Article
Oncology
Qiaojuan Guo, Nan Xiao, Hanchuan Xu, Jingfeng Zong, Youping Xiao, Tianzhu Lu, Yun Xu, Bingyi Wang, Bijuan Chen, Jianji Pan, Shaojun Lin
Summary: This study investigated the feasibility of level Ib sparing in selected nasopharyngeal carcinoma patients during intensity-modulated radiation therapy based on the International Guideline. The results showed that level Ib-sparing IMRT is safe and feasible for patients who meet certain criteria.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Oncology
Wai Tong Ng, James C. H. Chow, Jonathan J. Beitler, June Corry, William Mendenhall, Anne W. M. Lee, K. Thomas Robbins, Sandra Nuyts, Nabil F. Saba, Robert Smee, William A. Stokes, Primoz Strojan, Alfio Ferlito
Summary: This article discusses the considerations, practical pearls, and recent advances in radiotherapy for nasopharyngeal carcinoma (NPC), emphasizing the importance of optimal radiotherapy planning and precise beam delivery for treatment efficacy.
Article
Oncology
Wen-Shan Liu, Kuo-Wang Tsai, Bor-Hwang Kang, Ching-Chieh Yang, Wei-Lun Huang, Ching-Chih Lee, Yu-Chang Hu, Kuo-Ping Chang, Hsiu-Min Chen, Yaoh-Shiang Lin
Summary: The study compared the treatment outcomes and adverse effects in patients with nasopharyngeal carcinoma using different treatment methods. The group with simultaneously reduced volume and dose showed better overall survival and salvage survival, along with a lower ratio of severe lung infection.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Pharmacology & Pharmacy
Wenwen Hao, Lisha Wu, Linhui Cao, Jinxiu Yu, Li Ning, Jingshu Wang, Xiaoping Lin, Yanfeng Chen
Summary: Cisplatin resistance in nasopharyngeal carcinoma is correlated with radioresistance, with upregulation of SLC1A6 gene leading to reduced sensitivity to cisplatin, suggesting a potential novel therapeutic target for resistant patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Zhaodong Fei, Ting Xu, Xiufang Qiu, Mengying Li, Taojun Chen, Li Li, Chaoxiong Huang, Chuanben Chen
Summary: In patients with T4 nasopharyngeal carcinoma, an additional boost dose of radiation therapy can significantly improve overall survival and local recurrence-free survival. Boost dose was shown to be the only protective prognostic factor in multivariate analysis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Fen Xue, Dan Ou, Xiaomin Ou, Xin Zhou, Chaosu Hu, Xiayun He
Summary: A dose and volume de-escalated IMRT based on response to IC was associated with high progression-free survival and mild late neurological toxicities. Further exploration of de-escalation strategies in appropriate patients is needed.
Article
Oncology
Wei-Xiong Xia, Xing Lv, Hu Liang, Guo-Ying Liu, Rui Sun, Qi Zeng, Si-Wei Li, Hao-Yuan Mo, Fei Han, Dong-Hua Luo, Qing Liu, Meng-Yun Shi, Yan-Fang Ye, Jing Yang, Liang-Ru Ke, Meng-Yun Qiang, Wen-Ze Qiu, Ya-Hui Yu, Kui-Yuan Liu, Xin-Jun Huang, Wang-Zhong Li, Shu-Hui Lv, Zhuo-Chen Cai, Jing-Jing Miao, Ling Guo, Ming-Yuan Chen, Ka-Jia Cao, Lin Wang, Chong Zhao, Pei-Yu Huang, Qiu-Yan Chen, Yi-Jun Hua, Lin-Quan Tang, Chao-Nan Qian, Hai-Qiang Mai, Xiang Guo, Yan-Qun Xiang
Summary: The study found that once-every-3-weeks cisplatin is noninferior to once-a-week cisplatin for locoregionally advanced nasopharyngeal carcinoma treatment. However, the former has lower acute toxicities and late-onset auditory loss compared to the latter.
