Article
Medicine, Research & Experimental
Eveliina Taavitsainen-Wahlroos, Ines Reigada, Ilaria Sulmona, Leena Hanski
Summary: This study investigated the effects of azithromycin and doxycycline on amoxicillin-induced persistence of Chlamydia pneumoniae. The results showed that amoxicillin failed to eradicate C. pneumoniae infection in respiratory epithelial cells and limited the antichlamydial effect of azithromycin and doxycycline. However, azithromycin was superior to doxycycline in eliminating C. pneumoniae.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Adane Kassa, Meareg Amare
Summary: This study successfully determined cefadroxil concentrations in tablet and human urine samples using poly(alizarin)/GCE, with a wider linear range, extremely low detection limit, excellent accuracy, and selectivity. This method proves to be an outstanding candidate for cefadroxil determination in real samples.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Hye-Ri Jung, Yu Jin Lee, Serim Hong, Sunghyun Yoon, Suk-Kyung Lim, Young Ju Lee
Summary: Beta-lactam antibiotics are widely used in human and veterinary medicine, but their excessive use has led to the spread of deadly antibiotic-resistant bacteria. This study found that beta-lactam antibiotics were commonly prescribed in integrated broiler operations, and their use was associated with an increase in beta-lactam-resistant E. coli isolates. These findings highlight the importance of strengthening farm management practices and reducing antibiotic use.
Article
Electrochemistry
Adane Kassa, Atakilt Abebe, Meareg Amare
Summary: UV-Vis and FT-IR results confirmed the synthesis of a novel complex, ACP(2)CuIH, through a simple ion exchange reaction. Potentiodynamically fabricated poly(ACP(2)CuIH)/GCE displayed modification of the electrode surface by a conductive, electroactive polymer film, showing catalytic effect towards the oxidation of amoxicillin.
ELECTROCHIMICA ACTA
(2021)
Article
Immunology
Katrine Baekby Graversen, Jeppe Madura Larsen, Signe Schultz Pedersen, Laila Vestergaard Sorensen, Heidi Frahm Christoffersen, Lotte Neergaard Jacobsen, Susanne Halken, Tine Rask Licht, Martin Iain Bahl, Katrine Lindholm Bogh
Summary: The study found that partially hydrolysed whey products were superior in preventing whey-specific sensitisation compared to intact and extensively hydrolysed whey products. Oral amoxicillin administration disrupted gut microbiota but did not impair the prevention of whey-specific sensitisation. Partially hydrolysed whey products might confer a selective advantage to certain gut bacteria.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Christie M. Bertram, Michael Postelnick, Christian M. Mancini, Xiaoqing Fu, Yuqing Zhang, Lucas T. Schulz, Tanaya Bhowmick, Francesca Lee, Kimberly G. Blumenthal
Summary: The study found that using alternative antibiotics for surgical prophylaxis poses an increased risk of adverse events and surgical site infection compared to cefazolin. Additionally, patients with documented beta-lactam allergy were more likely to be prescribed clindamycin instead of cefazolin.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Rosalino Vazquez-Lopez, Tanya Hernandez-Martinez, Selene Ivonne Larios-Fernandez, Celia Pina-Leyva, Manuel Lara-Lozano, Tayde Guerrero-Gonzalez, Javier Martinez-Bautista, Eduardo Gomez-Conde, Juan Antonio Gonzalez-Barrios
Summary: This study investigated the conformation of the beta-lactam resistome in Escherichia coli strains causing nosocomial infections. The results showed a multi-drug-resistance phenotype against beta-lactam drugs, primarily driven by the expression of the blaTEM gene family.
