Article
Oncology
Irene Canales Ruiz, Maurizio Martelli, Laurie H. Sehn, Umberto Vitolo, Tina G. Nielsen, Gila Sellam, Alessia Bottos, Dirk Klingbiel, Lale Kostakoglu
Summary: This article studied the risk factors for early treatment failure in patients with diffuse large B-cell lymphoma and found that total metabolic tumor volume is an important indicator in identifying patients at risk of early treatment failure.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Multidisciplinary Sciences
Pierre Pinochet, Edgar Texte, Aspasia Stamatoullas-Bastard, Pierre Vera, Sorina-Dana Mihailescu, Stephanie Becker
Summary: The study demonstrates the prognostic value of initial total metabolic tumor volume (TMTV) in predicting outcomes for patients with advanced-stage Hodgkin's lymphoma (HL). TMTV is useful for predicting 5-year progression-free survival and PET response after chemotherapy, and remains a baseline prognostic factor even when considering other treatment variables.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
S. Jemaa, J. N. Paulson, M. Hutchings, L. Kostakoglu, J. Trotman, S. Tracy, A. de Crespigny, R. A. D. Carano, T. C. El-Galaly, T. G. Nielsen, T. Bengtsson
Summary: This study proposes an AI-based tool that enables real-time assessment of risk factors in DLBCL and improves prognostic evaluation and risk stratification of patients by extracting FDG-PET imaging metrics.
Article
Hematology
Enora Le Goff, Paul Blanc-Durand, Louise Roulin, Charlotte Lafont, Romain Loyaux, Diana-Laure MBoumbae, Ichrafe Benmaad, Alexis Claudel, Elsa Poullot, Cyrielle Robe, Guillaume Gricourt, Abdelrazak Aissat, Christiane Copie-Bergman, Francois Lemonnier, Philippe Gaulard, Emmanuel Itti, Corinne Haioun, Marie-Helene Delfau-Larue
Summary: This study aimed to evaluate the prognostic value of circulating tumour DNA (ctDNA) and total metabolic tumour volume (TMTV) in large B-cell lymphoma (LBCL). High ctDNA load or high TMTV were associated with shorter 1-year progression-free survival (PFS). Combining ctDNA load with TMTV improved risk stratification in aggressive LBCL patients. Therefore, high-risk patients may benefit from CAR T-cell therapy or bispecific antibodies as first-line treatments in the future.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huanyu Gong, Tiannv Li, Jianyong Li, Lijun Tang, Chongyang Ding
Summary: This study aimed to investigate the prognostic value of baseline metabolic parameters in AITL patients using F-18-FDG PET/CT imaging. Results showed that baseline TMTV and PIT were independent prognostic predictors in AITL patients, with the combination of TMTV and PIT potentially improving risk stratification and personalized therapy for these patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Romain-David Seban, Roman Rouzier, Aurelien Latouche, Nicolas Deleval, Jean-Marc Guinebretiere, Irene Buvat, Francois-Clement Bidard, Laurence Champion
Summary: The study found that high total metabolic tumor volume and high spleen glucose metabolism on baseline [F-18]-FDG PET/CT were associated with poor 5-year recurrence-free survival after surgical resection in patients with breast cancer of no special type. Spleen metabolism was inversely correlated with stromal tumor-infiltrating lymphocytes levels and may reflect an immunosuppressive tumor microenvironment.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alessio Annovazzi, Virginia Ferraresi, Sandra Rea, Michelangelo Russillo, Davide Renna, Silvia Carpano, Rosa Sciuto
Summary: The study found that baseline TMTV and metabolic response may be useful prognostic indicators for PFS and OS in patients with advanced melanoma treated with BRAF/MEK inhibitors.
EUROPEAN RADIOLOGY
(2022)
Article
Hematology
Lale Kostakoglu, Federico Mattiello, Maurizio Martelli, Laurie H. Sehn, David Belada, Chiara Ghiggi, Neil Chua, Eva Gonzalez-Barca, Xiaonan Hong, Antonio Pinto, Yuankai Shi, Yoichi Tatsumi, Christopher Bolen, Andrea Knapp, Gila Sellam, Tina Nielsen, Deniz Sahin, Umberto Vitolo, Marek Trneny
Summary: This study found that baseline total metabolic tumor volume and total lesion glycolysis are independent predictors of progression-free survival in treatment-naive diffuse large B-cell lymphoma patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chong Jiang, Kai Chen, Yue Teng, Chongyang Ding, Zhengyang Zhou, Yang Gao, Junhua Wu, Jian He, Kelei He, Junfeng Zhang
Summary: This study aims to demonstrate the effectiveness of automatic segmentation of diffuse large B-cell lymphoma (DLBCL) in 3D FDG-PET scans using a deep learning approach and validate its value in prognosis. The results showed that the FCN model with a U-Net architecture can accurately segment lymphoma lesions and allow fully automatic assessment of total metabolic tumor volume (TMTV) on PET scans for DLBCL patients. Furthermore, predictive TMTV (pTMTV) was shown to be an independent prognostic factor of survival in DLBCL patients.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peng Zhao, Tao Yu, Zheng Pan
Summary: The study findings suggest that NCCNIPI score and MTV are independent predictors of prognosis in DLBCL patients, which can be used for risk stratification and prognostic assessment.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian Eude, Florian Guisier, Mathieu Salaun, Luc Thiberville, Thibault Pressat-Laffouilhere, Pierre Vera, Pierre Decazes
Summary: This study evaluates the prognostic value of total tumour volume (TTV) by adding necrotic tumour volume (NTV) to metabolic tumour volume (MTV) in immunotherapy for non-small cell lung cancer (NSCLC) patients. The results show that TTV has a higher predictive value in prognostic assessment.
ANNALS OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mourtaza Karimdjee, Gauthier Delaby, Damien Huglo, Clio Baillet, Alexandre Willaume, Simon Dujardin, Alban Bailliez
Summary: New PET data-processing tools using artificial intelligence (AI) provide automated lesion selection and segmentation, allowing for the routine acquisition of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) at the clinical workstation. This study evaluated the implementation of AI in commercial software, demonstrating its reproducibility, time savings, and reliable performance. The results showed that AI-enabled software offers an automated, fast, and consistently performing tool for obtaining TMTV and TLG.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Xiaoyan Feng, Xin Wen, Ling Li, Zhenchang Sun, Xin Li, Lei Zhang, Jingjing Wu, Xiaorui Fu, Xinhua Wang, Hui Yu, Xinran Ma, Xudong Zhang, Xinli Xie, Xingmin Han, Mingzhi Zhang
Summary: This study found that high baseline SUVmax, TMTV, and TLG measured on PET-CT are strong predictors of worse outcome in T-LBL patients. A risk model integrating these parameters with CNS involvement can identify patients at high risk of disease progression.
CANCER RESEARCH AND TREATMENT
(2021)
Review
Oncology
Weibo Wen, Dongyuan Xu, Yongnan Piao, Xiangdan Li
Summary: The present study conducted a systematic review and meta-analysis on the prognostic value of SUVmax, TLG, and MTV in MPM cases, finding an association between increased SUVmax and TLG values with an increased risk of mortality. However, there was no significant relationship between increased MTV and overall survival. The study suggests that PET/CT can significantly impact the prognosis prediction in MPM cases.
CANCER CELL INTERNATIONAL
(2022)
Review
Hematology
Tarec Christoffer El-Galaly, Diego Villa, Chan Yoon Cheah, Lars C. Gormsen
Summary: Positron emission tomography/computed tomography (PET/CT) is used for lymphoma staging, with total metabolic tumor volume (tMTV) measured as a potential prognostic factor. However, there is no consensus on the definition and standardization of tMTV, and technical factors can influence its measurement. In certain lymphoma types, tMTV has been shown to predict progression-free survival and overall survival. However, the evaluation methods for the prognostic value of tMTV have limitations.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
