Article
Cardiac & Cardiovascular Systems
Marco Franchin, Viviana Grassi, Gabriele Piffaretti, Ruth L. Bush, Matteo Tozzi, Chiara Lomazzi
Summary: This study reported the outcomes of thoracic endovascular aortic repair (TEVAR) for shaggy thoracic aortic aneurysms (STA) in a high-risk cohort. Only 2.3% of the patients met the inclusion criteria, with low rates of operative-related embolization and no major complications during follow-up period observed in all patients.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Peripheral Vascular Disease
Stefano Gennai, Nicola Leone, Luigi A. Maria Bartolotti, Tea Covic, Antonio Lauricella, Francesco Andreoli, Giuseppe Saitta, Roberto Silingardi
Summary: This study compared endoleak outcomes after thoracic endovascular aneurysm repair with different stent-graft generations over long-term follow-up. Endoleak incidence significantly decreased over evolving stent-grafts generations, with newer generations showing better long-term outcomes. Ongoing updates are necessary to confirm the reliability and durability of these newer stent-graft generations.
Article
Surgery
Seon Hee Kim, Up Huh, Seunghwan Song, Min Su Kim, Chang Won Kim, Chang Ho Jeon, Hoon Kwon, Il Jae Wang
Summary: This study compared the outcomes of TEVAR and open repair for blunt traumatic aortic injury over a 5-year period. The study demonstrated that TEVAR is ideal for older or severely injured patients, while open repair is a better alternative for young patients or patients with unsuitable aortic anatomy.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Biophysics
Yonghui Qiao, Le Mao, Yan Wang, Jingyang Luan, Yanlu Chen, Ting Zhu, Kun Luo, Jianren Fan
Summary: This study evaluates the hemodynamic effects of the stent-graft introducer sheath during thoracic endovascular aortic repair (TEVAR). The results show that the introducer sheath can increase blood flow to the supra-aortic branches and potentially increase thrombus formation. The pressure magnitude in peak systole increases significantly, but a similar phenomenon is not observed in early diastole. The introducer sheath also significantly alters the blood viscosity distribution in the aortic arch and descending aorta.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Surgery
Stefano Gennai, Nicola Leone, Luigi A. M. Bartolotti, Francesco Andreoli, Ginevra Pizzarelli, Roberto Silingardi
Summary: This study analyzed the learning curve of a widely used stent-graft for thoracic endovascular repair (TEVAR) by examining procedural variables and their impact on long-term outcomes. The results showed that the learning curve was reached after 10 patients and the secondary outcomes improved significantly with experience. The Relay stent-graft demonstrated satisfactory long-term results with a short learning curve in a high-volume endovascular center.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Surgery
Marissa C. Kuo, R. Anthony Meena, Christopher R. Ramos, Jaime Benarroch-Gampel, Bradley G. Leshnower, Yazan Duwayri, William D. Jordan, Ravi R. Rajani
Summary: This analysis demonstrates that female gender is a significant nonmodifiable risk factor for intragraft luminal narrowing after TEVAR. The increased occurrence of this phenomenon was associated with a higher need for reintervention, potentially due to differences in aortic compliance or gender-associated differences in coagulation pathways. Further investigation is warranted to better understand these findings.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Fabio Verzini, Nimesh Desai, Frank R. Arko, Jean M. Panneton, Fabien Thaveau, Francois Dagenais, Jia Guo, Ali Azizzadeh
Summary: The study presented the 1-year clinical trial outcomes of the Valiant Navio stent graft system, indicating high survival rates and low rates of endoleak. Changes in aortic morphology post-graft implantation were primarily observed in elongation and dilation at different regions.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Ludovic Canaud, Lucien Chassin-Trubert, Issam Abouliatim, Kheira Hireche, Christophe Bacri, Pierre Alric, Thomas Gandet
Summary: This study evaluated the early and medium-term outcomes of double fenestrated physician-modified endovascular grafts for total endovascular aortic arch repair. The results showed that this approach is both feasible and effective, avoiding the need for anatomical and extra-anatomical surgical revascularization. Long-term durability needs to be assessed in further studies with long-term follow-up.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Surgery
