Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is the leading cause of cardiovascular disease worldwide, and it shares several risk factors with chronic kidney disease. Patients with chronic kidney disease are more susceptible to cardiovascular problems.
Review
Pharmacology & Pharmacy
Angelo Zinellu, Arduino A. Mangoni
Summary: This study suggests that statins significantly lower homocysteine concentrations, which can be beneficial in reducing the risk of atherosclerosis.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Deqiang Yuan, Jiapeng Chu, Hao Lin, Guoqi Zhu, Jun Qian, Yunan Yu, Tongqing Yao, Fan Ping, Fei Chen, Xuebo Liu
Summary: This review summarizes the mechanism of Hcy-induced endothelial injury and the treatment methods to alleviate the Hcy induced endothelial dysfunction, in order to provide new thoughts for the diagnosis and treatment of Hcy-induced endothelial injury and subsequent AS-related diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Dongye Li, Huiyu Qiao, Xieqing Yang, Jin Li, Wei Dai, Xiaoyi Chen, Jun Shen, Xihai Zhao
Summary: Co-existing hypertension and hyperhomocysteinemia (H-Hcy) are associated with carotid vulnerable plaque features, and the combination of the two has a stronger predictive value for subsequent vascular events than each measurement alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ping Jin, Dengfeng Gao, Guangzhi Cong, Ru Yan, Shaobin Jia
Summary: The study revealed that PCSK9 plays a crucial role in Hcy-induced lipid accumulation in macrophages and atherosclerotic lesions, with inhibiting PCSK9 potentially having anti-atherosclerotic effects in HHcy-accelerated atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Gunter Almer, Peter Opriessnig, Heimo Wolinski, Gerhard Sommer, Clemens Diwoky, Margarete Lechleitner, Dagmar Kolb, Vladimir Bubalo, Markus S. Brunner, Andreas N. Schwarz, Gerd Leitinger, Gabriele Schoiswohl, Gunther Marsche, Tobias Niedrist, Silvia Schauer, Wolfgang Oswald, Andrea Groselj-Strele, Margret Paar, Gerhard Cvirn, Gerald Hoefler, Gerald N. Rechberger, Markus Herrmann, Sasa Frank, Gerhard A. Holzapfel, Dagmar Kratky, Harald Mangge, Gerd Hoerl, Oksana Tehlivets
Summary: Elevated plasma homocysteine is an independent risk factor for atherosclerosis and is strongly linked to cardiovascular mortality. This study developed an automated system for vessel wall injury, leading to more homogenous damage and more pronounced atherosclerotic plaque development. The deficiency of B vitamins can cause atherogenic transformation of the aorta even in the absence of hypercholesterolemia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Je Hun Song, Hyuk Huh, Eunjin Bae, Jeonghwan Lee, Jung Pyo Lee, Jong Soo Lee, Gwang Sil Kim, Kyung Don Yoo
Summary: This study investigated the association between serum homocysteine levels and mortality rate, and found that there was a correlation only in the nonCKD group. This finding may be attributed to protein-energy wasting or the chronic inflammation status that accompanies CKD.
Article
Biochemistry & Molecular Biology
Lin Xie, Ning Ding, Honghong Zhang, Kun Liu, Jiantuan Xiong, Shengchao Ma, Anning Yang, Huiping Zhang, Yideng Jiang
Summary: The study revealed that Homocysteine (Hcy) exacerbates inflammation in atherosclerosis through promoting the expression of SNF5 and IL-1 beta, providing new insights into the specific mechanism of Hcy-induced inflammation.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuxia Li, Qun Zhao, Yuan Cao, Jigang Si, Jing Li, Kai Cao, Xiaoming Pang
Summary: The research found that probucol reduces homocysteine-induced CRP expression, inhibits oxidative stress in the inflammatory process, and thereby decreases CRP levels in both the vessel wall and circulation.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Shan Zhang, Ying Lv, Xing Luo, Xiuzhu Weng, Jinyu Qi, Xiaoxuan Bai, Chen Zhao, Ming Zeng, Xiaoyi Bao, Xinyu Dai, Ying Zhang, Yuwu Chen, Minghao Liu, Sining Hu, Ji Li, Haibo Jia
Summary: This study found that hyperhomocysteinemia can lead to larger atherosclerotic plaques and increased secretion of inflammatory cytokines, which can be attenuated by reducing Caspase-1 levels in mice. In vitro experiments demonstrated that homocysteine can activate the NLRP3 inflammasome and induce macrophage pyroptosis, which is inhibited by Caspase-1 inhibition. Furthermore, homocysteine promotes endoplasmic reticulum stress, endoplasmic reticulum-mitochondria coupling, and disturbs calcium homeostasis, contributing to macrophage pyroptosis.
MOLECULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mohetaboer Momin, Fangfang Fan, Ying Yang, Jianping Li, Jia Jia, Yan Zhang
Summary: This study investigates the association between high homocysteine (HCY) levels and the incidence of novel carotid plaque, and assesses the additive effect of HCY and low-density lipoprotein cholesterol (LDL-C). The findings show that high HCY levels are independently associated with the incidence of carotid plaque formation, and the risk is higher when combined with high LDL-C levels. These findings suggest that HCY may be a potential target for preventing carotid plaque formation.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Urology & Nephrology
Shutong Du, Hyunju Kim, Deidra C. Crews, Karen White, Casey M. Rebholz
Summary: Ultraprocessed foods consumption is positively associated with the risk of chronic kidney disease (CKD), suggesting that high intake of ultraprocessed foods increases the risk of developing CKD.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Medicine, Research & Experimental
Donghai Wen, Zihe Zheng, Aditya Surapaneni, Bing Yu, Linda Zhou, Wen Zhou, Dawei Xie, Haochang Shou, Julian Avila-Pacheco, Sahir Kalim, Jiang He, Chi-Yuan Hsu, Afshin Parsa, Panduranga Rao, James Sondheimer, Raymond Townsend, Sushrut S. Waikar, Casey M. Rebholz, Michelle R. Denburg, Paul L. Kimmel, Ramachandran S. Vasan, Clary B. Clish, Josef Coresh, Harold I. Feldman, Morgan E. Grams, Eugene P. Rhee
Summary: This study demonstrates the application of metabolomics in identifying potential biomarkers and causal pathways in the progression of chronic kidney disease (CKD).
Review
Medical Laboratory Technology
Huimin Hou, Huiying Zhao
Summary: Atherosclerosis, a complex disease influenced by both genetic and non-genetic factors, involves DNA methylation as a significant epigenetic mechanism. Deficiencies in folic acid and B vitamins can accelerate the pathological processes of atherosclerosis, while supplementation of these nutrients may help delay the progression of the disease. The influence of intestinal flora on folate metabolism and epigenetics is also a factor to be considered in the study of atherosclerosis.
CLINICA CHIMICA ACTA
(2021)
Review
Pharmacology & Pharmacy
S. S. Habib, T. Al-Khlaiwi, A. Almushawah, A. Alsomali, S. A. Habib
Summary: Hyperhomocysteinemia is associated with an increased risk of atherosclerosis in young adults and children. The relationship between homocysteine and cardiovascular injury is influenced by multiple factors, including smoking, genetic polymorphism, hormonal and renal disorders, nutritional deficiencies, and medication use.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Hematology
Dana Yelin, Ili Margalit
Summary: COVID-19 has affected a large number of people worldwide, with a substantial proportion experiencing ongoing, sometimes debilitating symptoms known as long COVID. The diagnosis and management of long COVID are challenging due to a lack of objective findings, despite the abundance of descriptive data published so far. This review aims to describe the common manifestations of long COVID, discuss diagnostic and management challenges, and address specific aspects in hematologic patients.
