Suppression of c‐Myc using 10058‐F4 exerts caspase‐3‐dependent apoptosis and intensifies the antileukemic effect of vincristine in pre‐B acute lymphoblastic leukemia cells

Small molecule inhibitor of c-Myc 10058-F4 inhibits proliferation and induces apoptosis in acute leukemia cells, irrespective of PTEN status

(2019) Davood Bashash et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

(2018) Franz X. Schaub et al.   Cell Systems

Anti-tumor activity of PI3K-δ inhibitor in hematologic malignant cells: Shedding new light on resistance to Idelalisib

(2017) Davood Bashash et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibitor of pan class-I PI3K induces differentially apoptotic pathways in acute leukemia cells: Shedding new light on NVP-BKM120 mechanism of action

(2016) Davood Bashash et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pin1 modulates chemo-resistance by up-regulating FoxM1 and the involvements of Wnt/β-catenin signaling pathway in cervical cancer

(2016) Tao Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Small-molecule inhibitors of the Myc oncoprotein

(2015) Steven Fletcher et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Autophagy in acute leukemias: A double-edged sword with important therapeutic implications

(2015) Cecilia Evangelisti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

(2015) Kwan-Young Jung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

(2015) Zheng Ge et al.   Oncotarget

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1

(2015) Kazuyuki Matsushita et al.   Oncotarget

TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis

(2014) A. Stengel et al.   BLOOD

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

(2014) J. E. Roderick et al.   BLOOD

Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells

(2014) Jiandong Wang et al.   Journal of Translational Medicine

C-myc protein expression in B-cell acute lymphoblastic leukemia, prognostic significance?

(2014) Ashleigh Allen et al.   LEUKEMIA RESEARCH

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

(2014) Daniel Herranz et al.   NATURE MEDICINE

PIN1 Inhibits Apoptosis in Hepatocellular Carcinoma through Modulation of the Antiapoptotic Function of Survivin

(2013) Chi-Wai Cheng et al.   AMERICAN JOURNAL OF PATHOLOGY

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

(2013) H. Zirath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Addiction to c-MYC in multiple myeloma

(2012) T. Holien et al.   BLOOD

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

(2012) C. J. Ott et al.   BLOOD

Direct Short-Term Cytotoxic Effects of BIBR 1532 on Acute Promyelocytic Leukemia Cells Through Induction of p21 Coupled with Downregulation of c-Myc and hTERT Transcription

(2012) D. Bashash et al.   CANCER INVESTIGATION

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Cytotoxic effect of arsenic trioxide on acute promyelocytic leukemia cells through suppression of NFkβ-dependent induction of hTERT due to down-regulation of Pin1 transcription

(2012) Seyed H. Ghaffari et al.   Hematology

Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells

(2012) Davood Bashash et al.   LEUKEMIA & LYMPHOMA

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications

(2011) C Grimaldi et al.   LEUKEMIA

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Human telomerase activity regulation

(2010) Aneta Wojtyla et al.   MOLECULAR BIOLOGY REPORTS

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

(2008) Jianxia Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Ets2 Maintains hTERT Gene Expression and Breast Cancer Cell Proliferation by Interacting with c-Myc

(2008) Dakang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE