RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy

(2018) Sébastien S. Dufresne et al.   Acta Neuropathologica Communications

TNFα Increases RANKL Expression via PGE2-Induced Activation of NFATc1

(2017) Hyun-Jung Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum Levels of a Cathepsin-K Generated Periostin Fragment Predict Incident Low-Trauma Fractures in Postmenopausal Women Independently of BMD and FRAX

(2017) Nicolas Bonnet et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Circulating osteoprotegerin in postmenopausal osteoporotic women

(2017) Margarita Mashavi et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes

(2017) Peng Duan et al.   International Journal of Endocrinology

Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

(2017) Xavier Brenachot et al.   Nature Communications

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

(2016) Sébastien S. Dufresne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Adeno-associated virus-mediated expression of myostatin propeptide improves the growth of skeletal muscle and attenuates hyperglycemia in db/db mice

(2016) J G Jiang et al.   GENE THERAPY

Low Lean Mass Predicts Incident Fractures Independently From FRAX: a Prospective Cohort Study of Recent Retirees

(2016) Mélany Hars et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

(2016) Lykke Sylow et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty

(2016) Jose Viña et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

(2016) João-Paulo G. Camporez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteoprotegerin Protects against Muscular Dystrophy

(2015) Sébastien S. Dufresne et al.   AMERICAN JOURNAL OF PATHOLOGY

Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5

(2015) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice

(2015) Marion Peyrou et al.   JOURNAL OF HEPATOLOGY

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

Age-associated declines in muscle mass, strength, power, and physical performance: impact on fear of falling and quality of life

(2015) A. Trombetti et al.   OSTEOPOROSIS INTERNATIONAL

Pharmacological repression of PPARγ promotes osteogenesis

(2015) David P. Marciano et al.   Nature Communications

Bilirubin Increases Insulin Sensitivity in Leptin-Receptor Deficient and Diet-Induced Obese Mice Through Suppression of ER Stress and Chronic Inflammation

(2014) Huansheng Dong et al.   ENDOCRINOLOGY

Impaired Musculoskeletal Response to Age and Exercise in PPARβ−/−Diabetic Mice

(2014) He Fu et al.   ENDOCRINOLOGY

METTL21CIs a Potential Pleiotropic Gene for Osteoporosis and Sarcopenia Acting Through the Modulation of the NF-κB Signaling Pathway

(2014) Jian Huang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Novel Genetic Models of Osteoporosis by Overexpression of Human RANKL in Transgenic Mice

(2013) Vagelis Rinotas et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

(2013) Stefan Kiechl et al.   NATURE MEDICINE

Myostatin Inhibition Prevents Diabetes and Hyperphagia in a Mouse Model of Lipodystrophy

(2012) T. Guo et al.   DIABETES

Denosumab reduces the risk of osteoporotic fractures in postmenopausal women, particularly in those with moderate to high fracture risk as assessed with FRAX

(2012) Eugene V McCloskey et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin

(2012) N. Bonnet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

(2008) Ann E. Kearns et al.   ENDOCRINE REVIEWS

RANKL Inhibition with Osteoprotegerin Increases Bone Strength by Improving Cortical and Trabecular bone Architecture in Ovariectomized Rats

(2008) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH