Article
Gastroenterology & Hepatology
Chrissy Bolton, Christopher S. Smillie, Sumeet Pandey, Rasa Elmentaite, Gabrielle Wei, Carmen Argmann, Dominik Aschenbrenner, Kylie R. James, Dermot P. B. McGovern, Marina Macchi, Judy Cho, Dror S. Shouval, Jochen Kammermeier, Sibylle Koletzko, Krithika Bagalopal, Melania Capitani, Athena Cavounidis, Elisabete Pires, Carl Weidinger, James McCullagh, Peter D. Arkwright, Wolfram Haller, Britta Siegmund, Lauren Peters, Luke Jostins, Simon P. L. Travis, Carl A. Anderson, Scott Snapper, Christoph Klein, Eric Schadt, Matthias Zilbauer, Ramnik Xavier, Sarah Teichmann, Aleixo M. Muise, Aviv Regev, Holm H. Uhlig
Summary: Our study establishes a quantitative integrated taxonomy that defines the cellular landscape of monogenic IBD gene expression across 102 genes with high and moderate penetrance. We illustrate distinct cellular networks, highlight expression profiles across understudied cell types, and define genotype phenotype associations. The taxonomy integrates genetic, clinical, and multi-omic data, providing a basis for genomic diagnostics and testable hypotheses for disease functions and treatment responses.
Article
Allergy
Craig D. Platt, Fatima Zaman, Wayne Bainter, Kelsey Stafstrom, Abuarahman Almutairi, Margot Reigle, Sabrina Weeks, Raif S. Geha, Janet Chou
Summary: This study compared targeted next-generation sequencing with whole-exome sequencing in a global population of patients with primary immunodeficiency. The results showed that whole-exome sequencing had advantages in diagnostic yield, cost savings, and the potential for identification of novel diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Lauren Collen, David Y. Kim, Michael Field, Ibeawuchi Okoroafor, Gwen Saccocia, Sydney Driscoll Whitcomb, Julia Green, Michelle Dao Dong, Jared Barends, Bridget Carey, Madison E. Weatherly, Shira Rockowitz, Piotr Sliz, Enju Liu, Alal Eran, Leslie Grushkin-Lerner, Athos Bousvaros, Aleixo M. Muise, Christoph Klein, Vanessa Mitsialis, Jodie Ouahed, Scott B. Snapper
Summary: This study aims to observe the clinical phenotypes and outcomes of VEOIBD patients, and it finds that monogenic disease is an important driver of disease severity in VEOIBD. Whole exome sequencing (WES) is a valuable tool in prognostication and management of VEOIBD.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Immunology
Yoji Sasahara, Takashi Uchida, Tasuku Suzuki, Daiki Abukawa
Summary: This review investigates the prevalence, clinical manifestation, genetic profile, and treatment of patients with early-onset inflammatory bowel disease (IBD) in Southeast and East Asia, specifically looking at the association with primary immunodeficiency diseases (PIDs). The study found that the prevalence of PID associated with IBD was higher in Southeast and East Asia compared to Western countries, and patients with bloody stools as an early symptom were more likely to have monogenic diseases. Comprehensive molecular diagnosis has been widely applied in this region to screen for PID-associated IBD patients. These findings contribute to the understanding of monogenic PIDs in early-onset IBD patients and their clinical manifestations and genetic profiles compared to Western countries.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Zinan Z. Zhang, Yu Zhang, Tingyan He, Colin L. Sweeney, Safa Baris, Elif Karakoc-Aydiner, Yikun Yao, Deniz Ertem, Helen F. Matthews, Claudia Gonzaga-Jauregui, Harry L. Malech, Helen C. Su, Ahmet Ozen, Kenneth G. C. Smith, Michael J. Lenardo
Summary: IL-37 mutation in a 4-month-old male from a consanguineous family led to infantile inflammatory bowel disease (I-IBD) with persistent diarrhea. The patient's cells showed increased intracellular IL-37 expression and proinflammatory cytokine production. Insights from this patient suggest a potential role of the IL-18 and IL-37 axis in colonic homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Monica H. Wojcik, Maya C. del Rosario, Pankaj B. Agrawal
Summary: A survey of neonatologists across the United States revealed that while most acknowledge the importance of genetic testing for their patients, availability of genetic consultations and exome or genome sequencing in NICUs is not always adequate.
GENETICS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Lauren Collen, Vanessa Mitsialis, David Y. Kim, Mairead Bresnahan, Jessica Yang, Margaret Tuthill, Abigail Combs, Jared Barends, Michael Field, Enju Liu, Richelle Bearup, Ibeawuchi Okoroafor, Christoph Klein, Aleixo M. Muise, Athos Bousvaros, Jodie Ouahed, Scott B. Snapper
Summary: The use of anti-TNF therapy in VEOIBD patients is associated with treatment failure. Predictive factors for treatment failure include ulcerative colitis/IBD-unclassified, stricturing, and younger age at diagnosis.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Pediatrics
Ryusuke Nambu, Aleixo M. Muise
Summary: Inflammatory bowel disease (IBD) is a group of chronic disorders including Crohn's disease, ulcerative colitis, and IBD-unclassified, recent advancements in genomic technologies have improved understanding of IBD pathogenesis, identification of pathogenic genetic mutations in monogenic IBD patients has helped in developing individualized treatment.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Julika Neumann, Erika Van Nieuwenhove, Lara E. Terry, Frederik Staels, Taylor R. Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R. Baker, Margaux Gerbaux, Mathijs Willemsen, John S. Barber, Irina I. Serysheva, Liesbeth De Waele, Francois Vermeulen, Susan Schlenner, Isabelle Meyts, David Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston
Summary: Calcium signaling is crucial for lymphocyte activation, and disruptions of store-operated calcium entry can lead to severe immunodeficiency. In this study, genetic variations of the ITPR3 gene were identified in two Caucasian patients with immunodeficiency, indicating a potential link between these variations and impaired immune responses. The findings demonstrate the functional connection between defective endoplasmic reticulum calcium channels and immunodeficiency, highlighting the importance of IP(3)Rs as diagnostic targets for patients with specific inborn errors of immunity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jia-Jia Lv, Wen Su, Xiao-Yan Chen, Yi Yu, Xu Xu, Chun-Di Xu, Xing Deng, Jie-Bin Huang, Xin-Qiong Wang, Yuan Xiao
Summary: Mutation of the IL10RA gene was identified in all four patients with VEO-IBD, with a novel 333-bp deletion found through whole-genome sequencing. This deletion was associated with abnormal serum IL-10 levels and impaired immune response in patient samples.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Holm H. Uhlig, Fabienne Charbit-Henrion, Daniel Kotlarz, Dror S. Shouval, Tobias Schwerd, Caterina Strisciuglio, Lissy de Ridder, Johan van Limbergen, Marina Macchi, Scott B. Snapper, Frank M. Ruemmele, David C. Wilson, Simon P. L. Travis, Anne M. Griffiths, Dan Turner, Christoph Klein, Aleixo M. Muise, Richard K. Russell
Summary: This paper provides recommendations for the use of genomics in evaluating potential monogenic causes of IBD, suggesting that routine genetic screening is not recommended for all IBD patients. Instead, genetic testing should be considered based on the age of IBD onset and other criteria, emphasizing the importance of genetic testing in clinical care.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Clinical Neurology
Yuhan Xie, Julian N. Acosta, Yixuan Ye, Zachariah S. Demarais, Carolyn J. Conlon, Ming Chen, Hongyu Zhao, Guido J. Falcone
Summary: This study used whole-exome sequencing data from 152,058 UK Biobank participants and identified a significant association between a rare genetic variant at CYP2R1 and the risk of ischemic stroke (IS). Validation analyses further confirmed this association in other cohorts and neuroimaging traits.
Article
Medical Laboratory Technology
Nguyen Thanh Binh, Nguyen Thi Kim Lien, Nguyen Thi Van Anh, Nguyen Thi Phuong Mai, Nguyen Thi Viet Ha, Dang Thuy Ha, Nguyen Van Tung, Nguyen Huy Hoang
Summary: This study identifies five mutations in six unrelated patients with CGD from different Vietnamese families and confirms three novel pathogenic mutations. The results contribute to the understanding of the etiology of the disease and the use of WES sequencing in diagnosing carriers, genetic counseling, and prenatal screening.
CLINICA CHIMICA ACTA
(2022)
Review
Gastroenterology & Hepatology
Ryusuke Nambu, Neil Warner, Daniel J. Mulder, Daniel Kotlarz, Dermot P. B. McGovern, Judy Cho, Christoph Klein, Scott B. Snapper, Anne M. Griffiths, Itaru Iwama, Aleixo M. Muise
Summary: Monogenic inflammatory bowel disease (IBD) cases have diverse clinical features and limited treatment options. Early identification and understanding of the characteristics of genes and underlying disease processes in monogenic IBD are important for effective management.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Genetics & Heredity
Elizabeth K. Baker, Elizabeth A. Ulm, Alyce Belonis, Diana S. Brightman, Barbara E. Hallinan, Nancy D. Leslie, Alexander G. Miethke, Marissa Vawter-Lee, Yaning Wu, Loren D. M. Pena
Summary: Exome sequencing (ES) is a clinically available technique that provides an unbiased and high-throughput sequencing platform for patients with symptoms believed to have a genetic cause. Recent studies have shown that a post-exome evaluation, including clinical re-phenotyping, functional studies, and variant reevaluation, can significantly increase the diagnostic yield.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Emanuele Marchi, Narayan Ramamurthy, M. Azim Ansari, Caroline E. Harrer, Eleanor Barnes, Paul Klenerman
Summary: This study aimed to profile the transcriptomics of HCV-infected livers and assess the effect of major predictors of clinical outcome such as IFNL4 host genotype and sex. The results showed that underlying cirrhotic state had the most substantial impact on transcriptional responses, and sex and IL28B/IFNL4 genotype also played important roles in antiviral responses.
Article
Gastroenterology & Hepatology
Stephan Buch, Hamish Innes, Philipp Ludwig Lutz, Hans Dieter Nischalke, Jens U. Marquardt, Janett Fischer, Karl Heinz Weiss, Jonas Rosendahl, Astrid Marot, Marcin Krawczyk, Markus Casper, Frank Lammert, Florian Eyer, Arndt Vogel, Silke Marhenke, Johann von Felden, Rohini Sharma, Stephen Rahul Atkinson, Andrew McQuillin, Jacob Nattermann, Clemens Schafmayer, Andre Franke, Christian Strassburg, Marcella Rietschel, Heidi Altmann, Stefan Sulk, Veera Raghavan Thangapandi, Mario Brosch, Carolin Lackner, Rudolf E. Stauber, Ali Canbay, Alexander Link, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Bernhard Scheiner, Christian Datz, Stefano Romeo, Stefano Ginanni Corradini, William Lucien Irving, Joanne R. Morling, Indra Neil Guha, Eleanor Barnes, M. Azim Ansari, Jocelyn Quistrebert, Luca Valenti, Sacha A. Mueller, Marsha Yvonne Morgan, Jean-Francois Dufour, Jonel Trebicka, Thomas Berg, Pierre Deltenre, Sebastian Mueller, Jochen Hampe, Felix Stickel
Summary: This study identifies rs2242652 in TERT as a novel protective factor for HCC in patients with alcohol-related cirrhosis.
Review
Gastroenterology & Hepatology
Eleanor Barnes, Graham S. Cooke, Georg M. Lauer, Raymond T. Chung
Summary: This article discusses the global health concern of hepatitis C virus (HCV) and the limitations of using directly acting antiviral (DAA) drugs for treatment. Without an effective HCV vaccine, the authors argue that the development of a controlled human infection model (CHIM) for HCV is crucial. They propose a study design for the HCV CHIM, including the selection of volunteers, development of an infectious inoculum, evaluation of immune and viral parameters, etc. The authors conclude that an HCV CHIM is realistic and can address safety and ethical concerns, and it is difficult to envision the development of an HCV vaccine without it.
Article
Immunology
Sarah Fidler, Julie Fox, Timothy Tipoe, Stephanie Longet, Tom Tipton, Movin Abeywickrema, Sandra Adele, Jasmini Alagaratnam, Mohammad Ali, Parvinder K. Aley, Suhail Aslam, Anbhu Balasubramanian, Anna Bara, Tanveer Bawa, Anthony Brown, Helen Brown, Federica Cappuccini, Sophie Davies, Jamie Fowler, Leila Godfrey, Anna L. Goodman, Kathrine Hilario, Carl-Philipp Hackstein, Moncy Mathew, Yama F. Mujadidi, Alice Packham, Claire Petersen, Emma Plested, Katrina M. Pollock, Maheshi N. Ramasamy, Hannah Robinson, Nicola Robinson, Patpong Rongkard, Helen Sanders, Teona Serafimova, Niamh Spence, Anele Waters, Danielle Woods, Panagiota Zacharopoulou, Eleanor Barnes, Susanna Dunachie, Philip Goulder, Paul Klenerman, Alan Winston, Adrian V. S. Hill, Sarah C. Gilbert, Miles Carroll, Andrew J. Pollard, Teresa Lambe, Ane Ogbe, John Frater
Summary: People with HIV on antiretroviral therapy and good CD4 T-cell counts can generate effective immune responses against SARS-CoV-2 after vaccination. A third vaccine dose can significantly enhance B- and T-cell immunity, including responses to known variants of concern.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Gastroenterology & Hepatology
Colleen Georgette Chantelle McGregor, Ruchi Tandon, Alison Simmons
Summary: Sustained, transmural inflammation of the bowel wall can lead to the development of a fistula in Crohn's disease (CD), a recognized complication observed in 40% of CD patients. Despite advanced treatment, one-third of patients experience recurrent fistulae. Understanding the pathogenesis of CD-associated fistulae is crucial for developing targeted treatments, but currently, the pathogenesis remains poorly defined due to the lack of accepted in vitro and in vivo models. This review summarizes the existing knowledge of histopathological, immune, cellular, genetic, and microbial factors contributing to CD-associated fistulae and explores the potential of advancing technologies in verifying and expanding our understanding and identifying novel therapeutic targets.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
C. Green, J. McGinley, C. Sande, S. Capone, S. Makvandi-Nejad, A. Vitelli, L. Silva-Reyes, S. Bibi, C. Otasowie, D. Sheerin, A. Thompson, C. Dold, P. Klenerman, E. Barnes, L. Dorrell, C. Rollier, A. Pollard, D. O'Connor
Summary: In this immunological study, cohorts of healthy younger and older adults were immunized with an adenovirus-vectored RSV vaccine either intramuscularly or intranasally. Differential gene expression was observed in blood samples after intramuscular prime vaccination, but not after intranasal prime vaccination. Intranasally primed participants showed more gene expression changes upon boosting. The gene expression changes mainly involved immune-related biological processes.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Victoria Hamill, Will Gelson, Douglas MacDonald, Paul Richardson, Stephen D. D. Ryder, Mark Aldersley, Stuart McPherson, Sumita Verma, Rohini Sharma, Sharon Hutchinson, Jennifer Benselin, Eleanor Barnes, Indra Neil Guha, William L. L. Irving, Hamish Innes
Summary: This study found that the uptake of biannual ultrasound surveillance in cured hepatitis C cirrhosis patients in the UK is low and there is inequity in its delivery. Only 19% of patients received biannual ultrasound in the first three years after achieving a sustained viral response, and this proportion decreased further to 9% during the follow-up years. The uptake of biannual ultrasound was associated with the hospital attended by the patient, as well as age and cirrhosis decompensation.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Aminata Sy, Leanne McCabe, Emma Hudson, Azim M. Ansari, Vincent Pedergnana, Shang-Kuan Lin, S. Santana, Marzia Fiorino, Aftab Ala, Ben Stone, M. Smith, Mark Nelson, Stephen T. Barclay, Stuart McPherson, Stephen D. Ryder, Jane Collier, Eleanor Barnes, Ann Sarah Walker, Sarah L. Pett, Graham Cooke
Summary: The CC genotype of the IFNL4 gene is associated with increased Hepatitis C cure rates. The Genedrive (R) IFNL4 is a CE marked Point of Care molecular diagnostic test for rapid detection of IFNL4 genotype status. Comparing buccal swab PoC testing with genetic sequencing, the buccal swab test showed better accuracy in identifying non-CC genotypes than CC genotypes.
