Unveiling the Interplay between the TLR4/MD2 Complex and HSP70 in the Human Cardiovascular System: A Computational Approach

HSP70 is a negative regulator of NLRP3 inflammasome activation

(2019) Pierre Martine et al.   Cell Death & Disease

Toll-Like Receptor 4 and Blood Pressure: Lessons From Animal Studies

(2019) Kenia Pedrosa Nunes et al.   Frontiers in Physiology

The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension

(2018) Bernardo Rodriguez-Iturbe et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting TLR4 signaling pathways: can therapeutics pay the toll for hypertension?

(2018) Kenia Pedrosa Nunes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bioconda: sustainable and comprehensive software distribution for the life sciences

(2018) Björn Grüning et al.   NATURE METHODS

Toll-Like Receptor 4 and Heat-Shock Protein 70: is it a New Target Pathway for Diabetic Vasculopathies?

(2018) Amanda Almeida de Oliveira et al.   CURRENT DRUG TARGETS

Mechanistic Insights into High Mobility Group Box-1 (HMGb1) induced Toll-like Receptor 4 (TLR4) Dimer Formation

(2018) Shan Sun et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats

(2018) Kenia Pedrosa Nunes et al.   Journal of Sexual Medicine

Modeling of Protein Structural Flexibility and Large-Scale Dynamics: Coarse-Grained Simulations and Elastic Network Models

(2018) Sebastian Kmiecik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective

(2017) Stefania Bellini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toll-like receptor 4 (TLR4) impairs nitric oxide contributing to Angiotensin II-induced cavernosal dysfunction

(2017) Kenia P. Nunes et al.   LIFE SCIENCES

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

Toll-Like Receptor 4 Inhibition Improves Oxidative Stress and Mitochondrial Health in Isoproterenol-Induced Cardiac Hypertrophy in Rats

(2017) Parmeshwar B. Katare et al.   Frontiers in Immunology

Putative model for heat shock protein 70 complexation with receptor of advanced glycation end products through fluorescence proximity assays and normal mode analyses

(2016) Marcelo Sartori Grunwald et al.   CELL STRESS & CHAPERONES

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

Computational Approaches to Toll-Like Receptor 4 Modulation

(2016) Jean-Marc Billod et al.   MOLECULES

Immune system and cardiovascular disease

(2016) Irene Fernández-Ruiz   Nature Reviews Cardiology

The emerging role of Toll-like receptor 4 in myocardial inflammation

(2016) Y Yang et al.   Cell Death & Disease

The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management

(2015) Mauricio Krause et al.   MEDIATORS OF INFLAMMATION

Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment

(2015) A Deguchi et al.   ONCOGENE

Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins

(2015) Gabrielle Stetz et al.   PLoS One

Substrate-binding domain conformational dynamics mediate Hsp70 allostery

(2015) Anastasia Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection

(2015) Muhammad Ayaz Anwar et al.   Scientific Reports

Tlr4 Deficiency Protects against Cardiac Pressure Overload Induced Hyperinflammation

(2015) Heidi Ehrentraut et al.   PLoS One

iMODS: internal coordinates normal mode analysis server

(2014) José Ramón López-Blanco et al.   NUCLEIC ACIDS RESEARCH

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Toll-Like Receptor 4 Upregulation by Angiotensin II Contributes to Hypertension and Vascular Dysfunction through Reactive Oxygen Species Production

(2014) Priscila R. De Batista et al.   PLoS One

Contribution of hydrogen bonds to protein stability

(2014) C. Nick Pace et al.   PROTEIN SCIENCE

Immunity, atherosclerosis and cardiovascular disease

(2013) Johan Frostegård   BMC Medicine

Lipid a from lipopolysaccharide recognition: Structure, dynamics and cooperativity by molecular dynamics simulations

(2013) Jose Antonio Garate et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Hsp70 chaperone dynamics and molecular mechanism

(2013) Matthias P. Mayer   TRENDS IN BIOCHEMICAL SCIENCES

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

(2012) Michael Luong et al.   Journal of Inflammation-London

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

The Emerging Role of Innate Immunity in the Heart and Vascular System

(2011) Douglas L. Mann   CIRCULATION RESEARCH

Role of Toll-like receptors in cardiovascular diseases

(2011) Jesus G. Vallejo   CLINICAL SCIENCE

Toll-like Receptor 4 (TLR4) Is Essential for Hsp70-like Protein 1 (HSP70L1) to Activate Dendritic Cells and Induce Th1 Response

(2011) Hongliang Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Toll-like receptor-4 and mitogen-activated protein kinase signal system are involved in activation of dendritic cells in patients with acute coronary syndrome

(2008) Lei Wang et al.   IMMUNOLOGY

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT