Article
Polymer Science
Yusser Olguin, Soledad Acuna-Mendoza, Carolina Otero, Cristian A. Acevedo, Cristian Covarrubias
Summary: Modulating the bio-regenerative characteristics of materials is crucial in tissue engineering, especially in bone tissue engineering where the promotion of osteoconduction determines the therapeutic properties of the material. In addition to chemical qualities, the three-dimensional surface structure plays a fundamental role and can be modulated through various methods, one of which is the use of different types of radiation.
Article
Engineering, Biomedical
Pengyue You, Yuhua Liu, Xinzhi Wang, Bowen Li, Weiyi Wu, Lin Tang
Summary: This study investigated the potential application of natural acellular porcine pericardium (APP) as a barrier membrane for guided bone regeneration (GBR). The results showed that APP exhibited osteoconductive and osteoinductive properties, promoting bone regeneration in a critical-sized calvarial defect model compared to collagen membrane and control group. Overall, APP demonstrated promising capabilities for GBR in terms of biomaterial properties and bone healing effects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Tatiana I. Vinogradova, Mikhail S. Serdobintsev, Evgenia G. Korzhikova-Vlakh, Viktor A. Korzhikov-Vlakh, Alexander S. Kaftyrev, Natalya M. Blum, Natalya Yu. Semenova, Dilyara S. Esmedlyaeva, Marina E. Dyakova, Yulia A. Nashchekina, Marine Z. Dogonadze, Natalia V. Zabolotnykh, Petr K. Yablonsky
Summary: This study compared the effects of autografting and implantation with a biodegradable composite scaffold for bone-defect regeneration in a tuberculosis rabbit model. The results showed that the porous three-dimensional composite materials prepared by 3D printing could promote bone regeneration and healing. This has important implications for the treatment of tuberculosis patients.
Article
Engineering, Biomedical
Jianping Mao, Pengfei Wei, Zuoying Yuan, Wei Jing, Jingjing Cao, Guangping Li, Jianxun Guo, Honggang Wang, Dafu Chen, Qing Cai
Summary: This study prepared microspheres with surface micropores using the double emulsion method, which showed increased cell affinity and enhanced osteogenic differentiation of BMSCs after further functionalization. By adsorbing BMP-2 onto the biomineralized microspheres, efficient ectopic osteogenesis was induced without causing biocompatibility problems. The study provided a simple strategy to prepare functionalized microspheres with great potential in promoting bone regeneration as injectable micro-scaffolds.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Biochemistry & Molecular Biology
Elia Bari, Fulvio Tartara, Fabio Cofano, Giuseppe di Perna, Diego Garbossa, Sara Perteghella, Marzio Sorlini, Delia Mandracchia, Lorella Giovannelli, Paolo Gaetani, Maria Luisa Torre, Lorena Segale
Summary: The study found that the mesenchymal stem cell-secretome Lyosecretome has a significant improvement effect on the osteoinductive and osteoconductive properties of titanium cages, leading to increased mineralized matrix when used during culturing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tao Wang, Jiaxiang Bai, Min Lu, Chenglong Huang, Dechun Geng, Gang Chen, Lei Wang, Jin Qi, Wenguo Cui, Lianfu Deng
Summary: In this study, a dual-effect coating was designed to modulate the osteoimmune microenvironment and enhance bone regeneration. The coating, which immobilized immunomodulatory metal ions and osteoinductive growth factors, significantly increased the recruitment of M2 macrophages and upregulated the expression of M2 cytokines. This led to improved bone-implant mechanical fixation and new bone ingrowth.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Physical
Matej Tomas, Marija Candrlic, Martina Juzbasic, Zrinka Ivanisevic, Nikola Matijevic, Aleksandar Vcev, Olga Cvijanovic Peloza, Marko Matijevic, Zeljka Peric Kacarevic
Summary: This article systematically reviewed the effect of injectable synthetic biomaterials on new bone formation in the maxilla and mandible in animals and humans. It found heterogeneity in animal and human studies, indicating the need for further research to better understand the advantages and disadvantages of these biomaterials.
Review
Engineering, Biomedical
Ehsan Zeimaran, Sara Pourshahrestani, Ali Fathi, Nasrul Anuar bin Abd Razak, Nahrizul Adib Kadri, Amir Sheikhi, Francesco Baino
Summary: Injectable composite hydrogels based on biodegradable polymers and bioactive glasses have gained attention in tissue engineering. These hydrogels combine the advantages of their constituents to provide tailored mechanical properties and biological functionalities.
ACTA BIOMATERIALIA
(2021)
Review
Materials Science, Biomaterials
Aleksandra Szwed-Georgiou, Przemyslaw Plocinski, Barbara Kupikowska-Stobba, Mateusz M. Urbaniak, Paulina Rusek-Wala, Konrad Szustakiewicz, Pawel Piszko, Agnieszka Krupa, Monika Biernat, Malgorzata Gazinska, Miroslaw Kasprzak, Katarzyna Nawrotek, Nuno Pereira Mira, Karolina Rudnicka
Summary: Novel tissue regeneration strategies, specifically in bone regeneration, are actively researched worldwide. Innovative biomaterials are being designed to reduce reliance on bone grafts and achieve well-controlled repair of bone fractures and loss. Coupling bioactive molecules with scaffold materials, such as growth factors, peptides, hormones, and flavonoids, allows for sustained activity and controlled release, and various delivery strategies are investigated to optimize the synthesis of the scaffold.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yiqing Zhang, Jie Zhou, Jiao-Lan Wu, Jian-Chao Ma, Hui Wang, Jing Wen, Shen Huang, Min Lee, Xiaochun Bai, Zhong-Kai Cui
Summary: In this study, we designed and prepared a novel drug delivery system (CPC/Oxy sterosomes) by selecting the antibacterial single-chain amphiphile (CPC) and osteoinductive sterol (Oxy). We demonstrated the excellent biocompatibility and antibacterial ability of CPC/Oxy sterosomes through in vitro 2D and 3D settings. Furthermore, we investigated the osteogenic differentiation of bone marrow mesenchymal stem cells and evaluated the effects of CPC/Oxy sterosomes in a rat infected critical-sized calvarial defect model. Our results showed that CPC/Oxy sterosomes not only exterminated bacterial infections, but also enhanced calvarial healing. This research provides a promising and effective multifunctional sterosomal platform for the treatment of infected bone defects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Claudia Sanhueza, Jeyson Hermosilla, Catherine Klein, Alejandra Chaparro, Ivan Valdivia-Gandur, Victor Beltran, Francisca Acevedo
Summary: Peri-implantitis is a serious condition that can lead to dental implant failure. This study aimed to develop an electrospun scaffold loaded with cholecalciferol to treat peri-implantitis. The scaffold exhibited good mechanical properties and supported cell attachment and proliferation. The cholecalciferol-loaded scaffold promoted bone tissue regeneration. Further studies are needed to confirm the efficacy and safety of the scaffold.
Review
Biotechnology & Applied Microbiology
Jin Liang, Xinyue Lu, Xinru Zheng, Yu Ru Li, Xiaoyu Geng, Kexin Sun, Hongxin Cai, Qi Jia, Heng Bo Jiang, Kai Liu
Summary: This review discusses the surface modification of titanium alloys with bioactive glass and their applications in bone restoration. The authors systematically reviewed relevant articles published from 2013 to the present, highlighting the different coating technologies and the biological properties of the materials. Despite the limited research, it is believed that bioactive glass-coated titanium implants have great clinical application prospects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Miguel Maureira, Felipe Cuadra, Monserrat Cadiz, Margarita Torres, Alfredo von Marttens, Cristian Covarrubias
Summary: The study revealed that ChG hydrogel beads containing homogeneously distributed bioactive glass nanoparticles can promote rapid bone-like apatite mineralization and induce osteogenic differentiation of DPSCs in vitro. The bionanocomposite beads loaded with either nBG or nMBG also exhibited greater bone tissue formation in vivo compared to Puros (R).
BIOMEDICAL MATERIALS
(2021)
Article
Orthopedics
Sebastian Butscheidt, Simon Von Kroge, Julian Stuerznickel, Frank Timo Beil, Thorsten Gehrke, Klaus Pueschel, Michael Amling, Michael Hahn, Tim Rolvien
Summary: The study found that using morselized allograft chips in revision total hip arthroplasty (THA) results in successful incorporation through ingrowth of the host bone (HB), forming an adequate osseous foundation. Larger defects were associated with fibrosis formation, potentially compromising stability.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Chemistry, Multidisciplinary
Munusamy Ramadas, Ravichandran Abimanyu, Jose M. F. Ferreira, Anbalagan M. Ballamurugan
Summary: This study reports on the fabrication and characterization of 3D magnesium substituted bi-phasic calcium phosphate scaffolds by gel-casting, as well as their in vitro and in vivo performances. The scaffolds exhibited good biomineralization activity and biocompatibility, and successfully restored bone defects in an animal model.
