Article
Cell Biology
Jiaqi Bi, Jianxiong Shen, Chong Chen, Zheng Li, Haining Tan, Peiyu Sun, Youxi Lin
Summary: Melatonin has been shown to effectively ameliorate spinal cord injury by inhibiting neuronal apoptosis and promoting neuronal repair. Deficiency in melatonin delays recovery of sensory and motor functions in spinal cord injury rats.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Cell Biology
Lei Xie, Hang Wu, Xiaohong Huang, Tengbo Yu
Summary: Spinal cord injury (SCI) is a sudden disruption to the spinal neural tissue, causing loss of motor control and sensory function. Melatonin, a hormone with antioxidant properties, has been shown to have neuroprotective effects in SCI, reducing inflammation, oxidative stress, and cell death. This review highlights the potential applications of melatonin in SCI rehabilitation, including its synergistic effects with drugs, rehabilitation training, and stem cell therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Yue Guo, Peng Zhang, Haosen Zhao, Chang Xu, Sen Lin, Xifan Mei, He Tian
Summary: In this study, melatonin was found to promote the beneficial polarization of microglia from pro-inflammatory to anti-inflammation, decrease ROS activity, and restore mitochondrial metabolism. Melatonin may have therapeutic potential for neuroinflammation-related neurological disorders, such as spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Terese A. Garcia, Carrie R. Jonak, Devin K. Binder
Summary: Edema formation following traumatic spinal cord injury (SCI) worsens secondary injury and is correlated with worse neurological outcome. The aquaporin-4 (AQP4) water channel plays an important role in water homeostasis and has the potential to modulate edema resolution and functional recovery after SCI. Further research is needed to understand the expression and subcellular localization of AQP4 during specific phases after SCI for therapeutic optimization.
Review
Neurosciences
Yiwen Zhang, Rui Lang, Shunyu Guo, Xiaoqin Luo, Huiting Li, Cencen Liu, Wei Dong, Changshun Bao, Yang Yu
Summary: Recent studies have shown that spinal cord injury (SCI) is associated with an imbalance of intestinal microbiota and dysregulation of melatonin secretion. Melatonin plays a protective role in preventing secondary damage to the spinal cord and is related to the gut microbiota. The gut microbiota can influence melatonin production and function, as well as contribute to complications after SCI.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jiaqi Bi, Peiyu Sun, Erwei Feng, Jianxiong Shen, Chong Chen, Haining Tan, Zheng Li, Youxi Lin
Summary: This study demonstrated the synergistic therapeutic effects of melatonin and half-dose methylprednisolone for treating spinal cord injury. The combination of melatonin and half-dose methylprednisolone significantly reduced the dosage of methylprednisolone and limited its adverse reactions. The PI3K-AKT1 pathway was involved in the amelioration of acute SCI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Sisi Mi, Xue Wang, Jiaxin Gao, Yu Liu, Zhongquan Qi
Summary: After spinal cord injury (SCI), the microenvironment inhibits neural regeneration due to the abundance of inhibitory factors and lack of factors promoting nerve regeneration. This study developed a bioactive material, hp-SHED sheet, to mimic the natural spinal cord structure and enhance nerve cell attachment and migration. Implantation of hp-SHED sheet in SCI rats promoted nerve regeneration, axonal remyelination, and inhibited glial scarring, leading to the restoration of sensory and motor functions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Meng-Tong Xue, Wen-Jie Sheng, Xue Song, Yu-Jiao Shi, Zhi-Jun Geng, Lin Shen, Rui Wang, He-Zuo Lu, Jian-Guo Hu
Summary: ATL-III improves spinal cord injury by modulating microglial/macrophage polarization, and it possesses anti-inflammatory and neuroprotective effects.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Li Deng, Jun Qiao Lv, Lin Sun
Summary: This study systematically analyzed the experimental treatments and their mechanisms for reducing blood spinal cord barrier (BSCB) injury in the early stage of traumatic spinal cord injury (t-SCI). BMSC-Exos, which inhibit matrix metalloproteinases (MMPs) expression, are currently the most effective therapeutic modality for alleviating BSCB damage. In addition, the regulation of MMPs, the Akt pathway, and the ER stress pathway play important roles in alleviating BSCB injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini Ravandi, Mahmoudreza Hadjighassem
Summary: This study found that early administration of bumetanide after spinal cord injury can promote recovery of locomotor function. The results showed that bumetanide can reduce the expression of NKCC1 gene and increase GAP protein levels, thereby having neuroprotective and regenerative effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Jacek M. Kwiecien, Wojciech Dabrowski, Jordan R. Yaron, Liqiang Zhang, Kathleen H. Delaney, Alexandra R. Lucas
Summary: Massive spinal cord trauma leads to complex pathological events, forming a spinal cord cavity and causing persistent inflammatory response, ultimately resulting in neurological deficits.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Cell Biology
Haoyu Wang, Haifan Wang, Heng Huang, Zhigang Qu, Dong Ma, Xiaoqian Dang, Quanyu Dong
Summary: Melatonin inhibits the activation of the NLRP3 inflammasome through the stimulation of the Nrf2/ARE pathway, which suppresses neuroinflammation, reduces mitochondrial dysfunction, and improves the recovery of nerve function after spinal cord injury.
Article
Chemistry, Multidisciplinary
Bruce Harland, Zaid Aqrawe, Maria Vomero, Christian Boehler, Ernest Cheah, Brad Raos, Maria Asplund, Simon J. O'Carroll, Darren Svirskis
Summary: This study presents the development of a very thin flexible bioelectronic implant that can be inserted directly into the spinal cord of rats and maintain contact. The implant does not negatively impact the functionality of the rats' limbs and can record electrical signals of spinal cord activity. This device is important for monitoring spinal cord injury and recovery, and has the potential for localized treatments.
Article
Immunology
Chenxi Zhao, Tiangang Zhou, Xiaoqing Zhao, Yilin Pang, Wenxiang Li, Baoyou Fan, Ming Li, Xinjie Liu, Lei Ma, Jiawei Zhang, Chao Sun, Wenyuan Shen, Xiaohong Kong, Xue Yao, Shiqing Feng
Summary: This study provides preclinical information on the administration time window of 2-12 h post-injury for nafamostat in contusive SCI. It reveals that nafamostat functions by inhibiting thrombin-mediated BSCB breakdown and subsequent infiltration of peripheral immune cells.
JOURNAL OF NEUROINFLAMMATION
(2022)