Article
Chemistry, Analytical
Cassiano Cunha de Souza, Thalles Pedrosa Lisboa, Wallace Burger Verissimo de Oliveira, Rodrigo Alejandro Abarza Munoz, Maria Auxiliadora Costa Matos, Renato Camargo Matos
Summary: A simple and affordable method for manufacturing paper-based electrodes (PBE) using filter paper and conductive ink based on graphite and nail polish was presented in this study. Disposable sensors were applied for the first time to electrochemically monitor amoxicillin (AMX) in complex samples, such as milk, pharmaceutical formulations, and synthetic urine. The results showed that the proposed electrodes exhibited excellent electrochemical behavior, a wide linear working range, and good accuracy and precision.
Article
Microbiology
Nabeela Farhat, Divya Gupta, Abid Ali, Yogesh Kumar, Farheen Akhtar, Senthilguru Kulanthaivel, Prashant Mishra, Feroz Khan, Asad U. Khan
Summary: Antibiotic resistance has caused a global crisis, requiring the development of broad-spectrum inhibitor to combat emerging drug-resistant bacterial strains. This study identified three novel inhibitors effective against both SBLs and MBLs, showing promising results in treating infections caused by multidrug-resistant bacteria. These inhibitors bind to the active site residues of beta-lactamases crucial for antibiotic hydrolysis, making them potential future drug candidates in combination with antibiotics.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Scott A. Becka, Elise T. Zeiser, John J. LiPuma, Krisztina M. Papp-Wallace
Summary: The study demonstrates that the combination of imipenem-relebactam shows promising antimicrobial activity against MDR Bcc and B. gladioli strains, especially those resistant to ceftazidime-avibactam.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Environmental Sciences
Katrina Marie Sta Ana, Jonalyn Madriaga, Maria Pythias Espino
Summary: This article summarizes the research on beta-lactam antibiotics and beta-lactam antibiotic resistant bacteria and genes in Asian lake and river waters. It discusses methods for analyzing these antibiotics in water and the need for comprehensive investigations regarding their impact on aquatic biota. Studies have shown the presence of beta-lactam antibiotics in ng/L concentrations in Asian aquatic environments, but more research is needed in this area.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Jun Sato, Hiroki Kusano, Toshiaki Aoki, Satoru Shibuya, Katsuki Yokoo, Kazuo Komano, Takuya Oguma, Shuhei Matsumoto, Takafumi Sato, Kazuya Yasuo, Kenji Yamawaki
Summary: A series of tricyclic beta-lactams were synthesized and evaluated for antibacterial activities against carbapenem-resistant Enterobacterales (CBEs). Introducing sulfoxide resulted in potent antibacterial activities and strong therapeutic efficacy in a neutropenic mouse lung infection model. The tricyclic beta-lactam skeleton may serve as a promising scaffold for new antibacterial agents against CREs.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Parvaneh Ahmadvand, Johannetsy J. Avillan, Jacob A. Lewis, Douglas R. Call, ChulHee Kang
Summary: This study determined the crystal structures of CTX-M-15 in complex with different compounds and provided insights into its catalytic and binding mechanism. The affinity of CTX-M-15 for beta-lactam compounds was found to be similar, but lower for clavulanic acid. The presence of amine and furfural moieties in compounds could hinder the hydrolytic activity of CTX-M-15.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Yadav Sneha, Jijoe Samuel Prabagar, Thinley Tenzin, Behzad Shahmoradi, Kitirote Wantala, Sami Rtimi, Afshin Maleki, Diganta B. Das, Harikaranahalli Puttaiah Shivaraju
Summary: This study synthesized AgBiS2 nanorod-shaped material with visible-light absorption and used it for photocatalytic degradation of amoxicillin. The potential pathways and generated intermediates during the degradation process were investigated, and the material exhibited antibacterial and antibiofilm activity.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yiqiong Zhang, Bo Zhou, Zengxi Wei, Wang Zhou, Dongdong Wang, Jing Tian, Tehua Wang, Shuangliang Zhao, Jilei Liu, Li Tao, Shuangyin Wang
Summary: This study presents a novel and efficient hydrogen production system combining glucose-assisted Cu(I)/Cu(II) redox with HER, achieving lower electricity consumption and higher production efficiency.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Analytical
Caroline G. Sanz, Andreea C. Mihaila, Alexandru Evanghelidis, Victor C. Diculescu, Elena Butoi, Madalina M. Barsan
Summary: The present study introduces a new 2D model for human heart valve in tissue engineering, which incorporates valvular interstitial cells (VIC) encapsulated in gold covered electrospun polycaprolactone (PCL/Au) fibers. The model also serves as an electrochemical sensor for monitoring oxygen levels in cellular media. The biocompatibility of the materials with VIC was evaluated, and electrochemical techniques were used to investigate the effect of cell encapsulation and quantify dissolved oxygen levels. The study provides advancements in the field of heart valve tissue engineering.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Raphael P. Bacil, Pedro H. M. Garcia, Silvia Helena Pires Serrano
Summary: The classic epinephrine's ECE mechanism is revisited and found to be a multi-step irreversible electron transfer with a very fast intramolecular cyclization. It involves an EECEE with a potential inversion, instead of a couple of two-electron processes in a single-step transfer. The electrochemical and chemical steps are found to be pH dependent.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Caroline G. Sanz, Melania Onea, Anca Aldea, Madalina M. Barsan
Summary: A novel and disposable biosensor based on superoxide dismutase has been developed for the determination of superoxide in cell culture media. The biosensor was constructed using different immobilization methods and employed for electrochemical detection of superoxide. The biosensor with best performance was selected for superoxide monitoring in cell culture media.
Article
Chemistry, Analytical
Berna Dalkiran, Christopher M. A. Brett
Summary: This study presents a novel sensor for the simultaneous analysis of hydroquinone (HQ) and catechol (CAT), which utilizes safranine as a redox polymer and multiwalled carbon nanotubes-copper oxide nanoparticles as nanostructures. The sensor shows sensitive and selective detection of HQ and CAT, making it a promising analytical approach for monitoring their amounts in real samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Caroline G. Sanz, Daniel N. Crisan, Ricardo J. B. Leote, Melania Onea, Madalina M. Barsan
Summary: In this study, a biosensor for quantifying superoxide in cell culture media was successfully developed using gold nanoparticles and superoxide dismutase bioconjugates. The optimized biosensor achieved a sensitivity value of 41.2 nAμMcm(-2), a detection limit of 1.0μM, and showed excellent operational stability, indicating great potential for practical applications.
Review
Chemistry, Analytical
Daniela Oprea, Caroline G. Sanz, Madalina M. Barsan, Teodor Adrian Enache
Summary: PC-12 cells are widely used in biosensing devices due to their neurogenic characteristics and extensive evaluation in neuroscience research. Optical and electrochemical techniques play a key role in this field.
Article
Chemistry, Analytical
Ricardo J. B. Leote, Caroline G. Sanz, Victor C. Diculescu
Summary: Shikonin, a natural compound, shows anti-oxidant and anti-cancer activity, as well as the ability to inhibit cancer cell dsDNA transcription/replication. This study investigates the electrochemical behavior of shikonin, as well as its interaction with dsDNA, using cyclic and differential pulse voltammetry and an electrochemical biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Caroline G. Sanz, Anca Aldea, Daniela Oprea, Melania Onea, Adrian T. Enache, Madalina M. Barsan
Summary: A novel electrochemical biosensor was developed for the first time to monitor fibroblast cells stress levels in situ under external stimuli. The biosensor exhibited good detection performance in cell culture media, with high sensitivity and correlation. The results suggest the potential application of this biosensor in electrochemical screening of fibroblast cell stress.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Electrochemistry
Lucia Abad-Gil, Christopher M. A. Brett
Summary: A new electrochemical sensor based on a nanocomposite of an electroactive redox polymer and gold nanoparticles was developed. The nanocomposite was formed in a ternary deep eutectic solvent mixture. The sensor showed good performance in determining ascorbic acid and 5-aminosalicylic acid in pharmaceutical samples.
