Osthole inhibits osteoclasts formation and bone resorption by regulating NF‐κB signaling and NFATc1 activations stimulated by RANKL

Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma

(2018) Xinbing Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

The naturally derived small compound Osthole inhibits osteoclastogenesis to prevent ovariectomy-induced bone loss in mice

(2018) Dongfeng Zhao et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways

(2017) Jianwen Cheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anti-asthmatic activity of osthole in an ovalbumin-induced asthma murine model

(2017) Jingjing Wang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Osthole Enhances Osteogenesis in Osteoblasts by Elevating Transcription Factor Osterix via cAMP/CREB Signaling In Vitro and In Vivo

(2017) Zhong-Rong Zhang et al.   Nutrients

Osteoprotective effects of osthole in a mouse model of 5/6 nephrectomy through inhibiting osteoclast formation

(2016) Xiaofeng Li et al.   Molecular Medicine Reports

Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression

(2015) Xiang-zhou Zeng et al.   ACTA PHARMACOLOGICA SINICA

Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine

(2015) Zhong-Rong Zhang et al.   Evidence-based Complementary and Alternative Medicine

Immunomodulatory and Anti-Inflammatory Activity of Selected Osthole Derivatives

(2015) Michał Zimecki et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

RhoV mediates apoptosis of RAW264.7 macrophages caused by osteoclast differentiation

(2014) RUILONG SONG et al.   Molecular Medicine Reports

Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced nuclear factor-κB activation

(2013) Karl Wu et al.   OSTEOPOROSIS INTERNATIONAL

An overview of the regulation of bone remodelling at the cellular level

(2012) Jasreen Kular et al.   CLINICAL BIOCHEMISTRY

TRAF Family Member-Associated NF-κB Activator (TANK) Induced by RANKL Negatively Regulates Osteoclasts Survival and Function

(2012) Mengrui Wu et al.   International Journal of Biological Sciences

Inflammatory bone loss: pathogenesis and therapeutic intervention

(2012) Kurt Redlich et al.   NATURE REVIEWS DRUG DISCOVERY

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

Therapeutic targeting of osteoclast function and pathways

(2011) Matthew L Broadhead et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Polyubiquitination Events Mediate Polymethylmethacrylate (PMMA) Particle Activation of NF-κB Pathway

(2011) Yasuhiro Yamanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis

(2011) Aline G. Costa et al.   Nature Reviews Rheumatology

Osthol, a Coumarin Isolated from Common Cnidium Fruit, Enhances the Differentiation and Maturation of Osteoblasts in vitro

(2011) Lei-Guo Ming et al.   PHARMACOLOGY

Osthole stimulates osteoblast differentiation and bone formation by activation of β-catenin-BMP signaling

(2010) De-Zhi Tang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activation

(2009) Insun Song et al.   FEBS LETTERS

NF-κB modulators in osteolytic bone diseases

(2008) Jiake Xu et al.   CYTOKINE & GROWTH FACTOR REVIEWS