Article
Marine & Freshwater Biology
Marie-Jeanne Perrot-Minnot, Aude Balourdet, Olivier Musset
Summary: The study focused on the anesthetic effects of MS-222 and Eugenol in the freshwater amphipod Gammarus pulex, demonstrating the sedative and analgesic-like effects of MS-222, with Eugenol requiring a higher concentration for similar efficacy. Additionally, a new semi-automated electric shock device was used to induce nociception, offering a standardized and flexible protocol for studying nociceptive response and anesthesia in aquatic organisms.
AQUATIC TOXICOLOGY
(2021)
Article
Microbiology
Maja Chochevska, Elizabeta Jancovska Seniceva, Sanja Kostadinovic Velickovska, Galaba Naumova-Letia, Valentin Mirceski, Joao Miguel F. Rocha, Tuba Esatbeyoglu
Summary: The study found that all traditional homemade fruit vinegars had at least 10 times higher antioxidant activity than commercial fruit vinegars. Rose hip homemade vinegar showed the highest antioxidant capacity, while apple and persimmon homemade vinegars had the lowest levels of antioxidants, indicating the importance of fruit type in vinegar production. The use of traditional processes for fruit vinegar production showed promise in producing high-quality vinegars with high levels of health-promoting antioxidant capacities.
Article
Obstetrics & Gynecology
Hege N. N. Skytte, Jacob J. J. Christensen, Nina Gunnes, Kirsten B. B. Holven, Tove Lekva, Tore Henriksen, Trond M. M. Michelsen, Marie Cecilie P. Roland
Summary: This study aimed to compare the metabolic differences between women with preeclampsia and healthy pregnant women. The results showed that in early pregnancy, the metabolic differences were mainly influenced by body mass index (BMI), while in late pregnancy, specific metabolic changes related to preeclampsia were observed.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Biochemistry & Molecular Biology
Carolina Di Fabrizio, Veronica Giorgione, Asma Khalil, Colin E. Murdoch
Summary: Human pregnancy can be affected by various pathologies, including gestational diabetes mellitus and hypertensive disorders, which can have severe consequences. Health issues during pregnancy and postpartum contribute significantly to maternal mortality and morbidity. This review focuses on the latest evidence on oxidative stress in pregnancy complications, early diagnosis, and potential therapies.
Article
Peripheral Vascular Disease
Kyle R. Roell, Quaker E. Harmon, Kari Klungsoyr, Anna E. Bauer, Per Magnus, Stephanie M. Engel
Summary: This study investigated changes in gestational blood pressure trajectories among preeclampsia cases, finding that individuals with a more rapid increase in blood pressure and those with a high starting blood pressure experienced worse pregnancy outcomes.
Article
Peripheral Vascular Disease
Federica Piani, Davide Agnoletti, Alessandro Baracchi, Sara Scarduelli, Carmine Verde, Giovanni Tossetta, Elisa Montaguti, Giuliana Simonazzi, Daniela Degli Esposti, Claudio Borghi
Summary: The study aimed to test the relationship between serum uric acid to creatinine ratio (SUA/sCr) and the development of preeclampsia and maternal and neonatal complications. The results showed that higher SUA/sCr during pregnancy is associated with the development of preeclampsia and adverse pregnancy outcomes.
JOURNAL OF HYPERTENSION
(2023)
Article
Agronomy
Monika Sawicka, Piotr Latocha, Barbara Lata
Summary: Apples are consumed as one of the most popular fruits, with over ten thousand cultivars and diverse quality traits. Both consumers and producers are seeking new apple cultivars with specific quality attributes, such as resistance to stress and high health-promoting potential.
Review
Biochemistry & Molecular Biology
Ramana Vaka, Evangeline Deer, Babbette LaMarca
Summary: Despite extensive research, the pathogenesis of preeclampsia (PE) remains unclear and lacks FDA-approved treatments. Mitochondrial oxidative stress has been identified as a crucial factor in PE development and holds potential as a target for therapy.
Article
Food Science & Technology
Gultakin Hasanaliyeva, Eleni Chatzidimitrou, Juan Wang, Marcin Baranski, Nikolaos Volakakis, Panagiotis Pakos, Chris Seal, Eduardo A. S. Rosa, Emilia Markellou, Per Ole Iversen, Vanessa Vigar, Adam Willson, Bronwyn Barkla, Carlo Leifert, Leonidas Rempelos
Summary: The study found that grape variety choice had a more substantial effect on total phenolics, total antioxidant activity, and anthocyanins in grapes, while the production system had a relatively smaller impact. Organic Vidiano grapes had significantly higher total antioxidant activity compared to conventional Vidiano grapes, while production system did not have a significant effect on total antioxidant activity in Kotsifali and Villana grapes.
Review
Medicine, General & Internal
Elzbieta Poniedzialek-Czajkowska, Radzislaw Mierzynski, Dominik Dluski, Bozena Leszczynska-Gorzelak
Summary: Hypertensive disorders of pregnancy, such as preeclampsia, pose significant risks to both mother and fetus. Aspirin is currently the only recommended pharmacological agent for prevention in high-risk groups, while metformin shows potential as an interesting option for prophylaxis, although further research is needed to clarify its effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Eva G. Mulder, Chahinda Ghossein-Doha, Ella Cauffman, Veronica A. Lopes van Balen, Veronique M. M. M. Schiffer, Robert-Jan Alers, Jolien Oben, Luc Smits, Sander M. J. van Kuijk, Marc E. A. Spaanderman
Summary: Tailored circulatory normalization of nonphysiological hemodynamic changes during pregnancy can reduce the risk of recurrent preeclampsia in high-risk populations. This simple and innovative treatment strategy shows no adverse effects on offspring outcomes.
Article
Peripheral Vascular Disease
Anna Kivioja, Elli Toivonen, Jaakko Tyrmi, Sanni Ruotsalainen, Samuli Ripatti, Heini Huhtala, Tiina Jaaskelainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Tanja Saarela, Hannele Laivuori
Summary: The study found that the polygenic risk score for blood pressure (BP-PRS) is associated with an increased risk of preeclampsia and its severe subtypes, with women with high BP-PRS presenting higher blood pressure values during pregnancy.
Review
Physiology
Francisco J. Valenzuela-Melgarejo, Constanza Lagunas, Fabiola Carmona-Pasten, Kevins Jara-Medina, Gustavo Delgado
Summary: Disruption of factors in blood pressure regulation can lead to hypertension, with melatonin playing a crucial role during pregnancy in modulating physiological functions. Supplementation of melatonin can reduce blood pressure, prevent oxidative stress, and repair endothelial damage at the placental level.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michalina Bralewska, Tadeusz Pietrucha, Agata Sakowicz
Summary: Preeclampsia is a dangerous complication of pregnancy, with high risks of mortality and morbidity for both mother and fetus. The placenta, which produces hormones such as chromogranin A (CgA), is believed to play a central role in this condition. This study investigated the influence of the preeclamptic environment on CgA production in trophoblastic cell lines and tested the secretion of CgA-derived peptide catestatin (CST) as well as its correlation with apoptosis. The findings suggest that both CgA and CST may have roles in the complex pathogenesis of preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Giovanni Tossetta, Sonia Fantone, Federica Piani, Caterina Crescimanno, Andrea Ciavattini, Stefano Raffaele Giannubilo, Daniela Marzioni
Summary: Placentation is a crucial process for normal placental development and fetal growth. Preeclampsia (PE) is a pregnancy-related disorder involving hypertension and proteinuria. The NRF2/KEAP1 signaling pathway plays a protective role against oxidative stress in PE pregnancies. This review discusses the cellular modulators and compounds that can regulate the NRF2/KEAP1 pathway in preeclamptic pregnancies.
Article
Ophthalmology
Suryan Dunker, Bjorn Winkens, Frank van den Biggelaar, Rudy Nuijts, Pieter Jan Kruit, Mor Dickman
Summary: This Dutch registry study identified risk factors for rebubbling and early graft failure in DMEK. Rebubbling was associated with higher graft failure, while older recipient age and surgical complications were risk factors for rebubbling. Early graft failure risk factors included transplantation before 2016 and surgical complications. Rebubbling was also associated with significantly lower endothelial cell densities.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Gastroenterology & Hepatology
Michelle Bosman, Fabienne Smeets, Sigrid Elsenbruch, Jan Tack, Magnus Simren, Nicholas Talley, Bjorn Winkens, Ad Masclee, Daniel Keszthelyi
Summary: This study conducted a systematic review and meta-analysis to investigate the placebo response in pharmacological trials for functional dyspepsia (FD). The study found that the pooled placebo response rate ranged from 35.5% to 39.6% depending on the responder definition used. Lower baseline symptom scores were significantly associated with higher placebo response rates. The study suggests considering entry criteria based on symptom severity and separate reporting of core FD symptoms in future trials.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, General & Internal
M. M. Suverein, T. S. R. Delnoij, R. Lorusso, G. J. Brandon Bravo Bruinsma, L. Otterspoor, C. V. Elzo Kraemer, A. P. J. Vlaar, J. J. van der Heijden, E. Scholten, C. den Uil, T. Jansen, B. van den Bogaard, M. Kuijpers, K. Y. Lam, J. M. Montero Cabezas, A. H. G. Driessen, S. Z. H. Rittersma, B. G. Heijnen, D. Dos Reis Miranda, G. Bleeker, J. de Metz, R. S. Hermanides, J. Lopez Matta, S. Eberl, D. W. Donker, R. J. van Thiel, S. Akin, O. van Meer, J. Henriques, K. C. Bokhoven, L. Mandigers, J. J. H. Bunge, M. E. Bol, B. Winkens, B. Essers, P. W. Weerwind, J. G. Maessen, M. C. G. van de Poll
Summary: Extracorporeal cardiopulmonary resuscitation (CPR) and conventional CPR have similar effects on survival with a favorable neurologic outcome in patients with refractory out-of-hospital cardiac arrest.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Neurosciences
Elske Gravesteijn, Jos J. Adam, Ronald P. Mensink, Bjorn Winkens, Jogchum Plat
Summary: This study found that NWT-03 egg protein hydrolysate can improve cognitive function in patients with metabolic syndrome, especially in the executive function domain. The specific mechanism of action needs further research.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Sport Sciences
Yingyi Wu, Pascal W. M. Van Gerven, Renate H. M. de Groot, Bert O. O. Eijnde, Bjorn Winkens, Hans H. C. M. Savelberg
Summary: University students often engage in prolonged sitting, which negatively affects their cognition and mood. Light-intensity physical activity (LIPA) breaks may improve attention and executive functioning. However, interrupting sitting with LIPA did not have significant acute effects on attention, response inhibition, working memory updating, or mood.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Ophthalmology
Lotte M. J. Scheres, Frank J. H. M. van den Biggelaar, Bjorn Winkens, Stefani Kujovic-Aleksov, Rogier P. H. M. Muskens, Peter W. T. de Waard, Ronald M. P. C. de Crom, Paul J. G. Ernest, Benjamin J. Pijl, Wishal D. Ramdas, Laurentius J. van Rijn, Annelie Tan, Carmen D. Dirksen, Henny J. M. Beckers
Summary: This study aims to compare the effectiveness and cost-effectiveness of MicroShunt implantation with standard trabeculectomy, and to address the lack of evidence in this area. It also aims to determine if MicroShunt implantation is non-inferior to trabeculectomy in terms of postoperative intraocular pressure.
Editorial Material
Biochemistry & Molecular Biology
Guido R. M. M. Haenen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Anouk A. S. van den Bosch, Johanna M. A. Pijnenborg, Andrea Romano, Bjorn Winkens, Louis J. M. van der Putten, Roy F. P. M. Kruitwagen, Henrica M. J. Werner
Summary: This systematic review found that adipose tissue (AT) distribution plays a significant role in the development and prognosis of endometrial cancer (EC), correlating with obesity measures, histological subtypes, lymph node metastasis, and sex steroid levels. Further well-designed prospective studies are needed to explore these differences more specifically and understand how it can contribute to the prediction and therapy of EC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
L. M. Janssen, A. Rezazadeh Ardabili, M. J. L. Romberg-Camps, B. Winkens, R. J. van den Broek, J. Hulst, H. J. A. Verwijs, D. Keszthelyi, D. M. A. E. Jonkers, A. A. van Bodegraven, M. J. Pierik, Z. Mujagic
Summary: Abdominal pain is common in patients with IBD in remission and is associated with psychosocial factors. A more holistic treatment approach for patients with IBD suffering from abdominal pain may improve quality of care and subjective wellbeing.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Yaping Xu, Zhengwen Li, Yue Wang, Chujie Li, Ming Zhang, Haiming Chen, Wenxue Chen, Qiuping Zhong, Jianfei Pei, Weijun Chen, Guido R. M. M. Haenen, Mohamed Moalin
Summary: It has been found that 2R,3R-DHQ does not convert into quercetin in an oxidative environment, but forms an unstable oxidation product. The addition of glutathione leads to the formation of a 2R,3R-DHQ-GSH adduct, indicating oxidation of the B-ring. Ascorbate can reduce the quinone back to 2R,3R-DHQ. This suggests that the redox-modulating activity of 2R,3R-DHQ quinone resides in its B-ring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Monse W. M. Wieland, Walmari Pilz, Bjorn Winkens, Ann Hoeben, Anna C. H. Willemsen, Bernd Kremer, Laura W. J. Baijens
Summary: Oropharyngeal dysphagia, malnutrition, sarcopenia, and frailty are common risks in newly diagnosed head-and-neck cancer patients. Early identification through multi-domain screening can help prevent complications and improve treatment outcomes.
Article
Endocrinology & Metabolism
Kelly G. H. van de Pas, Maartje A. P. de Krom, Bjorn Winkens, Francois M. H. van Dielen, Anita C. E. Vreugdenhil
Summary: This study aimed to evaluate the health-related quality of life (HRQoL) in treatment-seeking children and adolescents with overweight, obesity, and severe obesity. The results showed that individuals with severe obesity had significantly lower physical and psychological wellbeing compared to those with overweight and obesity. It is important for lifestyle intervention programs to consider the specific needs of this vulnerable group.
Meeting Abstract
Gastroenterology & Hepatology
J. Snijkers, B. Winkens, L. Vork, Z. Z. Weerts, Z. Mujagic, C. Leue, J. Kruimel, D. Jonkers, A. Masclee, D. Keszthelyi
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Geriatrics & Gerontology
Anne G. R. Visser, Bjorn Winkens, Jos M. G. A. Schols, Rob Janknegt, Bartholomeus Spaetgens
Summary: This study assessed the impact of polypharmacy on 30-day COVID-related mortality in nursing home residents. The results showed that nursing home residents with a higher number of medications and who were not vaccinated had a higher 30-day COVID-related mortality. These findings have important implications for managing COVID-19 in the frail nursing home population.
EUROPEAN GERIATRIC MEDICINE
(2023)