ELECTROCHIMICA ACTA
(2022)
Review
Chemistry, Medicinal
Caroline G. Sanz, Victor C. Diculescu
Summary: Proteins are critical in living cells and their dysfunction is associated with various medical conditions. Investigating protein microenvironment is important for developing therapeutic approaches and electrochemistry provides a fast and adaptable method for protein and drug assessment. This review summarizes the use of electrochemical assays and biosensors in the past decade, focusing on integrating proteins with nanostructured materials and conductive polymers. Applications include drug screening strategies, drug metabolism assays, electrochemical drug delivery systems, and quantitative drug assays.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xizhen Liang, Yueming Zhou, Joseany M. S. Almeida, Christopher M. A. Brett
Summary: A new electrochemical sensor based on a neutral red and multiwalled carbon nanotubes modified glassy carbon electrode, with neutral red electropolymerized in ternary deep eutectic solvents, has been developed. The sensor exhibited excellent performance towards acetaminophen (APAP) detection, with a high sensitivity (56.4 μA μM-1 cm-2) and a low limit of detection (0.015 μM). It also demonstrated outstanding selectivity, repeatability, reproducibility, and stability. This sensor has potential applications in pharmaceutical analysis.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Basant Elsebai, Mariana Emilia Ghica, Mohammed Nooredeen Abbas, Christopher M. A. Brett
Summary: A novel amperometric sensor based on organic chelator ionophore N, N di (2-hydroxy-5-[(4-nitrophenyl)diazenyl]benzaldehyde) benzene-1,2-diamine (NDBD) and multiwalled carbon nanotubes (MWCNT) immobilized on a glassy carbon electrode surface was developed for the direct determination of toxic mercury ions, Hg2+. The sensor response to Hg2+ was linear between 1-25 mu M with a limit of detection of 60 nM, and it showed excellent selectivity towards Hg2+ among other heavy metal ions. The method was successfully used for the determination of mercury ions in milk and water samples.
Article
Chemistry, Multidisciplinary
Sara M. A. Pinto, Ana R. R. Ferreira, Daniela S. S. Teixeira, Sandra C. C. Nunes, Ana L. M. Batista de Carvalho, Joseany M. S. Almeida, Zoltan Garda, Agnes Pallier, Alberto A. C. C. Pais, Christopher M. A. Brett, Eva Toth, Maria P. M. Marques, Mariette M. M. Pereira, Carlos F. G. C. Geraldes
Summary: A new fluorinated manganese porphyrin, (Mn-TPP-p-CF3), is capable of providing dual H-1 relaxivity and F-19 NMR response to redox changes based on the Mn(III)/Mn(II) equilibrium. The properties of H-1 relaxometry and F-19 NMR make it suitable for the detection of differential redox MRI. The physical-chemical characterization shows that the Mn(III)-F distance is well tailored to allow for adequate paramagnetic effect on F-19 T-1 and T-2 relaxation times.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Electrochemistry
Christopher M. A. Brett, Ana Maria Oliveira-Brett
Summary: This article discusses the approach to teaching electrochemistry to science and engineering students and presents the elements and components of a comprehensive course. It emphasizes the importance of critical reflection on acquired knowledge to make informed decisions in the fields of science, politics, and economics regarding various aspects of electrochemistry, particularly in energy, materials, health, food, and the environment.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2023)
Article
Chemistry, Analytical
Razieh Seyfi Zouleh, Mostafa Rahimnejad, Ghasem Najafpour-Darzi, Davood Sabour, Joseany M. S. Almeida, Christopher M. A. Brett
Summary: A new electrochemical enzyme biosensor has been developed for monitoring hydrogen peroxide. The sensor utilizes a multiwalled carbon nanotube modified glassy carbon electrode with a polymer film. The characteristics and morphology of the sensor were studied using electrochemical methods and microscopy. Catalase enzyme was immobilized on the electrode, and the biosensor exhibited a low detection limit for hydrogen peroxide and good recovery in commercial samples.
MICROCHEMICAL JOURNAL
(2023)
