Article
Plant Sciences
Xinzhu Wang, Peilei Hou, Yanbo Qu, Rizhen Huang, Yan Feng, Shifeng Zhao, Yeling Ding, Zhixin Liao
Summary: A new phenolic derivative, along with eighteen known compounds, was isolated from Tibetan herbal medicine Pulicaria insignis. Compound 1 showed moderate cytotoxicity against Hela and HepG2 cells, while compounds 3, 4, 5, 6, and 13 exhibited potential cytotoxic activities against the four cell lines. Compound 5 demonstrated significant anti-proliferative activities against HepG2 cell lines and could block HepG2 cells in the G1 phase of the cell cycle.
RECORDS OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Qingqing Li, Shuang Yang, Haida Teng, Xueni Li, Wenli Xie, Zhili Wu, Guangzhong Yang, Jing Xu, Yu Chen
Summary: The article presents the isolation and characterization of two rare compounds from fruits of two plants, which have unique ring systems and show potential for treating diabetes mellitus.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qingqing Li, Shuang Yang, Haida Teng, Xueni Li, Wenli Xie, Zhili Wu, Guangzhong Yang, Jing Xu, Yu Chen
Summary: In this study, rare polycyclic polyprenylated acylphloroglucinols compounds 1-2 were isolated from the fruits of Garcinia bracteata and Garcinia multiflora. The structures and activities of these compounds were investigated, and compound 1 showed hypoglycemic activity, making it a potential candidate for the treatment of diabetes.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Rosa M. Claramunt, Concepcion Lopez, Dionisia Sanz, Jose Elguero, Ibon Alkorta
Summary: This research paper presents a structural study of albendazole, focusing on the conformational properties of its amino and imino tautomers. Experimental measurements and computational calculations help to understand the complex issues in the structure of albendazole and explain some of the disorder phenomena.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Themistoklis Venianakis, Christina Oikonomaki, Michael G. Siskos, Alexandra Primikyri, Ioannis P. Gerothanassis
Summary: The DFT study of H-1 NMR chemical shifts for various conjugated trienyl compounds demonstrated its effectiveness in predicting chemical shifts accurately and identifying geometric isomers reliably. The approach is powerful for addressing issues related to resonance assignments and structure elucidation in solution.
Article
Chemistry, Physical
Alexandre S. Dumon, Henry S. Rzepa, Carla Alamillo-Ferrer, Jordi Bures, Richard Procter, Tom D. Sheppard, Andrew Whiting
Summary: This study evaluates the accuracy of predicting F-19 NMR chemical shifts using density-functional-theory (DFT) based procedures and identifies the best combination of methods and basis sets. The results can be used as a tool to characterize reaction intermediates and products, and aid in determining mechanistic pathways.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Masaya Miyamoto, Masahiko Hada
Summary: The study applied the NPO method to analyze the effects of NH2 and NO2 groups on C-13 NMR chemical shifts in monosubstituted benzenes. It was found that NH2 shielded ortho- and para-carbons, while NO2 deshielded the same carbons. Additionally, changes in the orbital energy gaps reflected these effects.
Article
Nanoscience & Nanotechnology
Hamadou Hadidjatou, Olivier Holtomo, Ousmanou Motapon
Summary: This study investigates the effects of solvents on the structures and nuclear magnetic resonance spectroscopy of three pro-lithospermate molecules. The solvent effects on the geometrical parameters are found to be weak, and better results are obtained by using the B3LYP-D3BJ/6-31++G(d,p) method in DMSO for the calculation of chemical shifts.
Article
Chemistry, Multidisciplinary
Ibon Alkorta, Rosa M. Claramunt, Dionisia Sanz, Jose Elguero, Wolfgang Holzer
Summary: This work reports the C-13 and N-15 chemical shifts of various iodopyrazoles, including both non-relativistic and relativistic calculations, and also investigates issues related to NH-pyrazoles. The manuscript aims to develop equations containing corrections for heavy atoms to predict C-13 and N-15 chemical shifts.
STRUCTURAL CHEMISTRY
(2021)
Article
Chemistry, Physical
B. Krishnapriya, R. Ida Malarselvi, C. Ramachandra Raja, R. Priscilla
Summary: Polymorphic Form-I and Form-II of N-salicylidene, also known as (E)-4-Bromo-2-[(phenylimino)methyl]phenol [4B2PMP], were identified and found to have different structures and properties. Structural confirmation was achieved through powder X-Ray diffraction patterns and nuclear magnetic resonance chemical shifts, and the optical behavior was studied using diffuse-reflectance UV-VIS spectroscopy. Molecular docking results showed variations between the two forms, with Form II crystal exhibiting higher binding affinity than Form I crystal.
