Review
Allergy
Heidi Makrinioti, Kohei Hasegawa, John Lakoumentas, Paraskevi Xepapadaki, Maria Tsolia, Jose A. Castro-Rodriguez, Wojciech Feleszko, Tuomas Jartti, Sebastian L. Johnston, Andrew Bush, Vasiliki Papaevangelou, Carlos A. Camargo, Nikolaos G. Papadopoulos
Summary: This study compares the associations of RSV-induced bronchiolitis and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma through a meta-analysis. The results show that the RV-bronchiolitis group is more likely to develop recurrent wheeze and asthma. This study is clinically significant for understanding the relationship between viruses and asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Immunology
Maarten van Wijhe, Caroline Klint Johannesen, Lone Simonsen, Inger Merete Jorgensen, Thea K. Fischer
Summary: Infants with RSV-associated hospitalization have a higher risk of recurrent wheeze or asthma compared to infants with other respiratory infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Pediatrics
Elly Binns, Jane Tuckerman, Paul Licciardi, Danielle Wurzel
Summary: Globally, respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in young children, and is associated with recurrent wheeze and asthma. While the causal link between RSV and wheeze/asthma is not yet proven, immunological evidence suggests a Th2-type response and dampening of antiviral immunity during RSV infection. There is currently no licensed RSV vaccine, but recent advancements in preventatives, such as monoclonal antibodies and maternal vaccinations, show promise. The disruption of RSV seasonality due to the COVID-19 pandemic has provided a rare opportunity to study the impact of delayed RSV infection on asthma prevalence.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Article
Allergy
Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo
Summary: This study aimed to investigate the association between severe bronchiolitis profiles identified by clustering and childhood asthma. The results showed that children with a history of wheezing and/or eczema and rhinovirus infection had a higher risk of developing childhood asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Pediatrics
Yunlian Zhou, Lin Tong, Mengyao Li, Yingshuo Wang, Lanxin Li, Dehua Yang, Yuanyuan Zhang, Zhimin Chen
Summary: The study found that RSV bronchiolitis may increase the incidence of recurrent wheezing and asthma in children, with patients who develop asthma having higher birth weight and older age of onset.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Immunology
Na Li, Tianyun Shi, Meng Zhang, Yanchao He, Jingjing Feng, Zhoufang Mei, Xiao Su, Zhijun Jie
Summary: Clarifying the pathogenesis of asthma and identifying the specific pathway underlying oral asthma tolerance (OT) is important. This study explores the effects of promyelocytic leukemia zinc finger (PLZF) on memory phenotypes in asthma and OT mouse models. The results suggest that PLZF may reduce memory cells and promote the establishment of OT.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Heidi Makrinioti, Andrew Bush, James Gern, Sebastian Lennox Johnston, Nikolaos Papadopoulos, Wojciech Feleszko, Carlos A. Camargo, Kohei Hasegawa, Tuomas Jartti
Summary: Bronchiolitis is a common cause of hospitalization in infants and is associated with a higher risk of childhood asthma development. The mechanisms underlying asthma development following bronchiolitis hospitalization are complex and involve immune responses to respiratory viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Erwan Sallard, Frank Schult, Carolin Baehren, Eleni Buedding, Olivier Mboma, Parviz Ahmad-Nejad, Beniam Ghebremedhin, Anja Ehrhardt, Stefan Wirth, Malik Aydin
Summary: Respiratory viruses play a significant role in exacerbating asthma, and human rhinovirus (HRV) infection is a strong biomarker for exacerbation.
Article
Immunology
Mohinder Sarna, Amanuel Gebremedhin, Peter C. Richmond, Kathryn Glass, Avram Levy, Hannah C. Moore
Summary: This study examined the association between sociodemographic and perinatal factors and childhood respiratory morbidity following early-life respiratory syncytial virus (RSV) infection. The results showed that in addition to preterm and young infants, children aged 12-<24 months could also be potential target groups for RSV prevention.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Studying the economic burden of RSV-associated illness can help inform decisions on the implementation of maternal vaccines and monoclonal antibodies. A costing study conducted in South Africa estimated the cost of RSV-associated illness in infants and found that the highest cost burden was in the youngest infants.
Article
Virology
Fung-Chang Sung, Chang-Ching Wei, Chih-Hsin Muo, Shan P. Tsai, Chao W. Chen, Dennis P. H. Hsieh, Pei-Chun Chen, Chung-Yen Lu
Summary: This study evaluated the risks of childhood acute bronchitis and bronchiolitis for children with asthma or allergic rhinitis. The results showed that children with asthma or allergic rhinitis had a higher risk of developing these respiratory diseases compared to those without these conditions. The incidence rates decreased with increasing age, but were relatively similar for boys and girls.
Article
Immunology
Mauricio T. Caballero, Ashish Satav, Christopher J. Gill, Saad B. Omer, Rachel C. Pieciak, Abdul Momin Kazi, Eric Af Simoes, Fernando P. Polack
Summary: The study found that there are obstacles and challenges in conducting research in developing countries to determine the factors associated with community mortality due to RSV, including obtaining family consent for testing, sampling at the household level, supporting grieving parents, developing tailored strategies for challenging settings, and integrating data from different sources.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Clara Calvert, Jade Carruthers, Cheryl Denny, Jack Donaghy, Lisa E. M. Hopcroft, Leanne Hopkins, Anna Goulding, Laura Lindsay, Terry McLaughlin, Emily Moore, Bob Taylor, Maria Loane, Helen Dolk, Joan Morris, Bonnie Auyeung, Krishnan Bhaskaran, Cheryl L. Gibbons, Srinivasa Vittal Katikireddi, Maureen O'Leary, David McAllister, Ting Shi, Colin R. Simpson, Chris Robertson, Aziz Sheikh, Sarah J. Stock, Rachael Wood
Summary: This study using electronic health records from Scotland found no increased risk of congenital anomalies associated with COVID-19 vaccination or SARS-CoV-2 infection during early pregnancy.
NATURE COMMUNICATIONS
(2023)
Review
Infectious Diseases
Lorenzo Chiusaroli, Cecilia Liberati, Luigi Rulli, Elisa Barbieri, Marica De Pieri, Costanza Di Chiara, Daniele Mengato, Carlo Giaquinto, Daniele Dona
Summary: Methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant coagulase-negative Staphylococci (MR-CoNS), and vancomycin-resistant Enterococci (VRE) are increasing worldwide, posing a threat to the treatment options in pediatric patients and neonates compared to adults. Current recommendations in pediatrics are mainly extrapolated from adults' studies.
Article
Pediatrics
Ruud G. Nijman, Chantal D. Tan, Nienke N. Hagedoorn, Daan Nieboer, Jethro Adam Herberg, Anda Balode, Ulrich von Both, Enitan D. Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Benno Kohlmaier, Emma Lim, Federico Martinon-Torres, Marko Pokorn, Franc Strle, Maria Tsolia, Shunmay Yeung, Joany M. Zachariasse, Dace Zavadska, Werner Zenz, Michael Levin, Clementien L. Vermont, Henriette A. Moll, Ian K. Maconochie
Summary: This study aimed to describe the characteristics and clinical outcomes of children with fever lasting >= 5 days presenting to emergency departments. The study found that children with prolonged fever have a higher risk of serious bacterial infection (SBI). However, warning signs of SBI were observed infrequently, highlighting the need for careful clinical assessment and diagnostic workup.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Letter
Respiratory System
Sonia Ares-Gomez, Narmeen Mallah, Jacobo Pardo-Seco, Victoria Nartallo-Penas, Susana Miras-Carballal, Carmen Rodriguez-Tenreiro-Sanchez, Irene Rivero-Calle, Marta Pineiro-Sotelo, Carmen Duran-Parrondo, Federico Martinon-Torres
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Gastroenterology & Hepatology
Alex S. Genshaft, Sonu Subudhi, Arlin Keo, Juan Diego Sanchez Vasquez, Nadia Conceicao-Neto, Deeqa Mahamed, Lauke L. Boeijen, Nadia Alatrakchi, Chris Oetheimer, Mike Vilme, Riley Drake, Ira Fleming, Nancy Tran, Constantine Tzouanas, Jasmin Joseph-Chazan, Martin Arreola Villanueva, Harmen J. G. van de Werken, Gertine W. van Oord, Zwier M. A. Groothuismink, Boris J. Beudeker, Zgjim Osmani, Shirin Nkongolo, Aman Mehrotra, Kurt Spittaels, Jordan Feld, Raymond T. Chung, Robert J. de Knegt, Harry L. A. Janssen, Jeroen Aerssens, Jacques Bollekens, Nir Hacohen, Georg M. Lauer, Andre Boonstra, Alex K. Shalek, Adam J. Gehring
Summary: This study aims to comprehensively compare the immune cells in the blood and liver of patients with chronic hepatitis B using single-cell RNA sequencing, in order to identify biomarkers for intrahepatic immune activity. The results show that both Seq-Well S3 and 10x Chromium technologies can capture the cellular diversity of the liver, but Seq-Well S3 is more effective in capturing neutrophils that are absent in the 10x dataset. CD8 T cells and neutrophils show distinct gene expression profiles between blood and liver.
Article
Infectious Diseases
Deidre Wilkins, Annefleur C. Langedijk, Robert Jan Lebbink, Christopher Morehouse, Michael E. Abram, Bahar Ahani, Anastasia A. Aksyuk, Eugenio Baraldi, Tyler Brady, Albert Tian Chen, Hsin Chi, Eun Hwa Choi, Robert Cohen, Daria M. Danilenko, Vancheswaran Gopalakrishnan, Anne Greenough, Terho Heikkinen, Mitsuaki Hosoya, Christian Keller, Elizabeth J. Kelly, Leyla Kragten-Tabatabaie, Federico Martinon-Torres, Abiel Homero Mascarenas de los Santos, Marta C. Nunes, Maria Angelica Palomino, Jesse Papenburg, Jeffrey M. Pernica, Peter Richmond, Renato Stein, Kevin M. Tuffy, Charl Verwey, Mark T. Esser, David E. Tabor, Louis J. Bont, INFORM RSV Study Grp
Summary: This study evaluated the geotemporal distribution of RSV A and RSV B between 2015 and 2021 and functionally characterized the nirsevimab binding-site substitutions during this period. The results showed that the nirsevimab binding site remained highly conserved, with only a few rare mutations affecting nirsevimab neutralization emerging between 2016 and 2021. The genetic diversity of RSV fusion protein was lower compared to influenza hemagglutinin and SARS-CoV-2 spike proteins.
LANCET INFECTIOUS DISEASES
(2023)
Editorial Material
Immunology
Siddhartha Sankar Datta, Federico Martinon-Torres, Nino Berdzuli, Niyazi Cakmak, Michael Edelstein, Simon Cottrell, Mark Muscat
Summary: Universal immunization greatly reduces the incidence and mortality of vaccine-preventable diseases. However, routine immunization coverage varies significantly between countries, populations, and districts, and has even declined in some cases. Insufficient immunization coverage leads to susceptible individuals and outbreaks of vaccine-preventable diseases. The European Immunization Agenda 2030 aims to promote equity in immunization and assist stakeholders in addressing local challenges to improve overall health in the WHO European Region.
Article
Medicine, General & Internal
Harsita Patel, Amalia Sintou, Rasheda A. Chowdhury, Stephen Rothery, Alma Octavia Iacob, Sanjay Prasad, Peter P. Rainer, Federico Martinon-Torres, Vanessa Sancho-Shimizu, Chisato Shimizu, Kirsten Dummer, Adriana H. Tremoulet, Jane C. Burns, Susanne Sattler, Michael Levin
Summary: This study investigated the presence of anticardiac autoantibodies in MIS-C or COVID-19 vaccine-induced myocarditis and found no evidence of antibody binding to cardiac tissue in these conditions. This suggests that the cardiac pathology in MIS-C and vaccine-induced myocarditis is unlikely to be driven by direct anticardiac antibody-mediated mechanisms.
Review
Medicine, General & Internal
Francesco Lapi, Nicoletta Cassano, Elisa Barbieri, Ettore Marconi, Gino Antonio Vena, Carlo Giaquinto, Claudio Cricelli
Summary: This study assessed the incidence and prevalence rates of pediatric psoriasis and its association with specific comorbidities. It found that allergic rhinitis, asthma, celiac disease, other malabsorption disease, and non-infective cutaneous diseases were significantly associated with psoriasis.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Multidisciplinary Sciences
Laura Lindsay, Clara Calvert, Ting Shi, Jade Carruthers, Cheryl Denny, Jack Donaghy, Lisa E. M. Hopcroft, Leanne Hopkins, Anna Goulding, Terry Mclaughlin, Emily Moore, Bob Taylor, Krishnan Bhaskaran, Srinivasa Vittal Katikireddi, Ronan Mccabe, Colin Mccowan, Colin R. Simpson, Chris Robertson, Aziz Sheikh, Rachael Wood, Sarah J. Stock
Summary: This study investigates the impact of SARS-CoV-2 infection and COVID-19 vaccination during pregnancy on neonatal and maternal outcomes. The findings suggest that infection is associated with adverse outcomes such as preterm birth and maternal morbidity, while vaccination does not increase the risk of any adverse outcomes. Therefore, COVID-19 vaccination is considered safe for pregnant women.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Mohamad Assaf, Daniela Costa, Janka Massag, Christoph Weber, Rafael Mikolajczyk, Sara Lena Lueckmann
Summary: This study compared the risk factors, treatment, and outcomes between in-hospital myocardial infarction (IHMI) and out-of-hospital myocardial infarction (OHMI), including both ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI). The results showed that IHMI patients were older and had more comorbidities, and IHMI was associated with higher odds of 30-day mortality and complications compared to OHMI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Hannah Wallis, Melanie Elgner, Marisa Schurr, Katrin Elisabeth Giel, Peter Martus, Gregor Paul, Jan Steffen Juergensen, Christine Allwang, Rafael Mikolajczyk, Annette Galante-Gottschalk, Stefan Ehehalt, Florian Junne, Marius Binneboese
Summary: This study investigated factors that impaired mental health during the COVID-19 pandemic. It found that worry was the strongest predictor of depressive and anxiety symptoms, while joy seemed to buffer these symptoms. Mitigating worry and increasing joy may promote resilience in future crises.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Laura Bubba, Kimberley S. M. Benschop, Soile Blomqvist, Erwin Duizer, Javier Martin, Alexander G. Shaw, Jean-Luc Bailly, Lasse D. Rasmussen, Anda Baicus, Thea K. Fischer, Heli Harvala
Summary: Wastewater surveillance (WWS) is a method used for detecting the transmission of pathogens through monitoring viral particles in sewage. It can monitor various pathogens, including those that affect children's health. While culture-based methods are still considered the gold standard, more advanced molecular detection and sequencing methods have been developed.
Article
Demography
George Palattiyil, Md. Tariqul Islam Limon, Md. Fahad Jubayer, Habibur Rahman, Irin Sultana, Mesbha Uddin Ahmed, Dina Sidhva, Harish Nair
Summary: While the COVID-19 pandemic affects people globally, the Rohingya refugees in Cox's Bazar, Bangladesh are particularly vulnerable due to poor healthcare, hygiene, and overcrowding. Superstitions and lack of trust in the healthcare system exacerbate the risks. A multi-sectoral approach is needed to implement an action plan that includes surveillance, testing, infection control measures, sufficient food supply, and improved healthcare services to minimize the impact of COVID-19 on this refugee population.
ASIAN AND PACIFIC MIGRATION JOURNAL
(2023)
Article
Medicine, Research & Experimental
Lisa Lokso Dietz, Anna Karina Juhl, Ole Schmeltz Sogaard, Joanne Reekie, Henrik Nielsen, Isik Somuncu Johansen, Thomas Benfield, Lothar Wiese, Nina Breinholt Staerke, Tomas Ostergaard Jensen, Stine Finne Jakobsen, Rikke Olesen, Kasper Iversen, Kamille Fogh, Jacob Bodilsen, Kristine Toft Petersen, Lykke Larsen, Lone Wulff Madsen, Susan Olaf Lindvig, Inge Kristine Holden, Dorthe Raben, Sidsel Dahl Andersen, Astrid Korning Hvidt, Signe Rode Andreasen, Eva Anna Marianne Baerends, Jens Lundgren, Lars Ostergaard, Martin Tolstrup
Summary: This study examines the immune response to SARS-CoV-2 vaccination in older Danish citizens and finds that age and disease burden can impact the vaccine-induced T cell immunity. These findings contribute to the understanding of immune responses in individuals at increased risk of severe COVID-19.
COMMUNICATIONS MEDICINE
(2023)