach, Michael Frass, Petra Weiermayer
Summary: This study aims to establish Summarizing evidence from Homeopathic Intervention Studies (Sum-HomIS recommendations) to address the issue of standardization in systematic reviews and meta-analyses of homeopathic intervention studies. The study presents five basic recommendations based on a literature review and expert discussions, including broad literature search, inclusion of different types of studies, clear clinical research question, comprehensive quality assessment, and choice of evidence summary method.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Article
Surgery
W. A. R. Zwaans, J. A. de Bruijn, J. P. Dieleman, E. W. Steyerberg, M. R. M. Scheltinga, R. M. H. Roumen
Summary: The purpose of this study was to examine whether patients tend to overestimate or underestimate their pre-operative pain levels when recalling them in the post-operative phase. The study found that a significant percentage of patients experienced recall bias, leading to misclassification of treatment outcomes.
Article
Critical Care Medicine
Anne A. H. de Hond, Ilse M. J. Kant, Mattia Fornasa, Giovanni Cina, Paul W. G. Elbers, Patrick J. J. Thoral, M. Sesmu Arbous, Ewout W. W. Steyerberg
Summary: This study aimed to assess the performance of a decision support tool based on a machine learning model in predicting readmission or death within 7 days after ICU discharge. Through independent validation and retraining on multiple datasets, it was found that the model performed well in new settings and can be considered as an effective clinical tool.
CRITICAL CARE MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Carlijn A. M. Roumans, Ruben D. van der Bogt, Daan Nieboer, Ewout W. Steyerberg, Dimitris Rizopoulos, Iris Lansdorp-Vogelaar, Katharina Biermann, Marco J. Bruno, Manon C. W. Spaander
Summary: In this multicenter prospective cohort study, it was found that half of Barrett's esophagus (BE) surveillance endoscopies do not adhere to guideline recommendations. However, there was no clear association between nonadherence and endoscopic curability of esophageal adenocarcinoma (EAC) or mortality, indicating the need for optimization of BE surveillance guidelines to minimize the burden of endoscopies.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Cardiac & Cardiovascular Systems
Steele C. Butcher, Benjamin Essayagh, Ewout W. Steyerberg, Giovanni Benfari, Clemence Antoine, Francesco Grigioni, Thierry Le Tourneau, Jean-Christian Roussel, Aniek van Wijngaarden, Nina Ajmone Marsan, Christophe Tribouilloy, Dan Rusinaru, Aviram Hochstadt, Yan Topilsky, Hector Michelena, Victoria Delgado, Jeroen J. Bax, Maurice Enriquez-Sarano
Summary: This study examined the impact of secondary outcome determinants on post-operative survival in patients with degenerative mitral regurgitation (DMR) and found that the number of these determinants was independently associated with increased mortality after surgery, providing better outcome discrimination than traditional indications for surgery.
EUROPEAN HEART JOURNAL
(2023)
Review
Health Care Sciences & Services
Mohammed T. Hudda, Lucinda Archer, Maarten van Smeden, Karel G. M. Moons, Gary S. Collins, Ewout W. Steyerberg, Charlotte Wahlich, Johannes B. Reitsma, Richard D. Riley, Ben Van Calster, Laure Wynants
Summary: The study aims to assess the improvement in reporting completeness of COVID-19 prediction models after peer review. The findings suggest that the reporting quality of preprints is poor and did not improve significantly after peer review, indicating that peer review had minimal effect on the completeness of reporting during the COVID-19 pandemic.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jesus Villar, Jesus M. Gonzalez-Martin, Jose M. Anon, Carlos Ferrando, Juan A. Soler, Fernando Mosteiro, Juan M. Mora-Ordonez, Alfonso Ambros, Lorena Fernandez, Raquel Montiel, Anxela Vidal, Tomas Munoz, Lina Perez-Mendez, Pedro Rodriguez-Suarez, Cristina Fernandez, Rosa L. L. Fernandez, Tamas Szakmany, Karen E. A. Burns, Ewout W. Steyerberg, Arthur S. Slutsky
Summary: Mortality assessment in clinical studies of acute respiratory distress syndrome (ARDS) has not been well-defined. This study aimed to determine the timing of mortality assessment in ICU patients with moderate-to-severe ARDS, and its predictive value for treatment response. Observational cohorts and a randomized trial were analyzed, and it was found that ICU mortality rates closely approximated 28-day mortality rates. ICU mortality assessment within the first week of a trial could serve as an early predictor of treatment response for moderate-to-severe ARDS patients.
SCIENTIFIC REPORTS
(2023)
Correction
Critical Care Medicine
Emanuele Rezoagli, Matteo Petrosino, Paola Rebora, David Menon, Stefania Mondello, D. James Cooper, Andrew I. R. Maas, Eveline J. A. Wiegers, Stefania Galimberti, Giuseppe Citerio, Cecilia Ackerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Gerard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras M. Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana D. Castano-Leon, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Veronique Keyser, Vincent Degos, Francesco Della Corte, Hugo Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Duliere, Ari Ercole, Erzsebet Ezer, Martin Fabricius, Kelly Foks, Shirin A. Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagos Golubovic, Pedro Gomez, Benjamin J. Gravesteijn, Francesca Grossi, Deepak Gupta, Iain Haitsma, Raimund G. Helbok, Eirik Helseth, Jilske Huijben, Peter Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, Angelos Kolias, Daniel Kondziella, Evgenios Kornaropoulos, Lars-Owe Koskinen, Noemi Kovacs, Ana Kowark, Alfonso Lagares, Steven Laureys, Aurelie Lejeune, Fiona Lecky, Didier Ledoux, Roger Lightfoot, Hester Lingsma, Alex Manara, Hugues Marechal, Costanza Martino, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Jozsef Nyiradi, Fabrizio Ortolano, Jean-Francois Payen, Vincent Perlbarg, Paolo P. Persona, Wilco Peul, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Oddrun Sandrod, Kari Schirmer-Mikalsen, Rico Frederik W. Schou, Charlie Sewalt, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Ewout Steyerberg, Nino Stocchetti, Nina Sundstroem, Riikka Takala, Viktoria Tamas, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils A. Valeinis, Shirley Vallance, Zoltan Vamos, Gregory Steen, T. J. M. van Dijck Jeroen, Thomas Essen, Roel Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Peter Vulekovic, Eveline A. Wiegers, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick Zeiler, Agate Ziverte, Tommaso V. Zoerle, Russel Gruen, Lynette Murray, Dinesh Varma, Christopher MacIsaac, Andrea Jordan
INTENSIVE CARE MEDICINE
(2023)
Article
Mathematical & Computational Biology
Doranne Thomassen, Ewout Steyerberg, Saskia le Cessie
Summary: In clinical practice, it is crucial to determine the absolute risk reduction of treatment for individual patients. However, logistic regression in trials with binary outcomes provides estimates of treatment effects in terms of log odds differences. In this study, we propose a new Bayesian regression model for binary outcomes on the additive risk scale, allowing for direct estimation of treatment effects on the linear scale of clinical interest. Comparisons were made with a previously proposed additive risk model and backtransforming predictions from a logistic model. Results showed that modelling untransformed risk can yield significantly different treatment effect estimates, particularly for small sample sizes or extreme predicted risks close to 0% or 100%. Our proposed model proved to be more sensitive in detecting all information in the data in a network meta-analysis.
STATISTICS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Nicole von Steinbuechel, Stefanie Hahm, Holger Muehlan, Juan Carlos Arango-Lasprilla, Fabian Bockhop, Amra Covic, Silke W. Schmidt, Ewout Steyerberg, Andrew I. R. Maas, David Menon, Nada Andelic, Marina Zeldovich, CTR TBI Participants Investigators
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. This study aims to understand the impact of TBI on various outcome domains, evaluating factors contributing to worsening or improving outcomes. The study used patient-reported outcome measures and identified different trajectory classes for outcome after TBI, including stable good health, persistent impairments, improving health, and deteriorating health. Individuals with persistent impairments and deterioration need special attention and long-term clinical monitoring and therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Alexandros Rekkas, David van Klaveren, Patrick B. Ryan, Ewout W. Steyerberg, David M. Kent, Peter R. Rijnbeek
Summary: This study proposes a standardized scalable framework to extend the assessment of treatment effect heterogeneity to the observational setting. The framework consists of five steps: definition of research aim, identification of relevant databases, development of prediction model, estimation of treatment effect within risk strata, and presentation of results. It allows for the evaluation of differential treatment effects across risk strata.
NPJ DIGITAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Anne A. H. de Hond, Vaibhavi B. B. Shah, Ilse M. J. Kant, Ben Van Calster, Ewout W. Steyerberg, Tina Hernandez-Boussard
Summary: The generalizability of predictive algorithms is crucial for their application in clinical practice. This article provides an overview of three types of generalizability, namely temporal, geographical, and domain generalizability, based on existing literature. These types of generalizability are associated with their respective goals, methodology, and stakeholders.
NPJ DIGITAL MEDICINE
(2023)
Review
Clinical Neurology
Yasmin Sadigh, Colin van Surksum, Philip H. D. Schroder, Ayca Cozar, Dalila Khandour, Lailla Talbi, Jochem K. H. Spoor, Oscar H. J. Eelkman Rooda, Victor Volovici, Marie-Lise C. van Veelen
Summary: Trapped or isolated fourth ventricle (TFV) is a rare but critical neurosurgical condition mostly affecting pediatric patients. This study reviewed available data on the treatment options for TFV, comparing their safety, efficacy, and durability. The meta-analysis revealed that primary endoscopic and microsurgical interventions were associated with lower revision rates compared to shunt placement. Endoscopy showed a significantly higher rate of clinical improvement, making it a preferred first-line treatment option for TFV. Microsurgery can be considered as a second treatment option due to its similar outcomes but more invasive nature.
NEUROSURGICAL REVIEW
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Siri Lise van der Meijden, Anna van Boekel, Laurens Schinkelshoek, Harry van Goor, Mark de Boer, Ewout Steyerberg, Bart Geerts, Sesmu Arbous
Summary: Currently, postoperative infections are identified through manual chart review. In this study, a validated automated labeling method based on registrations and treatments was used to develop a high-quality prediction model (AUC 0.81) for postoperative infections.
CARING IS SHARING-EXPLOITING THE VALUE IN DATA FOR HEALTH AND INNOVATION-PROCEEDINGS OF MIE 2023
(2023)
Article
Medicine, General & Internal
Franklin Chu Buh, Irene Ule Ngole Sumbele, Andrew I. R. Maas, Mathieu Motah, Jogi V. Pattisapu, Eric Youm, Basil Kum Meh, Firas H. Kobeissy, Kevin W. Wang, Peter J. A. Hutchinson, Germain Sotoing Taiwe
Summary: The study revealed that TBI in Cameroon is predominantly caused by road traffic incidents and primarily affects young adult males. Lack of pre-hospital care, financial constraints limiting both CT scanning and medical care, and a lack of acute physiotherapy services likely influenced care and outcomes adversely.
MEDICINA-LITHUANIA
(2023)