Article
Engineering, Biomedical
Gary Stinnett, Nasim Taheri, Jake Villanova, Arash Bohloul, Xiaoting Guo, Edward P. Esposito, Zhen Xiao, Deanna Stueber, Carolina Avendano, Paolo Decuzzi, Robia G. Pautler, Vicki L. Colvin
Summary: This study introduces shape-engineered plate-like nanocrystals with sulfonated surface polymers that promote second-sphere relaxation processes, providing remarkable contrast even at high fields. These noncytotoxic materials release no detectable free Gadolinium even under mild acidic conditions, and have a circulation half-life in the liver 50% longer than commercial agents. These features enable the first-time application of T-1 MRI contrast agents to the ex vivo detection of nonalcoholic fatty liver disease in mice.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Tyler A. Bailey, Veronika Mocko, Katherine M. Shield, Dahlia D. An, Andrew C. Akin, Eva R. Birnbaum, Mark Brugh, Jason C. Cooley, Jonathan W. Engle, Michael E. Fassbender, Stacey S. Gauny, Andrew L. Lakes, Francois M. Nortier, Ellen M. O'Brien, Sara L. Thiemann, Frankie D. White, Christiaan Vermeulen, Stosh A. Kozimor, Rebecca J. Abergel
Summary: The development of targeted alpha therapies can potentially revolutionize disease treatment by delivering destructive radiation to diseased cells while sparing healthy tissue. Despite challenges with incompatible isotopes, researchers successfully produced Ce-134 for PET imaging, demonstrating its potential as a candidate for imaging Ac-225 or Th-227. Rigorous control of the Ce-III/Ce-IV redox couple was crucial for success in these experiments.
Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Loredana Leone, Luca Guarnieri, Jonathan Martinelli, Massimo Sisti, Andrea Penoni, Mauro Botta, Lorenzo Tei
Summary: The first binuclear Gd-complex of the 12-membered pyridine-based polyaminocarboxylate macrocyclic ligand PCTA was successfully synthesized by connecting two different pyridine units. A dimeric AAZTA-ligand was also synthesized for comparison, showing that the rigidity and compactness of the two binuclear complexes led to significantly enhanced relaxometric properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Inorganic & Nuclear
Rocio Uzal-Varela, Aurora Rodriguez-Rodriguez, Huan Wang, David Esteban-Gomez, Isabel Brandariz, Eric M. Gale, Peter Caravan, Carlos Platas-Iglesias
Summary: This research developed a method for predicting Gd(III)-ligand formation constant and pGd at pH 7.4 using known stability constants and structural descriptors, showing strong predictive power and potential for screening potential ligands.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Yongkang Gai, Yuying Li, Shuangping Wu, Ling Xu, Yao Lu, Xiaoli Lan, Guangya Xiang, Xiang Ma
Summary: The aim of this study was to synthesize and characterize a new micelle-based TPGS gadolinium chelate as a biocompatible MRI contrast agent for prolonged blood circulation time and good tumor imaging contrast. The successfully prepared TPGS-L-NETA-Gd micelle exhibited improved cellular uptake in HepG2 cells and xenografts and high in vivo safety. The in vitro and in vivo properties of TPGS-L-NETA-Gd make it a favorable macromolecular MRI contrast agent for future in vivo imaging.
Article
Chemistry, Multidisciplinary
Connor M. Ellis, Daohe Yuan, Ferenc E. Mozes, Jack J. Miller, Jason J. Davis
Summary: Paramagnetically-doped polymer micelles with ionizable poly(acrylic acid) (PAA) block enable high-contrast MR imaging at clinically relevant field strengths with strong pH sensitivity. The reversible switch in polymer strand charge directly affects the local rigidity and rotational correlation time characteristics of the integrated Gd-chelate, resulting in a 50% amplitude switch in positive contrast.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Gaoji Wang, Goran Angelovski
Summary: A novel Gd3+ chelate has been developed that can selectively recognize Zn2+ and exhibit a significant increase in longitudinal relaxivity, representing a new momentum in developing suitable contrast agents for functional molecular imaging studies of Zn2+.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Urology & Nephrology
Michael R. Rudnick, Ihab M. Wahba, Amanda K. Leonberg-Yoo, Dana Miskulin, Harold Litt
Summary: Gadolinium-based contrast agents improve diagnostic capabilities of MRI, but can cause nephrogenic systemic fibrosis in severe chronic kidney disease patients. Restrictive policies and selective use of GBCAs with higher free gadolinium affinity have reduced NSF cases, yet physicians remain concerned about GBCA use in severe CKD. Recent observations of gadolinium deposition in the brain and a possible systemic syndrome attributed to GBCAs have magnified these concerns.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gulseren Dinc, Arif K. Salihoglu, Burak Ozgoren, Selcuk Akkaya, Ahmet Ayar
Summary: This study investigated the effects of selected GBCAs on rat myometrial contractility and found that these contrast agents can modulate myometrial contractions at clinically relevant concentrations, potentially explaining the known side effects of these agents.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Qilin Zou, Luan Passini, Laure Gibot, Delphine Lagarde, Jie Hu, Haomiao Zhu, Franck Desmoulin, Pierre Sicard, Nitchawat Paiyabhroma, Marc Verelst, Robert Mauricot, Clement Roux
Summary: This study presents a versatile strategy for synthesizing ultrasmall rare-earth oxysulfide (RE2O2S) nanoparticles ranging from 3 to 10 nm. The stability of PVP-coated Gd0.8Nd1.2O2S nanoparticles with a size of 6 nm in culture medium is investigated. The results demonstrate the potential of these nanoparticles for applications in various imaging techniques, including magnetic resonance, X-ray computed tomography, photoacoustic, ultrasound, and second near-infrared fluorescence imaging. This study lays the foundation for further research on the bioapplications of ultrasmall RE2O2S nanoparticles.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Environmental Sciences
DeAunne Denmark, Ilene Ruhoy, Bryan Wittmann, Haleh Ashki, Lorrin M. Koran
Summary: This study molecularly characterized and explored potential metabolic associations with symptoms of Gadolinium Deposition Disease (GDD), a syndrome characterized by the onset of severe symptoms after exposure to Gd-based contrast agents. The research found biochemical differences in plasma samples from GDD patients compared to a healthy reference cohort, with a notable proportion of these differences associated with mitochondrial function and related disorders. The study suggests a potential contributory role of mitochondrial dysfunction in persistent symptoms attributed to GBCA exposure.
Article
Chemistry, Physical
Yang Chen, Dan Wang, Haijun Yang, Kai Li, Yingfeng Wang, Zhongfeng Li
Summary: This study reported the fabrication of hybrid nanoparticles capable of emitting red light and exhibiting superior MRI contrast enhancement, making them potential dual-mode UCL/MRI bioimaging nanoprobes.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Physical
Divya Rajendran, Judith Elizabeth, Sundar Manoharan, Nagabhushan Vellala, Brahmadathan Kootallur, Abiram Angamuthu, Jebasingh Bhagavathsingh, Prince Makarios Paul
Summary: In this study, a novel Gd(III) complex was reported as a potential contrast agent for high resolution MRI images, and its molecular structure was predicted through DFT calculations. The complex displayed high relaxivity and enhanced image intensity in MRI, paving the way for higher resolution imaging.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Nanoscience & Nanotechnology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Changqiang Wu, Liang Du, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: Compared to traditional branched polymers, branched polymers with Gd(III) chelates as the internal skeleton show higher kinetic stability and better relaxivity enhancement for MRI contrast agents. Different poly-DOTA branched polymers were synthesized and the Gd(III) chelates displayed excellent stability and high T1 relaxivities. In vivo studies showed that P4-Gd had the best performance in terms of MRA effect, vascular stenosis detection, and longer observation window compared to Gd-DOTA. Overall, poly-DOTA branched polymers with Gd(III) chelates are promising candidates for MRI probes with improved relaxivity enhancement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xianzhi Meng, Brent Scheidemantle, Mi Li, Yun-yan Wang, Xianhui Zhao, Miguel Toro-Gonzalez, Priyanka Singh, Yunqiao Pu, Charles E. Wyman, Soydan Ozcan, Charles M. Cai, Arthur J. Ragauskas
Article
Chemistry, Physical
Maria C. Molina Higgins, Sajjad Ghobadi, Jessika V. Rojas, Carlos E. Castano
APPLIED SURFACE SCIENCE
(2020)
Article
Materials Science, Multidisciplinary
Rajnikant V. Umretiya, Santiago Vargas, Diana Galeano, Reza Mohammadi, Carlos E. Castano, Jessika V. Rojas
JOURNAL OF NUCLEAR MATERIALS
(2020)
Article
Chemistry, Physical
M. Molina Higgins, A. Banu, S. Pendleton, J. Rojas
RADIATION PHYSICS AND CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Miguel Toro-Gonzalez, Ashley N. Dame, Saed Mirzadeh, Jessika Rojas
Article
Materials Science, Multidisciplinary
Rajnikant Umretiya, Barret Elward, Donghwi Lee, Mark Anderson, Raul B. Rebak, Jessika Rojas
JOURNAL OF NUCLEAR MATERIALS
(2020)
Article
Thermodynamics
Donghwi Lee, Barret Elward, Paul Brooks, Rajnikant Umretiya, Jessika Rojas, Matteo Bucci, Raul B. Rebak, Mark Anderson
Summary: Flow boiling heat transfer tests were conducted on conventional and accident tolerant fuel cladding materials to evaluate the Critical Heat Flux (CHF) and Heat Transfer Coefficient (HTC). The results showed that the Zr4-Cr-CS coating had higher HTC due to increased void fraction and roughness, but also reduced CHF compared to bare Zr4. The study demonstrated that the surface roughness of Zr4-Cr-CS improved heat transfer performance while impacting CHF behavior.
APPLIED THERMAL ENGINEERING
(2021)
Article
Chemistry, Physical
Maria C. Molina Higgins, Hailey Hall, Jessika Rojas
Summary: The study revealed that X-ray irradiation can improve the catalytic activity of TiO2 nanoparticles by creating oxygen vacancies and chemisorbed oxygen on the surface, leading to delays in the recombination rate of electron-hole pairs, thus enhancing photocatalytic efficiency.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Engineering, Chemical
Noshin Mir, Carlos E. Castano, Jessika Rojas, Nazgol Norouzi, Amir R. Esmaeili, Reza Mohammadi
Summary: A self-floating adsorbent was developed to address the challenging adsorbent separation in solid phase extraction method, which efficiently extracts and recovers rare-earth elements, especially Yb3+. The adsorbent, prepared using alkyl ketene dimer, showed high adsorption capacity for REEs with smaller ionic radii.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Physical
Miguel Toro-Gonzalez, Dustin M. Clifford, Maria C. Molina, Carlos E. Castano, Jessika Rojas
Summary: Radiolytic synthesis has been successfully used to produce gold nanoparticles in continuous flow, demonstrating the potential for high-throughput formation of metallic nanoparticles under short reaction times, room temperature, and low concentrations of stabilizing and reducing agents.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
M. Toro-Gonzalez, A. N. Dame, C. M. Foster, L. J. Millet, J. D. Woodward, J. Rojas, S. Mirzadeh, S. M. Davern