Hanaa Dakour-Aridi, Kanhua Yin, Farhan Hussain, Satinderjit Locham, Ali Azizzadeh, Mahmoud B. Malas
Summary: The outcomes of thoracic endovascular aortic repair (TEVAR) in octogenarians for thoracic aortic aneurysms and dissection differ from those of nonoctogenarians. While there was no significant difference in in-hospital mortality in octogenarians undergoing TEVAR for thoracic aortic dissection, they may face a higher risk of in-hospital complications in thoracic aortic aneurysm repair.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Xiaoye Li, Wei Li, Xiangchen Dai, Wei Li, Jinlong Zhang, Zanxin Wang, Yuanhao Tong, Yonghui Chen, Lei Zhang, Chao Song, Qingyou Meng, Minxin Wei, Zhao Liu, Qingsheng Lu
Summary: The study evaluated the outcomes of TEVAR for aortic arch pathologies using surgeon modified fenestrated stent grafts, showing high technical success rate, low mortality, and low reintervention rate within 30 days post-operation. Follow-up data demonstrated good clinical outcomes at 24 months.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Yaojun Dun, Yi Shi, Hongwei Guo, Yanxiang Liu, Xiangyang Qian, Xiaogang Sun, Cuntao Yu
Summary: This study investigated the outcomes of secondary open arch operation in 57 patients who underwent prior TEVAR, revealing a 7.0% in-hospital mortality rate and a 32.2 ± 19.7 months mean follow-up time. Aortic events occurred in 7 patients during follow-up, with overall survival rates at 1 year, 3 years, and 6 years being 89.5%, 84.6%, and 79.9%, respectively, and no significant differences between elective and emergent groups in terms of survival and freedom from aortic events. Cox analysis identified additional coronary artery bypass grafting and hypothermic circulatory arrest as independent predictors of survival.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Franchin, Francesca Mauri, Federico Fontana, Filippo Piacentino, Luca Guzzetti, Matti Jubouri, Mohamad Bashir, Gabriele Piffaretti
Summary: The aim of this study was to evaluate the incidence and outcomes of ischaemic organ complications after thoracic endovascular aortic repair (TEVAR). The study found that aortic arch atherosclerotic overload and the presence of shaggy aorta are predictors of organ ischaemic complications following TEVAR, which are associated with perioperative mortality, prolonged hospitalization, and a negative impact on long-term survival.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Surgery
Alexander Kupferthaler, Sven R. Hauck, Michael Schwarz, Maximilian Kern, Julia Deinsberger, Theresa-Marie Dachs, Christoph Neumayer, Maria-Elisabeth Stelzmueller, Marek Ehrlich, Christian Loewe, Martin A. Funovics
Summary: This study reports the long-term outcomes of tubular and scalloped TEVAR in treating PAUs and compares the safety profile in both cohorts. The results show that TEVAR and scTEVAR provide excellent and similar clinical success and aortic survival with acceptable complication and reintervention rates. The clinical impact is that more patients can be treated with endovascular repair by including scTEVAR.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Surgery
Ga-Young K. Suh, Johan Bondesson, Yufei D. Zhu, Michael C. Nilson, Eric E. Roselli, Christopher P. Cheng
Summary: In this study, we aimed to quantify the deformation of the thoracic aorta after ascending TEVAR. The results showed that the pulsatile deformation of the ascending aorta was damped by the endograft, while the native thoracic aorta did not experience significant changes.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Surgery
Michele Piazza, Francesco Squizzato, Andrea Xodo, Gianna Saviane, Edoardo Forcella, Chiara Dal Pont, Franco Grego, Michele Antonello
Summary: The study aimed to determine the optimal and safest proximal sealing length during thoracic endovascular aortic repair (TEVAR). For type II and III aortic arches, a proximal sealing length of 25-30mm may be required for a safe and durable procedure.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Review
Pediatrics
Ahmad Salha, Tasnim Chowdhury, Saloni Singh, Jessica Luyt, Amer Harky
Summary: This article evaluates and summarizes the complications of ECMO postcardiotomy in the pediatric population, including renal, cardiovascular, hematological, infection, neurological, and hepatic complications. The incidence, risk factors, potential predictors, and scoring systems for the development of these complications have been explored.
JOURNAL OF PEDIATRIC INTENSIVE CARE
(2023)
Review
Cardiac & Cardiovascular Systems
Aimee-Louise Chambault, Kathryn Olsen, Louise J. Brown, Sophie L. Mellor, Nilofer Sorathia, Arthur E. Thomas, Neel Kothari, Amer Harky
Summary: This study compared the outcomes of transcatheter and surgical repair of atrial septal defects. The results showed that transcatheter closure had shorter hospital stays and fewer complications. Surgery was still suitable for more complex cases and did not show a significant difference in mortality compared to transcatheter closure.
CARDIOLOGY IN THE YOUNG
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
William Wang, Danish Iltaf Satti, Amer Harky, David Mayhew
JOURNAL OF CARDIAC SURGERY
(2022)
Review
Peripheral Vascular Disease
Kofi Cox, Ritika Dilip Sundaram, Mara Popescu, Kiran Pillai, Muhammed Kermali, Amer Harky
Summary: This review provides an overview of infection and inflammation of the thoracic aorta, discussing its causes, pathogenesis, and clinical presentation. Diagnostic methods such as MRI and multi-slice CT imaging are important for determining disease extent and planning surgical intervention. However, due to the rarity of the condition, there is a lack of large-scale comparative research on management options. Early diagnosis, advances in surgical options, and specific microbial therapy have improved post-treatment outcomes significantly.
Editorial Material
Oncology
Sundas Butt, Meera Shankar, Bothayna Amien, Oleg Fedevici, Amer Harky
ANNALS OF TRANSLATIONAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Bejoy Philip, Anchal Jain, Milosz Wojtowicz, Inayat Khan, Calum Voller, Roshni S. K. Patel, Darbi Elmahdi, Amer Harky
Summary: This narrative review compares the advantages and drawbacks of various imaging and investigation modalities in diagnosing and staging lung cancer. It discusses the use of plain film radiography, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, and newer techniques such as image-guided bronchoscopy (IGB) and robotic bronchoscopy (RB). The review finds that while a chest X-ray has high positive predictive value, its role in national screening programmes is questionable. CT is effective in lowering mortality for high-risk patients, and PET-CT is recommended for diagnosing malignant nodules and assessing small cell lung cancer spread. MRI is only recommended for isolated distant metastases, and ultrasound can be useful in assessing lymph node involvement. Endobronchial ultrasonography (EBUS) is often used for tissue sampling, but its diagnostic value varies. RB offers an alternative way to biopsy lesions, but further research is needed. Thoracic surgical biopsies, particularly minimally invasive techniques, have been increasingly used for diagnosis and staging.
INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Surgery
Bejoy Philip, Anchal Jain, Pranav Ramesh, Naomi Melamed, Mashal Qureshi, Iqra Ahmed, Amer Harky
Summary: This narrative review compared current guidelines on follow-up for lung cancer patients and evaluated the optimal imaging modality. The study found that there are differences in the frequency and breadth of investigations in current guidelines. CT is considered the most commonly used imaging modality for surveillance, but its high dose radiation poses risks to patients. There is scope for further research to explore these factors.
