Article
Polymer Science
Yubo Liu, Xiaohong Chen, Yuyang Liu, Yuhang Gao, Ping Liu
Summary: In this study, different physicochemical properties of polymeric fibers were successfully prepared for drug delivery system. The results showed that the weaker hydrophilicity of F2 fibers has longer drug dissolution time compared to the better hydrophilic F1 fibers.
Article
Biochemistry & Molecular Biology
Sameer Nadaf, Amrita Jadhav, Suresh Killedar
Summary: In this study, a novel Vigna radiata based porous starch (PS) was prepared and explored as a solubilizer for albendazole (ABZ). The PS showed significant improvement in dissolution rate and anthelmintic activity when used as a carrier for ABZ solid dispersions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Adrianna Dadej, Aneta Wozniak-Braszak, Pawel Bilski, Hanna Piotrowska-Kempisty, Malgorzata Jozkowiak, Malgorzata Geszke-Moritz, Michal Moritz, Daniela Dadej, Anna Jelinska
Summary: The study aimed to analyze the effect of two different APTES-modified SBA-15 silicas on the release profiles of sulindac and investigate the cytotoxicity of these molecules. The results showed that APTES-modified SBA-15 influenced the release of sulindac, both materials improved the dissolution rate in acidic pH, and exhibited insignificant cytotoxicity towards Caco-2 cells.
Article
Chemistry, Multidisciplinary
Aziz Maleki, Shayesteh Bochani, Mehraneh Kermanian, Pooyan Makvandi, Mir-Jamal Hosseini, Mehrdad Hamidi, Ali Kalantari-Hesari, Hamid Reza Kheiri, Mohammad Reza Eskandari, Maryam Rosta, Virgilio Mattoli, Seyed Hojjat Hosseini
Summary: This study aimed to develop a chitosan-grafted mesoporous silica material to enhance drug dissolution and investigate its effects in in vitro and in vivo conditions. The results showed successful loading of the drug into the silica host and no toxic effects on human cell lines. Furthermore, significant reduction in blood glucose was observed after oral administration of the biocomposites, and histopathological studies indicated no adverse effects on kidney and liver.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Michaela Slamova, Katerina Prausova, Julie Epikaridisova, Jana Brokesova, Martin Kuentz, Jan Patera, Petr Zamostny
Summary: Co-milling with a proper co-former can enhance the solubility of drugs, and the choice of co-former and consideration of drug properties are important factors affecting dissolution rate. Even without substantial amorphization, co-milling can still positively impact the dissolution behavior of drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Yrysbaeva Aidana, Yibin Wang, Jie Li, Shuyue Chang, Ke Wang, Deng-Guang Yu
Summary: Electrospinning is an industrial process that can be used to produce electrospun medicated nanofibers for fast-dissolving oral drug delivery systems. It requires the selection of appropriate polymer matrices and drug carriers, as well as addressing issues such as scalable production and solid dosage form conversion.
CURRENT DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Julian David Friedl, Marcel Walther, Pia Katharina Vestweber, Jana Wachter, Patrick Knoll, Arne Matteo Joergensen, Andreas Bernkop-Schnuerch, Maike Windbergs
Summary: To date, buccal administration of lipophilic drugs remains challenging due to poor solubility and limited penetration. In this study, researchers developed mucoadhesive electrospun SEDDS patches to overcome these limitations. The patches showed high encapsulation efficiency, improved drug penetration, and enhanced therapeutic effects, making them a promising approach for oromucosal delivery of lipophilic drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Applied
Ming Wu, Jing Xu, Xiong Lin, Xin Zhan, Kunyu Xiao, Lin Lei, Shuiqing Li, Yanju Liu
Summary: A novel meso/macroporous SiO2 support was introduced to enhance the release rate of Rg3; the excellent performance of the carrier drug was attributed to the structural characteristics of the hierarchically porous SiO2, which efficiently shortened the paths of transferring Rg3.
JOURNAL OF POROUS MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Valeria Ambrogi
Summary: Calcium carbonate is a versatile excipient that can be used to improve the dissolution rate of poorly soluble drugs. Its many interesting characteristics, including quick dissolution in gastric fluid, low cost, and safety, make it an attractive option. This review provides an overview of the use of calcium carbonate as an excipient for enhancing drug dissolution rates, including the drug loading procedure, physical characterization of the drug/CaCO3 samples, and discussion of potential mechanisms for dissolution improvement.
Article
Pharmacology & Pharmacy
Carl-Johan Carling, Mikael Brulls
Summary: This paper discusses the design concept of inhaled sustained drug delivery using the slow dissolution of drug crystals, which can achieve a reliable delivery profile in lung tissue by selecting compounds with appropriate dissolution rates. Through the utilization of two different milling techniques, various particle size distributions of drug crystals were successfully produced within the desired particle size range.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Maria Antonia Tanase, Adina Raducan, Petruta Oancea, Lia Mara Ditu, Miruna Stan, Cristian Petcu, Cristina Scomoroscenco, Claudia Mihaela Ninciuleanu, Cristina Lavinia Nistor, Ludmila Otilia Cinteza
Summary: Novel polymeric mixed micelles from Pluronic F127 and Cremophor EL were studied as drug delivery systems for Norfloxacin. The optimal molar ratio of surfactants was determined to prepare carriers with minimal surfactant concentrations. The mixed micelles showed tunable extended release of Norfloxacin and good activity against clinical isolated strains, while some cytotoxicity was found at high concentrations.
Review
Biochemistry & Molecular Biology
Dixit Bhalani, Bhingaradiya Nutan, Avinash Kumar, Arvind K. Singh Chandel
Summary: The low water solubility of pharmacoactive molecules limits their pharmacological potential, and the pharmaceutical industry faces challenges in enhancing the solubility and bioavailability of drugs. However, there are various technologies available to improve the solubility of poorly water-soluble drugs.
Article
Instruments & Instrumentation
Giovanna Rassu, Antonella Obinu, Carla Serri, Sandra Piras, Antonio Carta, Luca Ferraro, Elisabetta Gavini, Paolo Giunchedi, Alessandro Dalpiaz
Summary: In this study, PLGA nanoparticles (SS13NP) and solid lipid nanoparticles (SS13SLN) loaded with SS13 were prepared. SS13NP showed higher drug bioavailability and shorter time to reach peak concentration in oral administration compared with SS13SLN. These results confirm that the chemical composition of nanoparticles significantly affects the in vivo fate of a BCS IV drug. Moreover, PLGA nanoparticles appear more efficient and rapid than SLN in allowing drug absorption and transport to systemic circulation.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Xianbao Shi, Ping Zhang, Lingqiong Wu, Xiangyu Zhao, Jinzhu Jiang, Jing Li, Bo Yang
Summary: Mesoporous silica synthesized using biomimetic method, particularly the biomimetic large mesoporous silica (BL-MS), shows advantages in drug delivery, such as stronger adsorption capacity and better oral bioavailability, compared to commonly used mesoporous silica nanoparticles (MSNs). The large pores in BL-MS significantly improve the dissolution of poorly water-soluble drugs, demonstrating its potential in enhancing drug delivery efficiency.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Naveen K. Thakral, Eva Meister, Corinne Jankovsky, Li Li, Robert Schwabe, Laibin Luo, Shirlynn Chen
Summary: This review explores options for predicting in vivo supersaturation and precipitation of poorly water-soluble drugs, emphasizing the use of a combination of appropriate in vitro tools to obtain optimal predictive information. It discusses theoretical background and relevant case studies to address empirical issues encountered during small-scale and full-scale in vitro predictive testing, and recommends practical considerations for selecting appropriate tools at various stages of drug development. Additionally, upcoming technologies that may further reduce in vivo studies and expedite the drug development process are also discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Rossella Dorati, Enrica Chiesa, Federica Riva, Tiziana Modena, Stefania Marconi, Ferdinando Auricchio, Ida Genta, Bice Conti
Summary: The study aimed to design and produce 3D scaffold prototypes using a natural polymeric bioink made of chitosan and poly-gamma-glutamic acid. The prototypes were characterized for pore size, stability, swelling capability, and cell viability. The results showed a stable 3D structure with good biocompatibility and cell growth potential.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Silvia Pisani, Ida Genta, Rossella Dorati, Tiziana Modena, Enrica Chiesa, Giovanna Bruni, Marco Benazzo, Bice Conti
Summary: Design of Experiment (DOE) approach is an effective method to study and predict the interactions between electrospinning parameters, and it can calculate the desired output values by establishing mathematical models. In this study, the DOE method successfully predicted the effects of polymer solution concentration, needle gauge, and spinning time on the fiber diameter and elongation percentage.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Enrica Chiesa, Antonietta Greco, Federica Riva, Rossella Dorati, Bice Conti, Tiziana Modena, Ida Genta
Summary: This study investigates the cellular response to CD44-targeted nanoparticles and their internalization mechanism. The results demonstrate the biocompatibility of HA/CS NPs and the positive effect of low Mw HA on cell proliferation. CD44 and the molecular weight of HA play significant roles in the internalization of NPs, which occurs via multiple endocytic pathways simultaneously.
Article
Polymer Science
Valeria Friuli, Silvia Pisani, Bice Conti, Giovanna Bruni, Lauretta Maggi
Summary: This article discusses the challenge in the pharmaceutical sector of developing controlled release oral dosage forms for poorly soluble drugs. The researchers successfully prepared polymeric nanofibers loaded with two model drugs using the electrospinning technique. These nanofibers were then incorporated into tablet formulations, resulting in improved release performances.
Article
Biochemistry & Molecular Biology
Nora Bloise, Erik Waldorff, Giulia Montagna, Giovanna Bruni, Lorenzo Fassina, Samuel Fang, Nianli Zhang, Jiechao Jiang, James T. Ryaby, Livia Visai
Summary: This study investigates the in vitro biological reactivity of human bone-marrow-derived mesenchymal stem cells to micro- and nanotopographies on 3D-printed PEEK titanium composite endplates. The acid-etching process modifies the surface roughness and creates structures that support cell viability and osteogenic marker expression. The topography of the endplates influences the expression of osteogenic markers. Overall, the acid-etching process of the PEEK titanium composite endplates has potential clinical benefits for osteogenic differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lauretta Maggi, Valeria Friuli, Giovanna Bruni, Alessia Rinaldi, Marcella Bini
Summary: The search for effective systems for releasing poorly bioavailable drugs is a forefront topic in the pharmaceutical market. Hybrid nanocomposites of Tenoxicam with layered double hydroxides (LDHs) and hydroxyapatite (HAP) were obtained. Physicochemical characterization confirmed the formation of hybrids, but LDH showed low drug intercalation and did not improve the pharmacokinetic properties. On the other hand, the HAP-Tenoxicam hybrid exhibited excellent improvement in wettability, solubility, and release rate, delivering the entire daily dose in about 10 minutes.
Article
Biochemistry & Molecular Biology
Lauretta Maggi, Claudia Urru, Valeria Friuli, Chiara Ferrara, Debora Maria Conti, Giovanna Bruni, Doretta Capsoni
Summary: This study synthesized new carvedilol-etched halloysite nanotubes (HNTs) composites to enhance solubility and dissolution rate. The etched HNTs and carvedilol-loaded samples were characterized, showing no structural changes. The composites displayed enhanced dissolution rate, wettability, and solubility, with the best performance obtained for the carvedilol-halloysite system based on HNTs etched with HCl 8M.
Article
Chemistry, Multidisciplinary
Debora Maria Conti, Cristina Fusaro, Giovanna Bruni, Pietro Galinetto, Benedetta Albini, Chiara Milanese, Vittorio Berbenni, Doretta Capsoni
Summary: ZnS-graphene composites were synthesized and loaded onto carbon nanofibers to obtain self-standing anodes for SIBs. The ZnS nanocrystals with sphalerite structure covered by graphene sheets were successfully synthesized. The self-standing anodes showed improved specific capacity at high C-rate compared to the tape-casted example.
Article
Pharmacology & Pharmacy
Erika M. M. Tottoli, Laura Benedetti, Enrica Chiesa, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti, Gabriele Ceccarelli, Rossella Dorati
Summary: This study proposes a new electrospun dressing called Biofiber as a solution to prevent hypertrophic scar formation in complex wounds. Biofiber has excellent wetting properties and good absorbency and moisture vapor transmission rate. By controlling the release of the natural antifibrotic agent Naringin, Biofiber can demonstrate prolonged antifibrotic effects on normal human dermal fibroblasts. However, the effect on inhibiting hypertrophic scar formation is not significant.
Article
Biochemistry & Molecular Biology
Silvia Pisani, Deborah Di Martino, Silvia Cerri, Ida Genta, Rossella Dorati, Giulia Bertino, Marco Benazzo, Bice Conti
Summary: In this study, four different active encapsulation methods were compared for loading a model protein into liposomes. Electroporation yielded the highest encapsulation efficiency, but led to a significant increase in liposome size. Freeze-thawing was an effective method, allowing for high encapsulation efficiency while maintaining suitable size. Charged liposomes showed slower in vitro release and good cytocompatibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Erika Maria Tottoli, Laura Benedetti, Federica Riva, Enrica Chiesa, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti, Gabriele Ceccarelli, Rossella Dorati
Summary: This study proposes a new type of dressing, Biofiber PF, loaded with Pirfenidone, for the treatment of HTSs in complex wounds. It has antifibrotic properties and promotes physiological healing by modulating the fibrotic process.
Article
Pharmacology & Pharmacy
Silvia Pisani, Valeria Mauri, Erika Negrello, Valeria Friuli, Ida Genta, Rossella Dorati, Giovanna Bruni, Stefania Marconi, Ferdinando Auricchio, Andrea Pietrabissa, Marco Benazzo, Bice Conti
Summary: In this study, hybrid scaffolds were developed as a versatile platform for soft tissue regeneration. These scaffolds exhibited favorable cell adhesion and proliferation, and allowed for controlled drug release.
Article
Chemistry, Multidisciplinary
Mohammad Okkeh, Lorenzo De Vita, Giovanna Bruni, Lavinia Doveri, Paolo Minzioni, Elisa Restivo, Maddalena Patrini, Piersandro Pallavicini, Livia Visai
Summary: In this study, PEG-GNPs@TBO and PEG-GNSs@TBO nanoparticles were synthesized and found to have effective antimicrobial photodynamic inactivation (aPDI) effects, inhibiting the formation of Staphylococcus biofilms. In biofilm eradication treatments, PEG-GNSs@TBO showed better results in reducing viable counts of MRSA and S. epidermidis RP62A preformed biofilms compared to untreated samples. The aPDI treatment with PEG-GNSs@TBO caused significant changes in the integrity and morphology of biofilms, and the generation of reactive oxygen species (ROS) was observed.
Review
Biochemistry & Molecular Biology
Mariella Rosalia, Enrica Chiesa, Erika Maria Tottoli, Rossella Dorati, Ida Genta, Bice Conti, Silvia Pisani
Summary: Antimicrobial resistance, especially in Gram-negative bacteria, poses a significant challenge for antibiotic therapy. Repurposing Tobramycin into nanosized delivery systems has shown promising potential in overcoming AMR. Tobramycin's broad spectrum and fast bactericidal effect make it an attractive candidate for nanomedicine formulation despite its side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)