Article
Immunology
Anush Chakraborty, Gargi Roy, Bharati Swami, Sangeeta Bhaskar
Summary: A tumor targeted delivery system was developed using chitosan nanoparticles loaded with MIP adjuvants, which showed preferential accumulation within the tumor microenvironment. The MIP nano-formulations significantly reduced tumor volume and increased the frequency of activated immune cells in the TME. Combination therapy with MIP nano-formulation and Paclitaxel further decreased tumor volume.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dongguang Fan, Bin Wang, Giovanni Stelitano, Karin Savkova, Olga Riabova, Rui Shi, Xiaomei Wu, Laurent R. Chiarelli, Katarina Mikusova, Vadim Makarov, Yu Lu, Yuzhi Hong, Chunhua Qiao
Summary: Compound 37, an analogue of benzothiazinone (BTZ), inhibits the essential enzyme DprE1 and shows improved solubility and bioavailability compared to the lead compound. It exhibits bactericidal activity against Mycobacterium tuberculosis (Mtb) in an acute infection mouse model.
Article
Engineering, Environmental
Khalil T. Hassan, Ibraheem J. Ibraheem, Omar M. Hassan, A. S. Obaid, Hameed Hussein Ali, Thaer Abdulqader Salih, Mohammed S. Kadhim
Summary: This study presents a green synthesis pathway for Ag/AgCl nanoparticles derived from freshwater algae, confirming the structure and properties of the synthesized product and evaluating its antibacterial activity. The results suggest that combining Ag/AgCl nanoparticles with antibiotics may produce a synergistic antimicrobial effect, potentially inhibiting the development of antibiotic-resistant bacteria.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Environmental Sciences
Nguyen Thuy Lan Chi, Mathiyazhagan Narayanan, Arunachalam Chinnathambi, Chandramohan Govindasamy, Baskaran Subramani, Kathirvel Brindhadevi, Tipsukon Pimpimon, Surachai Pikulkaew
Summary: The research examined the ability of Azadirachta indica aqueous kernel extract to synthesize silver nanoparticles and its anti-inflammatory and anti-diabetic activity. The study found that the aqueous kernel extract was able to fabricate silver nanoparticles and showed promising anti-inflammatory and anti-diabetic properties.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Saurabh Garg, Rakesh Kumar, Dennis Kunimoto, Gina R. Rayat
Summary: This study evaluated the effectiveness of compounds 1-3 as anti-TB agents and found that compound 3 showed the strongest inhibitory effect against M. tuberculosis and M. avium. When combined with isoniazid or rifampicin, compounds 1-3 exhibited additive to synergistic interactions. Additionally, they also demonstrated synergistic effects when combined with certain other anti-TB drugs.
Article
Biochemistry & Molecular Biology
Ying Sun, Lishi Liang, Yang Yi, Yan Meng, Kaidi Peng, Xueyu Jiang, Hongxun Wang
Summary: In this study, yeast glucan with different degrees of amination (BNs) were used as stabilizers and capping agent to prepare dispersed SeNPs. BNs/SeNPs exhibited positive potential and spherical morphologies with stable sizes at room temperature. Cytotoxicity test showed that BNs/SeNPs had lower toxicity to RAW264.7 cells compared to SeNPs. Moreover, BNs/SeNPs showed excellent anti-inflammatory activity by inhibiting the generation of inflammatory factors and down-regulating mRNA transcription levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Bharathkumar Nagaraj, Shazia Anjum Musthafa, Sadiq Muhammad, Ganesh Munuswamy-Ramanujam, Woo Jin Chung, Hissah Abdulrahman Alodaini, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary, Venkatalakshmi Ranganathan
Summary: In this study, gold nanoparticles were synthesized using Clerodendrum infortunatum leaf extract and evaluated for their broad-spectrum antimicrobial activity and cytotoxicity to human cells. The results showed that the gold nanoparticles exhibited significant inhibitory effects on various pathogenic microorganisms and had low cytotoxicity to human cells.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Shuang Li, Hui Zhang, Bailin Cong, Peiqing He, Wenqi Liu, Shenghao Liu
Summary: A method for preparing biogenic silver and silver chloride nanoparticles (Ag@AgCl NPs) was developed using bacteria from the Arctic Ocean. The nanoparticles showed good dispersion and antimicrobial activity, and could be used for dye degradation and other applications. The synthesis mechanism of the nanoparticles might be related to specific functional groups in the supernatant of the bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Anupama Singh, Sateesha Shivally Boregowda, Afrasim Moin, Amr Selim Abu Lila, Mohammed F. Aldawsari, El-Sayed Khafagy, Hadil Faris Alotaibi, Rajamma Abburu Jayaramu
Summary: Synthesized silver nanoparticles using Commiphora mukul extract showed potential anti-inflammatory and antioxidant effects, making them a promising therapeutic option for rheumatoid arthritis (RA).
Article
Chemistry, Multidisciplinary
Krishna Kumar Jaiswal, Ishita Banerjee, Swapnamoy Dutta, Ravikant Verma, Lokanadhan Gunti, Sharad Awasthi, Mayank Bhushan, Vinod Kumar, Mohamed Fahad Alajmi, Afzal Hussain
Summary: The rapid emergence of multidrug-resistant microbes has become a major threat to public health worldwide. The preparation and application of nanomaterial-based antimicrobials are of great significance in addressing this problem. This study investigated the bio-fabrication of polycrystalline Ag-NCs using BCE as a reducer and stabilizer under microwave irradiation. The study optimized the formation of Ag-NCs and analyzed their structural and morphological characteristics. The prepared Ag-NCs exhibited antimicrobial activity against various bacteria and fungi.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Pankaj S. Girase, Sanjeev Dhawan, Vishal Kumar, Suraj R. Shinde, Mahesh B. Palkar, Rajshekhar Karpoormath
Summary: Piperazine, a nitrogen-containing heterocyclic compound, is widely used in medicinal chemistry for its diverse pharmacological activities, particularly in the development of anti-TB molecules. Studies have shown that molecules containing piperazine subunits exhibit potential activity against drug-resistant strains of Mycobacterium tuberculosis.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Thi Thanh Huong Le, Thu Ha Ngo, Thi Huong Nguyen, Van Hung Hoang, Van Hao Nguyen, Phu Hung Nguyen
Summary: The use of Ardisia gigantifolia extract for synthesizing silver nanoparticles with anticancer activity is reported in this study. The green synthesized silver nanoparticles (Arg-AgNPs) showed inhibitory effects on gastric cancer cells, causing cell cycle arrest, inhibition of cell migration, and induction of senescence and reactive oxygen species (ROS) production. Therefore, Arg-AgNPs could be a promising candidate for targeting human gastric cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Allan H. Pang, Keith D. Green, Nishad Thamban Chandrika, Atefeh Garzan, Ankita Punetha, Selina Y. L. Holbrook, Melisa J. Willby, James E. Posey, Oleg V. Tsodikov, Sylvie Garneau-Tsodikova
Summary: Eis acetyltransferase is a clinically significant mechanism of tuberculosis resistance to kanamycin. Inhibitors of Eis have been discovered, which can effectively abolish resistance to kanamycin in highly resistant strains. Additionally, several compounds with toxic effects on mycobacteria have been identified, with a mechanism of toxicity distinct from Eis inhibition.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Jincheng Zhang, Li Liang, Yimeng Shan, Xuewei Zhou, Baoguo Sun, Yuan Liu, Yuyu Zhang
Summary: This study investigated the antihypertensive effect and mechanism of umami peptides from yeast extract. The umami peptide LLLLPKP showed favorable ACE inhibitory activity and regulated blood pressure in a hypertensive rat model. It remained stable during simulated digestion and interacted with key sites in the active pockets. Developing umami peptides with antihypertensive effects holds substantial importance for long-term hypertension treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Engineering, Environmental
Xiaohan Zhang, Peng Wang, Wanzhen Meng, EnXin Cui, Qianqian Zhang, Zeyan Wang, Zhaoke Zheng, Yuanyuan Liu, Hefeng Cheng, Ying Dai, Baibiao Huang
Summary: Ag/AgCl nanoparticles exhibit excellent biocompatibility and efficient photocatalytic activity, generating reactive oxygen species to induce oxidative stress and apoptosis in cellular systems. Coating AgCl on Ag nanoparticles enhances visible light absorption, reduces recombination processes, and increases photocatalytic efficacy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Energy & Fuels
Sumit Chaturvedi, Shiv Vendra Singh, V. C. Dhyani, K. Govindaraju, R. Vinu, S. Mandal
Summary: This study characterized and pyrolyzed seven biomasses of Indian origin to produce biochars. The biochars were thoroughly characterized to assess their potential applications in energy, environment, and agriculture. Different biochars showed distinct properties, with some suitable for soil amelioration and others suitable for renewable solid fuel purposes.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Polymer Science
N. Amreena Jan, K. S. Subramanian, S. Ganapathy, J. Mohanraj, K. Govindaraju
Summary: In this study, hexanal-loaded nano-fibers were used to extend the shelf-life of fruits by slowing down the ripening process. The nano-fibers regulated the release of hexanal vapor, resulting in a longer preservation period for the fruits.
