Article
Health Care Sciences & Services
Massimo Mesolella, Sarah Buono, Roberto D'Aniello, Annarita Ascione, Gaetano Motta, Salvatore Allosso
Summary: Forestier's disease is a systemic, degenerative metabolic condition characterized by the progressive ossification of the ligaments and entheses. This case report presents a 63-year-old man who had a painless mass in the pre-auricular region, gradually worsening dysphonia, severe dysphagia relating to solids, stiffness, and mild pain at the back of the neck. After further diagnostic tests, diffuse spondylarthrosis and beak-like osteophytes at C2-C5 were identified, causing esophageal compression. Intensive logopedic and postural rehabilitative treatment led to significant improvement in dysphagia symptoms, while medical therapy was limited to indomethacin to control osteophytic process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Clinical Neurology
Netanja Harlianto, Jonneke S. Kuperus, Firdaus A. A. Mohamed Hoesein, Pim A. de Jong, Jacob A. de Ru, F. Cumhur Oner, Jorrit-Jan Verlaan
Summary: This article provides an updated systematic review on the epidemiology and clinical knowledge of dysphagia and airway obstruction caused by cervical diffuse idiopathic skeletal hyperostosis (DISH). The study found a significant increase in published cases over the past decade. Surgical treatment was the most commonly chosen option and showed effective results with a low complication rate. However, there is still a lack of randomized studies or guidelines on treatment and prevention of recurrence.
Review
Orthopedics
Torphong Bunmaprasert, Jakkrit Keeratiruangrong, Nantawit Sugandhavesa, K. Daniel Riew, Wongthawat Liawrungrueang
Summary: Surgical treatment for large bridging osteophytes of the anterior cervical spine from DISH, particularly for secondary dysphagia, has shown significant improvement in elderly patients. Different surgical techniques have been used, resulting in improved outcomes without recurrence, although concerns about cervical spine motion remain, especially with certain fusion techniques.
JOURNAL OF ORTHOPAEDIC SURGERY
(2021)
Article
Medicine, General & Internal
Ho Yong Choi, Dae Jean Jo
Summary: This article reports two cases of DISH-related dysphagia treated with surgical removal of osteophytes using the bottleneck point as an anatomical landmark. The symptoms of the patients improved following osteophyte removal without recurrence.
MEDICINA-LITHUANIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riku M. Vierunen, Ville V. Haapamaki, Mika P. Koivikko, Frank V. Bensch
Summary: This study retrospectively reviewed MRI findings of 70 patients with spinal ankylosis from DISH, revealing that 49% had spinal epidural hematoma and 4% had spinal subdural hematoma. It was found that spinal epidural hematoma can cause spinal cord impingement and progress to spinal cord injury.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacopo Ciaffi, Elena Borlandelli, Gaia Visani, Giancarlo Facchini, Marco Miceli, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Francesco Ursini
Summary: The purpose of this study was to provide updated information on the prevalence of DISH in Italy and describe the clinical and radiographic characteristics associated with the disorder. The results showed that the prevalence of DISH was higher in men and was significantly associated with factors such as age, BMI, diabetes, hypertension, and enthesopathies.
Article
Rheumatology
Geoffrey O. Littlejohn
Summary: Diffuse idiopathic skeletal hyperostosis (DISH) is a common disorder in human history with diverse distribution in ancient populations. Metabolic factors play an important role in ancient populations affected by DISH.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Medicine, General & Internal
Hisanori Ikuma, Tomohiko Hirose, Dai Nakamura, Kazutaka Yamashita, Masataka Ueda, Kazuhiro Sasaki, Keisuke Kawasaki
Summary: This study conducted a cross-sectional survey on DISH patients and found that DISH is most prevalent at the thoracolumbar junction. Age and hyperostosis around the costovertebral joint were identified as related factors.