Article
Engineering, Biomedical
Krzysztof Pietryga, Katarzyna Reczynska-Kolman, Janne E. Reseland, Havard Haugen, Veronique Larreta-Garde, Elzbieta Pamula
Summary: Biphasic monolithic materials were produced from polysaccharide hydrogel by enzymatic mineralization. The distribution of calcium phosphate mineral phase was achieved by limiting the availability of calcium glycerophosphate to specific parts of the hydrogel sample. The formation of CaP was confirmed by spectroscopy and mapping techniques.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Chemistry, Applied
Valeria Vanoli, Sara Delleani, Mose Casalegno, Fabio Pizzetti, Pooyan Makvandi, Havard Haugen, Andrea Mele, Filippo Rossi, Franca Castiglione
Summary: Hydrogels based on hyaluronic acid and agarose-carbomer have attracted attention as drug delivery systems. The structure of the polymer network greatly affects the release capability of these materials. Using HR-MAS NMR spectroscopy, this study investigated the motion of drugs within the hydrogels and found evidence of superdiffusive motion, which may be responsible for the faster release of sodium salicylate.
CARBOHYDRATE POLYMERS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fadela Alqassab, Amre R. Atmeh, Nada Aldossary, Nada Alzahrani, Marwa Madi, Omar Omar
Summary: This study aimed to investigate the interaction between human inflammatory monocytes with human regenerative fibroblasts after exposure to different calcium silicate materials. The results showed that calcium silicate materials can modulate the inflammatory response of monocytes and have different effects on recipient fibroblasts. MTA material can promote the secretion of prodifferentiation signals from monocytes, which subsequently promote the proliferation and differentiation of fibroblasts.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Orthopedics
Kerstin Hagberg, Shadi Afarin Ghasemi Jahani, Omar Omar, Peter Thomsen
Summary: This study found that ten years after using osseointegrated implants for patients with transfemoral amputations, patient-reported outcomes showed significant improvements, but the rate of mechanical complications increased.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Carolina Encalada Abad, Ignacio Sanz-Sanchez, Victor Serrano, Javier Sanz Esporrin, Ignacio Sanz-Martin, Mariano Sanz
Summary: This study aimed to evaluate the efficacy of leukocyte and platelet-rich fibrin (L-PRF) for alveolar ridge preservation (ARP) compared with spontaneous healing. The results showed that L-PRF did not minimize bone resorption after tooth extraction in non-molar sites or reduce the need for bone regeneration when placing implants. Furthermore, its use did not improve patient-reported outcome measures (PROM's).
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Enrique Bravo, Benjamin Serrano, Honorato Ribeiro-Vidal, Leire Virto, Ignacio Sanz Sanchez, David Herrera, Mariano Sanz
Summary: The study aims to evaluate biofilm formation on hybrid titanium implants with moderately rough and turned surface topographies. A dynamic in vitro multispecies biofilm model was used to assess biofilm formation on the tested implant surfaces. The study found that the moderately rough implant surfaces had significantly higher bacterial biomass and total bacterial counts compared to the turned surface area of HS implants. These findings highlight the importance of implant surface topography in influencing in vitro biofilm formation.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leire Virto, Veronica Odeh, Enrique Garcia-Quismondo, David Herrera, Jesus Palma, Faleh Tamimi, Mariano Sanz
Summary: The objective of this study was to investigate the effect of electrochemical treatment on biofilms developed on titanium dental implants. The study found that electrochemical treatment had an impact on the structure and bacterial composition of the biofilms. The reduction in bacterial counts, especially for Fusobacterium nucleatum, demonstrated a bactericidal effect of the treatment.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
David Palombo, Maryam Rahmati, Fabio Vignoletti, Javier Sanz-Esporrin, Mari Paz Salido, Havard Jostein Haugen, Mariano Sanz
Summary: The aim of this study was to evaluate the healing of hard and soft tissues around teeth prepared with different techniques, including the biologically oriented preparation technique (BOPT), chamfer technique, and non-prepared teeth. The results showed that both the BOPT and chamfer techniques resulted in a more apical location of the free gingival margin compared to non-prepared teeth. However, there were no significant differences between the two preparation techniques in terms of the healing of the periodontal tissues.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ilona Koronna, Beate Schacher, Iulia Dahmer, Katrin Nickles, Sarah K. Sonnenschein, Ti-Sun Kim, Peter Eickholz, Hari Petsos
Summary: The aim of this study was to assess the long-term stability of attachment gain in infrabony defects (IBDs) following regenerative treatment with an enamel matrix derivative (EMD). The results showed that regenerative therapy of IBDs exhibited stable clinical attachment levels (CAL) over 9 years, with significant improvements compared to baseline. CAL gain was associated with CAL after 12 months and the vertical extent of a three-walled defect component, while tooth loss was associated with plaque index after 12 months.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Daniel Hagenfeld, Sven Kleine Bardenhorst, Johannes Matern, Karola Prior, Inga Harks, Peter Eickholz, Katrin Lorenz, Ti-Sun Kim, Thomas Kocher, Jorg Meyle, Dogan Kaner, Ulrich Schlagenhauf, Dag Harmsen, Benjamin Ehmke
Summary: This study aimed to investigate the impact of adjunctive antibiotics on long-term microbiota changes in stage III-IV periodontitis patients. The results showed that mechanical periodontal therapy with adjunctive antibiotics induced significant changes in 16 bacterial strains, including Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans, over a 26-month period. The subgingival-microbial dysbiosis index (SMDI) decreased significantly in the antibiotic group, indicating a shift towards a healthier oral microbiome.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Peter Eickholz, Raphael Koch, Moritz Goede, Katrin Nickles, Thomas Kocher, Katrin Lorenz, Ti-Sun Kim, Joerg Meyle, Dogan Kaner, Ulrich Schlagenhauf, Inga Harks, Benjamin Ehmke
Summary: Assessment of treatment response after systemic amoxicillin/metronidazole adjunctive to subgingival instrumentation (SI) according to stages and grades of the 2018 classification of periodontal diseases. The percentage of disease progression was significantly lower in the treatment group compared to the placebo group in localized stage III, generalized stage III, and grade C.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Mechanics
Torstein Saeter, Olivier Galland, Blandine Feneuil, Havard J. Haugen, Andreas Carlson
Summary: Inspired by geological structures, we investigate the elastohydrodynamic growth of a viscoplastic blister under an elastic sheet resting on a prewetted substrate. The blister growth dynamics follow different regimes depending on how the fluid pressure is set. A plug-like flow inside the blister dictates its dynamics, while the blister's shape is determined by a balance between the fluid's yield stress and the pressure gradient induced by the sheet's deformation.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Multidisciplinary Sciences
Hatem Abuohashish, Abdulaziz Alamri, Suliman Shahin, Dalal Almazrou, Taleb Alkhamis, Omar Omar
Summary: This study aimed to evaluate the impact of bevacizumab on orthodontic tooth movement (OTM) in Wistar rats. The results showed that after 2 weeks, bevacizumab therapy resulted in a 42% increase in OTM distance. In addition, bevacizumab disturbed the morphometric structure at the pressure and tension sites, reducing bone resorption and formation.
Article
Dentistry, Oral Surgery & Medicine
Alberto Turri, Omar Omar, Margarita Trobos, Peter Thomsen, Christer Dahlin
Summary: This study compared the molecular events in the overlying soft tissue, membrane, and underlying bone defect during guided bone regeneration using dual-layered expanded PTFE membranes versus dense PTFE membranes. The results showed that both membranes promoted overall bone formation, with the dual-layered expanded PTFE membrane leading to a significantly higher proportion of new bone. The soft tissue in the dual-layered expanded PTFE group exhibited increased expression of genes related to regeneration and vascularization, as well as lower expression of proinflammatory cytokines, compared to the dense PTFE group.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Erika B. S. Carvalho, Mario Romandini, Sofya Sadilina, Adriana C. P. Sant'Ana, Mariano Sanz
Summary: This study aimed to answer the question: In systemically healthy human subjects, what are the differences in terms of bacterial presence/count between peri-implantitis and peri-implant health/mucositis? The results showed that peri-implantitis is associated with the presence of S. epidermidis and specific periodontopathogens (P. gingivalis, T. forsythia, T. denticola, F. nucleatum, and P. intermedia), while it is not associated with certain other bacteria (A. actinomycetemcomitans, S. aureus, and C. rectus).
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