CLINICAL CANCER RESEARCH
(2021)
Article
Otorhinolaryngology
Meng-Shan Ni, Fang-Fang Kong, Guang-Sen Pan, Cheng-Run Du, Rui-Ping Zhai, Chao-Su Hu, Hong-Mei Ying
Summary: The objective of this study was to analyze the interrelation between radiation dose and radiation-induced nasopharyngeal ulcer (RINU) in locoregional recurrent NPC treated with IMRT. The study found that all dosimetric parameters were significantly associated with the progression to RINU, and EQD(2)_ [Formula: see text](D80) could serve as an independent prognostic factor for RINU. The threshold dose tolerance for nasopharyngeal mucosa was proposed as 137.035 Gy.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Jiang Hu, Boji Liu, Weihao Xie, Jinhan Zhu, Xiaoli Yu, Huikuan Gu, Mingli Wang, Yixuan Wang, ZhenYu Qi
Summary: The automatic KBP method using the DVH prediction model provides a possible way to generate clinically acceptable plans in a short time for NPC patients, achieving significant dose reduction in critical organs but showing limitations in spinal cord protection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Yanyan Chen, Quxia Zhang, Tianzhu Lu, Cairong Hu, Jingfeng Zong, Yun Xu, Wei Zheng, Lisha Chen, Senan Lin, Sufang Qiu, Luying Xu, Jianji Pan, Qiaojuan Guo, Shaojun Lin
Summary: A retrospective review on T4 NPC patients found that it is feasible to achieve ideal local control by maximizing gross tumor volume dose coverage, even when exceeding the constraint standards for the central nervous system, without significantly increasing craniocerebral toxicity.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Multidisciplinary Sciences
Pooriwat Muangwong, Nontiya Homkham, Wattanapong Narueban, Chin Tadadoltip, Chayaporn Jongjumnien, Nuttida Taenawakun, Jutamas Teerapattanaphong, Imjai Chitapanarux
Summary: We studied the factors affecting NLR and Delta NLR in NPC patients undergoing CCRT followed by AC. Advanced cancer stage was associated with higher baseline NLR. Increased Delta NLR was associated with male gender at end-CCRT and male gender with age <= 51 years at end-AC. However, no relation between NLR and its dynamic change with either OS or DFS was demonstrated.
Article
Medicine, General & Internal
Zijing Li, Zongyi Zhan, Jianhui Xiao, Yuqing Lan
Summary: The study aimed to investigate early neurovascular alterations of the retina in RE patients with normal visual acuity after radiotherapy. OCTA was used to compare vessel density and thickness between RE patients and controls. Results showed significant reductions in GCC vessel density and thickness in RE patients, with correlations to HDL-C, ApoA1, age, and ApoB. VF parameters were also correlated with retinal vessel density in RE patients. By utilizing OCTA, potential retinal neurovascular alterations in RE patients were identified, suggesting the importance of early detection and monitoring to prevent delayed diagnosis of radiation-related eye diseases.
FRONTIERS IN MEDICINE
(2021)
Article
Otorhinolaryngology
Jianyun Jiang, Ruiping Zhai, Fangfang Kong, Chengrun Du, Hongmei Ying
Summary: The purpose of this study was to evaluate the impact of body dose on survival outcomes in nasopharyngeal carcinoma (NPC) patients and to develop novel nomograms incorporating body dose parameters for predicting survival. The study included 594 non-metastasis NPC patients who received intensity-modulated radiation therapy, and nomograms for overall survival (OS) and progression-free survival (PFS) were developed using selected predictors. The body dose-based risk score, N stage, age, and induction chemotherapy were found to be independent predictors for OS, while the body dose-based risk score, N stage, and induction chemotherapy were important predictors for PFS. The nomograms outperformed the TNM staging system in predicting outcomes.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Meiyan Yue, Xiaoguang Xue, Zhanyu Wang, Ricardo Lewis Lambo, Wei Zhao, Yaoqin Xie, Jing Cai, Wenjian Qin
