Article
Oncology
Ronda Copher, Arianna Kee, Aaron Gerds
Summary: Myelofibrosis results in increased resource utilization and costs for patients and the US healthcare system. This study provides insights into treatment patterns, healthcare resource utilization, and costs associated with myelofibrosis, particularly in patients treated with ruxolitinib.
Article
Gastroenterology & Hepatology
Grace Chen, Vasantha Pedarla, Kyle D. Null, Susan E. Cazzetta, Qasim Rana Khan, David A. Schwartz
Summary: Perianal fistula (PAF), a complication of Crohn's disease (CD), has a high prevalence in the United States and is associated with increased costs and healthcare resource utilization for patients.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Critical Care Medicine
Alexandra M. Nanzer, Adam Lawton, Grainne D'Ancona, Atul Gupta
Summary: Adolescent asthma patients require special attention and care, facing challenges in disease management and the need for transition during their adolescence.
Article
Medicine, General & Internal
Fatma Merve Tepetam, Ali Burkan Akyildiz, Seyma Ozden, Cihan Orcen, Tugce Yakut, Ozge Atik
Summary: This study compared the clinical, spirometric, and inflammatory efficacy of omalizumab and mepolizumab in atopic and eosinophilic overlap severe asthma patients. The results showed that there was no difference in terms of reduction in attacks and improvement in clinical control between the two biologics. However, mepolizumab treatment significantly reduced eosinophil levels and showed a greater improvement in lung function. Eosinophil counts did not affect the responder patient rates for either biological condition.
Article
Public, Environmental & Occupational Health
Jiahui Zhang, Xiaoning He, Jing Wu
Summary: In Chinese chronic kidney disease patients, hyperkalemia is associated with substantially increased clinical and economic burdens that are driven by the short period following the hyperkalemia events, which strengthens calls for sufficient supervision and management of serum potassium.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Allergy
Patrick W. Sullivan, Vahram H. Ghushchyan, David P. Skoner, Jason LeCocq, Siyeon Park, Robert S. Zeiger
Summary: The study found that asthmatic children and adolescents treated with systemic corticosteroids had an increased risk of developing complications and higher healthcare resource utilization in the first year of follow-up compared to those not receiving corticosteroids.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Critical Care Medicine
Mark H. Moss, Njira L. Lugogo, Mario Castro, Nicola A. Hanania, Andrea Ludwig-Sengpiel, Dinesh Saralaya, Rafal Dobek, Inigo Ojanguren, Ivan Vyshnyvetskyy, Jean-Marie Bruey, Robin Osterhout, Cindy-ann Tompkins, Karen Dittrich, Kartik Raghupathi, Hector Ortega
Summary: This study aimed to investigate the effect of DP2 antagonist GB001 on asthma worsening in patients with moderate to severe eosinophilic asthma. The results showed that GB001 did not significantly reduce the odds of asthma worsening, but reductions favoring GB001 were observed. Treatment effects were consistent regardless of the type 2 phenotype. However, the use of high-dose GB001 may be associated with the risk of liver injury compared to placebo and low-dose GB001.
Article
Critical Care Medicine
Joanne E. Kavanagh, Andrew P. Hearn, Jaideep Dhariwal, Grainne d'Ancona, Abdel Douiri, Cris Roxas, Mariana Fernandes, Linda Green, Louise Thomson, Alexandra M. Nanzer, Brian D. Kent, David J. Jackson
Summary: In patients with severe eosinophilic asthma treated with benralizumab, a significant reduction in asthma exacerbation rates was observed, with a subset of patients achieving super response. Blood eosinophil count increase was associated with treatment nonresponse.
Review
Allergy
Melissa B. Gilkey, Wei Yi Kong, Kathryn L. Kennedy, Jennifer Heisler-MacKinnon, Elena Faugno, Barbara Gwinn, Ann Chen Wu, Ceila E. Loughlin, Alison A. Galbraith
Summary: Telemedicine has the potential to reduce the financial burden of asthma care, but it may also increase costs. The research highlights the importance of care coordination and communication in telemedicine.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Respiratory System
Prabuddha S. Pathinayake, David W. Waters, Kristy S. Nichol, Alexandra C. Brown, Andrew T. Reid, Alan Chen-Yu Hsu, Jay C. Horvat, Lisa G. Wood, Katherine J. Baines, Jodie L. Simpson, Peter G. Gibson, Philip M. Hansbro, Peter A. B. Wark
Summary: Research demonstrates that endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are associated with disease severity and inflammatory phenotype in asthma.
Review
Biochemistry & Molecular Biology
Glenn Van Hulst, Fabrice Bureau, Christophe J. Desmet
Summary: Asthma is now recognized as a heterogeneous disease with different phenotypes driven by distinct pathophysiological mechanisms. Eosinophilic asthma is a common phenotype characterized by the presence of eosinophils, which have become a primary therapeutic target. Recent research suggests that different SEA phenotypes may involve differences in eosinophil biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Naeem Bhojani, Rutugandha Paranjpe, Ben Cutone, Sirikan Rojanasarot, Ben H. Chew
Summary: The study investigated the incidence, predictive factors, and healthcare utilization of sepsis post-ureteroscopy (URS) in commercially insured patients. It found that 5.5% of URS patients developed sepsis, with diabetes, older age, baseline sepsis, baseline inpatient visits, and higher comorbidity score being independent predictors of post-URS sepsis. Patients with sepsis post-URS had higher healthcare utilization and costs.
JOURNAL OF ENDOUROLOGY
(2022)
Article
Allergy
Giorgio Walter Canonica, Tim W. Harrison, Pascal Chanez, Francesco Menzella, Renaud Louis, Borja G. Cosio, Njira L. Lugogo, Arjun Mohan, Annie Burden, Esther Garcia Gil
Summary: The study showed that benralizumab can improve symptoms of NP and asthma outcomes in patients with severe, eosinophilic asthma and NP, with better effects observed in patients with high baseline SNOT-22 scores.
Review
Biochemistry & Molecular Biology
Alessandro Vatrella, Angelantonio Maglio, Corrado Pelaia, Luigi Ciampo, Giulia Pelaia, Carolina Vitale
Summary: This review focuses on severe asthma, its different subtypes, the role of eosinophilic inflammation, and the development of targeted anti-eosinophil therapies. It discusses the unique biology of eosinophils and their involvement in asthma, as well as current and prospective therapeutic strategies.
Article
Clinical Neurology
Raj G. Kumar, Evan Bollens Lund, Katherine A. Ornstein, Jing Li, Kenneth E. Covinsky, Amy S. Kelley
Summary: This study shows that individuals with dementia have higher healthcare utilization and costs in the years preceding dementia identification compared to those without dementia. This suggests a greater healthcare burden even before the clinical manifestation and recognition of dementia.
ALZHEIMERS & DEMENTIA
(2023)