Article
Polymer Science
M. Latha, K. Raja, K. S. Subramanian, K. Govindaraju, M. Karthikeyan, A. Lakshmanan, S. Srivignesh, M. S. Kumuthan
Summary: In this study, nanofibre from biodegradable polymer PVA was developed for encapsulation of tebuconazole fungicide molecule to effectively deliver bioactive molecules against root rot disease. The results showed successful loading and sustained release of tebuconazole in PVA nanofibres. Bio-efficacy tests demonstrated the significant inhibitory effect of tebuconazole-loaded nanofibre on dry root rot, and seed quality tests revealed positive effects on germination and growth.
Review
Pharmacology & Pharmacy
Radhakrishnan Manikkam, Krupakar Parthasarathy, Abirami Baskaran, Lavanya Dellibabu
Summary: The global coronavirus pandemic has posed severe threats to health and economy, but an ideal solution has not been found yet. Natural products, particularly from actinobacteria, have potential antiviral properties and could serve as important sources for future drug discovery.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Fisheries
Annamalai Natarajan, Radhakrishnan Prabakarakrishnan, Kasivelu Govindaraju, Vimal Sugumar, Kuppusamy Sathiskumar, Jayaraman Narenkumar, Aadhikesavan Ramanan, Balasubramanian Senthil Kumar
Summary: This study found that an ethanol extract of Kappaphycus alvarezii can effectively protect albino rats from cisplatin-induced hepato and nephrotoxicity. Cisplatin administration increased the levels of hepato-specific enzymes and lipid markers in rats, while the administration of K. alvarezii extract reduced these markers and improved histological architecture. The presence of nine distinct chemicals in the extract was confirmed by GC-MS analysis. Overall, the study suggests that K. alvarezii extract may protect albino rats against cisplatin-induced liver and kidney toxicity through its active chemicals.
AQUACULTURE INTERNATIONAL
(2023)
Article
Food Science & Technology
Adgunkar Neha Uttam, Shweta Padte, G. Joshua Vimal Raj, K. Govindaraju, Sourav Kumar
Summary: Wheat bran is a cost-effective by-product that contains high-quality proteins, minerals, vitamins, and bioactive compounds. The study focused on selecting appropriate bran streams from a commercial roller flour mill, optimizing the protein isolation process, characterizing amino acids, and developing high protein bread using the extracted albumin isolate.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Materials Science, Multidisciplinary
S. Supriya, D. I. Prerna, P. Santhiya, M. Kannan, S. U. Mohammed Riyaz, Sinouvassane Djearamane, M. Radhakrishnan, K. Govindaraju
Summary: Gold nanoparticles-Thymoquinone (Au NPs-TQ) were synthesized using a solid-state technique and characterized using various spectroscopic methods. In silico docking analyses showed that Au NPs-TQ exhibited inhibitory activity against virulent M. tuberculosis H37Rv strain protein and VP28 virus envelope protein. Molecular docking studies were also performed to investigate the binding of Au NPs-TQ with complex structures.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2023)
Article
Veterinary Sciences
K. E. Lawrence, R. G. Clark, H. Henderson, K. Govindaraju, C. Balcomb
Summary: This study aimed to compare the performance of two predictive models for the survival of downer cows. The original 1987 model, developed using a dataset with missing values, performed as well as the new model that utilized modern data imputation and analytical methods. The results showed that the original model had a slightly higher accuracy with specificities of 0.82 and sensitivities of 0.85, using a cut point for the probability of survival at 0.313.
NEW ZEALAND VETERINARY JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Sudhanarayani S. S. Rao, Krupakar Parthasarathy, Vignesh Sounderrajan, K. Neelagandan, Pradeep Anbazhagan, Vaishnavi Chandramouli
Summary: Animals and viruses have been co-evolving under natural circumstances and pandemic situations. They carry harmful coronaviruses that can easily spread. In recent times, we have witnessed pandemic-like situations caused by the spread of deadly viruses. There are four known genera of the coronavirus family, and animals have been infected by coronaviruses from all four genera. Severe acute respiratory syndromes like SARS CoV and MERS-CoV have emerged in the last few decades, and we are currently facing another pandemic situation due to the uncontrolled spread of SARSCoV-2. While these findings are based on a small number of animals and do not indicate human transmission, it has been discovered that several mammals can be naturally infected by the virus and can transmit the illness to other animals of the same species.
Article
Fisheries
S. Amreen Nisa, K. Govindaraju, R. Vasantharaja, M. Kannan, K. Raja
Summary: The study investigates the production of gold nanoparticles using jellyfish venom and their effectiveness in inhibiting the growth of cancer cells. The nanoparticles were characterized using various techniques and were found to have spherical and triangular shapes with different sizes. The results of the MTT assay showed that the venom-mediated nanoparticles significantly reduced the proliferation of MCF-7 cells compared to normal cells.
AQUACULTURE INTERNATIONAL
(2023)
Article
Environmental Sciences
S. Amreen Nisa, R. Vasantharaja, S. Supriya, D. Inbakandan, G. Dharani, K. Govindaraju
Summary: Plastic pollution is a major global problem that poses a serious threat to coastal and marine ecosystems. The accumulation of plastics in the aquatic environment due to human activities leads to disruptions in the functioning of the ecosystem. This study investigated the degradation ability of nematocyst protein extracted from lyophilized nematocyst samples using three different mediums. The results suggest that jellyfish nematocyst protein can biodeteriorate polyethylene without the need for external physicochemical processes, providing evidence for further research.
MARINE POLLUTION BULLETIN
(2023)
Article
Energy & Fuels
S. Amreen Nisa, R. Vasantharaja, K. Govindaraju
Summary: The present study aimed to investigate the antioxidant and antiproliferative activity of partially purified venom protein extracted from five different species of Chrysaora jellyfish. The venom protein of Chrysaora fuscescens exhibited strong free radical scavenging activity and inhibition properties on lipid peroxidase and nitric oxide. Furthermore, the venom protein showed dose-dependent antiproliferative activity against cancer cell lines MCF-7 and A549. Overall, this study demonstrates the potential of Chrysaora species venom protein in pharmaceutical industries.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Chemistry, Physical
S. Amreen Nisa, K. Govindaraju, R. Vasantharaja, M. Kannan, D. Karthickeyan
Summary: The study synthesized gold nanoparticles using jellyfish nematocyst venom protein extracted from PBS and DDW. The two different nanoparticles exhibited spherical morphology with sizes ranging from 31 nm to 27 nm respectively. The toxicity of the nanoparticles was analyzed using HEK293 cells through the MTT assay. Moreover, the anti-cancer activity of the venom protein, PBS/DDW-extracted venom protein-mediated synthesized gold nanoparticles, and standard drug 5-Fluorouracil was evaluated using MCF-7 cancer cells.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Immunology
Santhiya Panchalingam, Govindaraju Kasivelu, Manikandan Jayaraman, Rajalakshmi Kumar, Santhiya Kalimuthu, Jeyakanthan Jeyaraman
Summary: This study aimed to identify and investigate the differentially expressed genes (DEGs) primarily involved in Pulmonary TB. TNFAIP6 was identified as a significant DEG in TB datasets, and it was found to be closely associated with injury, inflammation, and arsenic poisoning. Further structural characterization studies confirmed the stability of TNFAIP6 models and revealed its potential as a viable biomarker for assessing the severity of pulmonary TB.
MICROBIAL PATHOGENESIS
(2023)
Article
Entomology
M. Kannan, K. Elango, S. A. Jayaprakash, P. Dinesh Kumar, K. Govindaraju
Summary: A total of 19 insect species from four major insect orders were identified as pests damaging common bean cultivation. The incidence of sucking insects was the highest, with aphids being the most prevalent. Weather factors such as temperature, relative humidity, and rainfall influenced the population dynamics of these pests. Different models were used to analyze the relationship between weather parameters and pest incidence.
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2023)