Article
Biology
Barnaby Flower, Le Manh Hung, Leanne Mccabe, M. Azim Ansari, Chau Le Ngoc, Thu Vo Thi, Hang Vu Thi Kim, Phuong Nguyen Thi Ngoc, Le Thanh Phuong, Vo Minh Quang, Thuan Dang Trong, Thao Le Thi, Tran Nguyen Bao, Cherry Kingsley, David Smith, Richard M. Hoglund, Joel Tarning, Evelyne Kestelyn, Sarah L. Pett, Rogier van Doorn, Jennifer Ilo Van Nuil, Hugo Turner, Guy E. Thwaites, Eleanor Barnes, Motiur Rahman, Ann Sarah Walker, Jeremy N. Day, Nguyen V. V. Chau, Graham S. Cooke, Harel Dahari
Summary: This study evaluated the use of early virological response to shorten the duration of SOF/DCV therapy for hepatitis C. It found that 4-week therapy with retreatment if necessary can achieve high cure rates for patients with mild liver disease. The study also found no evidence that treatment failure was associated with host IFNL4 genotype, viral subtype, baseline resistance-associated substitutions, or drug levels.
Article
Immunology
Sile A. Johnson, Eloise Phillips, Sandra Adele, Stephanie Longet, Tom Malone, Chris Mason, Lizzie Stafford, Anni Jamsen, Siobhan Gardiner, Alexandra Deeks, Janice Neo, Emily J. Blurton, Jemima White, Muhammed Ali, Barbara Kronsteiner, Joseph D. Wilson, Donal T. Skelly, Katie Jeffery, Christopher P. Conlon, Philip Goulder, Eleanor PITCH Consortium, Miles Carroll, Eleanor Barnes, Paul Klenerman, Susanna J. Dunachie
Summary: PITCH ELISpot S1 + S2 had greater sensitivity for SARS-CoV-2 specific T-cell responses compared with the QuantiFERON SARS-CoV-2 assay tube Ag3, except for the acute infection group. The QuantiFERON SARS-CoV-2 assay showed potential as a T-cell evaluation tool soon after SARS-CoV-2 infection but has lower sensitivity for use in reliable evaluation of vaccination or more distant infection.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Weiqi Liao, Carol A. C. Coupland, Hamish Innes, Peter Jepsen, Philippa C. Matthews, Cori Campbell, The DeLIVER consortium DeLIVER consortium, Eleanor Barnes, Julia Hippisley-Cox
Summary: This study aims to understand the disparities in epidemiology and clinical pathways of primary liver cancer in England. The findings show that age, sex, socioeconomic deprivation, ethnicity, and geographical regions are all significantly associated with liver cancer incidence. Patients aged 80 years and above have a higher risk of being diagnosed at late stages and have poorer survival rates. Men are at a higher risk of liver cancer than women, and survival rates are generally poor.
Article
Medicine, Research & Experimental
Shona C. Moore, Barbara Kronsteiner, Stephanie Longet, Sandra Adele, Alexandra S. Deeks, Chang Liu, Wanwisa Dejnirattisai, Laura Silva Reyes, Naomi Meardon, Sian Faustini, Saly Al-Taei, Tom Tipton, Luisa M. Hering, Adrienn Angyal, Rebecca Brown, Alexander R. Nicols, Susan L. Dobson, Piyada Supasa, Aekkachai Tuekprakhon, Andrew Cross, Jessica K. Tyerman, Hailey Hornsby, Irina Grouneva, Megan Plowright, Peijun Zhang, Thomas A. H. Newman, Jeremy M. Nell, Priyanka Abraham, Mohammad Ali, Tom Malone, Isabel Neale, Eloise Phillips, Joseph D. Wilson, Sam M. Murray, Martha Zewdie, Adrian Shields, Emily C. Horner, Lucy H. Booth, Lizzie Stafford, Sagida Bibi, Daniel G. Wootton, Alexander J. Mentzer, Christopher P. Conlon, Katie Jeffery, Philippa C. Matthews, Andrew J. Pollard, Anthony Brown, Sarah L. Rowland-Jones, Juthathip Mongkolsapaya, Rebecca P. Payne, Christina Dold, Teresa Lambe, James E. D. Thaventhiran, Gavin Screaton, Eleanor Barnes, Susan Hopkins, Victoria Hall, Christopher J. A. Ducan, Alex Richter, Miles Carroll, Thushan I. de Silva, Paul Klenerman, Susann Dunachie, Lance Turtle, PITCH Consortium
Summary: In this study, the researchers observed the immune response changes in 684 UK healthcare workers after receiving two doses of BNT162b2 or AZD1222 vaccines during a follow-up period of 6-9 months. The study found that the antibody and memory B cell responses were relatively stable, while the levels of binding and neutralizing antibodies declined. The study also found that individuals with prior infection had stronger and broader T cell responses to the vaccine, especially after receiving the third dose.
Article
Biochemistry & Molecular Biology
Eleanor Barnes, Carl S. Goodyear, Michelle Willicombe, Charlotte Gaskell, Stefan Siebert, Thushan I. de Silva, Sam M. Murray, Daniel Rea, John A. Snowden, Miles Carroll, Sarah Pirrie, Sarah J. Bowden, Susanna J. Dunachie, Alex Richter, Zixiang Lim, Jack Satsangi, Gordon Cook, Ann Pope, Ana Hughes, Molly Harrison, Sean H. Lim, Paul Miller, Paul Klenerman, Pitch Consortium, Neil Basu, Ashley Gilmour, Sophie Irwin, Georgina Meacham, Thomas Marjot, Stavros Dimitriadis, Peter Kelleher, Maria Prendecki, Candice Clarke, Paige Mortimer, Stacey McIntyre, Rachael Selby, Naomi Meardon, Dung Nguyen, Tom Tipton, Stephanie Longet, Stephen Laidlaw, Kim Orchard, Georgina Ireland, David Thomas, Pamela Kearns, Amanda Kirkham, Iain B. McInnes
Summary: Serological analysis and infection outcomes of 2,686 participants with immune-suppressive diseases who received two COVID-19 vaccines revealed specific clinical phenotypes that might benefit from targeted COVID-19 therapeutic strategies. Some patients failed to develop anti-SARS-CoV-2 antibodies, with the highest vaccine failure rates observed in ANCA-associated vasculitis, hemodialysis, and solid organ transplant recipients. Decreased serological and T cell responses were associated with severe COVID-19. In summary, we identified clinical phenotypes that may benefit from targeted COVID-19 therapeutic strategies.
Article
Genetics & Heredity
Chloe H. Lee, Jaesung Huh, Paul R. Buckley, Myeongjun Jang, Mariana Pereira Pinho, Ricardo A. Fernandes, Agne Antanaviciute, Alison Simmons, Hashem Koohy
Summary: The study presents a novel computational workflow, TRAP, for accurately predicting CD8 + T-cell epitopes. It outperformed other algorithms in both cancer and pathogenic settings. Additionally, a new metric called RSAT was developed to estimate the immunogenicity of pathogenic peptides.
Letter
Gastroenterology & Hepatology
Harvey J. Alter, Eleanor Barnes, Mia J. Biondi, Andrea L. Cox, Jake D. Eberts, Jordan J. Feld, T. Jake Liang, Josh Morrison, Charles M. Rice, Naglaa H. Shoukry, David L. Thomas, Jennifer Van Gennip, Charles Weijer
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
