Review
Oncology
Yu-Ling Bin, Hong-Sai Hu, Feng Tian, Zhen-Hua Wen, Mei-Feng Yang, Ben-Hua Wu, Li-Sheng Wang, Jun Yao, De-Feng Li
Summary: This review summarizes the impact of metabolic reprogramming on the tumor microenvironment and overcoming drug resistance in gastric cancer, and discusses clinical studies on combination treatments with conventional chemotherapy or molecular targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Irislene Costa Pereira, Isabele Frazao Mascarenhas, Vinicius Cooper Capetini, Paulo Michel Pinheiro Ferreira, Marcelo Macedo Rogero, Francisco Leonardo Torres-Leal
Summary: This review provides an overview of metabolic changes in breast cancer, including the impact of restrictive diets on chemotherapy resistance, the therapeutic potential of diet on tumor progression, pathways related to metabolic health in oncology, and future perspectives in the field of oncological nutrition.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Yuxin Cui, Liting Li, Zhilei Li, Jie Yin, Jane Lane, Jiafu Ji, Wen G. Jiang
Summary: High expression of S100A11 in gastric cancer is associated with poor patient survival and serves as a tumour promoter by regulating MMP activity and EMT processes. Knockdown of S100A11 suppresses metastatic properties of gastric cancer cells, enhances cell adhesion, and decreases cell migration and invasion, while also sensitizing the cells to chemotherapeutic drugs like 5-FU and cisplatin.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Ziyou Lin, Jingwei Li, Jian Zhang, Weineng Feng, Jiaye Lu, Xiaofan Ma, Wen Ding, Shumin Ouyang, Jinjian Lu, Peibin Yue, Guohui Wan, Peiqing Liu, Xiaolei Zhang
Summary: Acquired resistance is a bottleneck for targeted therapy in lung cancer, and metabolic adaptation may contribute to it. This study discovered a novel mechanism of acquired resistance to EGFR tyrosine kinase inhibitors mediated by IGF2BP3-dependent cross-talk between epigenetic modifications and metabolic reprogramming. IGF2BP3 upregulation is associated with reduced overall survival in TKI-resistant non-small cell lung cancer patients.
Review
Oncology
Christopher McCann, Emma M. Kerr
Summary: Tumour cell metabolism plays a crucial role in promoting cancer cell survival, evasion of cell death, and development of therapeutic resistance. Targeting therapeutically-imposed metabolic dependencies can potentially revert metabolic reprogramming and enhance treatment efficacy.
Review
Biochemistry & Molecular Biology
Tai-Na Wu, Hui-Ming Chen, Lie-Fen Shyur
Summary: Triple-negative breast cancer is typically treated with chemotherapy, but drug resistance often leads to poor prognosis. Abnormal tumor metabolism and immune cells in the tumor microenvironment may impact tumor growth and resistance to treatment. Phytochemicals have the potential to alter tumor metabolism and reprogram the tumor microenvironment, potentially suppressing cancer metastasis and overcoming chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ying Hua Su, Li Ping Tang, Xiang Yu Zhao, Xian Sheng Zhang
Summary: Plant cells have a strong capacity for reproduction, as a single plant cell can give rise to a whole plant via somatic embryogenesis without fertilization. Reprogramming somatic cells into totipotent cells is a critical step in somatic embryogenesis, inducible by stimuli such as plant hormones, transcriptional regulators and stress. Key molecular regulators and associated networks that control cell fate transition from somatic to totipotent cells are highlighted, with several outstanding questions proposed for further understanding of plant cell totipotency mechanisms.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Oncology
Tong Yu, Archana Chandrabhan Jadhav, Jiabao B. Xu, Adrian L. L. Harris, Venugopal Nair, Wei E. E. Huang
Summary: Understanding the development of cancer resistance to therapies is crucial. Newcastle disease virus (NDV) is a promising oncolytic agent, but some colon cancer cells show resistance to NDV reinfection. By using Raman spectroscopic and stable isotopic techniques, we found that the resistant cells slow down their replication and divert energy to protein and lipid synthesis. Understanding metabolic reprogramming could aid in developing precision cancer treatments that target resistant cells at the single-cell level.
Article
Gastroenterology & Hepatology
Feda H. Hamdan, Amro M. Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L. Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A. Hahn, Jens T. Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J. Truty, Steven A. Johnsen
Summary: This study discovered a group of enhancers called iHUBs, which are involved in transcriptional reprogramming and chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Inhibiting or deleting iHUBs can decrease the transcription of target genes and sensitize resistant cells to chemotherapy. Targeting eRNA production or signaling pathways upstream of iHUB activation can restore chemotherapy responsiveness in vitro and in vivo.
Review
Cell Biology
Macus Hao-Ran Bao, Carmen Chak-Lui Wong
Summary: Hypoxia, a hallmark of solid cancers like hepatocellular carcinoma, contributes to drug resistance through molecular mechanisms. This review focuses on HIF-mediated metabolic reprogramming in drug resistance in HCC and suggests combination therapies targeting hypoxia-induced metabolic enzymes to overcome resistance. Efforts to identify novel mechanisms to combat refractory hypoxic HCC are crucial for developing more effective treatment regimens.
Article
Oncology
Weizhu Zhao, Kai Liu, Zhikun Sun, Longgang Wang, Bing Liu, Luguang Liu, Xianlin Qu, Zhixiang Cao, Jujie Sun, Jie Chai
Summary: This study utilized the i-CR system to establish individualized chemotherapy regimens for gastric cancer, successfully creating a primary tumor cell bank and conducting drug screening. Results showed high conservation between i-CR cells of P0 and P5, with drug susceptibility results consistent with clinical efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Renjun Gu, Yawen Xia, Pengfei Li, Defang Zou, Keqin Lu, Lang Ren, Hongru Zhang, Zhiguang Sun
Summary: Gastric cancer is a common type of cancer with surgery as the main treatment method. However, it is expensive and painful, and patients often experience recurrence. Ferroptosis, a form of cell death dependent on iron, provides a new perspective in cancer therapy. This review summarizes the latest findings on ferroptosis regulation in gastric cancer, discusses the potential of drugs and genes in inducing ferroptosis for treatment and drug resistance, explores the relationship between ferroptosis and the tumor microenvironment in gastric cancer, and suggests areas for future research to accelerate the clinical utility of ferroptosis induction as a treatment strategy for gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Bogdan B. Grigorash, Dominic van Essen, Guixian Liang, Laurent Grosse, Alexander Emelyanov, Zhixin Kang, Alexey Korablev, Benoit Kanzler, Clement Molina, Elsa Lopez, Oleg N. Demidov, Carmen Garrido, Feng Liu, Simona Saccani, Dmitry V. Bulavin
Summary: Depletion of senescent cells can promote the reprogramming of somatic cells into totipotent-like stem cells and have positive effects on tissue rejuvenation.
NATURE CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rina Fujiwara-Tani, Takamitsu Sasaki, Tadataka Takagi, Shiori Mori, Shingo Kishi, Yukiko Nishiguchi, Hitoshi Ohmori, Kiyomu Fujii, Hiroki Kuniyasu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is often detected at an advanced stage, leading to poor prognosis. Drug resistance, particularly to gemcitabine (GEM), is a challenge in PDAC treatment. In this study, metabolic changes were investigated between a GEM-resistant PDAC cell line and its parental cell line. It was found that suppression of oxidative phosphorylation contributed to GEM resistance by reducing ROS production. These findings provide a new approach for reducing GEM resistance in PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Xinguang Cao, Rui Li, Huihua Xiong, Jinfang Su, Changqing Guo, Tianqi An, Hong Zong, Ruihua Zhao
Summary: Among the four Pt(IV) complexes, complex 14 shows promising potential in reversing cisplatin resistance and enhancing anticancer efficiency through multiple mechanisms. Its low systematic toxicity makes it a potential novel P-gp-mediated MDR modulator with increased tumor inhibition compared to cisplatin and oxaliplatin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Manas R. Purohit, Lakkakula Saikrishna, Henu Verma, L. V. K. S. Bhaskar, Syed A. Hussain
Summary: This meta-analysis evaluated the association between the MTHFD1 gene 1958G > A variant and non-syndromic cleft lip and palate (NSCLP), finding no significant relationship between the variant and NSCLP risk. Further studies are needed to better understand the role of MTHFD1 gene polymorphisms in the etiopathogenesis of NSCLP.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2022)
Review
Urology & Nephrology
Udit Narayan Padhi, Madhubala Mulkalwar, Lakkakula Saikrishna, Henu Kumar Verma, L. V. K. S. Bhaskar
Summary: The meta-analysis indicated that NOS3 intron 4a/b polymorphism is significantly associated with increased risk of ESRD in ADPKD patients. However, there was no significant association found between NOS3 894G>T (Glu298Asp) polymorphism and risk of ESRD in ADPKD patients.
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Article
Oncology
Giuseppina Bruno, Valeria Li Bergolis, Annamaria Piscazzi, Fabiana Crispo, Valentina Condelli, Pietro Zoppoli, Francesca Maddalena, Michele Pietrafesa, Guido Giordano, Danilo Swann Matassa, Franca Esposito, Matteo Landriscina
Summary: The study reveals the role of the TRAP1 gene in the adaptive response of human colorectal cancer cells to hypoxia. TRAP1 is involved in regulating HIF-1α stabilization, glycolytic metabolism, and gene expression reprogramming. It also affects glucose uptake, lactate production, and ribosome biogenesis through the mTOR pathway.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Annamaria Piscazzi, Valentina Condelli, Fabiana Crispo, Anna Rita Daniela Coda, Giovanni Calice, Giuseppina Bruno, Santina Venuto, Daniele Tibullo, Guido Giordano, Michele Pietrafesa, Arcangelo Liso, Matteo Landriscina
Summary: IGFBP6 downregulation is associated with the progression of ovarian cancer and the development of platinum resistance.