Article
Clinical Neurology
Giorgio Lofrese, Alba Scerrati, Massimo Balsano, Roberto Bassani, Michele Cappuccio, Michele A. Cavallo, Fabio Cofano, Francesco Cultrera, Federico De Iure, Francesco Di Biase, Roberto Donati, Diego Garbossa, Marta Menegatti, Alessandro Olivi, Giorgio Palandri, Antonino Raco, Luca Ricciardi, Giannantonio Spena, Luigino Tosatto, Jacopo Visani, Massimiliano Visocchi, Gianluigi Zona, Pasquale De Bonis
Summary: A retrospective multicenter study was conducted to analyze the impact of preoperative settings and intraoperative techniques on the outcome of patients undergoing surgery for DISH involving the cervical spine. The use of a chisel was found to be more effective than a burr, and early decompression and bone removal involving multiple levels positively influenced clinical outcome. Early decompression was preferred, resulting in a high percentage of patients experiencing symptom disappearance within a week after surgery.
GLOBAL SPINE JOURNAL
(2022)
Article
Rheumatology
Reuven Mader, Nicola Pappone, Xenofon Baraliakos, Iris Eshed, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Amir Bieber, Irina Novofastovski, David Kiefer, Jorrit-Jan Verlaan, Pasquale Ambrosino, Dan Buskila, Jacome Bruges Armas, Muhammad Asim Khan
Summary: Diffuse Idiopathic Skeletal Hyperostosis (DISH) is considered a metabolic condition with possible involvement of inflammation as a non-metabolic mechanism. Inflammation may play a role in promoting new bone formation in DISH, and further research is needed to better understand the mechanisms for early detection and management.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Mikolaj Dabrowski, Lukasz Kubaszewski
Summary: DISH is characterized by calcification and ossification of cervical spine ligaments, potentially leading to dysphagia. It is more common in men with metabolic disorders and is often asymptomatic, with poorly understood etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Alexander von Glinski, Ariel Takayanagi, Christopher Elia, Basem Ishak, Mishan Listmann, Clifford A. Pierre, Ronen Blecher, Erik Hayman, Jens R. Chapman, Rod J. Oskouian
Summary: The retrospective study aimed to evaluate the treatment effect of ACDF on patients with OALL, dysphagia, and concomitant myelopathy. The results showed good fusion and clinical outcomes with ACDF, but larger studies are needed to determine the optimal treatment.
GLOBAL SPINE JOURNAL
(2021)
Article
Medicine, General & Internal
Hideaki Nakajima, Kazuya Honjoh, Shuji Watanabe, Akihiko Matsumine
Summary: Lumbar spinal canal stenosis and diffuse idiopathic skeletal hyperostosis tend to develop in the elderly and may result in the need for lumbar surgery. However, diffuse idiopathic skeletal hyperostosis may be a risk factor for poor clinical outcomes following lumbar decompression surgery, especially in patients with diffuse idiopathic skeletal hyperostosis extending to the lumbar segment. This study aimed to identify prognostic factors of lumbar spinal canal stenosis with diffuse idiopathic skeletal hyperostosis and propose a surgical management approach to improve clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Stefanie F. Pini, Emilio Pariente, Jose M. Olmos, Marta Martin-Millan, Raquel Pascua, Victor M. Martinez-Taboada, Jose L. Hernandez
Summary: This study aimed to assess the association between trabecular bone score (TBS) and diffuse idiopathic skeletal hyperostosis (DISH) in postmenopausal women. The results showed a significant association between DISH and TBS, with lower TBS values in DISH patients and a higher prevalence of osteoporosis and vertebral fractures.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Emilio Pariente, Stefanie F. Pini, Jose M. Olmos, Patricia Fierro, Rosa Landeras, Carmen Ramos, Victor M. Martinez-Taboada, Jose L. Hernandez
Summary: This study aimed to investigate the potential relationship between early diffuse idiopathic skeletal hyperostosis (DISH) and chronic inflammation. The results showed that patients with early DISH had a higher prevalence of obesity, type 2 diabetes, and metabolic syndrome, and their lipid pattern was similar to that observed in chronic inflammatory diseases.
CLINICAL RHEUMATOLOGY
(2023)
Article
Clinical Neurology
Marc Hohenhaus, Ralf Watzlawick, Waseem Masalha, Florian Volz, Christoph Scholz, Ulrich Hubbe, Jan-Helge Klingler
Summary: The study compared the use of navigation and fluoroscopy in percutaneous lumbar instrumentations, finding no significant difference in reducing cranial facet violations between the two imaging techniques, but navigation was superior in terms of accurate pedicle screw positioning.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Jan-Helge Klingler, Christoph Scholz, Marie T. Krueger, Yashar Naseri, Florian Volz, Marc Hohenhaus, Johannes Broenner, Herbert Hoedlmoser, Ronen Sircar, Ulrich Hubbe
Summary: The study compared the radiation exposure of surgeons and patients using FLUORO and NAV intraoperative imaging techniques. The results showed that the average radiation exposure of surgeons was lower in the NAV group without statistical significance and the radiation exposure of the patient was significantly higher in the NAV group.
Article
Clinical Neurology
Jan-Helge Klingler, Christoph Scholz, Marc Hohenhaus, Florian Volz, Yashar Naseri, Marie T. Krueger, Ioannis Vasilikos, Roland Roelz, Johannes Broenner, Herbert Hoedlmoser, Ronen Sircar, Ulrich Hubbe
Summary: The study compared radiation exposure among scrub nurses, assistant surgeons, and anesthetists during minimally invasive lumbar fusion surgery using 2D fluoroscopy or 3D navigation. Results showed low radiation exposure for all personnel, but potential risk of exceeding the annual dose limit for the assistant surgeon's eye lens after a certain number of surgeries. It emphasizes the importance of strict adherence to radiation protection measures in the operating room.
CLINICAL SPINE SURGERY
(2021)
Article
Clinical Neurology
Christoph Scholz, Jan-Helge Klingler, Waseem Masalha, Marc Hohenhaus, Florian Volz, Ioannis Vasilikos, Roland Roelz, Christian Scheiwe, Ulrich Hubbe
Summary: This study compared the incidence of complications and revision rates in patients with multilevel degenerative cervical myelopathy undergoing fusion extending to C7 or T1-T3. Results indicated that fewer revisions were necessary when fusion extended to the thoracic spine, suggesting that bridging the cervicothoracic junction is recommended for fusion starting at C0-C3.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Jan-Helge Klingler, Ulrich Hubbe, Christoph Scholz, Florian Volz, Roland Roelz, Juergen Beck, Ralf Watzlawick, Johannes Broenner, Herbert Hoedlmoser, Marie T. Krueger, Marc Hohenhaus, Yashar Naseri
Summary: This prospective study evaluated a protocol for radiation-sparing kyphoplasty by assessing dosemetrically recorded radiation exposures to both patient and surgeon. The results showed that the implementation of a strict intraoperative radiation protection protocol allows for safely performed kyphoplasty with ultra-low radiation exposure for the patient and surgeon without exceeding the annual occupational dose limits.
GLOBAL SPINE JOURNAL
(2023)
Article
Orthopedics
Marc Hohenhaus, Florian Volz, Yorn Merz, Ralf Watzlawick, Christoph Scholz, Ulrich Hubbe, Jan-Helge Klingler
Summary: The manual measurement technique of spinal sagittal alignment on X-rays is susceptible to rater-dependent variability. This study found that different raters had different significance levels when evaluating the pre- to postoperative change of lumbar lordosis in patients receiving lumbar spondylodesis. Therefore, it is important to describe the evaluation process and validate the consistency of results through multiple raters in every publication.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Engineering, Biomedical
Christoph Scholz, Marc Hohenhaus, Ulrich Hubbe, Waseem Masalha, Yashar Naseri, Marie T. Krueger, Jan -Helge Klingler
Summary: This study found significant negative correlations between radiological cervical lordosis and objective measurements for rotation in patients with degenerative cervical myelopathy undergoing laminectomy and fusion surgeries. However, there was no strong correlation with subjective restriction, suggesting that a stronger postoperative cervical lordosis may not be favorable for rotational range of motion in this particular patient population.
CLINICAL BIOMECHANICS
(2021)
Article
Clinical Neurology
Christoph Scholz, Waseem Masalha, Yashar Naseri, Jan-Helge Klingler, Marc Hohenhaus, Ulrich Hubbe
Summary: For patients with multilevel degenerative cervical myelopathy (DCM), laminectomy and fusion is a common technique that can lead to restriction of cervical spine mobility. This study found a significant correlation between objective measurements and subjective reports of postoperative cervical spine mobility restriction, with a noticeable reduction in range of motion compared to non-operated patients.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ulrich Hubbe, Jan-Helge Klingler, Roland Roelz, Christoph Scholz, Katerina Argiti, Panagiotis Fistouris, Jurgen Beck, Ioannis Vasilikos
Summary: The study demonstrates that inserting a second tube during minimally invasive spinal surgery can significantly widen the surgical visual field.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Clinical Neurology
Marc Hohenhaus, Yorn Merz, Jan-Helge Klingler, Christoph Scholz, Ulrich Hubbe, Jurgen Beck, Katharina Wolf, Karl Egger, Marco Reisert, Nico Kremers
Summary: This prospective diagnostic study aimed to differentiate spinal cord tumor-suspected lesions using diffusion tensor imaging (DTI). The results showed that DTI metrics were feasible to separate inflammatory lesions, which may help avoid unnecessary surgery in patients with unclear intramedullary tumor-suspected lesions.
Article
Clinical Neurology
Jan-Helge Klingler, Yashar Naseri, Peter C. Reinacher, Herbert Hoedlmoser, Horst Urbach, Marc Hohenhaus
Summary: Intraoperative CT imaging results in higher radiation exposure for patients compared to 3D C-arm, highlighting the need for proper system selection and dose-saving protocols.
Article
Clinical Neurology
Marc Hohenhaus, Jan-Helge Klingler, Christoph Scholz, Florian Volz, Ulrich Hubbe, Juergen Beck, Marco Reisert, Urs Wuertemberger, Nico Kremers, Katharina Wolf
Summary: This study aimed to quantitatively analyze the T2 signal intensity of the spinal cord in degenerative cervical myelopathy (DCM) patients using high-resolution MRI segmentation. The results showed significantly increased signal variability in DCM patients compared to healthy volunteers, and the new analysis method demonstrated sufficient diagnostic accuracy.
Article
Clinical Neurology
J. Straehle, V. M. Ravi, D. H. Heiland, C. Galanis, M. Lenz, Junyi Zhang, N. N. Neidert, A. El Rahal, I. Vasilikos, P. Kellmeyer, C. Scheiwe, J. H. Klingler, C. Fung, A. Vlachos, J. Beck, O. Schnell
Summary: This study describes the technical aspects of microdissection and immediate handling of viable human cortical tissue for basic and clinical research purposes. Through multiple rounds of experiments and the application of specific surgical principles, usable brain tissue samples for research were successfully obtained from patients undergoing surgery.
ACTA NEUROCHIRURGICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Rau, Jakob Straehle, Thomas Stein, Thierno Diallo, Stephan Rau, Sebastian Faby, Konstantin Nikolaou, Stefan O. Schoenberg, Daniel Overhoff, Juergen Beck, Horst Urbach, Jan-Helge Klingler, Fabian Bamberg, Jakob Weiss
Summary: In this study, multispectral photon-counting computed tomography (PC-CT) was compared to energy-integrating CT (EID-CT) for evaluating surgical outcome after spinal interventions. The results showed that PC-CT provides sharper images, higher diagnostic confidence, and lower radiation dose.
EUROPEAN RADIOLOGY
(2023)
Letter
Clinical Neurology
Ulrich Hubbe, Jan-Helge Klingler, Roland Roelz, Christoph Scholz, Katerina Argiti, Panagiotis Fistouris, Juergen Beck, Ioannis Vasilikos
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)