Familial combined hyperlipidemia: An overview of the underlying molecular mechanisms and therapeutic strategies

Long-term generation of antiPCSK9 antibody using a nanoliposome-based vaccine delivery system

(2019) Amir Abbas Momtazi-Borojeni et al.   ATHEROSCLEROSIS

Harnessing nucleic acid-based therapeutics for atherosclerotic cardiovascular disease: state of the art

(2019) Fatemeh Vahdat Lasemi et al.   DRUG DISCOVERY TODAY

PCSK9 Inhibitors: Novel Therapeutic Strategies for Lowering LDL-Cholesterol

(2018) Zhao-Peng Liu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

(2017) Arrigo F G Cicero et al.   NUTRITION REVIEWS

Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms

(2016) Piotr Chruściel et al.   ATHEROSCLEROSIS

2016 ESC/EAS Guidelines for the Management of Dyslipidaemias

(2016) Alberico L. Catapano et al.   EUROPEAN HEART JOURNAL

The effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta -analysis of randomized controlled trials

(2016) Matteo Pirro et al.   PHARMACOLOGICAL RESEARCH

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

(2016) Pirkka-Pekka Laurila et al.   Science Translational Medicine

The impact of statin therapy on plasma levels of von Willebrand factor antigen

(2016) Amirhossein Sahebkar et al.   THROMBOSIS AND HAEMOSTASIS

Statin therapy reduces plasma endothelin-1 concentrations: A meta-analysis of 15 randomized controlled trials

(2015) Amirhossein Sahebkar et al.   ATHEROSCLEROSIS

Effects of Armolipid Plus on small dense LDL particles in a sample of patients affected by familial combined hyperlipidemia

(2015) Marco Gentile et al.   Clinical Lipidology

Association between statin use and plasma D-dimer levels

(2015) Dimitri Mikhailidis et al.   THROMBOSIS AND HAEMOSTASIS

A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations

(2015) Corina Serban et al.   Scientific Reports

Doses of rosuvastatin, atorvastatin and simvastatin that induce equal reductions in LDL-C and non-HDL-C: Results from the VOYAGER meta-analysis

(2015) Björn W Karlson et al.   European Journal of Preventive Cardiology

The pathophysiology of intestinal lipoprotein production

(2015) Antonina Giammanco et al.   Frontiers in Physiology

Bile acid synthesis precursors in familial combined hyperlipidemia: The oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol

(2014) Lucía Baila-Rueda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PCSK9

(2014) Nabil G. Seidah et al.   CIRCULATION RESEARCH

Familial combined hyperlipidemia

(2014) Marleen M.J. van Greevenbroek et al.   CURRENT OPINION IN LIPIDOLOGY

Recent advances in pharmacotherapy for hypertriglyceridemia

(2014) Amirhossein Sahebkar et al.   PROGRESS IN LIPID RESEARCH

Vitamin D concentrations in familial combined hyperlipidemia: effects of lipid lowering treatment

(2014) Inka Miñambres et al.   Diabetology & Metabolic Syndrome

Joint Linkage and Association Analysis with Exome Sequence Data Implicates SLC25A40 in Hypertriglyceridemia

(2013) Elisabeth A. Rosenthal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Treatment options for hypertriglyceridemia: From risk reduction to pancreatitis

(2013) Lars Berglund et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

New Therapies Targeting apoB Metabolism for High-Risk Patients with Inherited Dyslipidaemias: What Can the Clinician Expect?

(2013) Amirhossein Sahebkar et al.   CARDIOVASCULAR DRUGS AND THERAPY

Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia

(2013) M.C.G.J. Brouwers et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Potential Role of Upstream Stimulatory Factor 1 Gene Variant in Familial Combined Hyperlipidemia and Related Disorders

(2012) Simon Auer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia

(2012) María Solanas-Barca et al.   ATHEROSCLEROSIS

Apolipoprotein B Synthesis Inhibition With Mipomersen in Heterozygous Familial Hypercholesterolemia

(2012) Evan A. Stein et al.   CIRCULATION

Impact of Cardiometabolic Risk Factors on Major Cardiovascular Events in Patients With Familial Combined Hyperlipidemia

(2012) Ioannis Skoumas et al.   CIRCULATION JOURNAL

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

(2012) Marina Cuchel et al.   LANCET

Cholesterol metabolism differs after statin therapy according to the type of hyperlipemia

(2012) Graziana Lupattelli et al.   LIFE SCIENCES

The genetics of familial combined hyperlipidaemia

(2012) Martijn C. G. J. Brouwers et al.   Nature Reviews Endocrinology

Plasma proprotein convertase subtilisin kexin type 9 is a heritable trait of familial combined hyperlipidaemia

(2011) Martijn C.G.J. Brouwers et al.   CLINICAL SCIENCE

Linkage and association of phospholipid transfer protein activity toLASS4

(2011) Elisabeth A. Rosenthal et al.   JOURNAL OF LIPID RESEARCH

Simvastatin Therapy Reduces Prooxidant-Antioxidant Balance: Results of a Placebo-Controlled Cross-Over Trial

(2011) Seyyed M. R. Parizadeh et al.   LIPIDS

Dynamics of human adipose lipid turnover in health and metabolic disease

(2011) Peter Arner et al.   NATURE

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Genetic variants in adipose triglyceride lipase influence lipid levels in familial combined hyperlipidemia

(2010) Luisa Nanni et al.   ATHEROSCLEROSIS

Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

(2010) Hemang Parikh et al.   BMC Medical Genomics

Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus

(2010) Martijn CGJ Brouwers et al.   CURRENT OPINION IN LIPIDOLOGY

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Familial Combined Hyperlipidemia Is Associated With Alterations in the Cholesterol Synthesis Pathway

(2009) Thomas M. van Himbergen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of Two Common Variants Contributing to Serum Apolipoprotein B Levels in Mexicans

(2009) Daphna Weissglas-Volkov et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Familial-combined hyperlipidaemia in very young myocardial infarction survivors (

(2009) F. Wiesbauer et al.   EUROPEAN HEART JOURNAL

OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism

(2009) Julia Perttilä et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Small and dense LDL in familial combined hyperlipidemia and N291S polymorphism of the lipoprotein lipase gene

(2009) Antonio López-Ruiz et al.   Lipids in Health and Disease

A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia

(2009) Christopher L. Plaisier et al.   PLoS Genetics

Atorvastatin and Fenofibrate Have Comparable Effects on VLDL-Apolipoprotein C-III Kinetics in Men With the Metabolic Syndrome

(2008) Dick C. Chan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prevalence and determinants of coronary artery disease in males and females with familial combined hyperlipidaemia

(2008) Christos Pitsavos et al.   ATHEROSCLEROSIS

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

(2008) M. Orho-Melander et al.   DIABETES

Frequency of Low-Density Lipoprotein Receptor Gene Mutations in Patients With a Clinical Diagnosis of Familial Combined Hyperlipidemia in a Clinical Setting

(2008) Fernando Civeira et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

(2008) Yurii S Aulchenko et al.   NATURE GENETICS

Paraoxonase (PON1) is associated with familial combined hyperlipidemia

(2007) Thomas M. van Himbergen et al.   ATHEROSCLEROSIS

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY