Review
Public, Environmental & Occupational Health
Catherine Godfrey, Amber Prainito, Ilana Lapidos-Salaiz, Matthew Barnhart, D. Heather Watts
Summary: Women living with HIV face a significant burden of HPV-related cervical disease, leading to a higher risk of developing cervical cancer. The highest burden of HIV in women is found in sub-Saharan Africa, where diagnostic and treatment services for cervical disease are limited. This paper will discuss efforts to address precursor lesions in HIV programs supported by PEPFAR.
PREVENTIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jun-Yuan Yang, Dong Ke, Yanli Li, Jie Shi, Shi-Meng Wan, An-Jin Wang, Meng-Na Zhao, Han Gao
Summary: This study demonstrates that CNIH4 inhibits ferroptosis of human cervical cancer cells by upregulating SLC7A11, promoting cell survival. The expression of CNIH4 is closely associated with survival rates of cervical cancer patients.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Pediatrics
Rachel Y. Moon, Rebecca F. Carlin, Ivan Hand
Summary: Each year, around 3500 infants die of sleep-related infant deaths in the United States. The overall death rate has remained stagnant since 2000, and disparities persist. The triple risk model suggests that SIDS occurs when an infant with intrinsic vulnerability experiences an exogenous trigger event during a critical developmental period. The American Academy of Pediatrics recommends safe sleep environments and other measures to reduce the risk of sleep-related deaths.
Editorial Material
Nursing
Diane S. Aschenbrenner
Summary: The Food and Drug Administration supports primary prevention, harm reduction, evidence-based treatments, and protection against unapproved drugs to decrease opioid deaths. The Centers for Disease Control and Prevention has updated its opioid prescribing guidelines.
AMERICAN JOURNAL OF NURSING
(2023)
Article
Oncology
Jennifer C. Spencer, Noel T. Brewer, Tamera Coyne-Beasley, Justin G. Trogdon, Morris Weinberger, Stephanie B. Wheeler
Summary: The study shows that high-poverty counties in the United States are likely to be delayed in achieving near-elimination targets for cervical cancer by 14 years compared to low-poverty counties, with estimated increasing relative differences in disparities based on poverty levels.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Yuval Shalev Many, Pesach Shvartzman, Ido Wolf, Barbara G. Silverman
Summary: This study analyzed clinical and demographic characteristics of 209,158 cancer deaths in Israel between 1998 and 2018. The proportion of out-of-hospital deaths increased annually, with older patients and those with solid malignancies more likely to die at home. The study highlights the importance of increasing access to end-of-life care and educating patients, families, and physicians about the benefits of palliative care.
Editorial Material
Medicine, General & Internal
Roman Gulati
Summary: Prostate cancer is a major public health problem, and while PSA screening significantly reduces mortality risk, it also leads to overdiagnosis and complications associated with treatment.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Victor Serebruany, Jean-Francois Tanguay
Summary: The study found a potential link between antiplatelet agents and anticoagulants with excess cancer deaths, especially concerning ticagrelor, but the accuracy of related death reports needs further evaluation to determine the exact cause of death.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Erin J. Stringfellow, Tse Yang Lim, Keith Humphreys, Catherine DiGennaro, Celia Stafford, Elizabeth Beaulieu, Jack Homer, Wayne Wakeland, Benjamin Bearnot, R. Kathryn McHugh, John Kelly, Lukas Glos, Sara L. Eggers, Reza Kazemi, Mohammad S. Jalali
Summary: Opioid overdose deaths remain a major public health crisis. Our analysis shows that strategies including reducing fentanyl-related overdose risk, increasing naloxone distribution, and providing recovery support for individuals in remission can significantly reduce fatal opioid overdoses.
Article
Oncology
Qi Song, Juyi Wen, Weiping Li, Janxin Xue, Yufei Zhang, Hongyan Liu, Jixia Han, Tao Ning, Zejun Lu
Summary: This study investigated the mechanisms of HSP90 in regulating the radiosensitivity of cervical cancer cells. The findings showed that HSP90 promotes radioresistance by reducing the degradation of CD147 mediated by FBXO6.
Editorial Material
Oncology
Joseph E. Bauer
Summary: This study provides insights into the causes of death in prostate cancer survivors, offering valuable considerations for clinical practitioners. Particularly for primary care physicians managing the healthcare of prostate cancer survivors in the complex environment of coronavirus disease 2019, these findings can be beneficial.
Article
Oncology
Pengcheng Yang, Yongqiang Zheng, Jiayuan Chen, Haotian Ma, Kaixu Yu, Ying Chen, Yun Yang, Bian Wu
Summary: The study found that within the first year following a cancer diagnosis, approximately 15.9% of patients died from non-cancer causes, with cardiovascular diseases and infectious diseases being the leading causes. The risk of non-cancer deaths was highest within the first month after diagnosis and decreased rapidly thereafter.
Article
Cell Biology
Shikai Liu, Lili Song, Hairong Yao, Liang Zhang
Summary: This study demonstrated that overexpression of PGK1 in high-risk HPV-positive CESC is associated with poor prognosis and enhanced proliferation, migration, and invasion. HPV16 E6/E7 stabilizes PGK1 protein by reducing its poly-ubiquitination, indicating a potential mechanism for dysregulation of PGK1 in cervical cancer.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Tao Zhang, Liang Zhuang, Munawaer Muaibati, Dan Wang, Abuduyilimu Abasi, Qing Tong, Ding Ma, Lei Jin, Xiaoyuan Huang
Summary: This study identified cervical cancer stem cells and revealed the functional changes in cervical stem cells during malignant transformation. The original non-malignant stem cell properties gradually diminished, while the tumor stem cell properties were enhanced. Additionally, stem-like cells in the cervical microenvironment were associated with neoplastic recurrence, and interferon responses were upregulated during lesion progression.
Article
Oncology
Sylvia Kaljouw, Erik E. L. Jansen, Clare A. Aitken, Lotte M. Harrijvan, Steffie K. Naber, Inge M. C. M. de Kok
Summary: The aim of this study was to investigate how to safely reduce unnecessary referrals in HPV-based cervical cancer screening programmes in the Netherlands. Through simulation modeling, it was found that adjusting referral conditions and testing interval can effectively reduce the number of unnecessary referrals.
GYNECOLOGIC ONCOLOGY
(2021)