Article
Medicine, General & Internal
Michelle Petri, Ian N. Bruce, Thomas Doerner, Yoshiya Tanaka, Eric F. Morand, Kenneth C. Kalunian, Mario H. Cardiel, Maria E. Silk, Christina L. Dickson, Gabriella Meszaros, Lu Zhang, Bochao Jia, Youna Zhao, Conor J. McVeigh, Marta Mosca
Summary: Baricitinib, an oral inhibitor of Janus kinase 1 and 2, was evaluated as a treatment for patients with systemic lupus erythematosus (SLE) in a 52-week phase 3 study. The study found that baricitinib did not significantly improve SLE disease activity compared with placebo, and there were no new safety concerns.
Review
Medicine, Research & Experimental
Jianguo Zhou, Shiwei Liu, Shengrong Bi, Weihao Kong, Rui Qian, Xunlu Xie, Ming Zeng, Xiaowei Jiang, Zhibin Liao, Ming Shuai, Wei Liu, Long Cheng, Moujian Wu
Summary: Osteoporosis is a worldwide health issue characterized by imbalanced bone remodeling. The receptor for advanced glycation end product (RAGE), a transmembrane protein in the immunoglobin family, has been involved in many chronic diseases, including osteoporosis. Activation of RAGE signaling negatively affects bone remodeling by regulating osteoblast proliferation and differentiation, as well as osteoclastogenesis. The review discusses the structure of RAGE and its biological functions in the pathogenesis of osteoporosis, suggesting RAGE signaling as a potential therapeutic target.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Ami Schattner
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse and atypical presentations. Early diagnosis is crucial for better outcomes, but the nonspecific symptoms and unusual organ involvement often lead to diagnostic delays.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Ching-Mao Chang, Jr-Rung Lin, Tieh-Cheng Fu
Summary: The study found that in the United States, patients diagnosed with RA are less likely to develop HF or MI compared to those with SLE. There was no significant association between sarcopenia and the presence of HF or MI.
FRONTIERS IN MEDICINE
(2022)
Review
Neurosciences
Griffith Kyle Otazu, Mojtaba Dayyani, Behnam Badie
Summary: Gliomas, the most common form of brain cancer, have inconsistent response to immunotherapy despite its success in some cancer types. The RAGE pathway plays a crucial role in glioma progression, and inhibiting this pathway could disrupt cancer growth and metastasis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Harbinder Singh, Devendra K. Agrawal
Summary: In this article, the authors critically review the structural and functional mechanism of HMGB1 and RAGE in mediating inflammatory processes. They also summarize the recent therapeutic approaches that target the communication between HMGB1 and RAGE using small molecules, as well as their clinical progression in treating various inflammatory disorders. The article highlights the gaps in knowledge and future directions for the therapeutic potential of key molecules in HMGB1/RAGE signaling in inflammatory diseases.
Review
Pharmacology & Pharmacy
Yurong Huang, Qiuyun Xue, Chenglong Cheng, Yuting Wang, Xiao Wang, Jun Chang, Chenggui Miao
Summary: CircRNAs play an important role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and may become potential biomarkers. However, more comprehensive research is needed on the function and mechanism of circRNAs in autoimmune diseases.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cheuk-Chun Szeto, Ho So, Peter Yam-Kau Poon, Cathy Choi-Wan Luk, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Fernand Mac-Moune Lai, Lai-Shan Tam
Summary: Through the study of three cohorts of lupus nephritis patients and controls, we identified specific lncRNA targets in urine that are associated with the severity and histological classification of lupus nephritis. These urinary lncRNA levels may serve as biomarkers for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Xinyi Lv, Xiaomin Liu, Ming Zhao, Haijing Wu, Wuiguang Zhang, Qianjin Lu, Xiangmei Chen
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with limited targeted therapy. Recent studies suggest that RNA methylation may be related to the pathogenesis of SLE. Although some evidence supports the association between RNA methylation and SLE pathogenesis, further in-depth research and analysis are needed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang, Anne Davidson
Summary: The study found significant disruption of renal circadian rhythms in mice with lupus nephritis, affecting multiple renal pathways including homeostasis, metabolism, and blood pressure regulation. Induction of remission therapy partially reversed this circadian dysregulation.
MOLECULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Lin Chen, Xuejiao Sun, Xiaoning Zhong
Summary: Smoking is a significant risk factor for COPD, and even after smoking cessation, chronic lung inflammation and COPD progression continue. Current anti-inflammatory therapies are ineffective, highlighting the need for new molecular targets. RAGE, a genetic determinant of low lung function and COPD susceptibility, plays a crucial role in COPD pathogenesis. Both innate and acquired immunity are essential in the development of chronic inflammation and emphysema in COPD, where RAGE and its ligand HMGB1 contribute.
POSTGRADUATE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sakshi Taneja, Stefan W. Vetter, Estelle Leclerc
Summary: Hypoxia, characterized by inadequate oxygen supply to tissues, is common in solid tumors. Cellular response to hypoxic conditions is mediated by activating HIFs, which control the expression of many target genes. Recent studies suggest that RAGE signaling plays a crucial role in tumor biology under hypoxic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ming Yang, Pengpeng Cao, Zhidan Zhao, Zheyu Wang, Chen Jia, Yunkai Guo, Heng Yin, Ming Zhao, Yan Ding, Haijing Wu, Qianjin Lu
Summary: In this study, we investigated the expression levels of CCR4, CCR6 and CXCR3 on Tfh-like cells in the peripheral blood and skin lesions of SLE patients and normal controls. The results showed a decreased expression of CXCR3 on Tfh-like cells in lupus peripheral blood, while an increased expression was observed in skin lesions. Additionally, higher levels of CXCR3 were found in Tfh cells from human tonsils, suggesting a potential role of CXCR3 in guiding Tfh-like cells to migrate to inflammatory sites.
CLINICAL IMMUNOLOGY
(2021)
Article
Rheumatology
Patricia Corzo Garcia, Ivan Garcia-Duitama, Anna Agusti Claramunt, Xavier Duran Jorda, Jordi Monfort, Tarek C. Salman-Monte
Summary: Objective Joint involvement in SLE is frequent but underestimated. This study used contrasted MRI to describe the prevalence of joint and tendon involvement in hand and wrist of SLE patients, including those without symptoms. The results showed a high prevalence of inflammatory musculoskeletal alterations in SLE patients.
Article
Biochemistry & Molecular Biology
Pei-Fang Hsieh, Cheng-Chia Yu, Pei-Ming Chu, Pei-Ling Hsieh
Summary: The study demonstrated that verbascoside has a positive effect on improving cell viability and wound healing capacity under high glucose conditions, potentially by reducing oxidative stress to alleviate cytotoxicity and promote healing. Additionally, verbascoside exerts its reparative effects through modulation of multiple signaling pathways.
Article
Chemistry, Multidisciplinary
Stefan Woerner, Bernhard N. Bohnert, Matthias Woern, Mengyun Xiao, Andrea Janessa, Andreas L. Birkenfeld, Kerstin Amann, Christoph Daniel, Ferruh Artunc
Summary: High doses of aprotinin exert nephrotoxic effects in healthy mice by accumulating in the tubular system, inhibiting proximal tubular function, and counterregulatory stimulation of ENaC-mediated sodium transport. Under a low-salt diet, aprotinin impaired sodium preservation, stimulated excessive hyperaldosteronism, and unexpectedly, activated ENaC.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Haizhang Chen, Andrea Maul-Pavicic, Martin Holzer, Magdalena Huber, Ulrich Salzer, Nina Chevalier, Reinhard E. Voll, Hartmut Hengel, Philipp Kolb
Summary: The study developed a test system for detecting and quantifying the bioactivity of sICs, identifying Fc gamma RIIA(H) and Fc gamma RIIIA as the most sensitive Fc gamma Rs. The research has predictive capabilities regarding the severity of SLE disease and provides a sensitive and scalable tool for evaluating the size, amount, and bioactivity of sICs.
EMBO MOLECULAR MEDICINE
(2022)
Article
Urology & Nephrology
Wiebke Pirschel, Antonio N. Mestekemper, Bianka Wissuwa, Nadine Krieg, Sarah Kroller, Christoph Daniel, Florian Gunzer, Emanuela Tolosano, Michael Bauer, Kerstin Amann, Stefan H. Heinemann, Sina M. Coldewey
Summary: Thrombotic microangiopathy, hemolysis and acute kidney injury are typical characteristics of HUS. This study investigated the impact of haptoglobin and hemopexin on HUS. The results showed that haptoglobin deficiency decreased survival rate, while hemopexin deficiency reduced kidney inflammation and thrombotic microangiopathy. Low dose haptoglobin administration attenuated kidney damage. Signs of kidney hemoglobin degradation were observed in HUS.
KIDNEY INTERNATIONAL
(2022)
Article
Immunology
Janina Niederreiter, Christine Eck, Tajana Ries, Arndt Hartmann, Bruno Maerkl, Maike Buettner-Herold, Kerstin Amann, Christoph Daniel
Summary: Complement deposition is increased in the lungs and kidneys of critically ill COVID-19 patients, suggesting its involvement in exacerbating the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Maike Buettner-Herold, Nathalie Krieglstein, Teresa Chuva, Kaija Minuth, Frederick Pfister, Christoph Daniel, Monika Klewer, Anke Buttner, Fulvia Ferrazzi, Simone Bertz, Kerstin Amann
Summary: This study investigated the significance of light chain (LC) restriction or crystals (LC-R/C) in proximal tubules in the spectrum of LC-induced nephropathies. LC-R/C was found in a quarter of cases analyzed and was strongly associated with cast-NP, suggesting that a high load of clonal LC may be responsible for this phenomenon.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Eva Vonbrunn, Miriam Angeloni, Maike Buettner-Herold, Janina Mueller-Deile, Katharina Heller, Erik Bleich, Stefan Soellner, Kerstin Amann, Fulvia Ferrazzi, Christoph Daniel
Summary: This study explored the use of gene expression analysis of zero-time biopsies to predict complications in renal transplantation. The results showed marked differences in gene expression profiles between living and deceased donors, with some differentially expressed genes correlating with cold ischemia time. Additionally, immunoglobulin expression was found to be altered in transplants with rejection and previous acute renal failure. Further investigation is needed to confirm these findings in larger cohorts and to clarify the role of early immunoglobulin upregulation in zero-time biopsies.
FRONTIERS IN MEDICINE
(2022)
Article
Genetics & Heredity
Markus Toelle, Cornelia Henkel, Jaqueline Herrmann, Christoph Daniel, Milen Babic, Mengdi Xia, Anna M. Schulz, Kerstin Amann, Markus van der Giet, Mirjam Schuchardt
Summary: This study evaluated an adenine-based uremic mouse model to study medial vessel calcification and senescence-associated secretory phenotype (SASP) changes, providing a basis for understanding molecular pathogenesis and potential therapeutic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Cell Biology
Eva-Marie Bichlmayer, Lina Mahl, Leo Hesse, Eric Pion, Victoria Haller, Andreas Moehwald, Christina Hackl, Jens M. Werner, Hans J. Schlitt, Siegfried Schwarz, Philipp Kainz, Christoph Brochhausen, Christian Groeger, Felix Steger, Oliver Koelbl, Christoph Daniel, Kerstin Amann, Andre Kraus, Bjorn Buchholz, Thiha Aung, Silke Haerteis
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder that leads to the progressive enlargement of kidney cysts and renal failure. Current models for studying human cyst growth and drug trials are limited. In this study, a chorioallantoic membrane (CAM) model was used to culture renal tissue from ADPKD patients and mouse kidney slices, and successfully evaluated cystic tissue growth. The CAM model may provide a valuable platform for bridging the gap between animal studies and clinical trials of human cyst growth.
Article
Pathology
Nassim Bouteldja, David Laurin Hoelscher, Barbara Mara Klinkhammer, Roman David Buelow, Johannes Lotz, Nick Weiss, Christoph Daniel, Kerstin Amann, Peter Boor
Summary: This research proposes a novel concept of stain augmentation to develop stain-independent CNNs for digital pathology. It outperforms state-of-the-art techniques and enables segmentation on immunohistochemical stainings without additional annotations, achieving performance comparable to the annotated stain. Examples of application in inflammation and fibrosis quantification are presented, indicating the effectiveness of stain augmentation in deep-learning segmentation algorithms.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Eva Vonbrunn, Maike Buettner-Herold, Kerstin Amann, Christoph Daniel
Summary: Kidney transplantation is a life-saving strategy for end-stage renal disease patients, but long-term organ survival remains a challenge due to surgical techniques, immunosuppression, and organ shortage. The complement system, part of the innate immune system, plays a crucial role in transplantation-related pathological events. Dysregulation or activation of the complement system can lead to tissue damage and inflammation. This review discusses the role of the complement system in transplantation and potential therapeutic approaches.
Article
Biotechnology & Applied Microbiology
Michaela Alexandra Anna Fuchs, Julia Schrankl, Charlotte Wagner, Christoph Daniel, Armin Kurtz, Katharina Anna-Elisabeth Broeker
Summary: This study characterizes the cellular origin of Penk expression in renal fibrosis models and provides fundamental information about the potential new biomarker Penk.
Article
Multidisciplinary Sciences
Sambhasan Banerjee, Julian Baur, Christoph Daniel, Peter Benedikt Pfeiffer, Manuel Hitzenberger, Lukas Kuhn, Sebastian Wiese, Johan Bijzet, Christian Haupt, Kerstin U. Amann, Martin Zacharias, Bouke P. C. Hazenberg, Gunilla T. Westermark, Matthias Schmidt, Marcus Fandrich
Summary: This study reports the cryo-EM structures of AA amyloid fibrils from two patients with vascular AA amyloidosis, indicating that different disease variants in systemic amyloidosis are associated with different fibril structures.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Antoine N. Kraemer, Anna-Lena Schaefer, Dalina T. L. Sprenger, Bettina Sehnert, Johanna P. Williams, Aileen Luo, Laura Riechert, Qusai Al-Kayyal, Helene Dumortier, Jean-Daniel Fauny, Zoltan Winter, Kathrin Heim, Maike Hofmann, Martin Herrmann, Guido Heine, Reinhard E. Voll, Nina Chevalier
Summary: Vitamin D deficiency is highly prevalent worldwide and is associated with the development of systemic lupus erythematosus (SLE) and other immune-mediated diseases. In this study, low vitamin D intake was found to accelerate lupus progression in lupus-prone mice, possibly by affecting the regulatory phenotype of lymphocytes. Correcting vitamin D deficiency can not only prevent osteoporosis but also serve as an important component in the prevention and treatment of lupus and other immune-mediated diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Anna-Lena Schaefer, Paola Fernanda Ruiz-Aparicio, Antoine N. Kraemer, Nina Chevalier
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Salvador Cazorla-Vazquez, Peter Koesters, Simone Bertz, Frederick Pfister, Christoph Daniel, Mark Dedden, Sebastian Zundler, Tilman Jobst-Schwan, Kerstin Amann, Felix B. Engel
Summary: In this study, the expression of Gpr126 in zebrafish, mice, and humans during kidney development and adulthood was characterized using RNAscope technology. The results showed that Gpr126 was enriched in the epithelial lineage during nephrogenesis and persisted in various cell types in the adult kidney. Single-cell RNA sequencing analysis revealed that Gpr126 expression was detected in a distinct ionocyte sub-population in zebrafish, which is involved in acid secretion, pH buffering, and calcium regulation. The expression patterns of Gpr126 and related genes in mouse kidneys were highly similar. These findings provide insights into the spatio-temporal expression and potential physiological role of Gpr126 in the kidney.
