Journal
BIOMEDICAL MICRODEVICES
Volume 17, Issue 5, Pages -Publisher
SPRINGER
DOI: 10.1007/s10544-015-0003-5
Keywords
Acoustophoresis; Blood component preparation; IgA deficiency
Funding
- Swedish Governmental Agency for Innovation Systems, VINNOVA
- project CellCARE [2009-00236]
- Swedish Research Council FORMAS through the Strong Research Environments project BioBridges [221-2011-1692]
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This work presents the development of a miniaturized system for removing plasma proteins and other low-molecular-weight compounds from red blood cell (RBC) concentrate in a simple one-step-process using integrated ultrasound. The technology utilizes the principles of acoustophoresis to transfer the RBCs from the original plasma-containing solution into a protein-free SAG-M additive solution in a continuous flow process. The preparation of protein free RBC concentrate is important for blood transfusion to patients suffering from immunoglobulin A (IgA)-deficiency and developing antibodies against IgA. We show a nearly complete removal of both albumin and IgA from concentrated RBCs via this one-step-processes in samples obtained from RBC concentrate. The cell recovery of our technology is close to 97 %, compared to just above 90 % of the current procedure of repeated dilution and centrifugation steps. This work clearly shows the potential of integrated acoustophoresis in a miniaturized system for clinical applications.
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