Article
Chemistry, Analytical
Chang-Lin Hu, I-Cheng Cheng, Chih-Hsien Huang, Yu-Te Liao, Wei-Chieh Lin, Kun-Ju Tsai, Chih-Hsien Chi, Chang-Wen Chen, Chia-Hsi Wu, I-Te Lin, Chien-Ju Li, Chii-Wann Lin
Summary: The study proposed textile electrodes integrated with a clothing belt to address issues such as evaporation of conductive gel and deterioration of signal quality during long-term EIT usage. Experimental results validated the effectiveness of the portable EIT system, and performance comparison with commercial electrocardiogram electrodes was conducted.
Article
Computer Science, Information Systems
Matias Rusanen, Sami Myllymaa, Laura Kalevo, Katja Myllymaa, Juha Toyras, Timo Leppanen, Samu Kainulainen
Summary: In this study, the FocusBand textile electrodes were compared with medical-grade wet electrodes to investigate the differences in skin-electrode interface behavior and EEG signals' quality. The textile electrodes showed higher skin-electrode impedance initially, but this difference decreased over time, producing consistent EEG signals at forehead Fp1 and Fp2 locations. While the FocusBand device can be used to record forehead biopotential signals, the quality is not as consistent as with the medical-grade system.
Article
Chemistry, Analytical
Katya Arquilla, Laura Devendorf, Andrea K. Webb, Allison P. Anderson
Summary: Wearable physiological monitoring systems are increasingly important in autonomous health monitoring and human-computer interaction. We propose woven textile electrodes integrated into garments as an option for capturing complete ECG waveforms.
Article
Chemistry, Analytical
Chang-Lin Hu, Zong-Yan Lin, Shu-Yun Hu, I-Cheng Cheng, Chih-Hsien Huang, Yu-Hao Li, Chien-Ju Li, Chii-Wann Lin
Summary: This study proposes a method for detecting faulty electrodes using the differential voltage value of the detached electrode in an EIT system, and suggests the voltage-replace and voltage-shift methods to compensate for invalid data from the faulty electrodes.
Article
Engineering, Biomedical
Shang-You Yang, Yuan-Pin Lin
Summary: Wearable low-density dry EEG headsets have broad applications in decoding brain activity and brain-triggered interaction for healthy individuals. However, movement artifacts present challenges to their validity outside laboratory settings. This study explored the effectiveness of hardware and software solutions for low-density and dry EEG recordings in non-tethered settings. Results showed that active-electrode designs effectively corrected movement artifacts for dry electrodes, while the ASR pipeline was compromised by limited electrodes. This suggests that lightweight, minimally obtrusive dry EEG headsets should at least include an active-electrode infrastructure to maintain their validity and applicability in real-world scenarios.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Review
Materials Science, Textiles
Emanuel Gunnarsson, Fernando Seoane
Summary: The rise of interest in wearable sensing of bioelectrical signals has led to investigations on developing and evaluating such systems. An easy-to-use and reliable three-lead in vivo method is presented as a more accurate alternative to the common two-lead method for measuring skin-electrode impedance.
TEXTILE RESEARCH JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Chaehyun Kim, Ahram Jang, Sebin Kim, Sungbo Cho, Donghun Lee, Young-Joon Kim
Summary: In this study, a simple and minimally invasive ECG measurement system for mice was developed. It consists of a miniaturized wearable ECG monitoring device and a smartphone application that displays real-time ECG waveform and heart rate. The system proved to be feasible through validation experiments.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Yiping Huang, Yatong Song, Li Gou, Yuanwen Zou
Summary: Wearable flexible silver electrodes based on cowhide were prepared and tested for their waveform transmission and impedance. The results showed that these electrodes were comparable to standard gel electrodes when the skin is moist enough, and had higher signal-to-noise ratios than the standard electrodes in the standing posture.