CHEMICAL PHYSICS IMPACT
(2023)
Article
Crystallography
Vidak Raicevic, Nikola D. Radnovic, Marko V. Rodic, Niko S. Radulovic
Summary: This paragraph describes the molecular structure and crystallographic data of 3-hydroxy-2-nitroestra-1,3,5(10)trien-17-one (2-nitroestrone).
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
(2023)
Article
Immunology
Nikola M. Stojanovic, Katarina Mitic, Slavica Stojnev, Dusan Sokolovic, Marija Vukelic Nikolic, Dragana Trickovic-Vukic, Pavle J. Randjelovic, Miljan Krstic, Niko S. Radulovic
Summary: The present study investigated the metabolic activity and adherence capacity of whole bone marrow cells (wBMC) and changes in bone marrow architecture following acute pancreatitis (AP) induction. The adherence capacity and total number of wBMCs significantly increased after AP induction, while pre-treatment with allopurinol reduced their adherence capability. No significant changes were observed in the metabolic activity of wBMCs. The alterations in bone marrow may reflect the general activation of myelopoiesis, consistent with increased mobilization of mesenchymal stem cells after AP induction.
EUROPEAN JOURNAL OF INFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Niko S. Radulovic, Marko Z. Mladenovic, Milan S. Dekic, Fabio Boylan
Summary: This study collected comprehensive data from NMR, MS, IR, and GC-MS on esters of different structures. A synthetic library was created, which successfully identified a new constituent in P. austriacum essential oil. The accumulated data provides chemists with a straightforward tool for future identification of related natural compounds.
Article
Plant Sciences
Marko Z. Mladenovic, Milenko N. Ristic, Andrija I. Bogdanovic, Novica R. Ristic, Fabio Boylan, Niko S. Radulovic
Summary: GC-MS analysis, synthesis, and chemical transformations were used to identify 275 constituents of Dianthus species and one Petrorhagia taxon from Serbia, including 17 completely new compounds. Multivariate statistical analysis revealed that the chemical profile of Dianthus taxa's surface waxes is influenced by both genetic and ecological factors, with ecological factors playing a more important role in the studied samples.
Article
Biochemistry & Molecular Biology
Nikola M. Stojanovic, Pavle J. Randjelovic, Aleksandra Maslovaric, Milos Kostic, Vidak Raicevic, Marija Sakac, Srdan Bjedov
Summary: This study evaluated the immunomodulatory potential of a selected library of bile acid derivatives (BAD) and found that these substances can affect the function of macrophages and have anti-inflammatory effects within a certain concentration range.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Nikola M. Stojanovic, Marko Z. Mladenovic, Pavle J. Randjelovic, Niko S. Radulovic
Summary: This study evaluated the anxiolytic activity of lemon balm essential oil on anxiety. The results show that lemon balm essential oil has anti-anxiety potential in different experimental settings and can affect multiple neurotransmitter systems. This provides a basis for future mechanistic studies.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Vidak Raicevic, Marko Mladenovic, Milica Acimovic, Niko Radulovic
Summary: This study identified and analyzed volatile compounds extracted from elderflowers, discovering 252 compounds, including 115 new compounds. These findings are important for further understanding the unique scent contributions of elderflowers.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Medicine, General & Internal
Vesna Nikolov, Misa Radisavljevic, Boban Jelenkovic, Nikola Stojanovic
Summary: The study aims to assess the efficacy of treatment modalities for brain metastasis patients based on the type (solitary or multiple) and primary cancer site. The retrospective study found that multiple metastases were more common in primary lung cancer, while single metastases were more common in adenocarcinoma patients. Surgery and radiation remain the cornerstone of therapy, and efforts should be made to improve surgical techniques and minimize damage to healthy tissue. Radiosurgery and whole brain radiotherapy are still the primary treatment for multiple metastases.
VOJNOSANITETSKI PREGLED
(2023)
Article
Medicine, General & Internal
Maja Simonovic, Bojan Nedovic, Misa Radisavljevic, Nikola Stojanovic
Summary: Post-traumatic stress disorder (PTSD) is a prevalent psychiatric disorder that often occurs following war trauma. Recent research has shed light on the biological basis of PTSD, with neuroimaging studies revealing altered brain connectivity patterns in affected individuals. This study aimed to compare the severity of PTSD and depression in patients with and without a history of traumatic brain injury (TBI) to shed light on the impact of comorbid TBI on the presentation of PTSD symptoms.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Nikola M. Stojanovic, Sara Mladenovic, Bogdan Stojiljkovic, Aleksandar Markovic, Dragana Pavlovic, Pavle Randjelovic, Jelena Zvezdanovic, Ljiljana Stanojevic
Summary: This study tested the effects of Melissa officinalis leaves hydrolate on gastric motility and found that low doses had no significant impact, while high doses increased basal tone of the stomach fundus. The dominant compound in the hydrolate was rosmarinic acid. Further research could explore the pharmacological activity and potential application of this by-product.
ACTA FACULTATIS MEDICAE NAISSENSIS
(2023)
