How glycogen sustains brain function: A plausible allosteric signaling pathway mediated by glucose phosphates

The Strategic Location of Glycogen and Lactate: From Body Energy Reserve to Brain Plasticity

(2019) Corrado Calì et al.   Frontiers in Cellular Neuroscience

Inadequate brain glycogen or sleep increases spreading depression susceptibility

(2018) Kivilcim Kilic et al.   ANNALS OF NEUROLOGY

Astrocytic glycogen metabolism in the healthy and diseased brain

(2018) Lasse K. Bak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation

(2017) Anca Stoica et al.   GLIA

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous astrocytic patterns

(2016) Yuki Oe et al.   GLIA

Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism

(2016) Gerald A. Dienel et al.   JOURNAL OF NEUROCHEMISTRY

Glycolysis selectively shapes the presynaptic action potential waveform

(2016) Brendan Lujan et al.   JOURNAL OF NEUROPHYSIOLOGY

Computational Flux Balance Analysis Predicts that Stimulation of Energy Metabolism in Astrocytes and their Metabolic Interactions with Neurons Depend on Uptake of K+ Rather than Glutamate

(2016) Mauro DiNuzzo et al.   NEUROCHEMICAL RESEARCH

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport

(2016) María-Victoria Hinckelmann et al.   Nature Communications

Brain glycogen in health and disease

(2015) Jordi Duran et al.   MOLECULAR ASPECTS OF MEDICINE

Revisiting Glycogen Content in the Human Brain

(2015) Gülin Öz et al.   NEUROCHEMICAL RESEARCH

Monoaminergic Control of Cellular Glucose Utilization by Glycogenolysis in Neocortex and Hippocampus

(2015) Mauro DiNuzzo et al.   NEUROCHEMICAL RESEARCH

Central Presynaptic Terminals Are Enriched in ATP but the Majority Lack Mitochondria

(2015) Vrushali Chavan et al.   PLoS One

Role of brain glycogen in the response to hypoxia and in susceptibility to epilepsy

(2015) Juan C. López-Ramos et al.   Frontiers in Cellular Neuroscience

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Involvement of cellular metabolism in age-related LTP modifications in rat hippocampal slices

(2015) Dominika Drulis-Fajdasz et al.   Oncotarget

Non-preferential fuelling of the Na+/K+-ATPase pump

(2014) Ignacio Fernández-Moncada et al.   BIOCHEMICAL JOURNAL

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

Roles of astrocytic Na+,K+-ATPase and glycogenolysis for K+homeostasis in mammalian brain

(2014) Leif Hertz et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Contributions of glycogen to astrocytic energetics during brain activation

(2014) Gerald A. Dienel et al.   METABOLIC BRAIN DISEASE

Does abnormal glycogen structure contribute to increased susceptibility to seizures in epilepsy?

(2014) Mauro DiNuzzo et al.   METABOLIC BRAIN DISEASE

Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle

(2014) A. B. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices

(2013) Takahiro Takano et al.   GLIA

Impairment in Long-Term Memory Formation and Learning-Dependent Synaptic Plasticity in Mice Lacking Glycogen Synthase in the Brain

(2013) Jordi Duran et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kinetic Analysis of Glycogen Turnover: Relevance to Human Brain 13C-NMR Spectroscopy

(2013) Mauro DiNuzzo   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell-Specific mRNA Alterations in Na+, K+-ATPase α and β Isoforms and FXYD in Mice Treated Chronically with Carbamazepine, an Anti-Bipolar Drug

(2013) Baoman Li et al.   NEUROCHEMICAL RESEARCH

Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes

(2013) Mauro DiNuzzo et al.   NEUROCHEMISTRY INTERNATIONAL

Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions

(2012) Igor Marin de Mas et al.   BMC Systems Biology

Diffusion of d-glucose measured in the cytosol of a single astrocyte

(2012) Marko Kreft et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of Astrocytic Glycogen in Supporting the Energetics of Neuronal Activity

(2012) Mauro DiNuzzo et al.   NEUROCHEMICAL RESEARCH

Requirement of Glycogenolysis for Uptake of Increased Extracellular K+ in Astrocytes: Potential Implications for K+ Homeostasis and Glycogen Usage in Brain

(2012) Junnan Xu et al.   NEUROCHEMICAL RESEARCH

Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase

(2012) Hyun B. Choi et al.   NEURON

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Glycogenolysis in Astrocytes Supports Blood-Borne Glucose Channeling Not Glycogen-Derived Lactate Shuttling to Neurons: Evidence from Mathematical Modeling

(2010) Mauro DiNuzzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

(2009) Gautam K. Gandhi et al.   JOURNAL OF NEUROCHEMISTRY

Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness

(2009) Florence D. Morgenthaler et al.   NEUROCHEMISTRY INTERNATIONAL

Mammalian Phosphomannomutase PMM1 Is the Brain IMP-sensitive Glucose-1,6-bisphosphatase

(2008) Maria Veiga-da-Cunha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Vesicle-bound Pyruvate Kinase can Support Vesicular Glutamate Uptake

(2008) Atsuhiko Ishida et al.   NEUROCHEMICAL RESEARCH