Summary: This study develops a deep learning method for dose prediction in nasopharyngeal carcinoma radiotherapy by utilizing distance information and mask information. The proposed method shows superior performance and provides better results in inverse planning.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Yun Xiao, Shiyi Peng, Yiqiang Tang, Honghui Xie, Min Huang, Jing Wang, Xiaochang Gong, Jingao Li
Summary: The study demonstrated that modified nasopharyngeal irrigation had a significantly positive effect on the recovery rates of patients with mild and moderate PRNN, compared to traditional methods. ICA exposure and re-irradiation were found to be independent prognostic factors affecting survival. Additionally, the modified irrigation was associated with better overall survival in certain groups of patients with PRNN.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kevin J. Harrington, Barbara Burtness, Richard Greil, Denis Soulieres, Makoto Tahara, Gilberto de Castro Jr, Amanda Psyrri, Irene Brana, Neus Baste, Prakash Neupane, Ase Bratland, Thorsten Fuereder, Brett G. M. Hughes, Ricard Mesia, Nuttapong Ngamphaiboon, Tamara Rordorf, Wan Zamaniah Wan Ishak, Jianxin Lin, Burak Gumuscu, Ramona F. Swaby, Danny Rischin
Summary: The study presents a post hoc analysis of the long-term efficacy and progression-free survival in recurrent/metastatic head and neck squamous cell carcinoma patients treated with pembrolizumab and pembrolizumab-chemotherapy as next-line therapy. The results demonstrate favorable clinical efficacy and progression-free survival with pembrolizumab and pembrolizumab-chemotherapy in patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) >= 20, CPS >= 1, and total populations. Subsequent treatments after pembrolizumab-based therapy also showed good efficacy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
W. K. Jacky Lam, Ann D. King, Jacob A. Miller, Zhiwei Liu, Kelly J. Yu, Melvin L. K. Chua, Brigette B. Y. Ma, Ming Yuan Chen, Benjamin A. Pinsky, Pei-Jen Lou, John K. S. Woo, Wan-Lun Hsu, Julia Simon, Denise L. Doolan, Tim Waterboer, Edwin P. Hui, Hui Li, Raymond K. Tsang, Kenneth C. W. Wong, Julian P. Goh, Alexander C. Vlantis, Qi Yong Ai, Lun M. Wong, Victor Abdullah, Jin Ching Lin, Chien-Jen Chen, Ruth M. Pfeiffer, Quynh-Thu Le, Anne W. M. Lee, Mingfang Ji, Sumei Cao, Jun Ma, Anthony T. C. Chan, K. C. Allen Chan, Allan Hildesheim
Summary: A meeting of experts in November 2021 discussed the performance and cost-effectiveness of EBV-based approaches for screening early stage nasopharyngeal carcinoma. Both serum EBV antibody and plasma EBV DNA testing methods were found to be favorable. Additionally, the use of MRI was recommended to increase the sensitivity of NPC detection without greatly impacting the cost-effectiveness of the screening program.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Eric J. Sherman, Jonathan Harris, Keith C. Bible, Ping Xia, Ronald A. Ghossein, Christine H. Chung, Nadeem Riaz, G. Brandon Gunn, Robert L. Foote, Sue S. Yom, Stuart J. Wong, Shlomo A. Koyfman, Michael F. Dzeda, David A. Clump, Saad A. Khan, Manisha H. Shah, Kevin Redmond, Pedro A. Torres-Saavedra, Quynh-Thu Le, Nancy Y. Lee
Summary: This study is the largest randomized anaplastic thyroid cancer study that has been completed, showing the feasibility and safety of the treatment combination. Although no significant improvement in overall survival was observed in the pazopanib group, hypothesis-generating data were generated that may warrant further investigation.
Review
Oncology
Robert I. Haddad, Kevin Harrington, Makoto Tahara, Petr Szturz, Christophe Le Tourneau, Satu Salmio, Marcis Bajars, Nancy Y. Lee
Summary: For the last 20 years, cisplatin-based chemoradiotherapy has been the standard treatment for locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) patients at high risk of recurrence. However, many patients are ineligible for this treatment due to various reasons. The criteria for cisplatin ineligibility, including age and renal impairment, are still debated. The proportion of cisplatin ineligible patients with resected LA SCCHN remains unclear. This review discusses cisplatin ineligibility considerations, limited clinical evidence, and ongoing clinical trials for alternative treatment options.
