Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

The PARP1-Siah1 Axis Controls HIV-1 Transcription and Expression of Siah1 Substrates

(2018) Dan Yu et al.   Cell Reports

The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency

(2018) Zichong Li et al.   PLoS Pathogens

Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16–STING–Type I IFN Pathway and AIM2 Sensor

(2017) Fengliang Liu et al.   JOURNAL OF IMMUNOLOGY

Drug Discovery Targeting Bromodomain-Containing Protein 4

(2017) Zhiqing Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

(2017) Ryan J. Conrad et al.   MOLECULAR CELL

HIV Drug Resistance — An Emerging Threat to Epidemic Control

(2017) Chris Beyrer et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

(2017) Cari F. Kessing et al.   Cell Reports

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   NATURE

Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

(2016) Fengliang Liu et al.   PLoS Pathogens

Understanding HIV Latency: The Road to an HIV Cure

(2015) Matthew S. Dahabieh et al.   Annual Review of Medicine

HIV reservoirs as obstacles and opportunities for an HIV cure

(2015) Tae-Wook Chun et al.   NATURE IMMUNOLOGY

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

(2015) Guillaume Mousseau et al.   mBio

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

(2014) Uri Mbonye et al.   VIROLOGY

Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

(2014) Alexandra Schuetz et al.   PLoS Pathogens

Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy

(2014) Mary F. Kearney et al.   PLoS Pathogens

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

The end of AIDS: HIV infection as a chronic disease

(2013) Steven G Deeks et al.   LANCET

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing

(2013) Kazuo Suzuki et al.   Molecular Therapy-Nucleic Acids

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

An Analog of the Natural Steroidal Alkaloid Cortistatin A Potently Suppresses Tat-Dependent HIV Transcription

(2012) Guillaume Mousseau et al.   Cell Host & Microbe

The Ubiquitin Ligase Siah1 Controls ELL2 Stability and Formation of Super Elongation Complexes to Modulate Gene Transcription

(2012) Min Liu et al.   MOLECULAR CELL

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

(2012) Zichong Li et al.   NUCLEIC ACIDS RESEARCH

Reactivation of Latent HIV-1 by Inhibition of BRD4

(2012) Jian Zhu et al.   Cell Reports

Short-Course Raltegravir Intensification Does Not Increase 2 Long Terminal Repeat Episomal HIV-1 DNA in Patients on Effective Antiretroviral Therapy

(2011) G. J. Besson et al.   CLINICAL INFECTIOUS DISEASES

Characterization of an HIV-Targeted Transcriptional Gene-Silencing RNA in Primary Cells

(2011) Anne-Marie W. Turner et al.   HUMAN GENE THERAPY

Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency

(2011) Haleh Rafati et al.   PLOS BIOLOGY

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

Epigenetic regulation of HIV latency

(2010) Shweta Hakre et al.   Current Opinion in HIV and AIDS

Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription

(2009) Makoto Yamagishi et al.   MICROBES AND INFECTION

Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA

(2008) B. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Mobilization-competent Lentiviral Vector–mediated Sustained Transcriptional Modulation of HIV-1 Expression

(2008) Anne-Marie W Turner et al.   MOLECULAR THERAPY