ACTA HAEMATOLOGICA
(2022)
Article
Infectious Diseases
Dana Yelin, Charalampos D. Moschopoulos, Ili Margalit, Effrossyni Gkrania-Klotsas, Francesco Landi, Jean-Paul Stahl, Dafna Yahav
Summary: This article provides guidelines for the assessment and management of individuals with persistent symptoms after acute COVID-19 infection, including a definition for 'long COVID'. The recommendations are based on a search of literature on epidemiology, symptoms, assessment, and treatment of long COVID. However, due to insufficient evidence, only conditional guidance is provided, and further high-quality research is recommended.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Medicine, General & Internal
Dana Yelin, Ili Margalit, Mayssam Nehme, Jaume Bordas-Martinez, Francesco Pistelli, Dafna Yahav, Idris Guessous, Xavier Dura-Miralles, Laura Carrozzi, Irit Shapira-Lichter, Pauline Vetter, Dolores Peleato-Catalan, Giusy Tiseo, Eytan Wirtheim, Laurent Kaiser, Carlota Gudiol, Marco Falcone, Leonard Leibovici
Summary: This study identified six unique patterns of symptoms in long COVID patients, including cognitive, pain-syndrome, pulmonary, cardiac, anosmia-dysgeusia, and headache. The cognitive pattern was the most common and was higher in outpatients during the acute phase. Only the cognitive and cardiac patterns were associated with failure to return to pre-COVID occupational and physical activity status.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Ili Margalit, Dana Yelin, Moshe Sagi, Maya Merav Rahat, Liron Sheena, Nadav Mizrahi, Yael Gordin, Hadar Agmon, Nitzan Karny Epstein, Alaa Atamna, Ori Tishler, Vered Daitch, Tanya Babich, Donna Abecasis, Yoni Yarom, Shirit Kazum, Dorit Shitenberg, Erik Baltaxe, Odelia Elkana, Irit Shapira-Lichter, Leonard Leibovici, Dafna Yahav
Summary: A study conducted in a COVID-19 recovery clinic showed that long-COVID fatigue may be related to autonomic dysfunction, impaired cognition, and decreased mood.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Giusy Tiseo, Ili Margalit, Marco Ripa, Vanni Borghi, Hefziba Green, Virginie Prendki, Niccolo Riccardi, Yael Dishon, Giovanni Battista Perego, Alessandro Grembiale, Laura Galli, Marco Tinelli, Antonella Castagna, Cristina Mussini, Dafna Yahav, Mical Paul, Marco Falcone
Summary: The objective of this study was to identify predictors of 30-day survival in elderly patients with COVID-19. A retrospective cohort study was conducted on elderly patients hospitalized in six European sites. A predictive score (FLAMINCOV) was developed using logistic regression and validated in a separate cohort. The FLAMINCOV score showed good discrimination in predicting survival outcomes and may be beneficial for triage and management of elderly patients with COVID-19.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Hematology
Idan Goldberg, Eytan Cohen, Anat Gafter-Gvili, Tzippy Shochat, Eitan Kugler, Ili Margalit, Elad Goldberg, Pia Raanani, Ilan Krause
Summary: We analyzed the natural annual trends in haemoglobin, haematocrit, and mean corpuscular volume (MCV) in a population of adults and investigated the influence of clinical parameters. The study found a decline in haemoglobin and haematocrit levels and an increase in MCV, with the changes being more prominent in men. Gender was found to be the only parameter significantly associated with the decline in haemoglobin.
ACTA HAEMATOLOGICA
(2023)
Article
Infectious Diseases
Alaa Atamna, Ili Margalit, Gida Ayada, Tanya Babich, Pontus Naucler, John Karlsson Valik, Christian G. Giske, Natividad Benito, Ruben Cardona, Alba Rivera, Celine Pulcini, Manal Abdel Fattah, Justine Haquin, Alasdair Macgowan, Bibiana Chazan, Anna Yanovskay, Ronen Ben Ami, Michal Landes, Lior Nesher, Adi Zaidman-Shimshovitz, Kate McCarthy, David L. Paterson, Evelina Tacconelli, Michael Buhl, Susanna Mauer, Jesus Rodriguez-Bano, Marina de Cueto, Antonio Oliver, Enrique Ruiz de Gopegui, Angela Cano, Isabel Machuca, Monica Gozalo-Marguello, Luis Martinez-Martinez, Eva M. Gonzalez-Barbera, Iris Gomez Alfaro, Miguel Salavert, Bojana Beovic, Andreja Saje, Manica Mueller-Premru, Leonardo Pagani, Virginie Vitrat, Diamantis Kofteridis, Maria Zacharioudaki, Sofia Maraki, Yulia Weissman, Mical Paul, Yaakov Dickstei, Dafna Yahav
Summary: This study aimed to evaluate outcomes of P. aeruginosa bacteremia among older adults (> 80 years) and found that disease severity, place of acquisition, and background conditions were associated with mortality, while antimicrobial regimen was not. Therefore, preventive efforts and early diagnosis might be beneficial for improving outcomes in older adults with P. aeruginosa bacteremia.
