Article
Food Science & Technology
Laleewan Tajasuwan, Aikkarach Kettawan, Thanaporn Rungruang, Kansuda Wunjuntuk, Pinidphon Prombutara, Chawanphat Muangnoi, Aurawan Kringkasemsee Kettawan
Summary: Defatted rice bran (DRB) is a popular food with nutritional and functional aspects. This study found that DRB supplementation has a chemopreventive effect on colitis-associated colorectal cancer (CRC) in rats, reducing CRC symptoms and inhibiting inflammation and cancer cell proliferation. These findings suggest that DRB could be a natural dietary chemopreventive agent for cancer prevention.
Article
Biochemistry & Molecular Biology
Martin Schepelmann, Nadja Kupper, Valeriya Gushchina, Ildiko Mesteri, Teresa Manhardt, Stefan Moritsch, Christian Mueller, Karina Piatek, Martina Salzmann, Andrea Vlasaty, Robert Eferl, Enikoe Kallay
Summary: Colitis is a significant risk factor for the development of colorectal cancer, and the azoxymethane-dextran sulphate-sodium (AOM/DSS) model is commonly used to study colitis-associated colorectal cancer (CAC). This study conducted a pilot study using 14-month-old Balb/C and C57/Bl6 mice to induce CAC with different concentrations of DSS. The results showed that the DSS dose was correlated with the development of CAC, but different mouse strains had varied responses to the induction. The optimal conditions for CAC induction were found to be 3% DSS, except for Balb/C mice which reacted severely to this concentration. Therefore, 2.5% DSS may be more suitable for future experiments comparing CAC in aged Balb/C and C57/Bl6 mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Annika M. Weber, Hend Ibrahim, Bridget A. Baxter, Robin Kumar, Akhilendra K. Maurya, Dileep Kumar, Rajesh Agarwal, Komal Raina, Elizabeth P. Ryan
Summary: Heat-stabilized rice bran is a nutrient-dense food ingredient with potential colorectal cancer control and prevention properties. This study discovered novel mechanisms by which rice bran metabolism in feces may contribute to its anti-cancer activity. The findings suggest that certain fecal metabolites may serve as dietary biomarkers for colorectal cancer prevention.
Article
Biochemistry & Molecular Biology
Xuejun Zeng, Hang Jia, Yiheng Shi, Ke Chen, Zhouli Wang, Zhenpeng Gao, Yahong Yuan, Tianli Yue
Summary: This study investigated the therapeutic effects of Lactobacillus kefiranofaciens JKSP109 (LK) and Saccharomyces cerevisiae JKSP39 (SC) on colon inflammation and colorectal carcinogenesis. The results showed that administration of LK, SC, and their combination improved body weight, decreased disease activity index, and reduced tumor multiplicity. These treatments also positively regulated gut microbiota, enhanced gut barrier function, reduced inflammation, and promoted apoptosis of tumor cells. The combination of LK and SC showed superior effects compared to single strain groups.
Article
Oncology
Ling Wang, Qing-Qing Zhang, Yu-Yu Xu, Rui Zhang, Qing Zhao, Yu-Qing Zhang, Xue-Hong Huang, Bin Jiang, Min Ni
Summary: Ginsenoside Rb1 can effectively prevent inflammation-associated colorectal cancer by relieving chronic inflammation and restoring the gut microenvironment, providing a promising therapeutic strategy for CRC.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Mai Hashimoto, Noriyuki Uesugi, Mitsumasa Osakabe, Naoki Yanagawa, Koki Otsuka, Yoshiki Kajiwara, Hideki Ueno, Akira Sasaki, Tamotsu Sugai
Summary: In this study, immunohistochemical techniques were used to evaluate biological markers expressed in cancer cells and cancer-associated fibroblasts in colorectal cancer (CRC). The high expression of TNC was identified as a prognostic marker for stages II and III CRC, suggesting that a specific subgroup defined by multiple markers can be used for prediction of CRC outcome.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Dzhuliia Dzhalilova, Natalia Zolotova, Nikolai Fokichev, Olga Makarova
Summary: This review discusses existing murine models of CRC, with a particular focus on colitis-associated CRC models. The AOM/DSS model is found to be the most commonly used model for studying colitis-associated cancer, as it closely resembles human CAC in histological and molecular characteristics and is highly reproducible, inexpensive, and easy to use.
Article
Oncology
Christina Heichler, Anabel Schmied, Karin Enderle, Kristina Scheibe, Marta Murawska, Benjamin Schmid, Maximilian J. Waldner, Markus F. Neurath, Clemens Neufert
Summary: This study explores the role of cancer-associated fibroblasts in inflammation-associated colorectal cancer and suggests that targeting the activation of that cell type could be a promising therapeutic option.
Article
Multidisciplinary Sciences
Huixia Wu, Zhengchun Wu, Yilan Qiu, Fangjian Zhao, Minjing Liao, Zhihong Zhong, Jian Chen, Yiliang Zeng, Rushi Liu
Summary: This study found that a specific synbiotic intervention can protect the intestinal barrier, inhibit the occurrence of colitis-associated cancer (CAC), and improve the intestinal microecological environment. The synbiotic upregulates tight junction proteins and anti-inflammatory cytokines, while downregulating pro-inflammatory cytokines. It also improves the disorder of the colonic microbiota, promotes the formation of SCFAs and the production of secondary bile acids, and alleviates the accumulation of primary bile acids in CAC mice. Additionally, it inhibits the abnormal activation of the intestinal Wnt/β-catenin signaling pathway related to IL-23.
Article
Biochemistry & Molecular Biology
Hoi Kit Matthew Leung, Emily Kwun Kwan Lo, Hani El-Nezami
Summary: Theabrownin (TB), an antioxidant from Pu-erh tea, has been found to inhibit tumor formation and potentially be a promising candidate for colorectal cancer (CRC) treatment. TB exerts its antitumor effects by suppressing cell proliferation and enhancing apoptosis through modulation of PI3K/Akt/mTOR signaling pathway. TB also modifies the gut microbiota composition, increasing the abundance of short chain fatty acid-producing bacteria and decreasing CRC-related bacteria. This study provides valuable insights into potential therapeutic options for CRC.
Article
Nanoscience & Nanotechnology
Xiao-Min Liu, Wen-Ting Zhu, Meng-Lei Jia, Yu-Ting Li, Ye Hong, Zhong-Qiu Liu, Peng-Ke Yan
Summary: The study demonstrated that the combination of Rapa/Lps and 5-FU effectively suppressed colorectal tumor formation by inhibiting angiogenesis and proliferation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Cell Biology
Yingjie Dong, Qiuli Yang, Ruiying Niu, Zhiyuan Zhang, Yijin Huang, Yujing Bi, Guangwei Liu
Summary: Intestinal macrophages play a crucial role in maintaining intestinal homeostasis, inflammation, and cancer development. Understanding their functions and regulatory mechanisms is of great importance for the treatment of intestinal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemical Research Methods
Wenbo Sun, Ji Gao, Bing Yang, Xiangjun Chen, Na Kang, Wanli Liu
Summary: This article describes a step-by-step protocol for constructing a murine model of colitis-associated colorectal cancer (CRC) using azoxymethane and dextran sulfate sodium. It also provides detailed steps for assessing the degree of intestinal inflammation and generating colorectum Swiss roll for histopathological analyses. This protocol offers a convenient and reproducible method for inducing colitis-associated CRC in mice using general chemical reagents.
Article
Oncology
Josefine Schardey, Can Lu, Jens Neumann, Ulrich Wirth, Qiang Li, Tianxiao Jiang, Petra Zimmermann, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner, Florian Kuehn
Summary: Chronic inflammation plays a significant role in the development of colorectal cancer, particularly in colitis-associated colorectal cancer. This study examined the differences in immune infiltration patterns between colitis-associated colorectal cancer and sporadic colorectal cancer and their impact on prognosis.
Article
Nutrition & Dietetics
Seonghwan Moon, Minju Kim, Yeonhee Kim, Seungmin Lee
Summary: This study investigated the effects of dietary iron deficiency and non-heme iron on the development of colitis-associated colorectal cancer (CAC). It was found that both iron deficiency and iron overload diets suppressed the growth of colonic tumors in a mouse model. Long-term iron deficiency or overload may negate the progression of CAC.
Article
Multidisciplinary Sciences
Natsumi Oshida, Takashi Shida, Sechang Oh, Taeho Kim, Tomonori Isobe, Yoshikazu Okamoto, Takashi Kamimaki, Kosuke Okada, Hideo Suzuki, Shun-ichi Ariizumi, Masakazu Yamamoto, Junichi Shoda
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Takako Takayama, Hideo Suzuki, Kosuke Okada, Takeshi Yamada, Kazushi Maruo, Yoko Saito, Yuji Mizokami
Article
Environmental Sciences
Fumihiko Uchida, Sechang Oh, Takashi Shida, Hideo Suzuki, Kenji Yamagata, Yuji Mizokami, Hiroki Bukawa, Kiyoji Tanaka, Junichi Shoda
Summary: The study found that exercise can improve the oral environment of NAFLD patients by increasing the diversity of oral microflora and reducing the number of periodontal bacteria that produce LPS and its capability.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Kazuto Ikezawa, Mitsuaki Hirose, Tsunehiko Maruyama, Koichiro Yuji, Yoshito Yabe, Takeshige Kanamori, Naohiro Kaide, Yusuke Tsuchiya, Seigo Hara, Hideo Suzuki
Summary: The study found that early nutritional initiation within the first 3 days of admission significantly increased home discharge rates in patients with cerebral infarction. These results indicate the importance of early nutritional support in improving patient outcomes.
NUTRITION & DIETETICS
(2022)
Article
Biochemistry & Molecular Biology
Takahisa Watahiki, Kosuke Okada, Ikuru Miura, Keii To, Seiya Tanaka, Eiji Warabi, Naomi Kanno, Kenji Yamagata, Naohiro Gotoh, Hideo Suzuki, Shunichi Ariizumi, Kiichiro Tsuchiya, Yukio Nagasaki, Junichi Shoda
Summary: Antioxidative self-assembling nanoparticles can reduce the development of NASH and HCC by improving endoplasmic reticulum stress and gut microbiota.
Article
Gastroenterology & Hepatology
Sechang Oh, Takehiko Tsujimoto, Bokun Kim, Fumihiko Uchida, Hideo Suzuki, Seiichiro Iizumi, Tomonori Isobe, Takeji Sakae, Kiyoji Tanaka, Junichi Shoda
Summary: Exercise has significant weight-loss-independent benefits for patients with non-alcoholic fatty liver disease (NAFLD), including reductions in liver steatosis and stiffness, as well as improvements in inter-organ crosstalk, inflammation, and oxidative stress.
Article
Multidisciplinary Sciences
Kan Uchiyama, Shinichiro Takami, Hideo Suzuki, Kiyotaka Umeki, Satoshi Mochizuki, Nobushige Kakinoki, Junichi Iwamoto, Yoko Hoshino, Jun Omori, Shunji Fujimori, Akinori Yanaka, Yuji Mizokami, Toshifumi Ohkusa