Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 120, Issue 11, Pages 18845-18853Publisher
WILEY
DOI: 10.1002/jcb.29200
Keywords
ceRNA network; endometrial cancer; lncRNA
Categories
Funding
- National Natural Science Foundation of China [81402135, 81572547, 81172477]
Ask authors/readers for more resources
Endometrial cancer is one of the most common gynecological malignant tumors. The roles of competing endogenous RNAs (ceRNAs) in this disease, however, remain unclear. In this study, we constructed a ceRNA network to reveal the core ceRNAs in endometrial cancer. Differentially expressed genes were summarized from The Cancer Genome Atlas database, whereupon 140 genes were identified for building the network. Further correlation, survival, and enrichment analyses suggested that these genes may help towards elucidating the molecular mechanisms of endometrial cancer. After validation of the findings with the GSE17025 data set, LINC00958, microRNA-761, and DOLPP1 were highlighted as the critical genes in the ceRNA network. Our work suggests that LINC00958 may regulate DOLPP1 by sponging miR-761 in endometrial cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available