Article
Oncology
Donatella Malanga, Carmelo Laudanna, Teresa Mirante, Fabiana Colelli, Simona Migliozzi, Pietro Zoppoli, Gianluca Santamaria, Luca Roberto, Carmela De Marco, Marzia Scarfo, Donatella Montanaro, Orlando Paciello, Serenella Papparella, Chiara Mignogna, Alfonso Baldi, Giuseppe Viglietto
Summary: The gain-of-function mutation AKT1E17K is demonstrated to be a bona fide oncogene for mammary epithelium, capable of efficiently initiating breast cancer in mice. The AKT1E17K strain may serve as an appropriate model for human basal-like breast cancer and may aid in the identification of novel therapies specific to this type of tumor.
Article
Biology
Giuseppina Divisato, Andrea M. Chiariello, Andrea Esposito, Pietro Zoppoli, Federico Zambelli, Maria Antonietta Elia, Graziano Pesole, Danny Incarnato, Fabiana Passaro, Silvia Piscitelli, Salvatore Oliviero, Mario Nicodemi, Silvia Parisi, Tommaso Russo
Summary: The study indicates that Hmga2 interacts with chromatin and nuclear lamina, affecting the establishment of inter-TAD interactions.
Review
Cell Biology
Poojarani Panda, Henu Kumar Verma, Saikrishna Lakkakula, Neha Merchant, Fairrul Kadir, Shamsur Rahman, Mohammad Saffree Jeffree, Bhaskar V. K. S. Lakkakula, Pasupuleti Visweswara Rao
Summary: Cardiovascular disease is a group of conditions that affect the blood vessels and the heart, and it is a leading cause of death worldwide. Oxidative stress, which generates reactive oxygen species, plays a vital role in the development of cardiovascular disease. Increased ROS production disrupts cell function and leads to inflammation and cell apoptosis. Mitochondria is the primary source of ROS production. Antioxidants can reduce oxidative stress in cardiovascular disease. Inflammation and endothelial dysfunction are also associated with cardiovascular disease.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Neurosciences
Tarun Sahu, Babita Pande, Meenakshi Sinha, Ramanjan Sinha, Henu Kumar Verma
Summary: This review focuses on the neurocognitive aspects of SCD patients, including the use of different imaging techniques, psychological batteries, associated neuromarkers, and interventions for managing cognitive deficiencies. Acute anemia caused by SCD can lead to cognitive impairments, which are associated with poor functional outcomes.
ANNALS OF NEUROSCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nani, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchiano, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo
Summary: TRPM8 is overexpressed in colorectal cancer and its high expression is associated with lower survival rate of patients and hyperactivation of related signaling pathways. TRPM8 may serve as a prognostic marker and potential drug target for colorectal cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Rosj Gallicchio, Alessia Giordano, Mariarita Milella, Rebecca Storto, Teresa Pellegrino, Anna Nardelli, Antonio Nappi, Luigia Tarricone, Giovanni Storto
Summary: This study retrospectively assessed the prognostic significance of somatostatin receptor (SSTR) standardized uptake value (SUVmax(sstr)), SSTR representative tumor volume (RTVsstr), and total lesion SSTR expression (TLsstr) obtained by [Ga-68]Ga-edotreotide PET/CT ([Ga-68]Ga-SSTR PET/CT) in patients with primary gastroenteropancreatic neuroendocrine tumors (GEP-NET) before surgery. The results showed that only RTVsstr values were predictive, and the magnitude of the SSTR representative tumor burden holds a predominant value for determining the response to therapy in GEP-NET patients before surgery, rather than the maximal SSTR representation at single voxel.
Article
Biochemistry & Molecular Biology
Simona Laurino, Mariarita Brancaccio, Tiziana Angrisano, Giovanni Calice, Sabino Russi, Pellegrino Mazzone, Giuseppina Di Paola, Michele Aieta, Vitina Grieco, Gabriella Bianchino, Geppino Falco, Tiziana Notarangelo
Summary: Gastric cancer, a leading cause of death globally, is difficult to treat with chemotherapy due to multidrug resistance. This study investigated the role of STAT3 in gastric cancer drug efficiency through gene expression analysis. The study found that gastric cancer cells become resistant to chemotherapy by activating alternative signaling pathways. However, inhibiting IL-6/STAT3 in combination with cisplatin treatment prevented STAT3 activation and increased lethality compared to single-agent treatment. This suggests that IL-6/STAT3 axis blockage may be a strategy to overcome resistance.
Article
Medicine, Research & Experimental
Ilaria Laurenzana, Luciana De Luca, Pietro Zoppoli, Giovanni Calice, Alessandro Sgambato, Angelo Michele Carella, Antonella Caivano, Stefania Trino
Summary: The methylation profile of HSPCs following AHSCT was analyzed and found to undergo changes that may be useful in transplant diagnostics. The methylation signature was also found to be related to patient outcome. This study suggests that the methylation profile of HSPCs can provide prognostic information for engraftment success and graft failure prediction in AHSCT.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
