ISM1 regulates NODAL signaling and asymmetric organ morphogenesis during development

Identification ofIsthmin 1as a Novel Clefting and Craniofacial Patterning Gene in Humans

(2017) Lisa A. Lansdon et al.   GENETICS

A right-handed signalling pathway drives heart looping in vertebrates

(2017) Oscar H. Ocaña et al.   NATURE

Left–Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis

(2017) Daniel T. Grimes et al.   TRENDS IN GENETICS

Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning

(2017) Jose L Pelliccia et al.   eLife

Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm

(2017) Tessa G Montague et al.   eLife

Identification ofIsthmin 1as a Novel Clefting and Craniofacial Patterning Gene in Humans

(2017) Lisa A. Lansdon et al.   GENETICS

The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer

(2016) Jie Tang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Extracellular interactions and ligand degradation shape the nodal morphogen gradient

(2016) Yin Wang et al.   eLife

Distinct spatiotemporal expression ofISM1during mouse and chick development

(2014) Liliana OSÓRIO et al.   CELL CYCLE

Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction

(2014) M Chen et al.   CELL DEATH AND DIFFERENTIATION

Nodal·Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

(2014) Christophe Fuerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nodal signaling promotes a tumorigenic phenotype in human breast cancer

(2014) Gina Kirsammer et al.   SEMINARS IN CANCER BIOLOGY

Regulation of TGFβ and related signals by precursor processing

(2014) Daniel B. Constam   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dvr1 transfers left–right asymmetric signals from Kupffer's vesicle to lateral plate mesoderm in zebrafish

(2013) Annita G. Peterson et al.   DEVELOPMENTAL BIOLOGY

NODAL in the Uterus Is Necessary for Proper Placental Development and Maintenance of Pregnancy1

(2012) Craig B. Park et al.   BIOLOGY OF REPRODUCTION

Left-right patterning: conserved and divergent mechanisms

(2012) T. Nakamura et al.   DEVELOPMENT

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nodal Expression in the Uterus of the Mouse Is Regulated by the Embryo and Correlates with Implantation1

(2011) Craig B. Park et al.   BIOLOGY OF REPRODUCTION

The Thrombospondins

(2011) J. C. Adams et al.   Cold Spring Harbor Perspectives in Biology

Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state

(2011) Y Zhang et al.   Cell Death & Disease

Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish

(2011) Kelly A. Smith et al.   PLoS Genetics

Transcriptomic landscape of the primitive streak

(2010) C. Alev et al.   DEVELOPMENT

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation

(2010) Jianguang Du et al.   DEVELOPMENTAL BIOLOGY

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

(2009) J. Rossant et al.   DEVELOPMENT

Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice

(2009) Wei Xiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A right-sided pathway involving FGF8/Snai1 controls asymmetric development of the proepicardium in the chick embryo

(2009) J. Schlueter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nodal Morphogens

(2009) A. F. Schier   Cold Spring Harbor Perspectives in Biology

GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses

(2008) Ariel J. Levine et al.   DEVELOPMENTAL BIOLOGY