Article
Biochemistry & Molecular Biology
Jonatan Warme, Martin O. Sundqvist, Marcus Hjort, Stefan Agewall, Olov Collste, Christina Ekenback, Mats Frick, Loghman Henareh, Claes Hofman-Bang, Jonas Spaak, Peder Sorensson, Shams Y-Hassan, Per Svensson, Bertil Lindahl, Robin Hofmann, Per Tornvall
Summary: Helicobacter pylori (Hp) infection is associated with protein biomarkers of inflammation and cardiovascular disease (CVD) in patients with myocardial infarction (MI) irrespective of the presence of obstructive coronary artery disease (CAD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xixi Chen, Yuanqi Gao, Jinfang Xie, Huiying Hua, Chun Pan, Jiebin Huang, Mengxia Jing, Xuehua Chen, Chundi Xu, Yujing Gao, Pu Li
Summary: The incidence of pediatric inflammatory bowel disease (PIBD) is increasing globally and delayed diagnosis contributes to complications and growth retardation. This study identifies FCN1 as a potential novel diagnostic biomarker for PIBD and investigates its role in the disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Gemma A. Figtree, Philip D. Adamson, Charalambos Antoniades, Roger S. Blumenthal, Michael Blaha, Matthew Budoff, David S. Celermajer, Mark Y. Chan, Clara K. Chow, Damini Dey, Girish Dwivedi, Nicola Giannotti, Stuart M. Grieve, Christian Hamilton-Craig, Bronwyn A. Kingwell, Jason C. Kovacic, James K. Min, David E. Newby, Sanjay Patel, Karlheinz Peter, Peter J. Psaltis, Stephen T. Vernon, Dennis T. Wong, Stephen J. Nicholls
Summary: Coronary artery disease (CAD) is the leading cause of adult mortality globally. Improvements in imaging techniques have provided a better understanding of different phenotypes of coronary atherosclerosis, which are associated with different risks for acute ischemic events. Noninvasive coronary imaging techniques have the potential to accelerate cardiovascular drug development and reduce costs and timelines.
Article
Biology
Ewelina Blazejowska, Tomasz Urbanowicz, Aleksandra Gasecka, Anna Olasinska-Wisniewska, Milosz J. Jaguszewski, Radoslaw Targonski, Lukasz Szarpak, Krzysztof J. Filipiak, Bartlomiej Perek, Marek Jemielity
Summary: Coronary artery bypass graft (CABG) surgery is a treatment for complex coronary artery stenosis by bypassing atherosclerotic lesions. Postoperative complications remain a challenge, with miRNAs showing potential as biomarkers for predicting outcomes. MiRNAs, noncoding RNA particles, change expression during CABG and could improve diagnosis and prognosis.
Article
Cardiac & Cardiovascular Systems
Yan Yi, Cheng Xu, Min Xu, Jing Yan, Yan-Yu Li, Jian Wang, Si-Jie Yang, Yu-Bo Guo, Yun Wang, Yu-Mei Li, Zheng-Yu Jin, Yi-Ning Wang
Summary: This study aimed to investigate the diagnostic value of deep learning-based image reconstruction and hybrid iterative reconstruction in evaluating calcification-related obstructive coronary artery disease. The results showed that DLR images had superior image quality and diagnostic accuracy compared to HIR images.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Eleftherios Panteris, Olga Deda, Andreas S. Papazoglou, Efstratios Karagiannidis, Theodoros Liapikos, Olga Begou, Thomas Meikopoulos, Thomai Mouskeftara, Georgios Sofidis, Georgios Sianos, Georgios Theodoridis, Helen Gika
Summary: Developing risk assessment tools for CAD prediction is challenging. This study developed a machine learning algorithm to predict the severity of CAD based on metabolic and clinical data. The algorithm incorporated clinical and metabolic features to estimate the pre-test likelihood of obstructive CAD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Masayuki Aoyama, Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kojiro Tanimoto, Masato Nakamura, Kazuo Kondo, Yukihiko Momiyama
Summary: This study found that plasma fortilin levels are elevated in patients with coronary artery disease (CAD), especially in those with severe disease involving multiple stenotic vessels. Fortilin levels were also found to be associated with the severity of CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Stephen T. Vernon, Katharine A. Kott, Thomas Hansen, Meghan Finemore, Karl W. Baumgart, Ravinay Bhindi, Jean Yang, Peter S. Hansen, Stephen J. Nicholls, David S. Celermajer, Michael R. Ward, Sheryl A. van Nunen, Stuart M. Grieve, Gemma A. Figtree