CANCER TREATMENT REVIEWS
(2023)
Article
Oncology
Yong Gan, Johannes A. Langendijk, Arjen van der Schaaf, Lisa van den Bosch, Edwin Oldehinkel, Zhixiong Lin, Stefan Both, Charlotte L. Brouwer
Summary: This study aimed to develop an efficient strategy to select candidates for adaptive radiotherapy (ART) in the first two weeks of head and neck cancer (HNC) radiotherapy. By retrospectively analyzing data from 110 HNC patients, it was found that using the difference between planning and actual dose and clinical relevance as cut-off points could identify potential candidates for ART. The proposed strategy showed improved sensitivity, specificity, and predictive values.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Yan Li, Nanna Maria Sijtsema, Suzanne Petronella Maria de Vette, Roel Johannes Henricus Marinus Steenbakkers, Fan Zhang, Walter Noordzij, Lisa Van den Bosch, Johannes Albertus Langendijk, Lisanne Vania van Dijk
Summary: This study aimed to validate the predictive ability of PET image biomarkers (PET-IBMs) for late-xerostomia after radiotherapy. The results showed that the PET-P90 model and PET-Mean model performed well in predicting late-xerostomia, and their performance was better than the base model.
RADIOTHERAPY AND ONCOLOGY
(2023)
Editorial Material
Oncology
Jesper Grau Eriksen, Birgitte Vrou Offersen, Morten Hoyer, Cai Grau, Jens Overgaard
Article
Oncology
Margot A. Stone, Birgit I. Lissenberg-Witte, Remco de Bree, Jose A. Hardillo, Femke Lamers, Johannes A. Langendijk, C. Rene Leemans, Robert P. Takes, Femke Jansen, Irma M. Verdonck-de Leeuw
Summary: This study investigated changes in sexuality and sexual dysfunction in head and neck cancer patients in the first two years after treatment, specifically looking at the impact of different treatments. Results showed that patients treated with chemoradiation experienced a deterioration in sexuality and sexual dysfunction, with differences observed between men and women. Men reported changes in erectile function, orgasm, satisfaction with intercourse, and overall satisfaction, while women reported changes in desire, arousal, and orgasm. These findings provide important information for improving sexual care for head and neck cancer patients.
Article
Oncology
Baoqiang Ma, Jiapan Guo, Hung Chu, Lisanne V. van Dijk, Peter M. A. van Ooijen, Johannes A. Langendijk, Stefan Both, Nanna M. Sijtsema
Summary: This study compared the prediction performance of radiomics, self-supervised learning, and end-to-end deep learning for OPSCC patients after (chemo)radiotherapy. The results showed that features extracted using self-supervised learning had the best internal prediction performance, while radiomics features had better external generalizability.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Claire Petit, Anne Lee, Jun Ma, Benjamin Lacas, Wai Tong Ng, Anthony T. C. Chan, Ruey-Long Hong, Ming-Yuan Chen, Lei Chen, Wen-Fei Li, Pei-Yu Huang, Terence Tan, Roger K. C. Ngan, Guopei Zhu, Hai-Qiang Mai, Edwin P. Hui, George Fountzilas, Li Zhang, Alexandra Carmel, Dora L. W. Kwong, James Moon, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon, Pierre Blanchard
Summary: This study updated the evaluation of chemotherapy for nasopharynx carcinoma through a network meta-analysis. The results showed that the addition of induction chemotherapy or adjuvant chemotherapy to chemoradiotherapy improved overall survival for patients with non-metastatic nasopharyngeal carcinoma compared to chemoradiotherapy alone.
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Femke Jansen, Birgit I. Lissenberg-Witte, Jose A. Hardillo, Robert P. Takes, Remco de Bree, Femke Lamers, Johannes A. Langendijk, C. Rene Leemans, Irma M. Verdonck-de Leeuw
Summary: Utilization of mental healthcare among head and neck cancer patients is limited and is associated with psychological symptoms, need for mental healthcare, and sociodemographic, clinical, and personal factors.
Article
Dentistry, Oral Surgery & Medicine
Jamie M. Alberga, Arjan Vissink, Anke Korfage, Sebastiaan A. H. J. de Visscher, Max J. H. Witjes, Johannes A. Langendijk, Gerry M. Raghoebar
Summary: By assessing radiation dosages on implant regions, it was found that an implant-specific D-mean higher than 50 Gy is associated with more peri-implant bone loss and eventual implant loss.