Article
Engineering, Electrical & Electronic
Salvatore Andrea Pullano, Venkata Deepa Kota, Karthik Kakaraparty, Antonino S. Fiorillo, Ifana Mahbub
Summary: In this paper, an optically unobtrusive dry electrode based on the iono-electric properties of zeolite is developed and proposed for continuous electrocardiogram (ECG) monitoring. The electrical and bio-electrical characterizations are evaluated for different types of electrodes, and the results show that certain parameters lead to the best performance.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Baoliang Feng, Hua Wei, Binjun Shi, Dazheng Zhao, Sijia Ye, Gang Wu, Rong Wang, Guokun Zuo, Zhisheng Wu, Jing Chen, Changcheng Shi
Summary: In this study, a cECG system with hydrogel-textile electrode was proposed for sleeping heart monitoring. The experimental results showed that the signal-noise ratio of the system was close to the wet-electrode based ECG system, and all subjects' heart rates were within the normal range.
IEEE SENSORS JOURNAL
(2022)
Review
Chemistry, Analytical
C. M. Vidhya, Yogita Maithani, Jitendra P. P. Singh
Summary: The technology of wearable medical equipment has advanced to the point where it is now possible to monitor the electrocardiogram and electromyogram comfortably at home. Fabrics or textiles, which were once meant to protect the human body, have been developed into intelligent textile materials for healthcare monitoring. Conductive textile electrodes provide breathability and comfort, and recent advancements have been made in their fabrication for biopotential signal monitoring.
Article
Engineering, Electrical & Electronic
N. Sriraam, Avvaru Srinivasulu, V. S. Prakash
Summary: This research evaluates the performance of ultralow power flexible dry ECG sensors. The study reveals that the use of dry textile electrodes increases skin-electrode contact impedance over time. However, rinsing the textile electrode with saltwater or normal water reduces the impedance. The proposed system shows good matching with existing systems during treadmill tests and performs well for various activities.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Luisa Euler, Li Guo, Nils-Krister Persson
Summary: This study compared the effects of different knitting construction parameters on electrode contact impedance, identifying the optimal electrode construction for reducing impedance. Wet electrodes showed significantly lower contact impedance and outperformed dry electrodes, but pressure applied to the system could enhance the performance of dry electrodes.
Article
Chemistry, Analytical
Vignesh Ravichandran, Izabela Ciesielska-Wrobel, Md Abdullah al Rumonl, Dhaval Solanki, Kunal Mankodiya
Summary: This study focuses on the impedance characteristics of dry e-textile electrodes and a laser-cut knit electrode under various contact forces and moisture conditions. The results showed that certain electrodes exhibited a significant decrease in impedance after moisture exposure, indicating the impact of stitch design and moisture. However, after controlled drying, some electrodes experienced an increase in impedance. Overall, the knit electrode and embroidered electrodes demonstrated superior performance in terms of impedance, moisture retention, and ECG signal quality.
Article
Chemistry, Physical
Yuan Gao, Chuan Xie, Zijian Zheng
Summary: The increasing demand for portable and wearable electronics has led to a growing interest in flexible lithium-ion batteries and supercapacitors. Textile composite electrodes have shown great promise for flexible, high-capacity, and long-cycle-life textile-based electrochemical energy storage devices, compared to traditional metal-foil-supported electrodes. Challenges associated with textile composite electrodes and textile-based electrochemical energy storage devices are discussed, along with potential solutions.
ADVANCED ENERGY MATERIALS
(2021)
Article
Endocrinology & Metabolism
Shinya Abe, Reijo Kouhia, Riku Nikander, Nathaniel Narra, Jari Hyttinen, Harri Sievanen
Summary: This study compared the fracture loads during falls of different sports athletes and controls, and found that high impact and repetitive impact athletes had higher fracture loads in all fall directions, while odd-impact athletes had higher fracture loads in specific fall directions.
Article
Biophysics
Sanna Halonen, Ali Ovissi, Sonja Boyd, Juho Kari, Kai Kronstrom, Juhani Kosunen, Hanna Lauren, Kirsti Numminen, Harri Sievanen, Jari Hyttinen
Summary: This study evaluated the clinical feasibility of a novel bioimpedance biopsy needle system in liver biopsy and collected in vivo bioimpedance data from human liver and tumor tissues. The results showed significant differences in median bioimpedance values between liver and tumor tissue at certain frequency ranges. This study provides preliminary evidence that tumor tissue differs from liver tissue in vivo and this difference is frequency-dependent.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Engineering, Biomedical
Antti Paldanius, Bachir Dekdouk, Jussi Toivanen, Ville Kolehmainen, Jari Hyttinen
Summary: This study investigates the importance of accurate head modeling and the impact of head inhomogeneities on electrical impedance tomography (EIT) measurements. The results highlight the significant influence of accurate tissue geometry and conductivity on EIT measurements, particularly the conductivity of cerebrospinal fluid. The study emphasizes the need to consider detailed cerebrospinal fluid geometry in EIT calculations.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Michael Taynnan Barros, Harun Siljak, Peter Mullen, Constantinos Papadias, Jari Hyttinen, Nicola Marchetti
Summary: This paper proposes a novel objective classification model of biological neuronal morphology and electrical types and their networks based on the attributes of neuronal communication. Experimental results show that the proposed method achieves an accuracy of up to 70% for classification and up to 65% for inferring biological network structures using network tomography. Support Vector Machine (SVM) methods perform better among the used techniques.
Article
Physiology
Mohamadamin Forouzandehmehr, Michelangelo Paci, Jussi T. Koivumaki, Jari Hyttinen
Summary: This study uses a new metabolite-sensitive computational model to analyze the effects of HCM mutations and MAVA, BLEB, and OM on cell mechano-energetics. The results show that MAVA, BLEB, and OM have positive effects on HCM pathophysiology and can restore normal cellular function.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Johannes Virta, Markus Hannula, Katri Lindfors, Ilmari Tamminen, Juha Taavela, Heini Huhtala, Katri Kaukinen, Paeivi Saavalainen, Jari Hyttinen, Kalle Kurppa
Summary: This study validated the use of micro-CT imaging method for accurate evaluation of duodenal histomorphometry and mucosal surface areas. The method showed excellent accuracy and reproducibility, making it a powerful tool for diagnosing celiac disease and conducting clinical and pharmacological studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Elina Mantyla, Toni Montonen, Lucio Azzari, Salla Mattola, Markus Hannula, Maija Vihinen-Ranta, Jari Hyttinen, Minnamari Vippola, Alessandro Foi, Soile Nymark, Teemu O. Ihalainen
Summary: Investigation of nuclear lamina architecture relies on superresolved microscopy. We developed an iterative indirect immunofluorescence staining approach combined with expansion microscopy (ExM) and structured illumination microscopy to improve superresolution microscopy of sub-nuclear nanostructures like lamins. Our method provides technical improvements to ExM including three-dimensional-printed gel casting equipment, and shows potential in quantitative superresolution ExM imaging of nuclear lamina and revealing nanoscopic details of the lamin network organization.
MOLECULAR BIOLOGY OF THE CELL
(2023)
Article
Cell & Tissue Engineering
Aapo Tervonen, Sanna Korpela, Soile Nymark, Jari Hyttinen, Teemu O. Ihalainen
Summary: The influence of mechanical forces and microenvironment on cellular behavior has been recognized. This study utilized experimental and computational methods to investigate the effects of substrate stiffness and heterogeneities on force transduction and cellular deformation. It was found that substrate stiffness and gradients can impact strain redistribution in cell monolayers, and the cells' apico-basal elasticity can provide mechanical isolation between cell-cell junctions and focal adhesions.
CELLULAR AND MOLECULAR BIOENGINEERING
(2023)
Article
Engineering, Biomedical
Birhanu Belay, Elina Mantyla, Christian Maibohm, Oscar F. Silvestre, Jari Hyttinen, Jana B. Nieder, Teemu O. Ihalainen
Summary: Cellular physiology has traditionally been studied using two-dimensional cell culture substrates, which do not accurately mimic the in vivo extracellular environment and interactions. This has led to a demand for more complex model systems in life sciences. Micro-engineered scaffolds have shown promise in understanding the role of physical cues in regulating cellular functions. In this study, we used direct laser writing via two-photon polymerization to create substrates with different surface microtopographies, and combined this with advanced high-resolution spectral imaging to investigate the effects on cellular alignment, nuclear morphology, and mechanics. We found that certain microtopographies influenced cell behavior, such as actin organization and nuclear force transduction.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Cell & Tissue Engineering
Reetta Sartoneva, Kaarlo Paakinaho, Markus Hannula, Kirsi Kuismanen, Heini Huhtala, Jari Hyttinen, Susanna Miettinen
Summary: This study evaluated the effect of A2P on vaginal tissue engineering for the first time and the results are highly encouraging. The scPLCL(A2P) scaffold showed potential as a scaffold for vaginal tissue engineering, promoting the viability, proliferation, and collagen production of vaginal cells.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Oncology
Rachel Kerslake, Birhanu Belay, Suzana Panfilov, Marcia Hall, Ioannis Kyrou, Harpal S. S. Randeva, Jari Hyttinen, Emmanouil Karteris, Cristina Sisu
Summary: This study evaluates the impact of growth conditions on cancer cells and compares their behavior to traditional two-dimensional models using transcriptomics, clinical, and novel experimental data. The results show that variability in growth conditions can affect key cancer genes and biological processes. It highlights the need for future studies to identify the most suitable in vitro/preclinical model for studying tumor microenvironments.
Article
Cell & Tissue Engineering
Alma Kurki, Kaarlo Paakinaho, Markus Hannula, Jari Hyttinen, Susanna Miettinen, Reetta Sartoneva
Summary: Tissue engineering offers a new approach for reconstructing large urethral defects, which currently lack optimal repair methods. Cell-seeded scaffolds, including the novel scPLCL(A2P) scaffold, show promise in preventing urethral stricture and promoting urothelial and stromal tissue regeneration. The scPLCL(A2P) scaffold supports the growth and phenotype maintenance of human urothelial cells (hUC) and human adipose-derived stromal cells (hASC) in both mono- and coculture environments.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Inari Lyyra, Nina Sandberg, Vijay Singh Parihar, Markus Hannula, Heini Huhtala, Jari Hyttinen, Jonathan Massera, Minna Kellomaki
Summary: Polylactides (PLAs) have been extensively studied for biomedical engineering applications, but their rigidity limits their use. Blending them with more flexible polymers, such as polybutylene succinate (PBSu), results in softer materials and expands their potential applications. Bioactivity is a limitation of biopolymers, which can be improved by adding bioactive glass. Blending and compounding PLA/PBSu blends with bioactive glass enables the production of materials with a wide range of mechanical properties, suitable for tissue engineering applications.
MATERIALS TODAY COMMUNICATIONS
(2023)
Proceedings Paper
Computer Science, Theory & Methods
Barbara Genocchi, Annika Ahtiainen, Michael T. Barros, Jarno M. A. Tanskanen, Jari Hyttinen, Kerstin Lenk
Summary: The study found a feedback excitation loop between astrocytes and neurons, with added astrocytes stabilizing neuronal activity and increasing the overall activity levels. Astrocyte activation was driven by proximity to highly active neurons rather than through gap junctions.
PROCEEDINGS OF THE 8TH ACM INTERNATIONAL CONFERENCE ON NANOSCALE COMPUTING AND COMMUNICATION (ACM NANOCOM 2021)
(2021)
Proceedings Paper
Computer Science, Theory & Methods
Jari Hyttinen, Barbara Genocchi, Annika Ahtiainen, Jarno M. A. Tanskanen, Kerstin Lenk, Michael Taynnan Barros
Summary: Astrocytes are crucial in modulating brain homeostasis, synaptic signaling, and molecular propagation. They also play a significant role in plasticity, learning, and the development of various diseases at different scales within the brain.
PROCEEDINGS OF THE 8TH ACM INTERNATIONAL CONFERENCE ON NANOSCALE COMPUTING AND COMMUNICATION (ACM NANOCOM 2021)
(2021)