VIDEO-ASSISTED THORACIC SURGERY
(2023)
Article
Emergency Medicine
Fausto Biancari, Angelo M. Dell'Aquila, Giuseppe Gatti, Andrea Perrotti, Amelie Herve, Joseph Touma, Matteo Pettinari, Sven Peterss, Joscha Buech, Konrad Wisniewski, Tatu Juvonen, Mikko Jormalainen, Caius Mustonen, Andreas Rukosujew, Till Demal, Lenard Conradi, Marek Pol, Petr Kacer, Francesco Onorati, Cecilia Rossetti, Igor Vendramin, Daniela Piani, Mauro Rinaldi, Luisa Ferrante, Eduard Quintana, Robert Pruna-Guillen, Javier Rodriguez Lega, Angel G. Pinto, Metesh Acharya, Zein El-Dean, Mark Field, Amer Harky, Manoj Kuduvalli, Francesco Nappi, Sebastien Gerelli, Dario Di Perna, Enzo Mazzaro, Stefano Rosato, Antonio Fiore, Giovanni Mariscalco
Summary: This study aimed to evaluate the impact of individual institutions on the outcome of surgery for Stanford type A aortic dissection. The results showed that certain hospitals had a higher risk of in-hospital mortality, while others had a lower risk. Hospitals with lower in-hospital mortality rates also had a decreased rate of stroke and/or global brain ischemia. The study concluded that hospital volume may be a determinant of poor outcome in surgery for aortic dissection.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Review
Pharmacology & Pharmacy
Jeffrey Shi Kai Chan, Francesco Perone, Yasmin Bayatpoor, Gary Tse, Amer Harky
Summary: SGLT2 inhibitors are effective in patients with both heart failure and chronic kidney disease, and should be initiated early to slow declines in renal function. Further research is needed to determine the optimal timing for initiating these agents, improve cost-effectiveness, and ensure equity of access. Prognostic implications of changes in biomarker levels and the potential of SGLT1 inhibition should also be explored.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Bleri Celmeta, Amer Harky, Antonio Miceli
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Bejoy Philip, Prerona Mukherjee, Yuti Khare, Pranav Ramesh, Sara Zaidi, Haytham Sabry, Amer Harky
Summary: COVID-19 can have potentially serious cardiovascular sequelae, including acute respiratory distress syndrome, multiorgan failure, and myocardial damage. Existing heart disease, medication usage, and age are risk factors for exacerbating cardiovascular complications. Further research is needed to improve our understanding of the virus and our ability to anticipate heart-related symptoms.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Mohammed Al-Tawil, Sundas Butt, Sophie Reap, Bea Duric, Tinotenda Harahwa, Ashwini Chandiramani, Mohamed Zeinah, Amer Harky
Summary: Transcatheter mitral valve replacement is a useful alternative for high-risk patients with failed mitral prosthesis or annuloplasty rings. This study compared the clinical outcomes of transseptal and transapical approaches in transcatheter mitral valve-in-valve and valve-in-ring implantation. The transseptal approach was associated with lower mortality, shorter hospital stays, and a trend towards lower complication rates.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Amer Harky, Avesta Ala'Aldeen, Sundas Butt, Bea Duric, Sakshi Roy, Mohamed Zeinah
Summary: In late December 2019, the novel coronavirus SARS-CoV-2 was discovered in Wuhan, China, causing a cluster of pneumonia cases. As the COVID-19 pandemic progressed in 2020, it became clear that the virus had the potential to affect multiple organ systems. Through extensive research on over 750 million cases worldwide, it has been found that COVID-19 is a complex disease with various theories on its pathophysiology and impact on the body, including direct viral infection, coagulation dysfunction, cytokine storm, and complement system activation. This paper focuses on the long-term effects of COVID-19 on the cardiovascular, respiratory, urinary, gastrointestinal, and vascular systems, as well as the changes in clinical management. Clearer guidelines are needed for the pharmacological, nonpharmacological, and psychological management of COVID-19 patients to improve survival rates and long-term outcomes.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Editorial Material
Surgery
Michael Shackcloth, Amer Harky
VIDEO-ASSISTED THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Abdul Badran, Youssef Elghazouli, Manasi Mahesh Shirke, Mohammed Al-Tawil, Amer Harky, Sunil K. Ohri
Summary: This study aimed to summarize the preoperative data and operative outcomes of 234 patients who underwent TAA repair at University Hospital Southampton. The study found a 30-day mortality rate of 5.13%, which was associated with female gender, aortic root surgery, and prosthetic valves. Additionally, several factors associated with complications and morbidity should be considered when discussing the risks of intervention.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