Article
Infectious Diseases
Ili Margalit, Giusy Tiseo, Marco Ripa, Vanni Borghi, Hefziba Green, Virginie Prendki, Niccolo Riccardi, Giovanni Battista Perego, Alessandro Grembiale, Laura Galli, Marco Tinelli, Antonella Castagna, Cristina Mussini, Marco Falcone, Dafna Yahav
Summary: This study assessed the effect of remdesivir on COVID-19 mortality among elderly individuals using real-world data. The results showed that remdesivir reduced mortality in patients requiring oxygen support or non-invasive mechanical ventilation, but no association was found among patients necessitating invasive mechanical ventilation.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Immunology
Dafna Yahav, Melissa R. Gitman, Ili Margalit, Tomer Avni, Mariska M. G. Leeflang, Shahid Husain
Summary: This meta-analysis examined the predictive value of TST and IGRA for active TB in solid organ transplantation patients. The results showed that both tests have a high negative predictive value but a low positive predictive value.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Review
Immunology
Lior Nave, Ili Margalit, Noam Tau, Ido Cohen, Dana Yelin, Florian Lienert, Dafna Yahav
Summary: This study evaluated the safety and immunogenicity of the Modified Vaccinia Ankara (MVA) vaccine. The results provide reassuring evidence of MVA's immunogenicity and safety, but further research is needed to confirm the immunogenicity of a single dose and its clinical effectiveness.
Article
Infectious Diseases
D. Yelin, V. Daitch, T. Kalfon, M. Mor, S. Buchrits, Y. Shafir, M. Awwad, N. Ghantous, I. Shapira-Lichter, L. Leibovici, D. Yahav, I. Margalit
Summary: This study examined sexual dysfunction in both men and women with Long COVID, and found that age, persistent cough, chest pain, irritability, paresthesia, and emotional distress were significantly associated with sexual dysfunction.
INFECTIOUS DISEASES NOW
(2023)
Article
Medicine, General & Internal
Dana Yelin, Ran Levi, Chinanit Babu, Roi Moshe, Dorit Shitenberg, Alaa Atamna, Ori Tishler, Tanya Babich, Irit Shapira-Lichter, Donna Abecasis, Nira Cohen Zubary, Leonard Leibovici, Dafna Yahav, Ili Margalit
Summary: This study assessed the functional capacity of individuals with long COVID and found that even mild cases resulted in decreased physical capacity. Severe cases and impaired diffusing capacity or myalgia during recovery were identified as risk factors.
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2023)
Article
Surgery
Dafna Yahav, Ruth Rahamimov, Tiki Mashraki, Naomi Ben-Dor, Tali Steinmetz, Timna Agur, Boris Zingerman, Michal Herman-Edelstein, Shelly Lichtenberg, Haim Ben-Zvi, Erez Bar-Haim, Hila Cohen, Shahar Rotem, Uri Elia, Ili Margalit, Benaya Rozen Zvi
Summary: The immune response to two doses of SARS-CoV-2 mRNA vaccine is limited among kidney transplant recipients. This study aimed to evaluate the humoral and cellular response to a third dose of the BNT162b2 vaccine. The results showed that the third dose improved the immune response among kidney transplant recipients, although 30% of them remained seronegative. Temporary reduction of immunosuppression before vaccination was found to improve the antibody response.
TRANSPLANT INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Inbar Nardi-Agmon, Alona Zer, Yuri Peysakhovich, Ili Margalit, Ran Kornowski, Nir Peled, Zaza Iakobishvili
Summary: EGFR/ALK mutations may be associated with the development of pericardial effusion in patients with non-small cell lung cancer. Pericardiocentesis has a high recurrence rate, while pericardial window procedure shows no recurrence.
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2022)
Article
Geriatrics & Gerontology
Alaa Atamna, Tanya Babich, Ili Margalit, Tomer Avni, Haim Ben Zvi, Noa-Eliakim Raz, Dafna Yahav, Jihad Bishara
Summary: After studying elderly patients with CDI, it was found that the traditional definition of CDI severity did not accurately predict poor outcomes in this population. Instead, advanced dementia and low albumin may be more accurate predictors.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)