Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms20122988
Keywords
pancreatic cancer; CKAAKN peptide; MRI contrast agent; polymer
Funding
- National Natural Science Foundation of China [81760643, 81571662]
- Guizhou Province Medicinal-Edible Homology Plant Resources Development Engineering and Technology Research Center [Qiankehe G (2015)4001]
- Program for Basic Research of Guizhou Province [Qiankehe Basics (2019)1039]
- Guizhou Provincial Department of Science and Technology [Qiankehe Platform Talent (2017)5735-28]
- Zhejiang Provincial Health Commission [2018KY833]
- Natural Science Foundation of Zhejiang Province [LQ19H180007]
- Guizhou discipline construction project [GNYL(2017)008]
- Guizhou University of Traditional Chinese Medicine
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Pancreatic cancer is a concealed and highly malignant tumor, and its early diagnosis plays an increasingly weighty role during the course of cancer treatment. In this study, we developed a polymeric magnetic resonance imaging (MRI) nanoplatform for MRI contrast agents. To improve tumor-targeting delivery of MRI contrast agents, we employed a pancreatic cancer targeting CKAAKN peptide to prepare a peptide-functionalized amphiphilic hyaluronic acid-vitamin E succinate polymer (CKAAKN-HA-VES) for delivering ultra-small superparamagnetic iron oxide (USPIO), namely, CKAAKN-HA-VES@USPIO. With the modification of the CKAAKN peptide, CKAAKN-HA-VES@USPIO could specifically internalize into CKAAKN-positive BxPC-3 cells. The CKAAKN-HA-VES@USPIO nanoparticles presented a more specific accumulation into pancreatic cancer cells than normal pancreatic cells, and an obvious decrease in signal intensity was observed in CKAAKN-positive BxPC-3 cells, compared with CKAAKN-negative HPDE6-C7 cells and non-targeting HA-VES@USPIO nanoparticles. The results demonstrated that our polymeric MRI nanoplatform could selectively internalize into CKAAKN-positive pancreatic cancer cells by the specific binding of CKAAKN peptide with pancreatic cancer cell membrane receptors, which provided a novel polymeric MRI contrast agent with high specificity for pancreatic cancer diagnosis, and makes it a very promising candidate for magnetic resonance imaging contrast enhancement.
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