Summary: Alpha-Gal sensitization is associated with coronary artery disease burden, noncalcified plaque, and obstructive CAD, and occurs at a higher frequency in STEMI patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Jaskanwal Deep Singh Sara, Elad Maor, Diana Orbelo, Rajiv Gulati, Lliach O. Lerman, Amir Lerman
Summary: This study found a significant association between a noninvasive voice biomarker and incident CAD events at follow-up, which may have important clinical implications for the remote and noninvasive screening of patients to identify those at risk of coronary disease and its complications.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Cardiac & Cardiovascular Systems
Laust Dupont Rasmussen, Line Emilie Brogger Albertsen, Louise Nissen, June Anita Ejlersen, Christin Isaksen, Theodore Murphy, Hanne Maare Sondergaard, Jane Kirk, Lau Brix, Lars Christian Gormsen, Steffen E. Petersen, Morten Bottcher, Simon Winther
Summary: This study investigated the ability of the ESC-PTP, RF-CL, and CACS-CL models to diagnose myocardial perfusion defects (MPDs). The results showed that compared with the ESC-PTP, the RF-CL and CACS-CL models can better classify patients into a low-risk group with a low prevalence of MPDs.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Biology
Sarena La, Rosanna Tavella, Jing Wu, Sivabaskari Pasupathy, Christopher Zeitz, Matthew Worthley, Ajay Sinhal, Margaret Arstall, John A. Spertus, John F. Beltrame
Summary: Angina and Non-Obstructive Coronary Artery (ANOCA) patients often lack a clear explanation for their symptoms, despite the available functional coronary angiography to identify potential underlying coronary vasomotor disorders. This study found that ANOCA patients diagnosed with coronary vasomotor disorders post elective coronary angiography were more likely to have emergency department visits and readmissions for chest pain compared to patients discharged with unspecified chest pain.
Article
Biochemistry & Molecular Biology
Luis Perpetuo, Antonio S. Barros, Jessica Dalsuco, Rita Nogueira-Ferreira, Pedro Resende-Goncalves, Ines Falcao-Pires, Rita Ferreira, Adelino Leite-Moreira, Fabio Trindade, Rui Vitorino
Summary: Coronary artery disease (CAD) and aortic valve stenosis (AVS) are common heart diseases with shared risk factors and pathogenesis. Urine, as a noninvasive collection method, is promising for biomarker assessment. This study identified dysregulated proteins in urine that could potentially differentiate these diseases from healthy subjects, and showed strong correlations between these proteins and a common cardiovascular risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Evangelos Tzolos, Rong Bing, Jack Andrews, Mark G. MacAskill, Adriana A. S. Tavares, Gillian Macnaught, Tim Clark, Nicholas L. Mills, Takeshi Fujisawa, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Marcus-Andre Deutsch, Edwin J. R. van Beek, Michelle C. Williams, Sven Hermann, Verena Hugenberg, Marc R. Dweck, David E. Newby
Summary: This study aimed to noninvasively detect in vivo thrombus formation in human coronary arteries using 18F-GP1 radiotracer through positron emission tomographic (PET) and computed tomographic (CT) imaging. The study found that coronary 18F-GP1 uptake was apparent in patients with acute myocardial infarction, which has the potential to inform the diagnosis, management, and treatment of these patients.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Joel G. Ray, Peter C. Austin, Alison L. Park, Eyal Cohen, Jiming Fang, Anna Chu
Summary: Women with a history of pre-eclampsia have a higher risk of premature coronary artery disease. The assessment of obstructive coronary artery stenosis through invasive coronary angiography has not been evaluated after pre-eclampsia.
Article
Food Science & Technology
Ye Yuan, Bin Zhang, Jing-liu He, Ting Wei, De-jun Liu, Wen-jun Yang, Cheng-Yi Guo, Xu-qiang Nie
Summary: This study investigated the preventive effect and safety of winter melon and lotus leaf Tibetan tea (WLTT) on obesity. The results showed that WLTT could improve obesity by regulating intestinal flora and had a good safety profile. Combinations of Tibetan tea and medicine food homology herbs could be a new option for obesity prevention.
FOOD SCIENCE & NUTRITION
(2023)
Article
Materials Science, Multidisciplinary
Taikun Wang, Fapeng Sun, Wenting Hong, Chuanyong Jian, Qinkun Ju, Xu He, Qian Cai, Wei Liu
Summary: In this paper, the growth of ultrathin MnTe nanosheets on mica by the chemical vapor deposition method is reported. The thickness of the nanosheets can be controlled by tuning the gas flow rate, and the shape can be controlled by the H-2 concentration. Furthermore, MnTe/WS2 heterojunctions fabricated by the mechanical stacking method exhibit excellent photoresponsivity, external quantum efficiency, and photodetectivity, as well as higher photoresponse speed compared with the MnTe-based photodetector. This work provides a possible application of MnTe-based heterojunctions for developing high-performance photodetectors.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Engineering, Environmental
Zhaoan Hong, Wengting Hong, Bicheng Wang, Qian Cai, Xu He, Wei Liu
Summary: By introducing an appropriate amount of antimony oxide, MoS2 nanosheets with high 1T content (61.5%) were successfully synthesized using a chemical vapor deposition method. The 1T-2H hybrid structures grown in this way are thermodynamically stable and exhibit enhanced hydrogen evolution reaction (HER) activity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Bicheng Wang, Yu Yao, Wenting Hong, Zhaoan Hong, Xu He, Taiku Wang, Chuanyong Jian, Qiankun Ju, Qian Cai, Zhihua Sun, Wei Liu
Summary: A molecular sieve-assisted strategy is used to synthesize ultrathin 2D iron sulfide with different phases. Hexagonal FeS, tetragonal FeS, and non-stoichiometric Fe7S8 can be precisely synthesized by tuning the growth temperatures. The synthesized 2D iron sulfides exhibit high conductivity, superconductivity, and ferrimagnetism, providing a potential route for synthesizing other 2D compounds with different phases.
Article
Chemistry, Multidisciplinary
Qingshun Fan, Haojie Xu, Shihai You, Yu Ma, Yi Liu, Wuqian Guo, Xinxin Hu, Beibei Wang, Changhao Gao, Wei Liu, Junhua Luo, Zhihua Sun
Summary: 2D Dion-Jacobson (DJ) phase lead-free hybrid perovskite has great potential in X-ray detection with high sensitivity, low detection limit, and superior anti-fatigue properties. The single-crystal-based X-ray detector of (HIS)(2)AgSbBr8 exhibited remarkable semiconductor characteristics and excellent photoelectric response. This innovative application of hybrid perovskites in eco-friendly and efficient X-ray detection opens up new possibilities in the field.
Article
Cardiac & Cardiovascular Systems
Yan Liu, Da Huang, Zhile Li, LiuFang Zhou, Tuan Cen, Baomin Wei, Liuqing Wei, Hongying Wu, Liye Su, Suren R. Sooranna, Xinshou Pan, ZhaoHe Huang
Summary: This study investigated the pathogenesis of disease progression in patients with heart failure after acute myocardial infarction using plasma proteomics. A comparison of the plasma proteomes of acute myocardial infarction patients with and without heart failure revealed a group of proteins related to the NF-kappa B signaling pathway, which may be useful for the diagnosis and pathophysiology research of MI-HF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Hui Li, Luming Hu, Liuqing Wei, Hong He, Xuemin Zhang
Summary: This study utilized a cross-channel visual-audio dual-task paradigm to investigate the role of working memory in multiple object tracking (MOT). The results showed that spatial working memory (SWM) significantly impaired the tracking capacity of the MOT task, while nonspatial object working memory (OWM) did not have a significant effect. These findings provide empirical evidence for the involvement of working memory, specifically spatial working memory, in multiple object tracking.
SCANDINAVIAN JOURNAL OF PSYCHOLOGY
(2023)
Article
Chemistry, Analytical
Chenying He, Yuanao Zhang, Ting Wen, Shenghai Pei, Zhixun Wang, Juan Xia, Guangcheng Xi, Wenjie Li, Jiahong Wang, Guoqiang Gu, Guohua Zhong, Lei Wei, Chunlei Yang, Ming Chen
Summary: A novel oxygen vacancy heteropolyacid (HFMO) is developed as a high-performance volume-enhanced Raman scattering (VERS)-active platform, which forms a special coordination bond with the probe molecule at the molecular level. This platform has excellent VERS enhancing effect and high selectivity for molecules containing the imino group. Rating: 9 out of 10.
ANALYTICAL CHEMISTRY
(2023)
Letter
Surgery
Ye Yuan, Rui Liu, Rifang Gu, Xuqiang Nie
ASIAN JOURNAL OF SURGERY
(2023)
Review
Pharmacology & Pharmacy
Jitao Chen, Penghui Ye, Rifang Gu, Huan Zhu, Wenjie He, Xingrui Mu, Xingqian Wu, Huiwen Pang, Felicity Han, Xuqiang Nie
Summary: This paper reviews the regulatory characteristics of neuropeptide substance P (SP) in normal and diabetic wound healing. SP actively regulates wound healing-related cells, exhibiting strong inflammatory properties, promoting cell proliferation and migration, and restoring skin cell activity and paracrine ability under diabetic conditions. Additionally, SP not only regulates healing-related cells but also orchestrates the immune environment, presenting unique and promising application prospects in wound intervention, particularly for diabetic foot ulcers (DFU) treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yiqiu Liu, Musen Lin, Xingrui Mu, Lin Qin, Junyu Deng, Ye Liu, Xingqian Wu, Wenjie He, Huiwen Pang, Felicity Han, Chengxin Sun, Xuqiang Nie
Summary: This study aimed to investigate the protective effect of solanesol against oxidative damage induced by high glucose on human normal hepatocytes. The results showed that solanesol effectively improved cell viability, decreased the contents of ALT, AST, and LDH, increased the enzyme activities of GSH-Px, SOD, and CAT, balanced ROS levels, inhibited lipid peroxidation, and restored MMP. In addition, solanesol inhibited Keap1 expression and promoted Nrf2 nuclear translocation, activating downstream antioxidant factors NQO1 and HO-1. These findings suggest solanesol may be a potential protectant against diabetic liver injury.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Polymer Science
Yu Yuan, Shihu Zhu, Jun Zhu, Peixin Niu, Ailing Sun, Xingjiang Liu, Liuhe Wei, Yuhan Li
Summary: This study developed a novel strategy to incorporate self-complementary quadruple hydrogen bonds into multi-branch polyurethane, constructing a supramolecular adhesive with high adhesion strength and multiple reusability. It is a promising candidate for practical use in portable electronics.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Weilong Wang, Hua Chen, Wei Liu, Qing Wang, Gang Wang
Summary: This paper introduces a trilinear decomposition method to estimate the 4-D parameters, including DOD, RFTT, DOA, and RFTR, for a MIMO array system with NF parameter estimation. The proposed method is search-free and has automatically paired results, providing accurate estimates from the velocity vector sensors. The performance of the method is demonstrated through numerical examples.
Article
Chemistry, Multidisciplinary
Chuanlong Li, Wenbo Dong, Longyu Li, Zhengli Dou, Yuhan Li, Liuhe Wei, Qin Zhang, Qiang Fu, Kai Wu
Summary: In this study, a self-reinforcing polyurethane adhesive is synthesized, which exhibits only interfacial failure but still possesses superior adhesive strength and toughness. The adhesive is designed by incorporating a hanging adhesive moiety, hierarchical H-bond moieties, and a crystallizable soft segment into one macromolecular polyurethane. The adhesive can effectively associate with the target substrate due to the hanging adhesive moiety, while the hierarchical H-bond moieties and crystallizable soft segment enable large lap-shear deformations and strain-induced crystallization, resulting in remarkable adhesive strength and work of debonding.
MATERIALS HORIZONS
(2023)
Article
Engineering, Electrical & Electronic
Zhicheng Zhang, Ye Tian, Wei Liu, Hua Chen
Summary: This paper proposes an efficient source enumeration algorithm for large-scale arrays using a two-step difference operation of linear shrinkage (LS) coefficients of the sample covariance matrix (SCM) in large-dimensional scenarios. It is shown that the difference between noise LS coefficients tends to zero and there exists a clear gap between the last signal LS coefficient (alpha) over cap ((d-1)) and the first noise LS coefficient (alpha) over cap ((d)) in relatively high signal-to-noise ratio (SNR) cases. This algorithm achieves initial source enumeration and improved estimation results, and it can estimate a large number of sources.
IEEE TRANSACTIONS ON SIGNAL PROCESSING
(2023)
